GREMLIN Database
Q97V69 - Thioredoxin reductase (TrxB-2)
UniProt: Q97V69 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 325 (285)
Sequences: 61260 (44231)
Seq/√Len: 2620.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
148_A228_V4.1531.00
146_P169_P3.5101.00
36_K82_E3.5101.00
171_Y198_L3.2871.00
205_E216_V3.1181.00
7_D105_R2.9551.00
169_P196_K2.9531.00
207_R216_V2.9391.00
214_E225_Q2.7291.00
259_D263_R2.6491.00
207_R214_E2.5781.00
146_P229_D2.4001.00
7_D30_S2.3971.00
8_T24_S2.3891.00
216_V225_Q2.3801.00
148_A173_I2.3721.00
9_I34_L2.3271.00
116_R238_T2.3231.00
202_R218_K2.2951.00
121_P205_E2.2921.00
204_L218_K2.2841.00
20_A108_I2.2821.00
32_L78_I2.2661.00
249_E257_I2.2491.00
6_Y32_L2.2001.00
91_D268_G2.1731.00
34_L102_Y2.1521.00
148_A215_L2.1131.00
187_K191_N2.1121.00
146_P171_Y2.0581.00
108_I297_A2.0541.00
9_I102_Y1.9911.00
204_L216_V1.9691.00
9_I95_I1.8861.00
88_Q266_R1.8681.00
214_E227_K1.8361.00
207_R225_Q1.8351.00
175_S202_R1.8031.00
7_D32_L1.8021.00
146_P227_K1.7461.00
106_A268_G1.7121.00
114_T240_K1.7111.00
171_Y196_K1.6991.00
201_S219_R1.6921.00
104_G107_L1.6661.00
16_A272_A1.6521.00
114_T238_T1.6401.00
173_I226_L1.6341.00
85_E96_K1.6171.00
145_K229_D1.6101.00
125_E208_G1.6091.00
9_I104_G1.5761.00
146_P168_N1.5691.00
217_I226_L1.5531.00
133_Y136_I1.5481.00
87_A90_S1.5351.00
294_A298_Y1.5141.00
251_N255_E1.5101.00
114_T242_E1.5091.00
97_G100_G1.4921.00
30_S76_E1.4811.00
208_G213_E1.4701.00
108_I272_A1.4531.00
10_I17_G1.4441.00
249_E265_S1.4431.00
9_I32_L1.4391.00
201_S217_I1.4371.00
270_F300_Y1.4361.00
206_I231_V1.4281.00
198_L201_S1.4171.00
94_I101_E1.3921.00
111_F275_V1.3921.00
198_L221_D1.3851.00
290_G294_A1.3841.00
94_I103_A1.3801.00
21_A33_V1.3731.00
147_A163_L1.3691.00
10_I21_A1.3311.00
106_A297_A1.3271.00
106_A270_F1.3261.00
293_A297_A1.3111.00
177_S200_S1.3081.00
97_G102_Y1.2741.00
270_F296_S1.2671.00
69_Q73_F1.2601.00
132_S136_I1.2571.00
8_T108_I1.2491.00
171_Y228_V1.2481.00
96_K101_E1.2411.00
67_E71_K1.2371.00
23_Y295_L1.2331.00
88_Q269_V1.2301.00
251_N257_I1.2271.00
64_Q68_K1.2151.00
58_G61_T1.2151.00
13_A35_S1.2071.00
119_N123_E1.2031.00
263_R267_E1.2021.00
87_A94_I1.1851.00
178_Y183_E1.1751.00
23_Y26_R1.1511.00
292_K296_S1.1491.00
206_I212_V1.1481.00
32_L102_Y1.1441.00
152_E174_T1.1431.00
86_I107_L1.1391.00
68_K71_K1.1351.00
212_V231_V1.1321.00
110_A272_A1.1251.00
164_S195_V1.1251.00
68_K72_K1.1211.00
258_V276_T1.1191.00
208_G212_V1.1181.00
173_I217_I1.1181.00
157_I172_Y1.1161.00
8_T29_L1.1141.00
27_Q298_Y1.1101.00
256_I271_A1.1081.00
143_K168_N1.1071.00
144_G168_N1.0901.00
209_N214_E1.0891.00
136_I139_A1.0871.00
266_R269_V1.0841.00
174_T199_T1.0831.00
84_K96_K1.0821.00
147_A230_G1.0791.00
251_N277_Q1.0781.00
16_A286_A1.0761.00
258_V262_G1.0681.00
189_V192_K1.0461.00
87_A96_K1.0411.00
6_Y9_I1.0371.00
180_A184_E1.0311.00
92_L103_A1.0281.00
93_F97_G1.0271.00
164_S169_P1.0271.00
129_K133_Y1.0251.00
34_L83_V1.0151.00
106_A300_Y1.0151.00
11_V109_L1.0061.00
150_I231_V1.0011.00
286_A290_G1.0001.00
82_E98_I0.9991.00
