GREMLIN Database
Q97V56 - Dehydrogenase
UniProt: Q97V56 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 292 (254)
Sequences: 32247 (20583)
Seq/√Len: 1291.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
43_R249_E3.1991.00
100_K138_V2.9431.00
34_D69_E2.8291.00
72_K107_G2.8121.00
217_Y263_D2.7041.00
260_S263_D2.5311.00
38_V73_E2.4541.00
99_A133_L2.4511.00
96_I132_K2.4031.00
96_I136_D2.3641.00
43_R47_L2.3611.00
216_K266_A2.1621.00
131_E135_D2.0861.00
38_V69_E2.0671.00
231_T264_W2.0261.00
109_Y140_R2.0101.00
211_A215_K2.0001.00
216_K263_D1.9931.00
132_K136_D1.9851.00
101_N105_R1.9831.00
185_Y189_N1.9561.00
245_I249_E1.9341.00
261_E265_R1.8981.00
75_S78_E1.8911.00
43_R245_I1.8681.00
186_A193_Y1.8651.00
212_N266_A1.8401.00
92_Y132_K1.8281.00
16_A51_V1.8191.00
47_L249_E1.7901.00
219_K257_W1.7861.00
153_E157_E1.7151.00
81_I108_T1.7071.00
114_L166_A1.7021.00
132_K135_D1.6981.00
44_A49_L1.6611.00
92_Y96_I1.6591.00
153_E185_Y1.6461.00
83_S110_I1.6361.00
47_L252_A1.6311.00
33_R36_E1.6261.00
38_V42_R1.6191.00
65_E105_R1.6121.00
85_V113_Y1.6011.00
83_S102_S1.5901.00
220_T250_E1.5891.00
192_M237_I1.5841.00
42_R73_E1.5831.00
43_R46_E1.5771.00
96_I100_K1.5741.00
227_N257_W1.5661.00
265_R269_E1.5601.00
99_A113_Y1.5581.00
209_F212_N1.5581.00
38_V70_A1.5531.00
85_V95_V1.5411.00
253_G256_G1.5381.00
129_A132_K1.5341.00
82_V114_L1.5171.00
19_T52_I1.4851.00
10_F141_F1.4651.00
97_K101_N1.4471.00
219_K223_Q1.4401.00
45_I79_L1.4371.00
181_R184_A1.4311.00
100_K104_R1.4241.00
114_L194_M1.4181.00
184_A188_K1.4171.00
34_D38_V1.4171.00
36_E39_G1.4131.00
56_E98_S1.4091.00
41_I70_A1.3701.00
156_R189_N1.3611.00
110_I139_I1.3591.00
148_D151_Q1.3571.00
249_E253_G1.3451.00
227_N231_T1.3261.00
10_F80_F1.3221.00
92_Y128_R1.3141.00
219_K224_V1.2951.00
156_R185_Y1.2921.00
42_R46_E1.2901.00
39_G43_R1.2861.00
101_N104_R1.2841.00
266_A269_E1.2831.00
242_A247_H1.2811.00
92_Y129_A1.2761.00
139_I142_F1.2651.00
76_R108_T1.2641.00
133_L139_I1.2611.00
96_I129_A1.2581.00
212_N216_K1.2571.00
135_D163_E1.2561.00
106_L110_I1.2441.00
80_F112_L1.2351.00
242_A248_I1.2341.00
149_V185_Y1.2291.00
220_T223_Q1.2251.00
68_G107_G1.2191.00
52_I67_V1.2141.00
209_F266_A1.2061.00
64_E102_S1.2001.00
124_C158_C1.1981.00
76_R109_Y1.1911.00
69_E107_G1.1911.00
187_E233_K1.1861.00
234_N268_D1.1771.00
35_N39_G1.1651.00
183_L187_E1.1551.00
211_A221_A1.1471.00
91_D94_N1.1361.00
118_P151_Q1.1331.00
93_D97_K1.1331.00
94_N97_K1.1191.00
246_P249_E1.1171.00
51_V82_V1.1091.00
65_E69_E1.1041.00
153_E188_K1.1041.00
229_Y238_P1.0991.00
131_E134_V1.0971.00
51_V194_M1.0951.00
99_A110_I1.0921.00
153_E189_N1.0861.00
212_N215_K1.0861.00
130_F142_F1.0761.00
213_I224_V1.0711.00
19_T67_V1.0661.00
39_G245_I1.0601.00
100_K136_D1.0591.00
