Q97V63 - SULSO - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

Q97V63 - 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (HpcE-2)

UniProt:	Q97V63	Sequences: MVKILLFSPNPNEFKRVGVYENGRVIDLVKAYELLYDAKPPNWFYDTKDLIEGGNGSILLIKSVLDSLRGKEDKVSYDPEKIFYYPPITNPEKIFLLAVNYKAHGKETNNEPPKEPYIFTKFSNALIGHNQPILYPKASNKVDYEIELGVIIGKQGKYVKRERAFDYVFGYTVFNDISYRDRQFPSEMPYGMRWVHGKGMDTGAPMGPWIVTKDEIPNPYELRLTLRVNGEVRQDAYAEDMIFKIDEIIEYLSNGITLKPGDIISTGTPPGVGLATGKFLKPGDTIEAEISKIGVLRNYLVKEE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	304 (245)
Sequences:	4719 (3212)
Seq/√Len:	205.2

ECOLI - YCGM
BACSU - YISK
HALSA - Q9HQR6
SULSO - Q97V63 Q97VT9 Q97UR1 KDAD

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
174_F	265_S	3.964	1.00
229_N	284_D	3.715	1.00
223_R	235_D	3.566	1.00
160_K	163_R	3.554	1.00
289_E	295_V	3.137	1.00
156_G	159_V	3.124	1.00
161_R	250_E	2.975	1.00
149_G	174_F	2.962	1.00
227_R	232_V	2.875	1.00
244_K	247_E	2.708	1.00
163_R	166_D	2.649	1.00
165_F	168_V	2.611	1.00
159_V	167_Y	2.580	1.00
232_V	235_D	2.542	1.00
161_R	247_E	2.526	1.00
146_I	226_L	2.493	1.00
225_T	235_D	2.439	1.00
227_R	287_E	2.378	1.00
201_D	257_T	2.358	1.00
146_I	288_A	2.314	1.00
225_T	289_E	2.279	1.00
206_M	263_I	2.254	1.00
156_G	167_Y	2.224	1.00
171_Y	213_K	2.142	1.00
144_Y	233_R	2.127	1.00
236_A	240_D	2.103	1.00
287_E	295_V	2.099	1.00
161_R	244_K	2.055	1.00
155_Q	259_K	2.009	1.00
227_R	289_E	1.983	1.00
146_I	224_L	1.965	1.00
223_R	291_S	1.921	1.00
149_G	172_T	1.894	1.00
127_I	131_Q	1.884	1.00
155_Q	260_P	1.851	1.00
172_T	206_M	1.847	1.00
148_L	290_I	1.808	1.00
233_R	278_K	1.797	1.00
165_F	246_D	1.768	1.00
228_V	280_L	1.743	1.00
173_V	290_I	1.730	1.00
51_I	169_F	1.717	1.00
150_V	245_I	1.711	1.00
169_F	210_I	1.695	1.00
46_D	49_D	1.683	1.00
223_R	237_Y	1.672	1.00
152_I	249_I	1.671	1.00
212_T	215_E	1.666	1.00
78_D	81_K	1.656	1.00
118_I	252_L	1.656	1.00
134_L	202_T	1.654	1.00
149_G	265_S	1.629	1.00
128_G	131_Q	1.627	1.00
149_G	263_I	1.621	1.00
102_K	113_P	1.581	1.00
102_K	106_K	1.577	1.00
133_I	177_I	1.576	1.00
135_Y	142_V	1.558	1.00
103_A	240_D	1.554	1.00
124_N	259_K	1.520	1.00
216_I	222_L	1.516	1.00
97_L	118_I	1.509	1.00
125_A	257_T	1.506	1.00
151_I	210_I	1.486	1.00
122_F	199_G	1.472	1.00
83_F	131_Q	1.436	1.00
228_V	233_R	1.397	1.00
92_E	259_K	1.384	1.00
84_Y	129_H	1.336	1.00
172_T	293_I	1.324	1.00
231_E	278_K	1.315	1.00
103_A	270_P	1.313	1.00
139_S	181_D	1.302	1.00
