GREMLIN Database
Q97V75 - Molybdopterin oxidoreductase, iron-sulfur binding subunit
UniProt: Q97V75 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 409 (344)
Sequences: 107 (88)
Seq/√Len: 4.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
271_I275_A4.2060.91
69_P258_R2.9510.67
348_I355_S2.9450.67
198_L234_S2.9270.66
20_F60_S2.8850.65
279_F330_F2.8830.65
202_T301_K2.8580.64
238_A241_T2.7480.61
60_S64_N2.6530.58
28_C31_C2.6450.58
25_C31_C2.6450.58
25_C28_C2.6450.58
350_S354_R2.5820.56
288_T324_L2.5380.55
351_N357_V2.5020.53
16_L240_K2.4740.53
224_V268_L2.2800.46
77_A195_Y2.2760.46
268_L329_F2.2190.45
20_F64_N2.2180.44
285_L341_I1.9740.37
353_R356_N1.9660.37
350_S355_S1.9650.37
15_K239_R1.9500.36
346_I356_N1.9490.36
260_V283_A1.9350.36
103_W119_S1.8950.35
80_I195_Y1.8830.34
39_Y69_P1.8590.34
29_N32_V1.8400.33
69_P246_R1.8360.33
208_A221_I1.8280.33
188_H191_K1.8280.33
99_G201_F1.8190.33
20_F36_N1.8160.33
25_C35_C1.7870.32
31_C35_C1.7870.32
28_C35_C1.7870.32
336_T354_R1.7760.31
279_F319_I1.7710.31
60_S103_W1.7490.31
96_I247_V1.7390.30
18_F65_H1.7250.30
213_L278_L1.7030.29
21_D142_P1.6870.29
74_V104_A1.6800.29
332_H337_I1.6670.29
20_F202_T1.6660.29
96_I253_T1.6630.28
221_I313_V1.6250.27
285_L339_P1.6110.27
280_Y283_A1.6030.27
222_V281_Y1.5980.27
20_F103_W1.5930.27
284_I316_I1.5760.26
17_G30_A1.5740.26
51_T145_A1.5700.26
115_E346_I1.5600.26
33_D37_K1.5550.26
272_L329_F1.5430.25
69_P212_S1.5420.25
344_L358_R1.5410.25
52_H267_I1.5400.25
116_G246_R1.5320.25
167_T306_W1.5220.25
36_N60_S1.5160.25
351_N356_N1.5020.24
257_S261_L1.4890.24
348_I353_R1.4790.24
26_I64_N1.4700.24
223_S319_I1.4640.24
21_D264_S1.4510.23
339_P357_V1.4480.23
15_K199_L1.4370.23
222_V329_F1.4150.23
40_G193_E1.4030.22
286_F332_H1.3980.22
39_Y136_Y1.3950.22
329_F334_L1.3920.22
333_N356_N1.3780.22
343_T348_I1.3690.22
254_S306_W1.3670.21
228_V324_L1.3620.21
66_C71_C1.3530.21
63_C66_C1.3530.21
63_C71_C1.3530.21
155_E284_I1.3490.21
30_A169_P1.3430.21
328_Y351_N1.3380.21
198_L297_I1.3370.21
268_L347_E1.3340.21
222_V278_L1.3320.21
59_L80_I1.3310.21
19_I42_L1.3220.21
47_L238_A1.3210.21
352_N358_R1.3200.20
109_A122_H1.3090.20
338_I350_S1.3050.20
268_L348_I1.3020.20
116_G128_L1.3010.20
87_I255_W1.2910.20
14_R152_E1.2880.20
336_T352_N1.2810.20
337_I349_I1.2690.19
235_V272_L1.2660.19
47_L241_T1.2660.19
24_K143_T1.2640.19
347_E354_R1.2590.19
339_P348_I1.2560.19
45_R237_H1.2500.19
213_L349_I1.2420.19
237_H259_E1.2390.19
268_L271_I1.2360.19
231_L257_S1.2350.19
21_D25_C1.2340.19
21_D28_C1.2340.19
21_D31_C1.2340.19
337_I348_I1.2230.19
201_F244_F1.2200.19
182_L220_S1.2180.18
198_L237_H1.2180.18
69_P82_K1.2180.18
15_K123_F1.2130.18
346_I357_V1.2110.18
268_L340_L1.2100.18
338_I342_I1.2070.18
