GREMLIN Database
Q97V74 - Carbon monoxide dehydrogenase, large chain (CutA-5)
UniProt: Q97V74 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 762 (716)
Sequences: 5338 (3505)
Seq/√Len: 131.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
172_E286_K4.3681.00
39_L121_V4.2311.00
110_D113_E3.9031.00
382_T409_K3.7231.00
54_R122_D3.6831.00
174_T284_T3.6661.00
43_Y46_A3.6461.00
416_E419_D3.5891.00
290_K293_E3.5011.00
289_F369_I3.4521.00
298_I334_K3.4251.00
168_Y291_G3.2561.00
487_V526_V3.2481.00
375_I383_K3.1991.00
47_K126_E3.1971.00
168_Y290_K3.1811.00
34_Q60_F3.1701.00
294_I366_V3.0671.00
162_G166_K3.0651.00
39_L118_L3.0481.00
466_V493_I3.0471.00
159_F162_G3.0331.00
172_E284_T2.9441.00
490_V531_L2.8651.00
46_A125_Y2.8621.00
300_D336_R2.8371.00
43_Y127_P2.8231.00
329_K390_P2.7501.00
379_E383_K2.7481.00
45_W128_I2.7311.00
49_K124_D2.7211.00
558_T565_S2.7111.00
203_I217_L2.6741.00
286_K298_I2.6641.00
107_L254_A2.6401.00
109_R113_E2.5631.00
527_Y531_L2.5041.00
636_K700_E2.5001.00
731_I749_I2.4701.00
567_N570_E2.4631.00
202_T231_I2.4431.00
293_E383_K2.4351.00
746_E753_Y2.3541.00
432_L624_R2.3401.00
135_F282_H2.3371.00
36_M264_Y2.3351.00
193_D204_Y2.3101.00
375_I380_L2.3081.00
109_R260_R2.2971.00
200_N506_A2.2911.00
734_L749_I2.2751.00
52_P56_E2.2531.00
300_D338_S2.2451.00
61_N109_R2.2241.00
415_L620_G2.2161.00
624_R635_L2.2081.00
304_D344_K2.1951.00
229_R504_D2.1851.00
164_E288_L2.1831.00
369_I380_L2.1771.00
167_D288_L2.1331.00
136_K139_E2.1091.00
38_V250_M2.0981.00
410_K702_Q2.0901.00
410_K413_S2.0731.00
379_E382_T2.0661.00
465_D497_D2.0511.00
287_I365_L2.0481.00
382_T412_I2.0221.00
36_M105_L2.0181.00
42_N103_I2.0131.00
411_L620_G2.0091.00
460_I533_L2.0071.00
660_T699_F2.0031.00
169_H289_F1.9921.00
169_H291_G1.9741.00
52_P62_V1.9691.00
409_K413_S1.9491.00
661_T696_V1.9461.00
34_Q61_N1.9361.00
293_E329_K1.9351.00
176_R746_E1.9251.00
285_A365_L1.9191.00
621_I729_A1.9141.00
534_K538_R1.9091.00
9_V495_I1.8981.00
47_K94_E1.8691.00
51_D122_D1.8671.00
387_D390_P1.8601.00
378_I412_I1.8601.00
107_L258_T1.8531.00
458_M468_V1.8511.00
465_D499_K1.8441.00
484_S500_V1.8301.00
53_K56_E1.8221.00
54_R120_L1.8191.00
26_D263_K1.8191.00
47_K95_E1.8181.00
519_S647_I1.8141.00
461_D467_T1.8051.00
387_D405_R1.7971.00
108_G114_V1.7921.00
494_P497_D1.7781.00
105_L254_A1.7721.00
200_N227_K1.7671.00
133_D136_K1.7601.00
43_Y125_Y1.7591.00
486_V523_I1.7541.00
55_A121_V1.7461.00
548_E551_D1.7241.00
434_P624_R1.7231.00
36_M262_V1.7221.00
189_G265_I1.7061.00
414_Q700_E1.7051.00
183_A685_F1.7011.00
290_K295_L1.6861.00
10_K650_M1.6781.00
632_I754_V1.6721.00
652_V718_V1.6711.00
