GREMLIN Database
Q97V73 - Acyl-CoA dehydrogenase (Acd-5)
UniProt: Q97V73 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 398 (367)
Sequences: 33466 (18902)
Seq/√Len: 986.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
156_E228_K4.1781.00
160_N226_D3.9521.00
301_D341_R3.4731.00
33_V54_K3.3261.00
152_K231_T2.9631.00
153_L228_K2.9021.00
122_P127_D2.8791.00
113_E117_K2.8651.00
27_R85_E2.7931.00
194_S234_L2.7871.00
75_D78_S2.7511.00
40_R44_E2.7051.00
294_K345_R2.4341.00
273_N277_Q2.4081.00
122_P128_K2.3131.00
265_Q306_R2.2771.00
162_R223_L2.2641.00
179_A196_F2.1191.00
314_T318_N2.1121.00
237_E240_N2.0771.00
284_K287_E2.0741.00
113_E116_K2.0661.00
28_D32_N2.0551.00
153_L156_E2.0511.00
112_N115_L2.0271.00
357_T362_E2.0031.00
275_S349_V1.9951.00
362_E366_R1.9821.00
84_E306_R1.9351.00
240_N243_K1.9161.00
66_S108_S1.8971.00
175_Y200_K1.8801.00
157_Y196_F1.8471.00
337_E378_N1.8191.00
152_K238_E1.7981.00
19_H78_S1.7961.00
162_R221_E1.7631.00
268_L302_L1.7581.00
54_K57_E1.7481.00
53_Q57_E1.7451.00
265_Q269_E1.7351.00
153_L158_V1.7291.00
88_R269_E1.7271.00
279_S284_K1.7071.00
234_L238_E1.6871.00
158_V228_K1.6871.00
131_A175_Y1.6591.00
290_L293_T1.6451.00
151_K160_N1.6391.00
135_T165_F1.6341.00
315_L327_A1.6241.00
230_Q233_N1.6231.00
157_Y231_T1.6221.00
85_E88_R1.6171.00
275_S291_V1.6031.00
169_G220_A1.5951.00
202_A227_V1.5931.00
298_S342_I1.5931.00
155_G231_T1.5791.00
118_K232_E1.5631.00
304_V334_I1.5461.00
118_K122_P1.5421.00
199_E233_N1.5401.00
136_E163_K1.5371.00
158_V226_D1.5341.00
67_Q73_G1.5261.00
160_N225_E1.5251.00
20_E23_R1.5141.00
30_A89_I1.5141.00
353_Y359_T1.5121.00
122_P125_N1.5081.00
311_W315_L1.5031.00
19_H75_D1.4951.00
117_K121_I1.4921.00
90_W93_F1.4881.00
280_A288_F1.4871.00
21_L24_S1.4851.00
24_S28_D1.4821.00
69_L116_K1.4771.00
231_T234_L1.4741.00
291_V349_V1.4711.00
267_A343_I1.4641.00
283_K287_E1.4501.00
270_K273_N1.4481.00
150_A196_F1.4351.00
152_K156_E1.4271.00
303_E311_W1.4271.00
199_E202_A1.4201.00
159_I196_F1.4191.00
305_A335_S1.4131.00
21_L25_A1.4111.00
210_E357_T1.4061.00
266_A270_K1.3991.00
115_L119_Y1.3981.00
272_I276_L1.3831.00
23_R85_E1.3821.00
270_K360_G1.3811.00
333_F378_N1.3811.00
114_E118_K1.3811.00
19_H81_T1.3691.00
340_E372_K1.3651.00
344_L369_Q1.3591.00
88_R265_Q1.3561.00
341_R345_R1.3521.00
43_K210_E1.3511.00
298_S345_R1.3511.00
110_F247_S1.3491.00
84_E310_Y1.3441.00
170_D220_A1.3391.00
63_L82_A1.3331.00
207_S221_E1.3301.00
229_V233_N1.3261.00
77_L314_T1.3151.00
157_Y238_E1.3071.00
26_V60_L1.3041.00
114_E232_E1.3021.00
297_E382_R1.2861.00
76_Y317_R1.2791.00
49_L53_Q1.2791.00
156_E231_T1.2751.00
133_A166_I1.2621.00
17_Q20_E1.2581.00
84_E265_Q1.2571.00
202_A233_N1.2571.00
123_V130_A1.2501.00
264_G302_L1.2491.00
268_L272_I1.2341.00
152_K157_Y1.2341.00
302_L342_I1.2331.00
344_L372_K1.2291.00
20_E24_S1.2231.00
258_S309_T1.2181.00
271_M346_A1.2131.00
155_G228_K1.2091.00
17_Q21_L1.2081.00