272_L275_A1.2050.18
18_F103_W1.1940.18
90_I146_L1.1840.18
42_L60_S1.1830.18
354_R357_V1.1820.18
199_L291_V1.1800.18
352_N356_N1.1790.18
352_N355_S1.1760.18
268_L344_L1.1680.18
270_Y339_P1.1680.18
237_H257_S1.1670.18
157_E322_M1.1660.18
45_R259_E1.1620.17
343_T346_I1.1550.17
344_L350_S1.1520.17
108_E143_T1.1440.17
238_A323_S1.1410.17
200_A291_V1.1380.17
51_T114_N1.1350.17
334_L342_I1.1340.17
329_F353_R1.1210.17
146_L201_F1.1210.17
69_P203_I1.1190.17
146_L255_W1.1120.17
208_A224_V1.1100.17
259_E298_Y1.0940.16
198_L259_E1.0910.16
225_I281_Y1.0860.16
145_A197_G1.0850.16
82_K258_R1.0810.16
335_T345_V1.0810.16
116_G315_F1.0800.16
328_Y350_S1.0790.16
192_E234_S1.0780.16
185_S239_R1.0720.16
77_A100_F1.0690.16
77_A238_A1.0650.16
234_S297_I1.0630.16
241_T323_S1.0620.16
80_I110_L1.0550.16
35_C71_C1.0440.15
35_C63_C1.0440.15
35_C66_C1.0440.15
87_I146_L1.0350.15
33_D68_N1.0210.15
32_V138_V1.0150.15
20_F119_S1.0130.15
212_S282_P1.0120.15
213_L320_F1.0120.15
96_I142_P1.0110.15
82_K298_Y0.9950.15
330_F342_I0.9950.15
16_L65_H0.9890.15
178_S330_F0.9860.14
319_I353_R0.9810.14
246_R258_R0.9780.14
345_V356_N0.9690.14
276_E338_I0.9640.14
36_N64_N0.9640.14
332_H348_I0.9630.14
222_V327_V0.9620.14
331_S335_T0.9580.14
32_V257_S0.9580.14
69_P223_S0.9570.14
131_G167_T0.9490.14
104_A300_L0.9450.14
130_E286_F0.9390.14
222_V227_L0.9350.14
104_A156_A0.9340.14
178_S229_A0.9340.14
200_A288_T0.9330.14
213_L338_I0.9260.14
270_Y282_P0.9200.13
24_K253_T0.9190.13
276_E344_L0.9180.13
69_P72_M0.9140.13
229_A334_L0.9120.13
96_I255_W0.9110.13
271_I344_L0.9090.13
328_Y357_V0.9060.13
313_V339_P0.9040.13
234_S261_L0.9010.13
223_S267_I0.8960.13
51_T91_R0.8950.13
22_H134_I0.8900.13
290_G307_Y0.8890.13
210_G323_S0.8880.13
315_F319_I0.8830.13
235_V267_I0.8750.13
126_D297_I0.8730.13
142_P256_L0.8720.13
209_L287_L0.8720.13
344_L351_N0.8720.13
167_T173_I0.8680.13
298_Y311_T0.8670.13
31_C66_C0.8640.13
28_C66_C0.8640.13
25_C71_C0.8640.13
25_C63_C0.8640.13
25_C66_C0.8640.13
28_C63_C0.8640.13
28_C71_C0.8640.13
31_C63_C0.8640.13
31_C71_C0.8640.13
275_A332_H0.8550.13
45_R198_L0.8550.13
317_G321_T0.8520.12
171_I182_L0.8510.12
224_V319_I0.8470.12
342_I355_S0.8450.12
329_F336_T0.8390.12
164_S169_P0.8390.12
60_S119_S0.8340.12
336_T351_N0.8340.12
214_F222_V0.8330.12
27_I31_C0.8330.12
169_P174_K0.8290.12
110_L239_R0.8280.12
348_I351_N0.8220.12
37_K144_G0.8170.12
65_H103_W0.8160.12
269_F352_N0.8160.12
107_Y303_R0.8120.12
18_F303_R0.8110.12
64_N91_R0.8090.12
235_V339_P0.8090.12
180_E329_F0.8060.12
77_A122_H0.8050.12
42_L64_N0.8050.12
275_A285_L0.8030.12
99_G204_G0.8020.12
285_L289_V0.8020.12
341_I347_E0.7970.12
286_F289_V0.7970.12
48_I80_I0.7960.12
76_P101_C0.7950.12
75_C121_C0.7950.12
86_G141_C0.7950.12