645_T705_I1.6651.00
164_E286_K1.6481.00
461_D465_D1.6451.00
371_K735_E1.6421.00
431_A626_D1.6401.00
410_K414_Q1.6311.00
118_L121_V1.6301.00
287_I369_I1.6291.00
466_V491_L1.6201.00
456_V526_V1.6191.00
750_T753_Y1.6191.00
441_Q617_N1.6151.00
184_P241_G1.6101.00
54_R57_E1.6081.00
403_N406_E1.6011.00
174_T282_H1.6001.00
458_M530_S1.5971.00
619_H637_Y1.5921.00
195_D198_S1.5871.00
45_W95_E1.5871.00
468_V487_V1.5841.00
637_Y660_T1.5841.00
646_M703_H1.5791.00
105_L250_M1.5721.00
287_I294_I1.5601.00
169_H372_V1.5561.00
555_D560_K1.5531.00
433_E627_K1.5521.00
25_I189_G1.5521.00
30_L33_M1.5441.00
532_K590_V1.5421.00
167_D295_L1.5411.00
405_R409_K1.5361.00
552_V559_V1.5251.00
284_T300_D1.5171.00
652_V703_H1.5101.00
202_T229_R1.5051.00
621_I637_Y1.5021.00
643_C646_M1.5001.00
161_Y334_K1.4851.00
538_R552_V1.4851.00
431_A627_K1.4841.00
414_Q702_Q1.4811.00
490_V713_L1.4761.00
412_I418_K1.4761.00
632_I734_L1.4711.00
30_L193_D1.4701.00
170_Y286_K1.4641.00
169_H290_K1.4521.00
169_H369_I1.4461.00
66_E94_E1.4461.00
497_D569_K1.4431.00
61_N260_R1.4391.00
382_T405_R1.4381.00
116_D120_L1.4341.00
95_E147_K1.4341.00
223_I228_V1.4311.00
636_K698_N1.4301.00
411_L618_A1.4281.00
161_Y165_P1.4211.00
663_G726_P1.4191.00
553_K560_K1.4121.00
634_I664_I1.4121.00
490_V527_Y1.4071.00
38_V264_Y1.4021.00
61_N257_L1.3941.00
367_K732_N1.3931.00
528_I532_K1.3901.00
163_E296_G1.3901.00
305_F313_Q1.3831.00
371_K736_D1.3831.00
169_H373_N1.3821.00
63_I254_A1.3811.00
294_I330_M1.3751.00
217_L228_V1.3751.00
164_E296_G1.3731.00
113_E117_A1.3661.00
63_I258_T1.3631.00
218_S228_V1.3591.00
292_D383_K1.3581.00
432_L633_K1.3561.00
26_D265_I1.3551.00
34_Q260_R1.3481.00
176_R282_H1.3461.00
482_A519_S1.3441.00
532_K535_E1.3401.00
33_M263_K1.3391.00
488_A498_V1.3391.00
547_V561_I1.3371.00
48_F123_V1.3321.00
289_F373_N1.3301.00
160_E164_E1.3291.00
539_E549_K1.3241.00
192_A203_I1.3241.00
221_F252_A1.3231.00
156_S336_R1.3151.00
363_E381_R1.3131.00
431_A628_D1.3091.00
30_L191_I1.3081.00
486_V519_S1.3061.00
541_L571_A1.3041.00
350_Y662_M1.3031.00
367_K377_E1.3021.00
199_G227_K1.3001.00
483_I526_V1.2941.00
407_A618_A1.2941.00
173_K368_S1.2941.00
373_N380_L1.2921.00
224_P227_K1.2911.00
638_V700_E1.2841.00
414_Q640_L1.2841.00
415_L638_V1.2681.00
432_L626_D1.2651.00
201_L223_I1.2631.00
163_E332_Y1.2601.00
215_T225_R1.2581.00
254_A262_V1.2571.00
95_E128_I1.2571.00
22_G234_D1.2531.00
646_M652_V1.2491.00
103_I123_V1.2481.00
283_Y361_V1.2401.00
156_S334_K1.2361.00
276_I348_G1.2351.00
65_F93_K1.2341.00
37_A118_L1.2341.00
192_A251_T1.2341.00
192_A255_S1.2311.00
665_G691_P1.2261.00
201_L252_A1.2261.00
