GREMLIN Database
Q97V63 - 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (HpcE-2)
UniProt: Q97V63 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 304 (245)
Sequences: 4719 (3212)
Seq/√Len: 205.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
174_F265_S3.9641.00
229_N284_D3.7151.00
223_R235_D3.5661.00
160_K163_R3.5541.00
289_E295_V3.1371.00
156_G159_V3.1241.00
161_R250_E2.9751.00
149_G174_F2.9621.00
227_R232_V2.8751.00
244_K247_E2.7081.00
163_R166_D2.6491.00
165_F168_V2.6111.00
159_V167_Y2.5801.00
232_V235_D2.5421.00
161_R247_E2.5261.00
146_I226_L2.4931.00
225_T235_D2.4391.00
227_R287_E2.3781.00
201_D257_T2.3581.00
146_I288_A2.3141.00
225_T289_E2.2791.00
206_M263_I2.2541.00
156_G167_Y2.2241.00
171_Y213_K2.1421.00
144_Y233_R2.1271.00
236_A240_D2.1031.00
287_E295_V2.0991.00
161_R244_K2.0551.00
155_Q259_K2.0091.00
227_R289_E1.9831.00
146_I224_L1.9651.00
223_R291_S1.9211.00
149_G172_T1.8941.00
127_I131_Q1.8841.00
155_Q260_P1.8511.00
172_T206_M1.8471.00
148_L290_I1.8081.00
233_R278_K1.7971.00
165_F246_D1.7681.00
228_V280_L1.7431.00
173_V290_I1.7301.00
51_I169_F1.7171.00
150_V245_I1.7111.00
169_F210_I1.6951.00
46_D49_D1.6831.00
223_R237_Y1.6721.00
152_I249_I1.6711.00
212_T215_E1.6661.00
78_D81_K1.6561.00
118_I252_L1.6561.00
134_L202_T1.6541.00
149_G265_S1.6291.00
128_G131_Q1.6271.00
149_G263_I1.6211.00
102_K113_P1.5811.00
102_K106_K1.5771.00
133_I177_I1.5761.00
135_Y142_V1.5581.00
103_A240_D1.5541.00
124_N259_K1.5201.00
216_I222_L1.5161.00
97_L118_I1.5091.00
125_A257_T1.5061.00
151_I210_I1.4861.00
122_F199_G1.4721.00
83_F131_Q1.4361.00
228_V233_R1.3971.00
92_E259_K1.3841.00
84_Y129_H1.3361.00
172_T293_I1.3241.00
231_E278_K1.3151.00
103_A270_P1.3131.00
139_S181_D1.3021.00
133_I286_I1.2961.00
227_R295_V1.2861.00
225_T232_V1.2831.00
157_K201_D1.2801.00
177_I205_P1.2791.00
97_L248_I1.2711.00
120_T195_V1.2621.00
77_Y82_I1.2451.00
86_P129_H1.2361.00
148_L238_A1.2181.00
220_Y241_M1.2161.00
99_V108_T1.2071.00
155_Q167_Y1.2031.00
218_N221_E1.1871.00
130_N296_L1.1771.00
150_V264_I1.1741.00
79_P84_Y1.1641.00
217_P292_K1.1641.00
137_K158_Y1.1531.00
220_Y246_D1.1451.00
182_R200_M1.1341.00
44_F49_D1.1241.00
62_K66_D1.1091.00
211_V293_I1.1081.00
168_V245_I1.1031.00
155_Q159_V1.0921.00
48_K52_E1.0891.00
221_E239_E1.0721.00
54_G57_S1.0601.00
53_G56_G1.0521.00
226_L288_A1.0441.00
174_F206_M1.0401.00
100_N248_I1.0391.00
86_P126_L1.0311.00
116_P248_I1.0011.00
141_K181_D0.9851.00
127_I202_T0.9821.00
151_I172_T0.9821.00
138_A158_Y0.9811.00
161_R246_D0.9761.00
117_Y194_W0.9751.00
150_V249_I0.9741.00
258_L264_I0.9741.00
154_K166_D0.9631.00
173_V288_A0.9621.00
143_D180_R0.9570.99
136_P200_M0.9520.99
274_L279_F0.9440.99