167_A170_A0.9981.00
24_S294_A0.9981.00
160_I172_Y0.9951.00
37_D80_G0.9931.00
137_C140_A0.9891.00
23_Y27_Q0.9791.00
209_N227_K0.9761.00
81_E99_K0.9731.00
129_K132_S0.9721.00
212_V227_K0.9641.00
147_A168_N0.9581.00
165_N193_P0.9581.00
78_I81_E0.9571.00
256_I275_V0.9531.00
271_A275_V0.9521.00
242_E245_K0.9501.00
6_Y30_S0.9461.00
272_A293_A0.9431.00
34_L78_I0.9401.00
132_S140_A0.9361.00
48_I52_P0.9321.00
209_N213_E0.9311.00
263_R300_Y0.9311.00
274_D286_A0.9281.00
209_N212_V0.9251.00
11_V111_F0.9241.00
78_I102_Y0.9221.00
20_A272_A0.9201.00
27_Q295_L0.9161.00
63_A67_E0.9111.00
70_A73_F0.9101.00
188_N191_N0.9061.00
263_R268_G0.9031.00
184_E187_K0.8991.00
149_V160_I0.8991.00
156_G174_T0.8981.00
270_F297_A0.8961.00
25_S75_A0.8931.00
8_T106_A0.8911.00
148_A226_L0.8891.00
85_E246_G0.8891.00
276_T289_E0.8881.00
134_C137_C0.8811.00
171_Y226_L0.8801.00
24_S29_L0.8731.00
217_I221_D0.8731.00
23_Y291_V0.8721.00
122_G125_E0.8691.00
20_A290_G0.8691.00
65_K69_Q0.8671.00
262_G293_A0.8671.00
184_E188_N0.8661.00
258_V271_A0.8661.00
262_G292_K0.8611.00
201_S218_K0.8581.00
32_L104_G0.8551.00
7_D103_A0.8551.00
22_L26_R0.8531.00
7_D29_L0.8511.00
203_V215_L0.8501.00
6_Y106_A0.8471.00
32_L76_E0.8461.00
262_G276_T0.8441.00
84_K98_I0.8441.00
135_A139_A0.8371.00
217_I220_G0.8361.00
148_A231_V0.8311.00
89_E94_I0.8271.00
187_K199_T0.8231.00
59_G63_A0.8201.00
130_G133_Y0.8161.00
64_Q67_E0.8151.00
17_G21_A0.8091.00
65_K68_K0.8061.00
108_I293_A0.8051.00
285_V289_E0.8041.00
66_I69_Q0.8031.00
150_I235_M0.7931.00
134_C138_D0.7931.00
208_G211_K0.7921.00
150_I233_I0.7921.00
188_N192_K0.7901.00
179_L199_T0.7901.00
24_S297_A0.7881.00
107_L269_V0.7871.00
261_L296_S0.7851.00
198_L226_L0.7851.00
145_K168_N0.7821.00
206_I215_L0.7811.00
152_E179_L0.7801.00
29_L298_Y0.7801.00
183_E187_K0.7791.00
189_V193_P0.7791.00
17_G110_A0.7771.00
20_A293_A0.7721.00
173_I201_S0.7701.00
13_A33_V0.7691.00
10_I20_A0.7691.00
11_V83_V0.7681.00
109_L275_V0.7651.00
134_C140_A0.7561.00
7_D102_Y0.7501.00
122_G205_E0.7481.00
61_T65_K0.7481.00
21_A31_T0.7481.00
185_I189_V0.7461.00
83_V95_I0.7451.00
132_S230_G0.7441.00
61_T64_Q0.7421.00
228_V231_V0.7421.00
88_Q91_D0.7421.00
173_I198_L0.7401.00
150_I203_V0.7371.00
182_E185_I0.7341.00
106_A301_I0.7321.00
293_A296_S0.7291.00
271_A276_T0.7281.00
8_T297_A0.7261.00
21_A75_A0.7251.00
198_L217_I0.7231.00
218_K221_D0.7181.00
146_P228_V0.7151.00
153_G236_G0.7131.00
25_S31_T0.7121.00
41_Q44_L0.7111.00
19_S290_G0.7081.00
291_V295_L0.7061.00
125_E129_K0.7031.00
133_Y138_D0.7021.00
289_E293_A0.7021.00
191_N196_K0.7021.00
242_E246_G0.7011.00
113_K237_Y0.6961.00
38_L79_Y0.6921.00
69_Q72_K0.6911.00
272_A297_A0.6901.00
130_G233_I0.6861.00
250_L257_I0.6861.00
132_S135_A0.6821.00
132_S138_D0.6791.00
187_K197_I0.6761.00
117_E233_I0.6751.00
252_E257_I0.6691.00
24_S31_T0.6681.00
268_G300_Y0.6671.00
85_E88_Q0.6671.00
118_I233_I0.6651.00
90_S94_I0.6631.00
137_C163_L0.6631.00
6_Y105_R0.6631.00
164_S193_P0.6601.00
161_E165_N0.6581.00
7_D104_G0.6581.00
185_I188_N0.6571.00
80_G98_I0.6571.00
