GREMLIN Database
Q97V50 - Third ORF in transposon ISC1225
UniProt: Q97V50 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 203 (168)
Sequences: 149 (98)
Seq/√Len: 7.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
26_L123_S3.6860.95
144_L148_L3.2910.91
101_L118_N2.9230.84
28_A47_G2.9000.84
10_L153_Y2.5760.76
14_V24_I2.5630.75
21_I45_I2.4850.73
130_F153_Y2.3780.69
14_V44_Y2.3200.67
122_T125_R2.1190.60
31_Y155_L2.0710.58
133_F154_S2.0410.57
101_L136_S1.9520.53
101_L153_Y1.9270.52
39_I42_F1.7980.47
14_V19_F1.7610.46
6_I10_L1.7370.45
24_I101_L1.7080.44
175_I178_N1.6900.43
26_L31_Y1.6850.43
114_N154_S1.6480.41
122_T158_T1.6380.41
8_K68_K1.6220.40
128_K136_S1.6200.40
31_Y48_V1.6040.40
56_Y143_M1.5990.40
11_I30_F1.5860.39
19_F64_V1.5510.38
119_P149_D1.5470.38
46_I105_I1.5360.37
114_N119_P1.5340.37
80_L147_L1.5230.37
21_I124_Y1.5070.36
21_I52_D1.5030.36
21_I85_R1.4820.35
160_K164_K1.4790.35
101_L144_L1.4780.35
128_K153_Y1.4580.34
175_I179_I1.4540.34
31_Y49_P1.4250.33
80_L92_R1.4080.32
144_L152_V1.4060.32
49_P131_L1.4040.32
146_F153_Y1.3820.32
45_I55_I1.3740.31
117_R121_E1.3730.31
101_L146_F1.3590.31
27_D121_E1.3530.31
173_S177_E1.3340.30
121_E142_R1.3250.30
141_F155_L1.3230.30
18_G48_V1.3140.29
29_G49_P1.3070.29
46_I103_I1.3000.29
46_I133_F1.2990.29
27_D117_R1.2980.29
23_L129_S1.2940.29
117_R142_R1.2710.28
10_L124_Y1.2640.28
131_L143_M1.2610.28
35_V120_I1.2550.27
27_D142_R1.2530.27
127_V161_D1.2430.27
102_Q130_F1.2340.27
38_F41_Q1.2340.27
152_V163_V1.2260.26
23_L42_F1.2220.26
132_P137_T1.2190.26
39_I143_M1.1930.25
45_I70_H1.1530.24
173_S178_N1.1510.24
23_L103_I1.1500.24
65_T108_R1.1480.24
122_T155_L1.1470.24
90_R94_R1.1340.24
35_V122_T1.1340.24
48_V119_P1.1280.24
131_L135_C1.1260.23
73_D96_F1.1190.23
9_I94_R1.1120.23
35_V134_T1.1110.23
99_P118_N1.1070.23
80_L98_S1.0900.22
30_F124_Y1.0690.22
60_D122_T1.0630.22
10_L44_Y1.0600.22
112_W125_R1.0600.22
160_K178_N1.0540.21
52_D57_E1.0510.21
58_E61_G1.0440.21
99_P136_S1.0400.21
99_P146_F1.0380.21
8_K91_K1.0320.21
101_L148_L1.0290.21
102_Q146_F1.0070.20
39_I63_Y1.0000.20
36_I100_G0.9940.20
19_F48_V0.9840.20
102_Q118_N0.9720.19
113_S120_I0.9710.19
102_Q136_S0.9710.19
39_I46_I0.9690.19
64_V82_V0.9620.19
135_C147_L0.9460.19
62_E72_K0.9420.19
26_L39_I0.9360.18
128_K148_L0.9200.18
35_V113_S0.9190.18
36_I122_T0.9050.18
35_V124_Y0.9030.18
36_I39_I0.9030.18
31_Y122_T0.9020.18
63_Y68_K0.8980.18
42_F164_K0.8960.18
57_E61_G0.8780.17
41_Q114_N0.8780.17
34_E122_T0.8770.17
56_Y166_R0.8760.17
124_Y134_T0.8630.17
138_K151_L0.8560.17
44_Y102_Q0.8550.17
18_G144_L0.8540.17
53_V56_Y0.8450.16
83_Y124_Y0.8420.16
176_I179_I0.8370.16
118_N144_L0.8350.16
19_F24_I0.8340.16
40_S70_H0.8230.16
22_K131_L0.8110.16
37_K114_N0.8080.16
12_E35_V0.8060.16
118_N130_F0.8050.16
118_N136_S0.8040.16