42_R70_A1.0561.00
50_R80_F1.0521.00
133_L138_V1.0481.00
187_E234_N1.0451.00
170_H175_S1.0431.00
40_A248_I1.0431.00
8_K141_F1.0381.00
115_L130_F1.0371.00
208_E212_N1.0371.00
223_Q253_G1.0351.00
154_S158_C1.0231.00
125_K128_R1.0221.00
210_L221_A1.0071.00
176_R207_N1.0071.00
13_S50_R1.0061.00
7_F167_I1.0061.00
131_E163_E1.0021.00
149_V153_E0.9991.00
178_D193_Y0.9981.00
208_E211_A0.9951.00
90_A115_L0.9911.00
180_R184_A0.9791.00
64_E105_R0.9751.00
230_I254_A0.9691.00
187_E235_S0.9651.00
184_A187_E0.9601.00
223_Q250_E0.9571.00
14_P230_I0.9561.00
14_P255_M0.9551.00
128_R132_K0.9541.00
69_E73_E0.9491.00
124_C154_S0.9471.00
13_S49_L0.9461.00
194_M237_I0.9451.00
111_D140_R0.9441.00
248_I252_A0.9331.00
71_I79_L0.9311.00
96_I99_A0.9271.00
142_F164_I0.9211.00
133_L136_D0.9191.00
65_E104_R0.9111.00
141_F165_V0.9101.00
246_P250_E0.9061.00
39_G42_R0.9061.00
56_E94_N0.9061.00
97_K100_K0.9031.00
56_E89_H0.8971.00
250_E253_G0.8961.00
176_R179_E0.8921.00
112_L166_A0.8911.00
45_I75_S0.8891.00
185_Y188_K0.8881.00
89_H94_N0.8841.00
129_A133_L0.8831.00
41_I52_I0.8821.00
92_Y125_K0.8791.00
231_T258_R0.8741.00
144_L164_I0.8741.00
265_R268_D0.8721.00
82_V194_M0.8691.00
144_L152_I0.8551.00
244_K247_H0.8551.00
128_R131_E0.8541.00
262_E266_A0.8531.00
96_I133_L0.8491.00
131_E162_Y0.8461.00
82_V112_L0.8451.00
178_D271_F0.8411.00
226_L254_A0.8321.00
262_E265_R0.8301.00
152_I191_L0.8291.00
134_V165_V0.8271.00
131_E142_F0.8251.00
8_K134_V0.8231.00
19_T63_A0.8221.00
216_K260_S0.8221.00
56_E105_R0.8191.00
169_N193_Y0.8181.00
225_A229_Y0.8131.00
154_S157_E0.8111.00
213_I217_Y0.8091.00
103_S138_V0.8071.00
17_F44_A0.8061.00
146_N196_Y0.7951.00
103_S108_T0.7841.00
231_T261_E0.7821.00
56_E101_N0.7761.00
43_R248_I0.7741.00
227_N254_A0.7671.00
209_F270_H0.7601.00
217_Y260_S0.7541.00
183_L234_N0.7521.00
47_L253_G0.7491.00
198_P240_V0.7481.00
83_S113_Y0.7441.00
183_L193_Y0.7421.00
243_S247_H0.7421.00
35_N38_V0.7411.00
195_A198_P0.7391.00
42_R75_S0.7271.00
149_V182_A0.7231.00
49_L252_A0.7231.00
149_V181_R0.7231.00
228_W268_D0.7211.00
54_T67_V0.7201.00
182_A186_A0.7191.00
127_I142_F0.7181.00
127_I155_A0.7181.00
122_P125_K0.7171.00
99_A138_V0.7121.00
117_A146_N0.7081.00
15_L230_I0.7061.00
45_I52_I0.7051.00
144_L147_F0.7041.00
259_L264_W0.7021.00
77_E109_Y0.7021.00
95_V133_L0.7021.00
134_V164_I0.7011.00
102_S113_Y0.7001.00
173_L225_A0.6991.00
222_T250_E0.6971.00
40_A245_I0.6961.00
16_A240_V0.6961.00
90_A126_T0.6921.00
98_S101_N0.6851.00
37_W66_L0.6841.00
114_L143_G0.6801.00
171_Y179_E0.6751.00
215_K218_N0.6751.00
195_A238_P0.6751.00
217_Y224_V0.6741.00
186_A191_L0.6741.00
229_Y236_L0.6741.00
158_C162_Y0.6681.00
95_V126_T0.6641.00
17_F22_I0.6631.00
214_G224_V0.6581.00
198_P229_Y0.6571.00