76_P124_C0.7950.12
76_P105_C0.7950.12
76_P121_C0.7950.12
124_C135_P0.7950.12
76_P120_K0.7950.12
75_C97_G0.7950.12
75_C101_C0.7950.12
75_C105_C0.7950.12
120_K124_C0.7950.12
76_P97_G0.7950.12
120_K137_C0.7950.12
76_P86_G0.7950.12
76_P95_C0.7950.12
124_C141_C0.7950.12
124_C137_C0.7950.12
75_C86_G0.7950.12
75_C120_K0.7950.12
137_C141_C0.7950.12
121_C141_C0.7950.12
121_C137_C0.7950.12
75_C95_C0.7950.12
75_C137_C0.7950.12
121_C135_P0.7950.12
135_P141_C0.7950.12
75_C135_P0.7950.12
75_C124_C0.7950.12
121_C124_C0.7950.12
120_K141_C0.7950.12
75_C141_C0.7950.12
120_K135_P0.7950.12
86_G97_G0.7950.12
95_C135_P0.7950.12
95_C137_C0.7950.12
95_C141_C0.7950.12
86_G95_C0.7950.12
86_G124_C0.7950.12
97_G105_C0.7950.12
97_G120_K0.7950.12
97_G121_C0.7950.12
95_C124_C0.7950.12
95_C121_C0.7950.12
95_C120_K0.7950.12
86_G101_C0.7950.12
86_G105_C0.7950.12
86_G120_K0.7950.12
86_G121_C0.7950.12
86_G135_P0.7950.12
86_G137_C0.7950.12
95_C101_C0.7950.12
95_C105_C0.7950.12
97_G124_C0.7950.12
97_G101_C0.7950.12
101_C141_C0.7950.12
101_C124_C0.7950.12
101_C135_P0.7950.12
101_C137_C0.7950.12
105_C137_C0.7950.12
105_C135_P0.7950.12
76_P141_C0.7950.12
76_P137_C0.7950.12
105_C124_C0.7950.12
105_C120_K0.7950.12
101_C121_C0.7950.12
105_C121_C0.7950.12
97_G135_P0.7950.12
97_G137_C0.7950.12
97_G141_C0.7950.12
76_P135_P0.7950.12
101_C105_C0.7950.12
101_C120_K0.7950.12
105_C141_C0.7950.12
93_D288_T0.7940.12
59_L170_R0.7940.12
343_T353_R0.7930.12
77_A321_T0.7930.12
23_N39_Y0.7930.12
178_S353_R0.7920.12
26_I149_G0.7890.12
286_F329_F0.7870.12
237_H298_Y0.7820.12
77_A241_T0.7790.12
342_I350_S0.7750.11
190_K304_P0.7660.11
39_Y197_G0.7650.11
104_A149_G0.7640.11
100_F199_L0.7620.11
109_A243_R0.7570.11
218_L226_L0.7560.11
272_L291_V0.7560.11
87_I142_P0.7560.11
281_Y330_F0.7550.11
22_H250_N0.7550.11
273_S301_K0.7540.11
56_K64_N0.7530.11
339_P342_I0.7530.11
193_E247_V0.7530.11
213_L344_L0.7520.11
108_E233_L0.7500.11
112_F244_F0.7490.11
169_P173_I0.7480.11
18_F240_K0.7460.11
99_G148_F0.7460.11
20_F26_I0.7410.11
157_E180_E0.7360.11
340_L351_N0.7340.11
142_P255_W0.7300.11
298_Y315_F0.7250.11
99_G146_L0.7240.11
26_I51_T0.7230.11
345_V349_I0.7170.11
110_L123_F0.7160.11
342_I347_E0.7110.11
29_N47_L0.7110.11
284_I288_T0.7100.11
17_G43_N0.7090.11
324_L344_L0.7080.11
90_I201_F0.7060.11
22_H64_N0.7050.11
341_I346_I0.7030.11
69_P145_A0.7030.11
269_F351_N0.7020.11
208_A313_V0.7020.11
16_L21_D0.7000.11
339_P353_R0.6960.10
178_S355_S0.6960.10
214_F266_A0.6950.10
36_N59_L0.6900.10
283_A335_T0.6820.10
136_Y238_A0.6820.10
167_T303_R0.6810.10
346_I349_I0.6800.10
48_I118_M0.6800.10
65_H119_S0.6780.10
333_N346_I0.6780.10
61_I80_I0.6770.10
74_V290_G0.6750.10
123_F239_R0.6750.10
341_I345_V0.6720.10