72_K78_F0.7960.15
74_E141_F0.7910.15
105_I145_I0.7890.15
47_G113_S0.7850.15
44_Y126_S0.7830.15
172_I179_I0.7820.15
52_D154_S0.7710.15
54_K81_I0.7630.15
107_P157_T0.7610.15
127_V149_D0.7590.15
101_L130_F0.7590.15
68_K71_S0.7570.15
148_L162_N0.7570.15
127_V146_F0.7540.14
48_V109_I0.7500.14
95_L163_V0.7490.14
57_E74_E0.7470.14
28_A150_V0.7460.14
159_L162_N0.7390.14
45_I83_Y0.7340.14
83_Y154_S0.7320.14
25_A132_P0.7300.14
39_I75_Q0.7260.14
139_F154_S0.7250.14
21_I79_R0.7250.14
8_K145_I0.7240.14
68_K72_K0.7220.14
9_I47_G0.7100.14
57_E60_D0.7090.14
148_L159_L0.7060.14
162_N178_N0.7040.14
20_R74_E0.7030.14
156_Y160_K0.7020.13
97_T159_L0.7010.13
25_A145_I0.6950.13
113_S121_E0.6930.13
12_E24_I0.6920.13
143_M150_V0.6770.13
72_K138_K0.6750.13
29_G112_W0.6750.13
146_F162_N0.6730.13
59_F138_K0.6730.13
136_S148_L0.6720.13
157_T160_K0.6710.13
48_V66_N0.6650.13
7_V14_V0.6630.13
131_L150_V0.6610.13
24_I136_S0.6600.13
23_L164_K0.6600.13
67_S78_F0.6570.13
29_G111_S0.6550.13
43_N97_T0.6480.13
12_E132_P0.6430.12
99_P102_Q0.6410.12
174_K179_I0.6380.12
6_I143_M0.6380.12
48_V124_Y0.6360.12
120_I156_Y0.6340.12
5_E41_Q0.6330.12
77_K105_I0.6310.12
36_I46_I0.6300.12
45_I110_R0.6290.12
81_I106_Y0.6290.12
64_V134_T0.6230.12
32_T122_T0.6220.12
144_L149_D0.6190.12
60_D129_S0.6190.12
33_V75_Q0.6150.12
113_S117_R0.6060.12
28_A61_G0.6020.12
11_I51_D0.6010.12
44_Y136_S0.5950.12
30_F121_E0.5950.12
27_D113_S0.5910.12
134_T143_M0.5840.11
99_P160_K0.5820.11
82_V140_I0.5790.11
24_I93_R0.5780.11
29_G149_D0.5780.11
13_Q137_T0.5770.11
42_F147_L0.5770.11
12_E38_F0.5760.11
46_I100_G0.5750.11
39_I145_I0.5690.11
75_Q80_L0.5690.11
83_Y129_S0.5670.11
47_G134_T0.5660.11
22_K111_S0.5660.11
10_L40_S0.5630.11
12_E179_I0.5610.11
20_R43_N0.5600.11
57_E152_V0.5590.11
113_S142_R0.5590.11
65_T162_N0.5580.11
172_I175_I0.5560.11
102_Q110_R0.5550.11
81_I134_T0.5550.11
49_P149_D0.5540.11
45_I152_V0.5390.11
149_D166_R0.5390.11
21_I120_I0.5350.11
128_K132_P0.5310.11
40_S166_R0.5290.11
35_V77_K0.5290.11
36_I139_F0.5280.11
55_I111_S0.5280.11
43_N60_D0.5270.11
131_L149_D0.5260.11
101_L128_K0.5240.10
136_S153_Y0.5220.10
64_V140_I0.5200.10
15_V35_V0.5200.10
20_R92_R0.5200.10
15_V149_D0.5180.10
34_E97_T0.5150.10
22_K118_N0.5140.10
30_F117_R0.5080.10
115_K122_T0.5060.10
30_F134_T0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1musA 2 0.9212 98.7 0.836 Contact Map
1f6yA 2 0.5172 14.2 0.958 Contact Map
2yciX 2 0.5172 11.7 0.959 Contact Map
4ggjA 2 0.5222 9.4 0.961 Contact Map
4gelA 2 0.5862 7.4 0.963 Contact Map
4o1eA 2 0.5468 6.4 0.964 Contact Map
3fp5A 1 0.1773 3.7 0.968 Contact Map
1iukA 1 0.2857 3.4 0.968 Contact Map
2e9fA 4 0.3251 3.2 0.969 Contact Map
3hh1A 2 0.2315 3 0.969 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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