GREMLIN Database
Q97V53 - Transposase ISC1316
UniProt: Q97V53 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 374 (331)
Sequences: 4585 (2902)
Seq/√Len: 159.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
233_D237_K5.2511.00
307_A337_N4.1861.00
255_H258_Q4.1771.00
287_L294_L3.5311.00
174_L279_L2.9481.00
280_R296_L2.9311.00
251_M283_I2.9101.00
250_V346_A2.8951.00
240_K244_E2.8281.00
278_E282_L2.7071.00
317_S320_D2.5801.00
135_V147_I2.5011.00
260_I272_S2.4261.00
193_L269_R2.3981.00
301_Y304_K2.3391.00
278_E281_D2.3041.00
243_A287_L2.2751.00
284_K296_L2.2671.00
297_V342_I2.2621.00
305_T312_V2.2461.00
345_G348_S2.2271.00
279_L283_I2.2261.00
133_K152_D2.2011.00
199_L216_A2.1351.00
249_V287_L2.0681.00
324_V331_I2.0551.00
236_M282_L2.0451.00
11_L57_A2.0431.00
13_W17_Y2.0271.00
192_A230_L2.0201.00
236_M285_Y2.0031.00
302_T342_I1.9911.00
232_T278_E1.9841.00
309_C328_C1.9581.00
306_C309_C1.9571.00
239_G282_L1.9551.00
304_K316_L1.9531.00
28_Q32_R1.9371.00
251_M294_L1.9221.00
309_C325_C1.8931.00
16_I74_F1.8801.00
29_T32_R1.8641.00
216_A220_L1.8601.00
28_Q58_D1.8511.00
265_R268_R1.8231.00
236_M286_Q1.8011.00
284_K288_E1.8001.00
321_R334_R1.7951.00
211_N214_F1.7841.00
247_D292_K1.7801.00
325_C328_C1.7601.00
308_R330_W1.7291.00
236_M239_G1.7271.00
174_L234_L1.7241.00
235_Y282_L1.6961.00
306_C325_C1.6801.00
59_R87_V1.6701.00
306_C328_C1.6481.00
323_F332_A1.6361.00
202_E206_K1.6331.00
6_E44_E1.6311.00
262_K268_R1.6091.00
203_L217_K1.6081.00
206_K216_A1.5841.00
167_I175_I1.5731.00
12_R60_Y1.5691.00
235_Y278_E1.5511.00
251_M296_L1.5221.00
251_M280_R1.5051.00
214_F217_K1.4911.00
322_V331_I1.4781.00
70_G73_R1.4631.00
253_D296_L1.4631.00
177_T181_E1.4581.00
323_F330_W1.4571.00
340_L344_K1.4511.00
239_G285_Y1.4481.00
176_V336_Y1.4201.00
16_I20_Q1.4191.00
66_R72_A1.4191.00
111_L147_I1.4111.00
311_Y326_S1.4101.00
164_V343_L1.4091.00
51_Q89_P1.4001.00
17_Y21_R1.3981.00
316_L320_D1.3921.00
29_T33_Q1.3901.00
61_Y65_Q1.3721.00
209_L213_W1.3701.00
165_V177_T1.3681.00
239_G286_Q1.3641.00
252_E299_P1.3401.00
51_Q90_Q1.3231.00
64_R74_F1.3171.00
15_D31_L1.3061.00
173_K176_V1.3011.00
239_G279_L1.2941.00
262_K265_R1.2841.00
271_L276_F1.2761.00
313_K316_L1.2731.00
225_E229_N1.2721.00
11_L60_Y1.2691.00
318_L321_R1.2671.00
199_L202_E1.2631.00
284_K294_L1.2401.00
307_A340_L1.2221.00
140_T143_E1.2101.00
142_S225_E1.2041.00
27_T30_E1.2021.00
195_K199_L1.1971.00
164_V248_V1.1921.00
165_V246_Y1.1911.00
144_R225_E1.1911.00
62_E66_R1.1841.00
192_A227_L1.1831.00
255_H299_P1.1811.00
199_L223_A1.1811.00
65_Q69_E1.1671.00
140_T144_R1.1661.00
243_A290_Y1.1591.00
32_R58_D1.1561.00