282_P351_N0.6700.10
21_D233_L0.6660.10
131_G224_V0.6610.10
27_I136_Y0.6580.10
190_K216_L0.6580.10
214_F278_L0.6570.10
221_I326_I0.6570.10
37_K61_I0.6550.10
19_I147_A0.6500.10
93_D331_S0.6500.10
348_I352_N0.6480.10
52_H123_F0.6480.10
68_N275_A0.6460.10
123_F315_F0.6440.10
55_S346_I0.6410.10
33_D41_D0.6410.10
249_Y293_S0.6410.10
18_F107_Y0.6410.10
341_I357_V0.6410.10
73_Q89_R0.6400.10
145_A166_I0.6390.10
80_I206_E0.6370.10
327_V338_I0.6340.10
145_A258_R0.6330.10
45_R60_S0.6300.10
100_F110_L0.6280.10
26_I31_C0.6280.10
130_E342_I0.6270.10
32_V122_H0.6270.10
295_I308_N0.6240.10
223_S280_Y0.6230.10
51_T64_N0.6230.10
30_A34_A0.6200.10
272_L340_L0.6200.10
346_I358_R0.6150.10
45_R298_Y0.6080.09
350_S357_V0.6070.09
233_L327_V0.6060.09
92_D314_S0.6040.09
208_A326_I0.6040.09
42_L114_N0.5970.09
257_S315_F0.5970.09
281_Y334_L0.5940.09
72_M81_E0.5930.09
32_V89_R0.5920.09
61_I64_N0.5910.09
26_I171_I0.5860.09
328_Y336_T0.5810.09
181_T316_I0.5810.09
259_E311_T0.5810.09
154_G288_T0.5800.09
344_L357_V0.5790.09
20_F42_L0.5790.09
344_L347_E0.5770.09
246_R257_S0.5760.09
122_H243_R0.5760.09
54_E207_F0.5730.09
277_P329_F0.5670.09
255_W303_R0.5670.09
36_N62_A0.5590.09
208_A264_S0.5590.09
26_I56_K0.5520.09
68_N233_L0.5520.09
207_F322_M0.5520.09
338_I356_N0.5500.09
288_T357_V0.5500.09
41_D111_K0.5490.09
82_K306_W0.5470.09
64_N103_W0.5460.09
122_H203_I0.5460.09
334_L353_R0.5460.09
214_F332_H0.5460.09
224_V336_T0.5440.09
29_N64_N0.5430.09
197_G239_R0.5430.09
269_F275_A0.5420.09
349_I353_R0.5400.09
33_D80_I0.5400.09
253_T287_L0.5370.09
201_F259_E0.5340.09
102_T227_L0.5340.09
65_H71_C0.5340.09
208_A235_V0.5310.09
175_Q178_S0.5310.09
54_E320_F0.5300.09
200_A271_I0.5270.09
161_L296_M0.5250.09
110_L118_M0.5240.09
87_I117_V0.5230.09
285_L337_I0.5220.09
232_L275_A0.5220.09
64_N119_S0.5220.09
38_A60_S0.5210.09
338_I344_L0.5180.09
107_Y167_T0.5180.09
218_L222_V0.5180.09
187_L325_P0.5170.09
23_N246_R0.5170.09
65_H240_K0.5150.09
337_I341_I0.5150.09
341_I350_S0.5140.09
255_W294_S0.5130.09
106_P167_T0.5110.08
27_I241_T0.5110.08
25_C30_A0.5100.08
61_I77_A0.5090.08
222_V344_L0.5090.08
267_I274_I0.5060.08
60_S250_N0.5060.08
150_W317_G0.5050.08
148_F185_S0.5030.08
48_I237_H0.5020.08
211_Y235_V0.5010.08
42_L162_P0.5000.08
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ivfB 1 0.5844 100 0.74 Contact Map
1ti6B 2 0.5746 100 0.746 Contact Map
1kqfB 3 0.5746 100 0.751 Contact Map
1h0hB 1 0.423 100 0.761 Contact Map
2vpzB 2 0.4303 100 0.766 Contact Map
1q16B 2 0.6993 100 0.816 Contact Map
4z3xE 2 0.3936 100 0.823 Contact Map
2vpzC 2 0.5061 99.8 0.871 Contact Map
3mm5B 2 0.4743 99.8 0.871 Contact Map
1jnrB 1 0.357 99.5 0.904 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0113 seconds.