133_I	286_I	1.296	1.00
227_R	295_V	1.286	1.00
225_T	232_V	1.283	1.00
157_K	201_D	1.280	1.00
177_I	205_P	1.279	1.00
97_L	248_I	1.271	1.00
120_T	195_V	1.262	1.00
77_Y	82_I	1.245	1.00
86_P	129_H	1.236	1.00
148_L	238_A	1.218	1.00
220_Y	241_M	1.216	1.00
99_V	108_T	1.207	1.00
155_Q	167_Y	1.203	1.00
218_N	221_E	1.187	1.00
130_N	296_L	1.177	1.00
150_V	264_I	1.174	1.00
79_P	84_Y	1.164	1.00
217_P	292_K	1.164	1.00
137_K	158_Y	1.153	1.00
220_Y	246_D	1.145	1.00
182_R	200_M	1.134	1.00
44_F	49_D	1.124	1.00
62_K	66_D	1.109	1.00
211_V	293_I	1.108	1.00
168_V	245_I	1.103	1.00
155_Q	159_V	1.092	1.00
48_K	52_E	1.089	1.00
221_E	239_E	1.072	1.00
54_G	57_S	1.060	1.00
53_G	56_G	1.052	1.00
226_L	288_A	1.044	1.00
174_F	206_M	1.040	1.00
100_N	248_I	1.039	1.00
86_P	126_L	1.031	1.00
116_P	248_I	1.001	1.00
141_K	181_D	0.985	1.00
127_I	202_T	0.982	1.00
151_I	172_T	0.982	1.00
138_A	158_Y	0.981	1.00
161_R	246_D	0.976	1.00
117_Y	194_W	0.975	1.00
150_V	249_I	0.974	1.00
258_L	264_I	0.974	1.00
154_K	166_D	0.963	1.00
173_V	288_A	0.962	1.00
143_D	180_R	0.957	0.99
136_P	200_M	0.952	0.99
274_L	279_F	0.944	0.99
66_D	70_G	0.941	0.99
139_S	142_V	0.941	0.99
129_H	296_L	0.930	0.99
154_K	260_P	0.928	0.99
222_L	290_I	0.927	0.99
58_I	62_K	0.925	0.99
50_L	61_I	0.916	0.99
152_I	258_L	0.910	0.99
273_G	276_T	0.910	0.99
59_L	214_D	0.909	0.99
150_V	171_Y	0.909	0.99
173_V	293_I	0.907	0.99
178_S	183_Q	0.899	0.99
160_K	250_E	0.899	0.99
64_V	68_L	0.896	0.99
157_K	257_T	0.891	0.99
120_T	199_G	0.886	0.99
133_I	201_D	0.885	0.99
221_E	237_Y	0.879	0.99
154_K	167_Y	0.874	0.99
241_M	248_I	0.867	0.99
141_K	279_F	0.866	0.99
53_G	57_S	0.860	0.99
225_T	291_S	0.858	0.99
104_H	143_D	0.854	0.99
60_L	63_S	0.852	0.99
105_G	112_P	0.851	0.99
196_H	255_G	0.850	0.99
153_G	169_F	0.849	0.99
146_I	173_V	0.848	0.99
220_Y	244_K	0.848	0.99
54_G	58_I	0.847	0.99
155_Q	257_T	0.844	0.99
135_Y	282_P	0.838	0.99
230_G	285_T	0.829	0.99
140_N	181_D	0.828	0.98
101_Y	266_T	0.826	0.98
144_Y	280_L	0.825	0.98
47_T	210_I	0.825	0.98
49_D	53_G	0.821	0.98
95_F	256_I	0.819	0.98
165_F	245_I	0.817	0.98
57_S	60_L	0.816	0.98
142_V	200_M	0.814	0.98
54_G	59_L	0.811	0.98
149_G	206_M	0.811	0.98
186_S	196_H	0.807	0.98
166_D	213_K	0.804	0.98
97_L	252_L	0.804	0.98
228_V	286_I	0.803	0.98
108_T	178_S	0.803	0.98
219_P	238_A	0.801	0.98
247_E	250_E	0.796	0.98
164_A	168_V	0.791	0.98
179_Y	182_R	0.785	0.98
45_Y	49_D	0.785	0.98
195_V	199_G	0.782	0.98