66_D70_G0.9410.99
139_S142_V0.9410.99
129_H296_L0.9300.99
154_K260_P0.9280.99
222_L290_I0.9270.99
58_I62_K0.9250.99
50_L61_I0.9160.99
152_I258_L0.9100.99
273_G276_T0.9100.99
59_L214_D0.9090.99
150_V171_Y0.9090.99
173_V293_I0.9070.99
178_S183_Q0.8990.99
160_K250_E0.8990.99
64_V68_L0.8960.99
157_K257_T0.8910.99
120_T199_G0.8860.99
133_I201_D0.8850.99
221_E237_Y0.8790.99
154_K167_Y0.8740.99
241_M248_I0.8670.99
141_K279_F0.8660.99
53_G57_S0.8600.99
225_T291_S0.8580.99
104_H143_D0.8540.99
60_L63_S0.8520.99
105_G112_P0.8510.99
196_H255_G0.8500.99
153_G169_F0.8490.99
146_I173_V0.8480.99
220_Y244_K0.8480.99
54_G58_I0.8470.99
155_Q257_T0.8440.99
135_Y282_P0.8380.99
230_G285_T0.8290.99
140_N181_D0.8280.98
101_Y266_T0.8260.98
144_Y280_L0.8250.98
47_T210_I0.8250.98
49_D53_G0.8210.98
95_F256_I0.8190.98
165_F245_I0.8170.98
57_S60_L0.8160.98
142_V200_M0.8140.98
54_G59_L0.8110.98
149_G206_M0.8110.98
186_S196_H0.8070.98
166_D213_K0.8040.98
97_L252_L0.8040.98
228_V286_I0.8030.98
108_T178_S0.8030.98
219_P238_A0.8010.98
247_E250_E0.7960.98
164_A168_V0.7910.98
179_Y182_R0.7850.98
45_Y49_D0.7850.98
195_V199_G0.7820.98
208_P211_V0.7760.98
230_G287_E0.7750.98
95_F252_L0.7710.98
273_G279_F0.7700.98
186_S192_M0.7670.98
96_L195_V0.7660.98
165_F220_Y0.7660.98
192_M196_H0.7640.97
145_E198_K0.7630.97
209_W293_I0.7590.97
100_N269_P0.7570.97
223_R226_L0.7550.97
48_K90_N0.7500.97
126_L206_M0.7500.97
105_G110_N0.7500.97
148_L171_Y0.7460.97
216_I293_I0.7450.97
55_N58_I0.7430.97
174_F202_T0.7410.97
64_V67_S0.7400.97
153_G260_P0.7310.97
159_V250_E0.7300.97
63_S67_S0.7300.97
170_G210_I0.7280.97
86_P128_G0.7270.97
206_M265_S0.7250.97
115_E185_P0.7240.96
238_A291_S0.7240.96
200_M255_G0.7170.96
105_G109_N0.7170.96
103_A106_K0.7120.96
55_N59_L0.7110.96
250_E254_N0.7100.96
243_F247_E0.7100.96
159_V253_S0.7090.96
104_H180_R0.7080.96
102_K112_P0.7070.96
177_I286_I0.7060.96
99_V105_G0.7050.96
172_T207_G0.7040.96
183_Q193_R0.7040.96
61_I64_V0.7030.96
59_L62_K0.7020.96
95_F120_T0.7000.96
156_G160_K0.6980.96
108_T275_A0.6920.95
65_L69_R0.6890.95
165_F213_K0.6870.95
133_I202_T0.6860.95
139_S179_Y0.6850.95
186_S255_G0.6840.95
151_I263_I0.6820.95
112_P242_I0.6770.95
248_I266_T0.6770.95
168_V171_Y0.6760.95
52_E92_E0.6730.95
249_I264_I0.6710.95
250_E253_S0.6700.95
44_F47_T0.6700.95
50_L57_S0.6690.95
121_K199_G0.6690.95
183_Q197_G0.6660.94
280_L286_I0.6660.94
122_F195_V0.6640.94
211_V216_I0.6600.94
105_G242_I0.6580.94
60_L64_V0.6550.94
226_L286_I0.6540.94
142_V179_Y0.6510.94
99_V110_N0.6490.94
227_R230_G0.6490.94
163_R167_Y0.6480.94
50_L58_I0.6480.94
75_V78_D0.6450.93
124_N201_D0.6440.93
160_K167_Y0.6440.93
47_T51_I0.6410.93
171_Y219_P0.6410.93
180_R183_Q0.6400.93