280_D304_D1.2241.00
547_V551_D1.2241.00
625_V632_I1.2181.00
656_L660_T1.2141.00
630_G754_V1.2131.00
160_E163_E1.2121.00
623_I734_L1.2121.00
411_L640_L1.2060.99
673_E682_Q1.2050.99
164_E170_Y1.1990.99
56_E61_N1.1990.99
161_Y298_I1.1980.99
37_A111_R1.1970.99
183_A690_I1.1960.99
385_F408_L1.1860.99
42_N125_Y1.1840.99
12_V484_S1.1790.99
173_K372_V1.1780.99
413_S418_K1.1780.99
97_K101_E1.1770.99
640_L702_Q1.1770.99
360_L731_I1.1750.99
45_W129_E1.1750.99
40_R270_E1.1750.99
16_R21_K1.1680.99
632_I668_L1.1660.99
47_K128_I1.1610.99
289_F380_L1.1590.99
37_A115_Y1.1560.99
12_V481_T1.1550.99
302_V338_S1.1540.99
742_I749_I1.1520.99
560_K565_S1.1430.99
379_E418_K1.1400.99
497_D557_G1.1390.99
45_W343_N1.1390.99
204_Y231_I1.1380.99
15_L19_T1.1370.99
421_D424_T1.1310.99
37_A114_V1.1300.99
532_K536_K1.1290.99
485_Q648_N1.1270.99
29_Y33_M1.1270.99
33_M191_I1.1260.99
378_I438_L1.1260.99
524_S527_Y1.1240.99
457_Y469_F1.1170.99
49_K122_D1.1150.99
551_D561_I1.1150.99
484_S495_I1.1140.99
117_A120_L1.1030.99
146_H341_V1.1010.99
287_I297_A1.0990.99
410_K640_L1.0990.99
368_S743_N1.0960.99
434_P622_V1.0950.99
135_F176_R1.0950.99
289_F294_I1.0920.99
621_I634_I1.0900.99
50_L123_V1.0900.99
194_F256_I1.0880.99
538_R554_I1.0870.99
434_P635_L1.0870.99
195_D202_T1.0860.99
487_V530_S1.0860.99
288_L295_L1.0800.99
406_E410_K1.0800.99
38_V105_L1.0780.99
675_D679_I1.0720.99
103_I125_Y1.0720.99
163_E288_L1.0680.99
674_Y680_P1.0680.99
184_P271_H1.0670.99
407_A640_L1.0670.99
752_E756_Q1.0670.99
162_G165_P1.0580.99
642_D706_N1.0570.99
621_I730_I1.0520.99
469_F501_I1.0490.99
537_M571_A1.0490.99
551_D562_G1.0460.99
171_V372_V1.0450.99
111_R115_Y1.0450.99
420_K622_V1.0440.99
468_V498_V1.0440.99
166_K295_L1.0410.98
48_F103_I1.0410.98
190_V251_T1.0400.98
34_Q258_T1.0400.98
535_E539_E1.0390.98
540_Y571_A1.0390.98
421_D736_D1.0380.98
58_R109_R1.0360.98
195_D200_N1.0350.98
288_L296_G1.0350.98
467_T501_I1.0350.98
138_I340_V1.0350.98
91_L250_M1.0340.98
366_V380_L1.0320.98
166_K290_K1.0310.98
138_I153_I1.0300.98
238_G475_M1.0260.98
32_N260_R1.0260.98
171_V289_F1.0260.98
96_A125_Y1.0250.98
668_L730_I1.0230.98
406_E704_M1.0210.98
64_T91_L1.0190.98
554_I559_V1.0170.98
749_I753_Y1.0170.98
50_L121_V1.0120.98
194_F255_S1.0080.98
68_T253_L1.0050.98
671_K753_Y0.9980.98
546_N551_D0.9970.98
175_F365_L0.9950.98
235_S475_M0.9930.98
490_V530_S0.9920.98
181_L672_V0.9920.98
385_F405_R0.9900.98
46_A128_I0.9850.98
531_L535_E0.9820.98
63_I257_L0.9800.98
134_P302_V0.9790.98
669_L695_E0.9790.98
46_A123_V0.9760.98
544_M574_M0.9740.98
321_I335_F0.9720.98
749_I754_V0.9710.98
481_T485_Q0.9690.98
206_N242_K0.9660.98