208_P	211_V	0.776	0.98
230_G	287_E	0.775	0.98
95_F	252_L	0.771	0.98
273_G	279_F	0.770	0.98
186_S	192_M	0.767	0.98
96_L	195_V	0.766	0.98
165_F	220_Y	0.766	0.98
192_M	196_H	0.764	0.97
145_E	198_K	0.763	0.97
209_W	293_I	0.759	0.97
100_N	269_P	0.757	0.97
223_R	226_L	0.755	0.97
48_K	90_N	0.750	0.97
126_L	206_M	0.750	0.97
105_G	110_N	0.750	0.97
148_L	171_Y	0.746	0.97
216_I	293_I	0.745	0.97
55_N	58_I	0.743	0.97
174_F	202_T	0.741	0.97
64_V	67_S	0.740	0.97
153_G	260_P	0.731	0.97
159_V	250_E	0.730	0.97
63_S	67_S	0.730	0.97
170_G	210_I	0.728	0.97
86_P	128_G	0.727	0.97
206_M	265_S	0.725	0.97
115_E	185_P	0.724	0.96
238_A	291_S	0.724	0.96
200_M	255_G	0.717	0.96
105_G	109_N	0.717	0.96
103_A	106_K	0.712	0.96
55_N	59_L	0.711	0.96
250_E	254_N	0.710	0.96
243_F	247_E	0.710	0.96
159_V	253_S	0.709	0.96
104_H	180_R	0.708	0.96
102_K	112_P	0.707	0.96
177_I	286_I	0.706	0.96
99_V	105_G	0.705	0.96
172_T	207_G	0.704	0.96
183_Q	193_R	0.704	0.96
61_I	64_V	0.703	0.96
59_L	62_K	0.702	0.96
95_F	120_T	0.700	0.96
156_G	160_K	0.698	0.96
108_T	275_A	0.692	0.95
65_L	69_R	0.689	0.95
165_F	213_K	0.687	0.95
133_I	202_T	0.686	0.95
139_S	179_Y	0.685	0.95
186_S	255_G	0.684	0.95
151_I	263_I	0.682	0.95
112_P	242_I	0.677	0.95
248_I	266_T	0.677	0.95
168_V	171_Y	0.676	0.95
52_E	92_E	0.673	0.95
249_I	264_I	0.671	0.95
250_E	253_S	0.670	0.95
44_F	47_T	0.670	0.95
50_L	57_S	0.669	0.95
121_K	199_G	0.669	0.95
183_Q	197_G	0.666	0.94
280_L	286_I	0.666	0.94
122_F	195_V	0.664	0.94
211_V	216_I	0.660	0.94
105_G	242_I	0.658	0.94
60_L	64_V	0.655	0.94
226_L	286_I	0.654	0.94
142_V	179_Y	0.651	0.94
99_V	110_N	0.649	0.94
227_R	230_G	0.649	0.94
163_R	167_Y	0.648	0.94
50_L	58_I	0.648	0.94
75_V	78_D	0.645	0.93
124_N	201_D	0.644	0.93
160_K	167_Y	0.644	0.93
47_T	51_I	0.641	0.93
171_Y	219_P	0.641	0.93
180_R	183_Q	0.640	0.93
86_P	89_T	0.638	0.93
177_I	202_T	0.637	0.93
99_V	117_Y	0.634	0.93
101_Y	238_A	0.633	0.93
79_P	209_W	0.632	0.93
50_L	54_G	0.632	0.93
95_F	122_F	0.630	0.93
108_T	184_F	0.630	0.93
241_M	246_D	0.626	0.92
104_H	183_Q	0.626	0.92
196_H	199_G	0.626	0.92
105_G	108_T	0.622	0.92
196_H	254_N	0.621	0.92
223_R	239_E	0.620	0.92
123_S	126_L	0.620	0.92
92_E	123_S	0.618	0.92
272_V	275_A	0.618	0.92
236_A	270_P	0.617	0.92
238_A	245_I	0.613	0.92
186_S	193_R	0.611	0.92
88_I	91_P	0.610	0.91
96_L	197_G	0.608	0.91
54_G	61_I	0.601	0.91
158_Y	254_N	0.601	0.91
99_V	178_S	0.600	0.91
50_L	53_G	0.599	0.91
147_E	268_T	0.597	0.91