192_M236_L0.6561.00
50_R78_E0.6561.00
219_K256_G0.6551.00
213_I263_D0.6521.00
247_H250_E0.6511.00
12_V237_I0.6501.00
57_M86_W0.6501.00
219_K253_G0.6481.00
126_T129_A0.6461.00
103_S109_Y0.6451.00
21_R201_N0.6401.00
173_L267_I0.6401.00
8_K165_V0.6361.00
134_V141_F0.6331.00
130_F134_V0.6321.00
210_L225_A0.6321.00
224_V259_L0.6321.00
41_I45_I0.6301.00
16_A237_I0.6281.00
110_I113_Y0.6271.00
207_N211_A0.6261.00
263_D266_A0.6201.00
20_W197_T0.6201.00
47_L248_I0.6201.00
121_V125_K0.6201.00
210_L267_I0.6191.00
46_E245_I0.6191.00
203_I206_R0.6181.00
95_V129_A0.6161.00
153_E156_R0.6141.00
204_L225_A0.6121.00
75_S79_L0.6121.00
213_I266_A0.6121.00
224_V257_W0.6111.00
36_E245_I0.6111.00
45_I50_R0.6111.00
74_F79_L0.6041.00
134_V139_I0.6011.00
219_K227_N0.5991.00
45_I78_E0.5971.00
103_S110_I0.5971.00
87_P90_A0.5961.00
123_I158_C0.5951.00
40_A242_A0.5931.00
96_I138_V0.5921.00
99_A103_S0.5921.00
10_F140_R0.5911.00
224_V263_D0.5871.00
259_L263_D0.5861.00
34_D66_L0.5861.00
203_I207_N0.5861.00
56_E86_W0.5841.00
24_G66_L0.5831.00
22_I37_W0.5811.00
197_T201_N0.5781.00
91_D126_T0.5781.00
85_V98_S0.5751.00
15_L255_M0.5741.00
195_A235_S0.5741.00
151_Q154_S0.5741.00
214_G217_Y0.5731.00
113_Y139_I0.5651.00
206_R211_A0.5621.00
7_F190_G0.5611.00
214_G221_A0.5601.00
41_I67_V0.5581.00
16_A239_I0.5551.00
168_Q172_S0.5531.00
242_A251_N0.5511.00
224_V267_I0.5511.00
144_L155_A0.5511.00
12_V51_V0.5501.00
113_Y130_F0.5491.00
17_F40_A0.5481.00
230_I238_P0.5451.00
210_L214_G0.5451.00
150_D153_E0.5411.00
166_A194_M0.5381.00
223_Q257_W0.5381.00
22_I40_A0.5371.00
134_V162_Y0.5361.00
171_Y193_Y0.5351.00
156_R191_L0.5341.00
92_Y95_V0.5331.00
51_V80_F0.5331.00
123_I126_T0.5331.00
76_R111_D0.5311.00
64_E83_S0.5281.00
173_L271_F0.5271.00
118_P147_F0.5271.00
123_I154_S0.5261.00
156_R163_E0.5261.00
23_G63_A0.5251.00
217_Y257_W0.5251.00
69_E72_K0.5231.00
44_A52_I0.5221.00
127_I164_I0.5211.00
45_I70_A0.5211.00
54_T63_A0.5201.00
115_L126_T0.5161.00
52_I71_I0.5141.00
123_I151_Q0.5141.00
213_I270_H0.5121.00
99_A129_A0.5121.00
245_I248_I0.5081.00
124_C128_R0.5051.00
65_E107_G0.5041.00
226_L240_V0.5031.00
67_V70_A0.5021.00
38_V66_L0.5011.00
227_N258_R0.5011.00
85_V90_A0.5001.00
174_L203_I0.5001.00
264_W268_D0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3v0sA 1 0.8767 100 0.149 Contact Map
1pyfA 1 0.9212 100 0.15 Contact Map
3lutA 3 0.9281 100 0.155 Contact Map
4xk2A 5 0.9555 100 0.156 Contact Map
1pz1A 1 0.9829 100 0.163 Contact Map
5c7hA 1 0.9418 100 0.165 Contact Map
1lqaA 2 0.9349 100 0.167 Contact Map
3n2tA 1 0.9521 100 0.17 Contact Map
4wghA 1 0.9384 100 0.171 Contact Map
3erpA 6 0.9212 100 0.175 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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