252_A375_E1.2081.00
41_G216_S1.2071.00
116_K120_V1.2071.00
181_T194_S1.2061.00
80_L313_G1.1911.00
121_I125_N1.1881.00
242_F246_V1.1861.00
87_A94_S1.1841.00
264_G342_I1.1841.00
294_K379_D1.1831.00
75_D317_R1.1781.00
65_A124_A1.1781.00
311_W314_T1.1761.00
346_A361_L1.1761.00
339_A368_L1.1751.00
23_R81_T1.1731.00
74_A78_S1.1731.00
266_A364_M1.1691.00
151_K158_V1.1651.00
250_D325_T1.1631.00
118_K233_N1.1621.00
53_Q56_K1.1561.00
80_L258_S1.1561.00
270_K350_Y1.1551.00
119_Y174_Y1.1471.00
148_T159_I1.1461.00
25_A58_I1.1461.00
283_K288_F1.1431.00
149_T160_N1.1361.00
138_V147_K1.1361.00
315_L320_K1.1351.00
115_L197_V1.1261.00
111_G115_L1.1231.00
205_P225_E1.1221.00
299_L303_E1.1211.00
54_K58_I1.1211.00
329_S381_Q1.1151.00
37_Y41_G1.1141.00
177_I198_V1.1121.00
128_K173_D1.1081.00
159_I177_I1.1011.00
369_Q372_K1.1011.00
300_A330_L1.0991.00
26_V30_A1.0951.00
340_E344_L1.0921.00
178_A195_M1.0911.00
305_A338_S1.0901.00
228_K231_T1.0851.00
301_D345_R1.0761.00
261_L302_L1.0611.00
114_E117_K1.0571.00
133_A175_Y1.0571.00
53_Q127_D1.0561.00
39_E43_K1.0551.00
56_K61_Y1.0551.00
175_Y222_I1.0521.00
157_Y181_T1.0491.00
372_K378_N1.0481.00
159_I179_A1.0431.00
150_A179_A1.0421.00
25_A60_L1.0291.00
194_S238_E1.0281.00
130_A174_Y1.0241.00
151_K226_D1.0231.00
178_A193_I1.0231.00
154_D228_K1.0211.00
68_D117_K1.0181.00
37_Y40_R1.0181.00
177_I224_L1.0121.00
275_S285_L1.0051.00
206_V223_L1.0011.00
343_I368_L1.0011.00
103_F130_A0.9951.00
301_D338_S0.9911.00
333_F382_R0.9881.00
337_E341_R0.9841.00
109_R247_S0.9841.00
261_L309_T0.9831.00
337_E372_K0.9821.00
50_E53_Q0.9801.00
260_A371_M0.9781.00
142_D145_G0.9731.00
196_F234_L0.9641.00
213_G367_D0.9621.00
29_F54_K0.9621.00
133_A224_L0.9591.00
115_L233_N0.9551.00
340_E365_L0.9491.00
276_L286_A0.9461.00
151_K182_S0.9441.00
307_L311_W0.9411.00
159_I229_V0.9391.00
272_I295_V0.9371.00
267_A364_M0.9371.00
118_K199_E0.9311.00
378_N382_R0.9301.00
212_T365_L0.9281.00
26_V82_A0.9221.00
204_K227_V0.9211.00
43_K357_T0.9161.00
165_F353_Y0.9151.00
214_L370_I0.9121.00
42_E366_R0.9101.00
103_F176_L0.9071.00
338_S341_R0.9051.00
312_A331_A0.9021.00
337_E382_R0.9021.00
299_L330_L0.8971.00
49_L173_D0.8961.00
297_E301_D0.8941.00
65_A104_I0.8921.00
131_A200_K0.8921.00
370_I374_Y0.8921.00
30_A86_I0.8921.00
336_T378_N0.8901.00
112_N116_K0.8901.00
27_R31_E0.8801.00
174_Y199_E0.8761.00
141_S380_I0.8751.00
68_D113_E0.8731.00
29_F58_I0.8721.00
110_F244_Y0.8701.00
164_I221_E0.8701.00
269_E273_N0.8671.00
77_L317_R0.8671.00
131_A172_A0.8671.00
66_S69_L0.8631.00
275_S286_A0.8621.00
165_F356_T0.8611.00
347_M365_L0.8591.00
180_R193_I0.8571.00
92_S216_S0.8501.00
29_F55_A0.8451.00
134_V249_F0.8431.00
301_D334_I0.8431.00
203_V228_K0.8421.00
68_D71_G0.8371.00
340_E369_Q0.8371.00
371_M374_Y0.8361.00
173_D201_D0.8331.00
31_E88_R0.8331.00
273_N276_L0.8331.00
293_T383_I0.8321.00
69_L113_E0.8301.00
271_M349_V0.8291.00
275_S295_V0.8271.00
157_Y234_L0.8271.00
