GREMLIN Database
Q97V72 - Electron transfer flavoprotein, subunit alpha (EtfA)
UniProt: Q97V72 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 287 (275)
Sequences: 4022 (2489)
Seq/√Len: 150.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
271_G276_F5.2531.00
262_L268_L3.8351.00
232_L253_V3.5841.00
169_D227_K3.5671.00
173_G234_I3.4361.00
67_T77_A3.3161.00
171_V224_I2.8181.00
232_L277_C2.7431.00
174_V184_V2.7171.00
193_A281_L2.6441.00
12_F36_V2.5861.00
10_P34_E2.3771.00
211_V215_R2.2131.00
200_G211_V2.1721.00
185_K189_E2.1661.00
241_I264_N2.1491.00
249_I267_Y2.1351.00
185_K188_E2.1041.00
174_V187_A2.0951.00
252_A265_A2.0751.00
189_E281_L2.0421.00
92_V125_I1.9951.00
170_I196_G1.9941.00
201_S234_I1.9931.00
105_N114_L1.9631.00
190_L281_L1.9601.00
228_L251_V1.9561.00
183_N274_I1.9481.00
232_L273_A1.9381.00
188_E198_V1.9211.00
57_I65_I1.8991.00
94_S105_N1.8931.00
178_I187_A1.8731.00
173_G231_A1.8661.00
227_K248_K1.8531.00
229_Y240_H1.8161.00
187_A232_L1.7631.00
12_F62_P1.7621.00
279_A282_S1.7531.00
252_A261_I1.7521.00
190_L277_C1.7501.00
66_L125_I1.7371.00
224_I244_I1.7261.00
21_Q25_G1.7251.00
18_A42_L1.7221.00
173_G217_I1.7151.00
190_L194_L1.7081.00
164_N167_T1.6971.00
165_L171_V1.6851.00
171_V199_G1.6771.00
172_V190_L1.6701.00
12_F34_E1.6591.00
54_V83_R1.6431.00
50_E83_R1.6361.00
244_I247_S1.6051.00
54_V58_S1.5741.00
45_I48_I1.5721.00
32_D35_N1.5281.00
55_D59_S1.5261.00
77_A126_T1.5081.00
184_V198_V1.4961.00
96_K105_N1.4671.00
22_S25_G1.4671.00
212_S215_R1.4581.00
21_Q143_K1.4511.00
59_S142_E1.4301.00
189_E193_A1.4181.00
199_G217_I1.4031.00
188_E192_K1.3901.00
29_G137_L1.3791.00
193_A284_L1.3711.00
231_A240_H1.3681.00
55_D58_S1.3631.00
186_Y277_C1.3611.00
231_A234_I1.3411.00
54_V80_V1.3371.00
80_V124_V1.3321.00
180_S210_W1.3311.00
46_D75_A1.3311.00
6_F96_K1.3241.00
103_T116_T1.3241.00
178_I273_A1.3241.00
15_M23_F1.3161.00
275_D279_A1.3141.00
26_E29_G1.3061.00
41_K45_I1.3021.00
269_V276_F1.2941.00
162_G192_K1.2781.00
93_V105_N1.2711.00
93_V114_L1.2671.00
279_A283_K1.2621.00
186_Y189_E1.2561.00
24_G28_I1.2531.00
178_I183_N1.2341.00
16_A52_G1.2331.00
18_A39_V1.2251.00
200_G206_A1.2221.00
28_I138_Q1.2211.00
63_D122_P1.2191.00
200_G205_A1.2171.00
91_D128_A1.2101.00
166_A222_L1.2081.00
50_E53_I1.2061.00
26_E137_L1.2041.00
108_A113_G1.1991.00
92_V127_I1.1921.00
173_G224_I1.1781.00
262_L270_V1.1741.00
96_K116_T1.1511.00
25_G29_G1.1481.00
29_G138_Q1.1341.00
51_D55_D1.1210.99
86_L124_V1.1050.99
173_G201_S1.1020.99
41_K52_G1.1000.99
88_I124_V1.0980.99
47_K50_E1.0930.99
55_D147_K1.0830.99
273_A278_K1.0820.99
84_L124_V1.0780.99
177_G210_W1.0720.99
271_G275_D1.0700.99
181_K211_V1.0670.99
186_Y281_L1.0650.99
174_V178_I1.0640.99
41_K46_D1.0560.99
165_L199_G1.0540.99
7_S66_L1.0530.99
173_G199_G1.0530.99
192_K195_G1.0510.99
13_L27_V1.0490.99
14_R53_I1.0450.99
56_L144_V1.0380.99
182_E185_K1.0330.99
36_V142_E1.0300.99
28_I35_N1.0300.99
37_K40_N1.0280.99