86_P89_T0.6380.93
177_I202_T0.6370.93
99_V117_Y0.6340.93
101_Y238_A0.6330.93
79_P209_W0.6320.93
50_L54_G0.6320.93
95_F122_F0.6300.93
108_T184_F0.6300.93
241_M246_D0.6260.92
104_H183_Q0.6260.92
196_H199_G0.6260.92
105_G108_T0.6220.92
196_H254_N0.6210.92
223_R239_E0.6200.92
123_S126_L0.6200.92
92_E123_S0.6180.92
272_V275_A0.6180.92
236_A270_P0.6170.92
238_A245_I0.6130.92
186_S193_R0.6110.92
88_I91_P0.6100.91
96_L197_G0.6080.91
54_G61_I0.6010.91
158_Y254_N0.6010.91
99_V178_S0.6000.91
50_L53_G0.5990.91
147_E268_T0.5970.91
175_N288_A0.5960.90
144_Y288_A0.5960.90
249_I253_S0.5950.90
49_D52_E0.5900.90
108_T274_L0.5890.90
47_T50_L0.5890.90
138_A254_N0.5880.90
224_L236_A0.5870.90
176_D198_K0.5850.90
222_L238_A0.5850.90
88_I151_I0.5840.90
87_P172_T0.5830.90
142_V177_I0.5830.90
246_D250_E0.5790.89
193_R277_G0.5770.89
126_L174_F0.5760.89
98_A104_H0.5760.89
138_A179_Y0.5740.89
249_I258_L0.5720.89
168_V249_I0.5670.88
142_V282_P0.5650.88
99_V113_P0.5630.88
126_L129_H0.5620.88
227_R235_D0.5610.88
103_A272_V0.5590.87
185_P251_Y0.5570.87
92_E124_N0.5550.87
102_K242_I0.5550.87
56_G60_L0.5540.87
133_I142_V0.5520.87
51_I88_I0.5510.87
165_F171_Y0.5510.87
245_I266_T0.5500.87
181_D185_P0.5490.87
118_I196_H0.5490.87
90_N259_K0.5470.86
63_S66_D0.5450.86
52_E260_P0.5430.86
228_V278_K0.5420.86
53_G58_I0.5400.86
115_E186_S0.5400.86
98_A101_Y0.5390.86
136_P139_S0.5390.86
89_T259_K0.5390.86
51_I151_I0.5380.85
147_E198_K0.5370.85
278_K281_K0.5340.85
237_Y291_S0.5330.85
105_G270_P0.5320.85
184_F274_L0.5320.85
252_L264_I0.5310.85
177_I280_L0.5290.84
96_L194_W0.5280.84
213_K249_I0.5270.84
146_I236_A0.5270.84
248_I252_L0.5260.84
143_D183_Q0.5250.84
178_S184_F0.5230.84
86_P210_I0.5220.84
56_G59_L0.5200.83
113_P243_F0.5200.83
220_Y245_I0.5190.83
106_K110_N0.5190.83
175_N286_I0.5170.83
67_S71_K0.5160.83
94_I265_S0.5160.83
118_I251_Y0.5150.83
199_G254_N0.5130.83
116_P251_Y0.5120.83
107_E271_G0.5120.83
120_T193_R0.5120.83
162_E250_E0.5110.82
77_Y81_K0.5110.82
85_Y128_G0.5100.82
148_L269_P0.5090.82
68_L71_K0.5070.82
85_Y131_Q0.5070.82
143_D280_L0.5060.82
141_K184_F0.5030.81
145_E176_D0.5030.81
252_L256_I0.5020.81
222_L291_S0.5020.81
223_R236_A0.5010.81
172_T210_I0.5000.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3r6oA 2 0.852 100 0.206 Contact Map
4qkuA 2 0.977 100 0.245 Contact Map
3lzkA 2 0.9441 100 0.252 Contact Map
4dbfA 2 0.8289 100 0.265 Contact Map
3rr6A 1 0.8289 100 0.272 Contact Map
1hyoA 2 0.9803 100 0.274 Contact Map
1wzoA 4 0.7895 100 0.292 Contact Map
2dfuA 2 0.7829 100 0.301 Contact Map
2q18X 3 0.8651 100 0.319 Contact Map
1gttA 1 0.9243 100 0.346 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0092 seconds.