40_G43_T0.6531.00
117_E124_Q0.6531.00
60_L64_Q0.6511.00
19_S23_Y0.6491.00
132_S137_C0.6491.00
134_C139_A0.6451.00
70_A75_A0.6431.00
288_A291_V0.6431.00
159_A162_L0.6431.00
263_R296_S0.6411.00
13_A38_L0.6411.00
20_A294_A0.6411.00
129_K135_A0.6411.00
123_E233_I0.6411.00
59_G66_I0.6401.00
80_G99_K0.6391.00
88_Q93_F0.6391.00
272_A290_G0.6351.00
159_A232_I0.6341.00
43_T46_D0.6281.00
257_I265_S0.6281.00
151_G236_G0.6281.00
270_F293_A0.6271.00
178_Y187_K0.6261.00
10_I110_A0.6261.00
54_I57_T0.6241.00
96_K99_K0.6221.00
34_L104_G0.6181.00
16_A110_A0.6171.00
181_G184_E0.6171.00
118_I123_E0.6141.00
132_S139_A0.6121.00
120_V123_E0.6111.00
29_L105_R0.6101.00
29_L297_A0.6081.00
19_S22_L0.6071.00
129_K136_I0.6051.00
282_Q285_V0.6051.00
262_G296_S0.6041.00
160_I195_V0.6021.00
39_G42_L0.6011.00
135_A138_D0.6001.00
206_I213_E0.6001.00
55_E58_G0.5981.00
250_L256_I0.5981.00
25_S30_S0.5941.00
47_L54_I0.5931.00
117_E133_Y0.5911.00
263_R270_F0.5911.00
190_V197_I0.5901.00
129_K140_A0.5881.00
145_K230_G0.5871.00
145_K169_P0.5871.00
129_K134_C0.5861.00
164_S194_T0.5841.00
47_L52_P0.5831.00
6_Y76_E0.5821.00
257_I260_E0.5821.00
93_F266_R0.5801.00
19_S287_A0.5801.00
34_L97_G0.5791.00
174_T179_L0.5781.00
62_L65_K0.5751.00
81_E97_G0.5731.00
201_S221_D0.5721.00
109_L243_F0.5721.00
44_L47_L0.5711.00
142_F145_K0.5701.00
133_Y137_C0.5691.00
295_L299_N0.5681.00
42_L46_D0.5681.00
25_S76_E0.5681.00
241_T250_L0.5671.00
25_S74_G0.5661.00
66_I70_A0.5641.00
264_T271_A0.5641.00
174_T177_S0.5631.00
288_A292_K0.5561.00
9_I93_F0.5551.00
146_P212_V0.5541.00
208_G214_E0.5541.00
48_I53_G0.5531.00
116_R235_M0.5521.00
297_A301_I0.5521.00
47_L53_G0.5521.00
120_V206_I0.5511.00
62_L66_I0.5501.00
200_S219_R0.5491.00
281_K285_V0.5461.00
10_I31_T0.5451.00
136_I140_A0.5441.00
130_G136_I0.5421.00
284_V288_A0.5411.00
263_R266_R0.5411.00
159_A234_E0.5401.00
147_A232_I0.5391.00
213_E216_V0.5381.00
172_Y197_I0.5381.00
133_Y139_A0.5381.00
48_I54_I0.5371.00
57_T61_T0.5311.00
156_G234_E0.5311.00
93_F98_I0.5301.00
173_I228_V0.5301.00
8_T294_A0.5291.00
35_S79_Y0.5291.00
129_K137_C0.5281.00
277_Q289_E0.5281.00
111_F243_F0.5271.00
97_G101_E0.5251.00
10_I33_V0.5251.00
76_E79_Y0.5251.00
117_E123_E0.5231.00
140_A230_G0.5221.00
154_E158_E0.5171.00
247_F250_L0.5131.00
89_E92_L0.5111.00
258_V261_L0.5111.00
148_A171_Y0.5101.00
118_I235_M0.5101.00
196_K199_T0.5101.00
107_L268_G0.5091.00
34_L81_E0.5071.00
186_V190_V0.5071.00
149_V156_G0.5051.00
69_Q74_G0.5051.00
141_F144_G0.5051.00
282_Q286_A0.5031.00
23_Y294_A0.5021.00
160_I170_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2q7vA 2 0.9292 100 0.279 Contact Map
3f8dA 2 0.9323 100 0.283 Contact Map
1fl2A 2 0.9292 100 0.289 Contact Map
2a87A 2 0.9446 100 0.292 Contact Map
2q0lA 2 0.92 100 0.292 Contact Map
3r9uA 2 0.92 100 0.297 Contact Map
4jnqA 2 0.9354 100 0.298 Contact Map
4gcmA 2 0.9385 100 0.301 Contact Map
3ctyA 2 0.9231 100 0.301 Contact Map
4up3A 2 0.92 100 0.302 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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