217_I231_A1.0280.99
44_I49_D1.0260.99
51_D148_E1.0220.99
277_C281_L1.0210.99
104_L125_I1.0180.99
183_N186_Y1.0110.99
77_A88_I1.0100.99
203_P208_L1.0080.99
88_I126_T1.0030.99
9_S63_D0.9960.99
17_A20_A0.9920.99
174_V211_V0.9880.99
53_I80_V0.9800.99
225_R246_D0.9790.99
36_V60_L0.9770.99
50_E79_R0.9740.99
191_A198_V0.9740.99
31_S136_E0.9730.99
179_G274_I0.9720.98
23_F26_E0.9700.98
197_A215_R0.9700.98
33_N36_V0.9660.98
253_V276_F0.9630.98
48_I51_D0.9520.98
74_R91_D0.9470.98
43_Y46_D0.9450.98
79_R83_R0.9420.98
58_S61_S0.9400.98
57_I84_L0.9370.98
180_S183_N0.9370.98
165_L222_L0.9320.98
187_A198_V0.9310.98
184_V211_V0.9300.98
14_R56_L0.9300.98
201_S217_I0.9290.98
31_S35_N0.9270.98
129_N223_R0.9160.98
184_V187_A0.9150.98
52_G55_D0.9150.98
67_T126_T0.9080.98
81_A88_I0.9060.98
206_A216_Q0.9050.98
89_A92_V0.9050.98
20_A38_F0.9030.98
41_K44_I0.8960.97
95_L104_L0.8940.97
34_E142_E0.8930.97
49_D53_I0.8920.97
99_D118_E0.8890.97
50_E55_D0.8770.97
230_I253_V0.8740.97
20_A23_F0.8660.97
203_P206_A0.8600.97
50_E80_V0.8570.97
186_Y278_K0.8560.97
189_E198_V0.8470.96
69_N91_D0.8460.96
178_I181_K0.8450.96
36_V56_L0.8400.96
92_V104_L0.8380.96
25_G28_I0.8370.96
29_G140_S0.8300.96
49_D76_I0.8300.96
105_N116_T0.8300.96
199_G215_R0.8280.96
205_A210_W0.8260.96
174_V205_A0.8200.96
10_P33_N0.8200.96
69_N73_D0.8160.96
30_I137_L0.8110.95
63_D121_L0.8080.95
30_I135_K0.8070.95
60_L142_E0.8040.95
177_G183_N0.8030.95
87_P120_E0.8020.95
178_I184_V0.8000.95
153_I156_R0.7970.95
104_L123_I0.7960.95
226_P247_S0.7920.95
230_I251_V0.7920.95
67_T73_D0.7880.95
177_G181_K0.7880.95
35_N142_E0.7860.95
16_A49_D0.7740.94
54_V84_L0.7730.94
178_I274_I0.7710.94
142_E145_Q0.7690.94
37_K143_K0.7670.94
77_A80_V0.7620.94
48_I53_I0.7600.94
181_K210_W0.7560.93
186_Y232_L0.7440.93
84_L122_P0.7410.93
92_V95_L0.7390.93
32_D36_V0.7380.93
178_I210_W0.7370.93
29_G136_E0.7340.92
28_I32_D0.7340.92
48_I149_G0.7330.92
244_I264_N0.7300.92
29_G139_P0.7280.92
47_K51_D0.7260.92
44_I75_A0.7260.92
49_D55_D0.7200.92
19_V39_V0.7200.92
26_E30_I0.7190.92
53_I57_I0.7150.91
184_V205_A0.7120.91
56_L60_L0.7110.91
180_S274_I0.7070.91
201_S241_I0.7010.91
176_R203_P0.6950.90
171_V197_A0.6910.90
57_I62_P0.6900.90
261_I268_L0.6890.90
178_I186_Y0.6870.90
106_R117_L0.6870.90
73_D76_I0.6860.90
99_D123_I0.6860.90
174_V200_G0.6840.89
201_S231_A0.6840.89
107_V128_A0.6840.89
272_N275_D0.6800.89
231_A261_I0.6750.89
177_G186_Y0.6730.89
170_I195_G0.6730.89
27_V30_I0.6720.89
27_V35_N0.6710.89
16_A41_K0.6710.89
58_S84_L0.6710.89
173_G240_H0.6670.88
217_I244_I0.6670.88
207_E216_Q0.6660.88
224_I247_S0.6650.88
38_F52_G0.6620.88
110_S128_A0.6600.88
44_I76_I0.6590.88
193_A196_G0.6590.88
13_L16_A0.6580.88
141_V144_V0.6560.87
184_V200_G0.6530.87
67_T80_V0.6500.87
88_I92_V0.6490.87
97_V118_E0.6470.87
89_A104_L0.6450.87
181_K185_K0.6430.86
40_N145_Q0.6410.86
31_S138_Q0.6380.86
104_L127_I0.6360.86
241_I263_E0.6330.85
92_V97_V0.6280.85
47_K53_I0.6250.85