271_M350_Y0.8251.00
256_V375_E0.8241.00
196_F229_V0.8241.00
263_I368_L0.8211.00
39_E363_R0.8201.00
180_R183_P0.8171.00
55_A60_L0.8171.00
263_I339_A0.8171.00
338_S342_I0.8161.00
263_I364_M0.8131.00
37_Y50_E0.8121.00
264_G338_S0.8121.00
303_E306_R0.8061.00
174_Y197_V0.8041.00
156_E230_Q0.8011.00
146_I178_A0.8001.00
293_T297_E0.7991.00
347_M361_L0.7981.00
23_R27_R0.7961.00
156_E232_E0.7961.00
25_A28_D0.7961.00
133_A222_I0.7951.00
150_A181_T0.7911.00
343_I364_M0.7891.00
224_L227_V0.7871.00
212_T362_E0.7871.00
128_K174_Y0.7851.00
77_L310_Y0.7851.00
64_F79_L0.7841.00
19_H77_L0.7841.00
133_A177_I0.7831.00
303_E307_L0.7831.00
176_L195_M0.7821.00
292_Q383_I0.7801.00
261_L305_A0.7751.00
194_S239_G0.7751.00
29_F33_V0.7741.00
148_T163_K0.7731.00
257_A331_A0.7731.00
150_A157_Y0.7721.00
322_N327_A0.7691.00
136_E148_T0.7681.00
77_L81_T0.7671.00
294_K349_V0.7661.00
182_S192_G0.7651.00
298_S346_A0.7651.00
50_E54_K0.7631.00
344_L365_L0.7621.00
146_I193_I0.7601.00
159_I198_V0.7571.00
300_A334_I0.7561.00
285_L288_F0.7561.00
271_M275_S0.7561.00
270_K364_M0.7521.00
49_L171_I0.7491.00
51_A93_F0.7471.00
210_E215_R0.7441.00
194_S236_G0.7421.00
274_Y353_Y0.7421.00
68_D116_K0.7391.00
268_L299_L0.7391.00
348_S369_Q0.7381.00
297_E341_R0.7351.00
81_T85_E0.7351.00
343_I365_L0.7341.00
297_E345_R0.7341.00
173_D200_K0.7341.00
214_L374_Y0.7331.00
267_A346_A0.7281.00
365_L369_Q0.7271.00
132_F245_A0.7261.00
288_F292_Q0.7251.00
104_I123_V0.7231.00
304_V308_I0.7221.00
289_Q293_T0.7221.00
134_V143_V0.7171.00
31_E89_I0.7171.00
176_L235_L0.7171.00
119_Y197_V0.7171.00
334_I338_S0.7161.00
300_A333_F0.7151.00
182_S239_G0.7141.00
34_L51_A0.7141.00
40_R43_K0.7131.00
88_R266_A0.7131.00
308_I330_L0.7121.00
383_I387_R0.7091.00
257_A309_T0.7051.00
63_L74_A0.7001.00
308_I331_A0.7001.00
31_E35_A0.6951.00
260_A336_T0.6901.00
265_Q299_L0.6901.00
146_I180_R0.6901.00
363_R367_D0.6871.00
81_T310_Y0.6861.00
381_Q384_S0.6831.00
119_Y233_N0.6821.00
268_L389_L0.6811.00
180_R192_G0.6791.00
181_T238_E0.6781.00
68_D73_G0.6781.00
343_I361_L0.6761.00
341_R344_L0.6761.00
184_P192_G0.6731.00
28_D31_E0.6711.00
257_A335_S0.6701.00
18_D21_L0.6671.00
119_Y128_K0.6671.00
347_M354_G0.6661.00
123_V174_Y0.6651.00
339_A343_I0.6641.00
38_V363_R0.6611.00
309_T335_S0.6601.00
30_A34_L0.6581.00
301_D304_V0.6561.00
213_G355_V0.6521.00
166_I222_I0.6501.00
155_G232_E0.6491.00
45_L210_E0.6491.00
292_Q386_A0.6481.00
65_A69_L0.6481.00
148_T224_L0.6471.00
330_L385_A0.6471.00
350_Y361_L0.6471.00
234_L237_E0.6471.00
42_E215_R0.6461.00
154_D158_V0.6441.00
51_A54_K0.6431.00
22_L82_A0.6421.00
240_N244_Y0.6421.00
377_T380_I0.6421.00
231_T238_E0.6411.00
170_D218_H0.6411.00
313_G317_R0.6401.00
23_R84_E0.6391.00
153_L231_T0.6381.00
306_R310_Y0.6371.00
111_G116_K0.6371.00
178_A245_A0.6341.00
308_I334_I0.6321.00
201_D204_K0.6321.00
115_L118_K0.6321.00
196_F231_T0.6271.00
152_K158_V0.6251.00
333_F385_A0.6251.00
215_R357_T0.6251.00