307_A332_A1.1491.00
178_S182_Y1.1471.00
232_T282_L1.1441.00
138_K148_T1.1281.00
196_V220_L1.1281.00
55_Q58_D1.1251.00
304_K315_D1.1231.00
196_V224_Y1.1171.00
304_K314_E1.1141.00
203_L220_L1.1131.00
241_W245_H1.1041.00
167_I177_T1.1031.00
33_Q36_L1.1011.00
332_A340_L1.0961.00
235_Y279_L1.0930.99
14_A34_L1.0930.99
169_V276_F1.0880.99
112_K118_T1.0840.99
28_Q57_A1.0740.99
161_T247_D1.0700.99
171_I274_V1.0690.99
282_L285_Y1.0640.99
313_K323_F1.0640.99
332_A336_Y1.0590.99
173_K184_P1.0580.99
55_Q89_P1.0550.99
203_L216_A1.0520.99
4_A56_I1.0520.99
336_Y340_L1.0450.99
200_H204_S1.0410.99
66_R71_L1.0410.99
166_A343_L1.0380.99
49_Y52_V1.0340.99
18_F26_L1.0300.99
317_S334_R1.0260.99
35_A57_A1.0240.99
169_V280_R1.0210.99
302_T345_G1.0180.99
243_A292_K1.0160.99
244_E290_Y1.0140.99
260_I268_R1.0130.99
297_V345_G1.0130.99
318_L334_R1.0080.99
87_V134_R1.0040.99
317_S321_R0.9990.99
239_G283_I0.9880.99
313_K326_S0.9830.99
93_W97_Q0.9830.99
18_F22_D0.9810.99
305_T345_G0.9800.99
182_Y333_D0.9800.99
243_A249_V0.9760.99
240_K290_Y0.9740.99
32_R57_A0.9730.99
88_Y91_Y0.9720.99
92_G114_S0.9720.99
112_K115_N0.9600.99
8_Y56_I0.9600.99
6_E10_T0.9560.99
253_D299_P0.9510.99
281_D284_K0.9470.99
10_T14_A0.9460.99
242_F249_V0.9450.99
286_Q289_K0.9400.98
39_R53_V0.9370.98
313_K317_S0.9360.98
59_R136_V0.9310.98
262_K266_S0.9290.98
123_V126_D0.9280.98
36_L39_R0.9270.98
51_Q55_Q0.9230.98
11_L31_L0.9220.98
316_L323_F0.9190.98
226_Y230_L0.9180.98
287_L292_K0.9170.98
297_V346_A0.9120.98
16_I64_R0.9110.98
235_Y275_A0.9090.98
94_K97_Q0.9080.98
39_R43_D0.9060.98
206_K212_N0.9050.98
200_H220_L0.9050.98
304_K312_V0.8990.98
164_V347_G0.8980.98
94_K112_K0.8970.98
19_Y23_G0.8920.98
87_V136_V0.8920.98
165_V178_S0.8900.98
110_T118_T0.8890.98
321_R333_D0.8860.98
235_Y239_G0.8830.98
228_K232_T0.8830.98
113_L137_V0.8820.98
200_H224_Y0.8810.98
12_R64_R0.8800.98
250_V342_I0.8800.98
192_A196_V0.8790.98
196_V204_S0.8770.98
67_F75_P0.8730.98
13_W16_I0.8720.98
196_V227_L0.8720.98
48_V51_Q0.8700.97
66_R69_E0.8680.97
345_G349_E0.8680.97
213_W217_K0.8660.97
320_D334_R0.8660.97
199_L220_L0.8660.97
13_W77_E0.8630.97
188_P230_L0.8620.97
340_L343_L0.8610.97
140_T225_E0.8570.97
256_V277_S0.8560.97
136_V148_T0.8550.97
35_A54_Q0.8520.97
203_L213_W0.8500.97
54_Q58_D0.8470.97
307_A338_A0.8460.97
173_K182_Y0.8430.97
322_V332_A0.8430.97
338_A341_N0.8420.97
248_V293_K0.8400.97
223_A227_L0.8380.97
320_D323_F0.8370.97
67_F74_F0.8350.97
311_Y327_N0.8350.97
175_I238_L0.8340.97
110_T115_N0.8320.97
336_Y339_S0.8290.97
197_K200_H0.8230.96
45_Y53_V0.8230.96
96_L112_K0.8150.96
305_T341_N0.8090.96
176_V182_Y0.8080.96
202_E205_R0.8080.96
