GREMLIN Database
Q97V66 - Uncharacterized protein
UniProt: Q97V66 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 308 (251)
Sequences: 11308 (8177)
Seq/√Len: 516.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
53_A92_A3.7231.00
290_M294_R3.6891.00
233_D291_R3.4831.00
148_T176_T3.4251.00
180_T190_F3.2161.00
240_K244_K3.0011.00
236_I287_K2.9681.00
259_E266_I2.8611.00
234_V296_L2.7811.00
292_T296_L2.7351.00
292_T295_E2.6951.00
246_L284_E2.5971.00
146_R176_T2.4991.00
258_L268_G2.4611.00
237_N241_E2.4531.00
203_I207_A2.4231.00
261_T266_I2.4081.00
231_D234_V2.3091.00
225_E264_T2.2441.00
241_E292_T2.2381.00
123_Q127_A2.2281.00
241_E245_K2.1571.00
239_L289_V2.1321.00
223_K268_G2.1311.00
282_R286_L2.1151.00
234_V237_N2.0601.00
223_K266_I2.0491.00
238_V292_T2.0191.00
181_D188_T1.9771.00
146_R178_T1.9391.00
288_I291_R1.9311.00
238_V296_L1.8941.00
150_S174_G1.8901.00
227_S299_K1.8781.00
236_I240_K1.8571.00
245_K288_I1.7981.00
225_E266_I1.7971.00
242_K292_T1.7661.00
226_V235_L1.7501.00
234_V238_V1.7401.00
148_T212_H1.7141.00
291_R295_E1.7021.00
242_K288_I1.6801.00
284_E288_I1.6741.00
257_V265_Y1.6571.00
191_T197_V1.6491.00
271_T285_I1.6381.00
243_I269_I1.6241.00
230_I299_K1.6211.00
138_S185_L1.6151.00
180_T196_P1.5931.00
233_D287_K1.5911.00
148_T210_F1.5411.00
65_R81_S1.5361.00
221_R268_G1.5281.00
146_R192_D1.5171.00
61_G85_R1.4761.00
124_D127_A1.4561.00
150_S208_A1.4361.00
141_Y187_T1.4291.00
273_C281_P1.4141.00
46_A100_I1.4101.00
224_Y289_V1.4071.00
293_V298_T1.4051.00
246_L288_I1.3921.00
245_K292_T1.3861.00
235_L267_L1.3821.00
116_L119_G1.3801.00
175_Y208_A1.3631.00
150_S207_A1.3551.00
188_T196_P1.3501.00
187_T201_N1.3491.00
197_V210_F1.3471.00
147_V179_V1.3011.00
238_V241_E1.3001.00
248_F284_E1.2911.00
145_D214_G1.2881.00
148_T174_G1.2861.00
177_G189_I1.2761.00
287_K291_R1.2741.00
237_N240_K1.2671.00
88_G92_A1.2611.00
288_I292_T1.2501.00
42_L45_Y1.2451.00
195_I210_F1.2431.00
280_P284_E1.2341.00
46_A96_F1.2191.00
241_E244_K1.2011.00
233_D237_N1.1881.00
110_A113_F1.1811.00
142_K214_G1.1811.00
239_L269_I1.1741.00
85_R89_Y1.1701.00
262_L266_I1.1661.00
244_K251_E1.1641.00
203_I206_Q1.1591.00
55_I59_F1.1521.00
97_F102_V1.1371.00
50_F54_V1.1351.00
229_D302_A1.1351.00
220_V271_T1.1311.00
54_V89_Y1.1111.00
219_K272_I1.1021.00
191_T195_I1.0921.00
230_I235_L1.0911.00
196_P214_G1.0911.00
203_I208_A1.0841.00
49_W99_L1.0791.00
229_D290_M1.0661.00
57_S85_R1.0621.00
96_F100_I1.0531.00
31_S34_K1.0511.00
53_A57_S1.0451.00
106_T109_A1.0451.00
149_V204_M1.0431.00
258_L266_I1.0391.00
223_K259_E1.0361.00
232_P267_L1.0311.00
243_I271_T1.0311.00
228_K260_T1.0201.00
229_D299_K1.0131.00
226_V230_I1.0121.00
61_G81_S1.0091.00
255_I269_I1.0091.00
233_D236_I0.9911.00