254_T313_G0.6211.00
326_V388_F0.6211.00
291_V295_V0.6141.00
281_F288_F0.6111.00
95_T214_L0.6091.00
106_A248_S0.6081.00
181_T192_G0.6081.00
211_T219_T0.6071.00
66_S71_G0.6041.00
22_L78_S0.6021.00
271_M298_S0.6021.00
250_D328_A0.6001.00
264_G305_A0.5941.00
305_A334_I0.5941.00
177_I227_V0.5921.00
169_G222_I0.5921.00
264_G267_A0.5921.00
104_I120_V0.5881.00
278_R281_F0.5851.00
49_L129_V0.5851.00
278_R352_G0.5841.00
34_L93_F0.5831.00
27_R88_R0.5801.00
291_V294_K0.5791.00
137_P162_R0.5771.00
280_A285_L0.5771.00
27_R89_I0.5761.00
95_T99_I0.5761.00
311_W327_A0.5751.00
305_A331_A0.5731.00
200_K205_P0.5731.00
258_S262_G0.5731.00
149_T183_P0.5701.00
266_A360_G0.5701.00
196_F233_N0.5691.00
205_P208_R0.5671.00
198_V224_L0.5661.00
266_A269_E0.5641.00
108_S116_K0.5641.00
294_K348_S0.5641.00
22_L26_V0.5621.00
238_E241_G0.5621.00
301_D337_E0.5611.00
215_R367_D0.5601.00
294_K297_E0.5591.00
55_A93_F0.5581.00
103_F106_A0.5581.00
41_G46_D0.5581.00
352_G355_V0.5581.00
303_E308_I0.5561.00
69_L121_I0.5551.00
79_L255_I0.5541.00
237_E244_Y0.5531.00
340_E368_L0.5531.00
189_R192_G0.5511.00
106_A110_F0.5491.00
41_G90_W0.5461.00
148_T161_G0.5451.00
308_I312_A0.5441.00
39_E360_G0.5431.00
167_T219_T0.5421.00
152_K155_G0.5411.00
300_A304_V0.5401.00
76_Y316_F0.5401.00
18_D78_S0.5381.00
336_T371_M0.5371.00
348_S379_D0.5371.00
274_Y359_T0.5361.00
298_S349_V0.5361.00
174_Y233_N0.5361.00
107_L111_G0.5361.00
209_I221_E0.5361.00
198_V227_V0.5351.00
134_V178_A0.5351.00
164_I209_I0.5311.00
333_F337_E0.5301.00
35_A38_V0.5301.00
62_G72_Q0.5291.00
92_S96_F0.5281.00
45_L215_R0.5261.00
380_I383_I0.5261.00
60_L82_A0.5261.00
360_G363_R0.5251.00
25_A72_Q0.5251.00
285_L291_V0.5251.00
265_Q302_L0.5251.00
118_K121_I0.5251.00
305_A342_I0.5241.00
369_Q373_T0.5221.00
261_L265_Q0.5221.00
157_Y229_V0.5221.00
209_I219_T0.5211.00
181_T196_F0.5211.00
81_T84_E0.5191.00
299_L389_L0.5191.00
91_P263_I0.5191.00
148_T179_A0.5171.00
297_E300_A0.5151.00
103_F123_V0.5141.00
236_G239_G0.5141.00
279_S287_E0.5141.00
274_Y277_Q0.5131.00
156_E233_N0.5121.00
197_V235_L0.5121.00
45_L357_T0.5121.00
381_Q385_A0.5121.00
254_T309_T0.5111.00
149_T182_S0.5101.00
80_L310_Y0.5091.00
131_A166_I0.5091.00
106_A244_Y0.5081.00
206_V221_E0.5081.00
297_E337_E0.5081.00
249_F252_A0.5071.00
152_K182_S0.5061.00
152_K196_F0.5041.00
86_I94_S0.5041.00
152_K228_K0.5031.00
148_T177_I0.5021.00
288_F291_V0.5021.00
139_A147_K0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4l1fA 4 0.9472 100 0.149 Contact Map
4p13A 4 0.9673 100 0.153 Contact Map
4rm7A 4 0.9347 100 0.153 Contact Map
1ukwA 4 0.9472 100 0.155 Contact Map
2d29A 4 0.9598 100 0.158 Contact Map
1ivhA 4 0.9598 100 0.159 Contact Map
2jifA 4 0.9497 100 0.159 Contact Map
3pfdA 4 0.9246 100 0.16 Contact Map
1bucA 4 0.9447 100 0.16 Contact Map
4m9aA 4 0.9372 100 0.161 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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