199_L219_K0.8080.96
66_R70_G0.8070.96
197_K201_R0.8060.96
305_T314_E0.8050.96
91_Y94_K0.8030.96
253_D280_R0.8030.96
189_Y193_L0.8020.96
14_A17_Y0.8010.96
163_K247_D0.8000.96
295_I346_A0.7980.96
307_A344_K0.7980.96
267_L271_L0.7970.96
277_S281_D0.7960.96
185_N274_V0.7930.96
307_A330_W0.7920.96
15_D61_Y0.7920.96
176_V183_F0.7920.96
11_L35_A0.7910.96
198_H202_E0.7890.96
217_K221_A0.7890.96
234_L238_L0.7870.95
185_N188_P0.7820.95
219_K222_R0.7810.95
164_V250_V0.7710.95
240_K286_Q0.7710.95
111_L135_V0.7710.95
31_L34_L0.7660.95
299_P302_T0.7640.95
248_V295_I0.7600.95
64_R67_F0.7600.95
172_E176_V0.7600.95
196_V200_H0.7550.94
181_E241_W0.7530.94
304_K313_K0.7530.94
189_Y192_A0.7490.94
165_V249_V0.7440.94
14_A18_F0.7430.94
204_S220_L0.7410.94
265_R272_S0.7410.94
55_Q59_R0.7390.94
51_Q91_Y0.7380.94
203_L206_K0.7370.94
51_Q54_Q0.7370.94
81_H84_Y0.7360.94
201_R205_R0.7300.93
316_L334_R0.7290.93
337_N341_N0.7290.93
171_I270_R0.7270.93
137_V147_I0.7240.93
30_E33_Q0.7240.93
134_R150_V0.7220.93
162_G247_D0.7220.93
110_T113_L0.7210.93
169_V175_I0.7210.93
301_Y345_G0.7180.93
308_R340_L0.7120.92
64_R68_F0.7100.92
179_D246_Y0.7100.92
323_F334_R0.7080.92
188_P192_A0.7000.92
171_I260_I0.6940.91
178_S339_S0.6920.91
14_A31_L0.6910.91
36_L40_K0.6900.91
250_V295_I0.6900.91
209_L214_F0.6880.91
109_I112_K0.6870.91
7_I56_I0.6860.91
314_E323_F0.6860.91
88_Y93_W0.6840.91
202_E219_K0.6800.91
92_G95_I0.6780.90
55_Q87_V0.6770.90
183_F238_L0.6770.90
244_E248_V0.6770.90
60_Y64_R0.6760.90
344_K347_G0.6760.90
158_L292_K0.6730.90
22_D25_G0.6720.90
256_V276_F0.6720.90
258_Q271_L0.6720.90
238_L241_W0.6710.90
314_E317_S0.6690.90
52_V86_L0.6680.90
170_G176_V0.6680.90
212_N215_K0.6650.90
51_Q92_G0.6580.89
183_F186_L0.6550.89
15_D18_F0.6550.89
242_F246_Y0.6530.89
16_I19_Y0.6520.89
112_K116_L0.6500.89
116_L120_K0.6480.88
254_I299_P0.6470.88
49_Y88_Y0.6460.88
8_Y60_Y0.6450.88
111_L114_S0.6430.88
311_Y323_F0.6410.88
20_Q23_G0.6400.88
160_N163_K0.6390.88
88_Y113_L0.6380.88
28_Q31_L0.6370.88
57_A61_Y0.6360.87
258_Q299_P0.6360.87
175_I279_L0.6350.87
140_T145_I0.6330.87
210_S213_W0.6330.87
183_F234_L0.6330.87
192_A223_A0.6320.87
174_L274_V0.6310.87
190_E269_R0.6310.87
144_R229_N0.6280.87
316_L321_R0.6280.87
182_Y336_Y0.6280.87
39_R45_Y0.6270.87
10_T13_W0.6260.87
131_K152_D0.6240.86
18_F23_G0.6240.86
32_R36_L0.6200.86
113_L116_L0.6200.86
301_Y305_T0.6190.86
249_V283_I0.6190.86
97_Q109_I0.6180.86
282_L286_Q0.6170.86
117_G120_K0.6160.86
186_L234_L0.6160.86
197_K204_S0.6140.86
48_V53_V0.6140.86
24_K30_E0.6140.86
14_A38_L0.6130.85
25_G31_L0.6130.85
315_D320_D0.6100.85
10_T44_E0.6020.84