168_Y295_L0.9630.97
279_P357_P0.9620.97
371_K739_K0.9600.97
63_I107_L0.9590.97
160_E298_I0.9580.97
182_P241_G0.9580.97
193_D202_T0.9580.97
106_V118_L0.9550.97
664_I696_V0.9520.97
223_I256_I0.9500.97
164_E298_I0.9480.97
367_K381_R0.9480.97
566_I574_M0.9480.97
171_V287_I0.9460.97
490_V534_K0.9440.97
65_F94_E0.9440.97
684_S687_D0.9430.97
302_V340_V0.9400.97
138_I302_V0.9390.97
460_I568_V0.9370.97
104_A121_V0.9340.97
45_W130_P0.9330.97
487_V498_V0.9290.97
422_K425_G0.9290.97
36_M254_A0.9290.97
193_D255_S0.9260.97
251_T264_Y0.9260.97
8_S653_D0.9240.97
653_D657_M0.9240.97
317_I337_V0.9230.97
535_E549_K0.9230.97
281_R320_Q0.9190.97
214_K225_R0.9140.97
472_T518_F0.9140.97
208_Q238_G0.9110.96
478_G651_I0.9110.96
131_I137_A0.9100.96
534_K554_I0.9090.96
528_I592_V0.9080.96
623_I634_I0.9080.96
378_I408_L0.9060.96
228_V252_A0.9050.96
63_I253_L0.9040.96
269_Y683_T0.9010.96
540_Y575_I0.9000.96
328_Y363_E0.8960.96
653_D703_H0.8920.96
286_K334_K0.8920.96
35_Y263_K0.8920.96
432_L627_K0.8910.96
160_E332_Y0.8910.96
408_L438_L0.8910.96
570_E573_N0.8890.96
457_Y591_S0.8860.96
406_E409_K0.8860.96
163_E295_L0.8850.96
485_Q649_P0.8840.96
16_R480_E0.8820.96
38_V102_P0.8810.96
422_K426_V0.8810.96
229_R506_A0.8790.96
223_I227_K0.8780.96
546_N561_I0.8780.96
459_R469_F0.8780.96
134_P282_H0.8780.96
467_T499_K0.8750.96
328_Y381_R0.8740.96
135_F174_T0.8720.95
62_V104_A0.8700.95
104_A123_V0.8700.95
160_E296_G0.8700.95
472_T479_H0.8700.95
537_M575_I0.8680.95
639_I660_T0.8660.95
48_F125_Y0.8660.95
537_M568_V0.8610.95
139_E142_S0.8610.95
243_I514_Y0.8610.95
423_Y426_V0.8600.95
408_L440_F0.8590.95
101_E308_Y0.8550.95
160_E334_K0.8530.95
39_L104_A0.8520.95
52_P121_V0.8520.95
680_P683_T0.8500.95
201_L256_I0.8500.95
298_I336_R0.8500.95
194_F199_G0.8470.95
170_Y288_L0.8390.94
532_K592_V0.8390.94
175_F368_S0.8380.94
206_N235_S0.8350.94
167_D296_G0.8340.94
114_V118_L0.8320.94
16_R234_D0.8310.94
17_F24_Y0.8310.94
281_R303_E0.8310.94
566_I571_A0.8310.94
52_P55_A0.8300.94
392_E398_I0.8290.94
52_P64_T0.8290.94
528_I531_L0.8290.94
108_G117_A0.8270.94
477_T513_F0.8260.94
643_C652_V0.8250.94
40_R274_S0.8210.94
430_F433_E0.8200.94
289_F365_L0.8200.94
533_L588_L0.8200.94
558_T567_N0.8200.94
132_T678_G0.8180.94
622_V636_K0.8180.94
39_L123_V0.8180.94
25_I28_I0.8180.94
364_N731_I0.8170.94
59_G117_A0.8170.94
53_K57_E0.8160.94
159_F332_Y0.8150.94
164_E167_D0.8140.94
46_A96_A0.8130.93
360_L364_N0.8120.93
67_D257_L0.8120.93
738_V757_L0.8110.93
445_V613_T0.8100.93
92_A96_A0.8100.93
50_L103_I0.8090.93
163_E167_D0.8060.93
460_I537_M0.8050.93
663_G723_A0.8050.93
486_V647_I0.8050.93
43_Y96_A0.8040.93