225_E261_T0.9901.00
274_K277_Y0.9771.00
224_Y239_L0.9721.00
220_V282_R0.9671.00
49_W92_A0.9611.00
225_E263_N0.9591.00
263_N302_A0.9551.00
248_F280_P0.9371.00
114_A118_L0.9361.00
186_Y198_K0.9291.00
227_S230_I0.9251.00
183_S188_T0.9081.00
39_D43_Y0.9021.00
41_L45_Y0.8991.00
45_Y99_L0.8991.00
179_V189_I0.8971.00
240_K255_I0.8971.00
54_V58_Y0.8961.00
121_A126_L0.8951.00
223_K258_L0.8911.00
246_L285_I0.8911.00
221_R270_D0.8881.00
108_L112_G0.8861.00
242_K285_I0.8761.00
283_S287_K0.8731.00
49_W53_A0.8731.00
259_E286_L0.8701.00
226_V267_L0.8671.00
122_A130_F0.8671.00
78_S82_F0.8661.00
139_R142_K0.8611.00
230_I234_V0.8561.00
225_E262_L0.8551.00
92_A96_F0.8501.00
194_Q272_I0.8491.00
190_F196_P0.8441.00
227_S301_A0.8391.00
248_F281_P0.8371.00
236_I283_S0.8361.00
34_K38_A0.8341.00
248_F277_Y0.8321.00
39_D42_L0.8321.00
232_P265_Y0.8311.00
239_L293_V0.8241.00
299_K304_S0.8241.00
285_I289_V0.8231.00
240_K253_P0.8221.00
127_A202_S0.8211.00
256_K268_G0.8191.00
113_F122_A0.8141.00
226_V293_V0.8121.00
150_S203_I0.8111.00
90_I94_V0.8111.00
260_T286_L0.8081.00
178_T190_F0.8071.00
254_S270_D0.8071.00
260_T265_Y0.8051.00
175_Y197_V0.8041.00
134_M205_I0.8031.00
125_V131_G0.8011.00
256_K283_S0.7971.00
53_A88_G0.7961.00
147_V189_I0.7961.00
48_I52_V0.7951.00
225_E228_K0.7951.00
262_L303_A0.7931.00
35_I38_A0.7891.00
238_V298_T0.7891.00
225_E302_A0.7851.00
238_V242_K0.7821.00
131_G205_I0.7821.00
81_S85_R0.7771.00
228_K302_A0.7771.00
258_L282_R0.7761.00
114_A117_V0.7751.00
242_K246_L0.7681.00
226_V298_T0.7671.00
257_V286_L0.7661.00
261_T264_T0.7641.00
57_S92_A0.7591.00
64_I67_R0.7581.00
31_S38_A0.7551.00
220_V273_C0.7511.00
138_S186_Y0.7491.00
98_V103_S0.7491.00
228_K300_T0.7441.00
110_A114_A0.7441.00
269_I289_V0.7431.00
34_K37_P0.7431.00
257_V260_T0.7391.00
37_P41_L0.7381.00
284_E287_K0.7371.00
60_I84_V0.7361.00
45_Y49_W0.7321.00
57_S61_G0.7311.00
243_I285_I0.7291.00
293_V300_T0.7281.00
57_S88_G0.7241.00
63_L67_R0.7231.00
109_A112_G0.7151.00
277_Y280_P0.7151.00
275_T278_E0.7101.00
222_T286_L0.7081.00
222_T271_T0.7011.00
57_S89_Y0.6941.00
149_V199_I0.6911.00
118_L126_L0.6901.00
232_P290_M0.6891.00
236_I255_I0.6871.00
89_Y93_F0.6831.00
110_A115_G0.6831.00
239_L255_I0.6791.00
242_K245_K0.6791.00
51_I55_I0.6781.00
219_K270_D0.6781.00
238_V295_E0.6771.00
141_Y204_M0.6751.00
235_L293_V0.6751.00
228_K265_Y0.6741.00
111_G115_G0.6711.00
137_I140_P0.6701.00
239_L243_I0.6661.00
118_L130_F0.6661.00
265_Y290_M0.6651.00
128_N202_S0.6631.00
227_S300_T0.6631.00
253_P256_K0.6601.00
33_F36_I0.6551.00
260_T290_M0.6551.00
226_V232_P0.6501.00
231_D291_R0.6451.00
44_I48_I0.6451.00
241_E296_L0.6441.00
250_I274_K0.6431.00
92_A95_G0.6421.00
55_I58_Y0.6421.00
238_V293_V0.6421.00
190_F194_Q0.6401.00