250_V343_L0.6010.84
121_V124_H0.6010.84
50_S89_P0.6000.84
15_D25_G0.5960.84
303_S316_L0.5940.84
175_I183_F0.5940.84
34_L38_L0.5940.84
53_V56_I0.5930.84
36_L50_S0.5930.84
163_K246_Y0.5930.84
178_S336_Y0.5920.83
58_D89_P0.5900.83
206_K210_S0.5900.83
15_D22_D0.5900.83
88_Y95_I0.5900.83
227_L273_D0.5870.83
301_Y312_V0.5870.83
238_L279_L0.5860.83
7_I53_V0.5850.83
116_L119_F0.5840.83
31_L35_A0.5830.83
231_R273_D0.5830.83
39_R42_D0.5820.82
26_L31_L0.5820.82
109_I115_N0.5780.82
324_V330_W0.5770.82
85_S136_V0.5770.82
342_I345_G0.5760.82
280_R284_K0.5740.82
192_A226_Y0.5740.82
201_R204_S0.5740.82
332_A337_N0.5730.81
305_T310_G0.5710.81
17_Y20_Q0.5690.81
246_Y249_V0.5690.81
232_T236_M0.5690.81
19_Y64_R0.5660.81
25_G61_Y0.5660.81
85_S89_P0.5660.81
111_L117_G0.5650.81
56_I60_Y0.5630.80
168_D335_D0.5610.80
18_F24_K0.5600.80
166_A250_V0.5570.80
287_L290_Y0.5570.80
190_E193_L0.5560.79
8_Y63_A0.5560.79
158_L161_T0.5560.79
300_A304_K0.5550.79
240_K243_A0.5550.79
308_R332_A0.5540.79
259_L271_L0.5540.79
285_Y289_K0.5530.79
275_A278_E0.5500.79
57_A60_Y0.5480.78
198_H201_R0.5470.78
4_A86_L0.5450.78
113_L119_F0.5430.78
191_K194_W0.5430.78
111_L115_N0.5430.78
224_Y228_K0.5410.78
326_S334_R0.5400.77
313_K334_R0.5390.77
166_A178_S0.5390.77
224_Y231_R0.5380.77
258_Q262_K0.5380.77
110_T114_S0.5360.77
172_E321_R0.5360.77
35_A39_R0.5350.77
13_W20_Q0.5340.77
32_R35_A0.5340.77
26_L35_A0.5330.77
4_A48_V0.5300.76
202_E216_A0.5300.76
125_R128_P0.5290.76
25_G30_E0.5280.76
214_F218_V0.5270.76
304_K317_S0.5250.76
109_I123_V0.5250.76
195_K198_H0.5240.75
320_D326_S0.5230.75
318_L333_D0.5220.75
229_N233_D0.5220.75
54_Q57_A0.5220.75
168_D303_S0.5220.75
15_D26_L0.5210.75
174_L235_Y0.5180.75
49_Y90_Q0.5180.75
15_D64_R0.5150.74
260_I265_R0.5130.74
344_K349_E0.5130.74
305_T323_F0.5120.74
30_E34_L0.5120.74
197_K265_R0.5110.74
11_L38_L0.5090.73
15_D19_Y0.5080.73
323_F326_S0.5080.73
283_I294_L0.5070.73
68_F71_L0.5060.73
10_T38_L0.5060.73
169_V256_V0.5050.73
155_F288_E0.5040.73
268_R272_S0.5040.73
140_T146_Y0.5030.72
267_L270_R0.5020.72
190_E270_R0.5020.72
10_T31_L0.5020.72
170_G173_K0.5000.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vhxA 2 0.3663 92.7 0.933 Contact Map
1nu0A 1 0.3476 92.3 0.934 Contact Map
1ffkW 1 0.1791 87.7 0.94 Contact Map
1iv0A 1 0.2594 86.3 0.941 Contact Map
4aybP 1 0.115 84.9 0.942 Contact Map
2k4xA 1 0.1444 82.3 0.944 Contact Map
1qypA 1 0.1203 81 0.945 Contact Map
1vq8Z 1 0.1765 80.4 0.945 Contact Map
3j20Y 1 0.1337 78.4 0.946 Contact Map
1vd4A 1 0.1497 74.1 0.948 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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