30_L204_Y0.8030.93
283_Y299_V0.8030.93
56_E66_E0.8020.93
735_E741_P0.8010.93
417_V420_K0.8000.93
675_D681_K0.8000.93
417_V438_L0.7990.93
188_N271_H0.7980.93
266_E271_H0.7980.93
56_E67_D0.7960.93
205_A213_F0.7960.93
362_L365_L0.7930.93
458_M533_L0.7900.92
285_A361_V0.7890.92
454_E522_G0.7880.92
625_V754_V0.7860.92
711_T715_T0.7860.92
9_V484_S0.7850.92
5_I489_D0.7850.92
466_V533_L0.7840.92
113_E116_D0.7840.92
187_T265_I0.7830.92
158_I163_E0.7820.92
440_F618_A0.7820.92
50_L62_V0.7800.92
129_E136_K0.7800.92
131_I343_N0.7800.92
619_H725_V0.7800.92
295_L332_Y0.7790.92
214_K505_T0.7790.92
172_E298_I0.7790.92
559_V571_A0.7760.92
115_Y267_T0.7760.92
685_F690_I0.7750.92
412_I417_V0.7740.92
468_V526_V0.7730.92
375_I379_E0.7730.92
489_D645_T0.7720.92
723_A727_P0.7720.92
643_C718_V0.7720.92
35_Y111_R0.7710.92
754_V757_L0.7700.91
380_L383_K0.7700.91
487_V490_V0.7700.91
307_A343_N0.7690.91
623_I632_I0.7690.91
360_L747_I0.7670.91
133_D282_H0.7670.91
482_A651_I0.7670.91
672_V680_P0.7660.91
254_A258_T0.7620.91
696_V699_F0.7610.91
142_S145_L0.7600.91
135_F302_V0.7600.91
210_P505_T0.7590.91
207_T213_F0.7590.91
458_M529_A0.7580.91
66_E93_K0.7580.91
140_P143_L0.7560.91
530_S533_L0.7560.91
297_A330_M0.7560.91
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213_F230_I0.5100.66
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238_G358_A0.5090.66
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731_I747_I0.5080.65
632_I751_P0.5080.65
414_Q638_V0.5080.65
436_S620_G0.5080.65
415_L418_K0.5070.65
486_V713_L0.5070.65
49_K66_E0.5070.65
99_F273_I0.5070.65
622_V635_L0.5070.65
287_I366_V0.5060.65
376_D380_L0.5060.65
137_A140_P0.5060.65
463_G497_D0.5060.65
144_I147_K0.5050.65
439_A728_A0.5050.65
130_P343_N0.5050.65
492_G556_N0.5040.65
38_V107_L0.5040.65
515_G659_G0.5040.65
407_A440_F0.5030.65
281_R357_P0.5030.65
164_E168_Y0.5030.65
370_S380_L0.5030.65
253_L257_L0.5030.65
181_L277_H0.5020.64
327_P440_F0.5020.64
566_I569_K0.5020.64
663_G667_S0.5010.64
425_G736_D0.5010.64
469_F507_G0.5010.64
370_S375_I0.5010.64
386_I399_Y0.5010.64
58_R61_N0.5000.64
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1rm6A 2 0.9659 100 0.128 Contact Map
1t3qB 2 0.9777 100 0.128 Contact Map
1ffvB 2 0.9724 100 0.135 Contact Map
1n62B 2 0.9751 100 0.139 Contact Map
2w3sB 2 0.9672 100 0.139 Contact Map
3uncA 2 0.9449 100 0.152 Contact Map
3nvzC 2 0.9423 100 0.165 Contact Map
3zyvA 3 0.9396 100 0.166 Contact Map
4usaA 2 0.9396 100 0.171 Contact Map
1dgjA 1 0.937 100 0.173 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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