175_N	288_A	0.596	0.90
144_Y	288_A	0.596	0.90
249_I	253_S	0.595	0.90
49_D	52_E	0.590	0.90
108_T	274_L	0.589	0.90
47_T	50_L	0.589	0.90
138_A	254_N	0.588	0.90
224_L	236_A	0.587	0.90
176_D	198_K	0.585	0.90
222_L	238_A	0.585	0.90
88_I	151_I	0.584	0.90
87_P	172_T	0.583	0.90
142_V	177_I	0.583	0.90
246_D	250_E	0.579	0.89
193_R	277_G	0.577	0.89
126_L	174_F	0.576	0.89
98_A	104_H	0.576	0.89
138_A	179_Y	0.574	0.89
249_I	258_L	0.572	0.89
168_V	249_I	0.567	0.88
142_V	282_P	0.565	0.88
99_V	113_P	0.563	0.88
126_L	129_H	0.562	0.88
227_R	235_D	0.561	0.88
103_A	272_V	0.559	0.87
185_P	251_Y	0.557	0.87
92_E	124_N	0.555	0.87
102_K	242_I	0.555	0.87
56_G	60_L	0.554	0.87
133_I	142_V	0.552	0.87
51_I	88_I	0.551	0.87
165_F	171_Y	0.551	0.87
245_I	266_T	0.550	0.87
181_D	185_P	0.549	0.87
118_I	196_H	0.549	0.87
90_N	259_K	0.547	0.86
63_S	66_D	0.545	0.86
52_E	260_P	0.543	0.86
228_V	278_K	0.542	0.86
53_G	58_I	0.540	0.86
115_E	186_S	0.540	0.86
98_A	101_Y	0.539	0.86
136_P	139_S	0.539	0.86
89_T	259_K	0.539	0.86
51_I	151_I	0.538	0.85
147_E	198_K	0.537	0.85
278_K	281_K	0.534	0.85
237_Y	291_S	0.533	0.85
105_G	270_P	0.532	0.85
184_F	274_L	0.532	0.85
252_L	264_I	0.531	0.85
177_I	280_L	0.529	0.84
96_L	194_W	0.528	0.84
213_K	249_I	0.527	0.84
146_I	236_A	0.527	0.84
248_I	252_L	0.526	0.84
143_D	183_Q	0.525	0.84
178_S	184_F	0.523	0.84
86_P	210_I	0.522	0.84
56_G	59_L	0.520	0.83
113_P	243_F	0.520	0.83
220_Y	245_I	0.519	0.83
106_K	110_N	0.519	0.83
175_N	286_I	0.517	0.83
67_S	71_K	0.516	0.83
94_I	265_S	0.516	0.83
118_I	251_Y	0.515	0.83
199_G	254_N	0.513	0.83
116_P	251_Y	0.512	0.83
107_E	271_G	0.512	0.83
120_T	193_R	0.512	0.83
162_E	250_E	0.511	0.82
77_Y	81_K	0.511	0.82
85_Y	128_G	0.510	0.82
148_L	269_P	0.509	0.82
68_L	71_K	0.507	0.82
85_Y	131_Q	0.507	0.82
143_D	280_L	0.506	0.82
141_K	184_F	0.503	0.81
145_E	176_D	0.503	0.81
252_L	256_I	0.502	0.81
222_L	291_S	0.502	0.81
223_R	236_A	0.501	0.81
172_T	210_I	0.500	0.81

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3r6oA	2	0.852	100	0.206	Contact Map
4qkuA	2	0.977	100	0.245	Contact Map
3lzkA	2	0.9441	100	0.252	Contact Map
4dbfA	2	0.8289	100	0.265	Contact Map
3rr6A	1	0.8289	100	0.272	Contact Map
1hyoA	2	0.9803	100	0.274	Contact Map
1wzoA	4	0.7895	100	0.292	Contact Map
2dfuA	2	0.7829	100	0.301	Contact Map
2q18X	3	0.8651	100	0.319	Contact Map
1gttA	1	0.9243	100	0.346	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0093 seconds.