113_F117_V0.6381.00
48_I51_I0.6351.00
256_K270_D0.6341.00
243_I249_V0.6331.00
38_A42_L0.6291.00
35_I39_D0.6281.00
32_V36_I0.6271.00
263_N304_S0.6261.00
78_S181_D0.6251.00
150_S175_Y0.6251.00
249_V281_P0.6241.00
65_R69_G0.6241.00
176_T212_H0.6201.00
227_S304_S0.6191.00
141_Y147_V0.6181.00
75_D136_V0.6151.00
188_T198_K0.6131.00
196_P215_E0.6111.00
235_L298_T0.6111.00
249_V271_T0.6111.00
242_K296_L0.6091.00
127_A206_Q0.6081.00
149_V175_Y0.6071.00
125_V205_I0.6031.00
33_F37_P0.6031.00
232_P257_V0.6031.00
183_S186_Y0.6021.00
58_Y62_S0.6021.00
50_F53_A0.6011.00
175_Y210_F0.5990.99
236_I267_L0.5980.99
243_I255_I0.5960.99
124_D202_S0.5960.99
103_S106_T0.5950.99
199_I208_A0.5930.99
32_V35_I0.5910.99
74_Y77_A0.5900.99
95_G99_L0.5900.99
138_S188_T0.5890.99
40_Y44_I0.5880.99
232_P236_I0.5880.99
59_F63_L0.5850.99
61_G65_R0.5850.99
237_N244_K0.5790.99
50_F96_F0.5780.99
147_V204_M0.5770.99
123_Q202_S0.5750.99
108_L117_V0.5750.99
60_I88_G0.5740.99
141_Y209_I0.5730.99
193_D219_K0.5710.99
36_I39_D0.5690.99
300_T304_S0.5680.99
193_D221_R0.5680.99
190_F215_E0.5680.99
224_Y269_I0.5660.99
105_G109_A0.5650.99
260_T289_V0.5640.99
82_F85_R0.5630.99
176_T192_D0.5620.99
124_D206_Q0.5590.99
217_K274_K0.5590.99
91_I95_G0.5550.99
244_K253_P0.5540.99
149_V208_A0.5520.99
112_G115_G0.5510.99
229_D294_R0.5510.99
264_T302_A0.5510.99
286_L289_V0.5510.99
249_V252_E0.5500.99
86_L90_I0.5490.99
68_L77_A0.5480.99
255_I267_L0.5470.99
293_V296_L0.5440.99
112_G116_L0.5430.99
178_T192_D0.5400.99
228_K263_N0.5370.99
67_R70_D0.5370.99
232_P291_R0.5350.99
149_V207_A0.5320.99
263_N303_A0.5320.99
31_S36_I0.5300.99
31_S37_P0.5300.99
235_L239_L0.5290.99
259_E282_R0.5280.99
120_L123_Q0.5280.99
116_L124_D0.5250.99
95_G98_V0.5250.99
113_F116_L0.5230.99
35_I40_Y0.5210.99
65_R77_A0.5200.99
82_F86_L0.5200.99
40_Y43_Y0.5200.99
77_A81_S0.5200.99
148_T175_Y0.5190.99
195_I212_H0.5180.99
46_A50_F0.5180.99
82_F181_D0.5180.99
59_F62_S0.5160.98
131_G202_S0.5150.98
49_W95_G0.5120.98
281_P284_E0.5120.98
218_R278_E0.5100.98
42_L99_L0.5070.98
234_V241_E0.5050.98
240_K243_I0.5040.98
202_S205_I0.5030.98
108_L113_F0.5020.98
120_L125_V0.5020.98
257_V287_K0.5010.98
126_L130_F0.5010.98
268_G283_S0.5000.98
228_K264_T0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
5ajiA 3 0.8279 100 0.284 Contact Map
4hw9A 3 0.7987 100 0.288 Contact Map
3udcA 3 0.8052 100 0.325 Contact Map
1nz9A 1 0.1721 50.4 0.944 Contact Map
3j1zP 8 0.9026 36.4 0.949 Contact Map
2e6zA 1 0.1818 36.2 0.949 Contact Map
2mi6A 1 0.1851 29.3 0.951 Contact Map
3h90A 3 0.8669 27 0.952 Contact Map
1rqgA 2 0.2987 17.6 0.956 Contact Map
4l5gA 1 0.4416 14.3 0.958 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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