276_F279_A0.6180.84
128_A219_L0.6160.84
202_R216_Q0.6160.84
241_I244_I0.6150.84
51_D147_K0.6140.84
53_I76_I0.6120.84
205_A211_V0.6120.84
163_V197_A0.6120.84
103_T118_E0.6110.83
172_V198_V0.6090.83
21_Q147_K0.6080.83
170_I227_K0.6080.83
201_S242_A0.6070.83
87_P115_V0.6060.83
133_Q136_E0.6060.83
143_K146_L0.6040.83
106_R239_Q0.6040.83
249_I266_D0.6030.83
178_I205_A0.6030.83
28_I140_S0.6020.83
50_E54_V0.6020.83
220_S238_P0.6020.83
174_V232_L0.6020.83
184_V219_L0.5980.82
120_E123_I0.5980.82
173_G229_Y0.5960.82
205_A273_A0.5960.82
12_F60_L0.5950.82
178_I277_C0.5950.82
229_Y234_I0.5930.82
89_A196_G0.5930.82
200_G216_Q0.5930.82
47_K150_R0.5920.81
183_N189_E0.5910.81
252_A262_L0.5900.81
136_E140_S0.5900.81
16_A53_I0.5890.81
13_L33_N0.5880.81
51_D54_V0.5850.81
118_E121_L0.5800.80
47_K52_G0.5770.80
67_T76_I0.5770.80
47_K149_G0.5760.80
39_V143_K0.5760.80
24_G141_V0.5720.79
163_V171_V0.5710.79
42_L45_I0.5660.79
250_I264_N0.5660.79
98_E103_T0.5640.78
77_A124_V0.5630.78
177_G273_A0.5620.78
29_G32_D0.5600.78
64_V123_I0.5590.78
36_V144_V0.5590.78
164_N222_L0.5590.78
74_R90_T0.5580.78
40_N52_G0.5560.77
172_V281_L0.5560.77
79_R82_G0.5550.77
61_S122_P0.5530.77
72_R76_I0.5530.77
274_I278_K0.5520.77
177_G201_S0.5490.76
15_M24_G0.5490.76
171_V217_I0.5470.76
172_V193_A0.5440.76
194_L230_I0.5440.76
137_L140_S0.5440.76
252_A268_L0.5430.76
30_I33_N0.5420.76
162_G188_E0.5420.76
188_E215_R0.5410.75
41_K48_I0.5400.75
260_P263_E0.5400.75
158_S257_K0.5390.75
267_Y274_I0.5370.75
25_G38_F0.5370.75
28_I141_V0.5360.75
49_D72_R0.5360.75
22_S26_E0.5340.74
7_S11_V0.5340.74
172_V194_L0.5330.74
162_G165_L0.5330.74
81_A124_V0.5330.74
183_N273_A0.5330.74
53_I59_S0.5300.74
7_S10_P0.5300.74
170_I194_L0.5300.74
190_L193_A0.5290.74
177_G270_V0.5270.74
41_K49_D0.5270.74
51_D149_G0.5270.74
187_A217_I0.5270.74
47_K55_D0.5270.74
198_V215_R0.5260.73
174_V198_V0.5250.73
50_E59_S0.5230.73
8_E11_V0.5220.73
65_I124_V0.5220.73
170_I230_I0.5220.73
257_K260_P0.5210.73
55_D145_Q0.5210.73
97_V103_T0.5200.73
21_Q38_F0.5190.72
188_E196_G0.5180.72
19_V147_K0.5170.72
234_I247_S0.5140.72
21_Q39_V0.5120.71
244_I261_I0.5120.71
173_G244_I0.5120.71
188_E211_V0.5120.71
46_D79_R0.5080.71
245_R263_E0.5080.71
165_L168_A0.5080.71
256_D259_A0.5050.70
172_V277_C0.5050.70
86_L122_P0.5040.70
213_E217_I0.5040.70
224_I264_N0.5030.70
187_A277_C0.5030.70
181_K188_E0.5030.70
20_A42_L0.5030.70
189_E282_S0.5000.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4l2iA 1 0.993 100 0.049 Contact Map
1o97D 1 0.9686 100 0.068 Contact Map
1efvA 1 0.9791 100 0.069 Contact Map
1efpA 1 0.9652 100 0.087 Contact Map
3ih5A 6 0.5679 100 0.696 Contact Map
1efpB 1 0.6132 99.9 0.742 Contact Map
1efvB 1 0.6341 99.9 0.743 Contact Map
4l2iB 1 0.6725 99.9 0.746 Contact Map
1o97C 1 0.6376 99.9 0.747 Contact Map
3fetA 2 0.5017 99.9 0.748 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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