GREMLIN Database
Q97V47 - Transposase ISC1316
UniProt: Q97V47 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 399 (353)
Sequences: 4598 (2971)
Seq/√Len: 158.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
258_D262_K5.3451.00
280_H283_Q4.2731.00
332_A362_N4.2431.00
312_L319_L3.7331.00
275_V371_S3.0751.00
305_R321_L2.9681.00
199_L304_L2.9591.00
276_M308_I2.8761.00
265_K269_E2.7771.00
303_E307_L2.7121.00
342_S345_D2.5821.00
159_V171_I2.5451.00
330_T337_V2.4441.00
285_I297_S2.4381.00
326_Y329_K2.4331.00
309_K321_L2.4321.00
303_E306_D2.4111.00
218_L294_R2.3871.00
370_G373_S2.3351.00
268_A312_L2.2261.00
322_V367_I2.2121.00
349_V356_I2.1941.00
224_L241_A2.1811.00
304_L308_I2.1501.00
276_M319_L2.1401.00
36_W40_Y2.1361.00
327_T367_I2.0821.00
274_V312_L2.0691.00
329_K341_L2.0571.00
217_A255_L2.0551.00
13_D16_T2.0281.00
261_M307_L2.0071.00
261_M310_Y1.9971.00
157_K176_E1.9971.00
51_Q55_R1.9931.00
290_R293_R1.9451.00
331_C334_C1.9441.00
39_I97_F1.9231.00
257_T303_E1.8991.00
334_C353_C1.8961.00
34_L80_A1.8591.00
52_T55_R1.8331.00
241_A245_L1.8321.00
260_Y307_L1.8251.00
264_G307_L1.8131.00
333_R355_W1.8071.00
21_K169_I1.8051.00
309_K313_E1.7961.00
236_N239_F1.7751.00
272_D317_K1.7731.00
51_Q81_D1.7541.00
22_A70_Q1.7501.00
199_L259_L1.7241.00
334_C350_C1.7171.00
9_R168_R1.7081.00
35_R83_Y1.7061.00
261_M311_Q1.6891.00
261_M264_G1.6891.00
82_R110_V1.6801.00
350_C353_C1.6721.00
331_C353_C1.6671.00
348_F357_A1.6331.00
287_K293_R1.6271.00
239_F242_K1.6191.00
192_I200_L1.6181.00
260_Y303_E1.6151.00
346_R359_R1.6101.00
29_E67_E1.6051.00
276_M305_R1.5511.00
276_M321_L1.5501.00
227_E231_K1.5411.00
231_K241_A1.5241.00
18_R22_A1.5231.00
20_L169_I1.5101.00
135_L171_I1.5051.00
331_C350_C1.5051.00
74_Q113_Q1.5021.00
278_D321_L1.4971.00
89_R95_A1.4891.00
17_L21_K1.4721.00
52_T56_Q1.4631.00
190_V202_T1.4621.00
228_L242_K1.4601.00
365_L369_R1.4451.00
202_T206_E1.4431.00
84_Y88_Q1.4361.00
338_K348_F1.4341.00
347_V356_I1.4321.00
74_Q112_P1.4241.00
338_K341_L1.4161.00
201_V361_Y1.4161.00
189_V368_L1.4121.00
348_F355_W1.4061.00
341_L345_D1.3901.00
5_G172_T1.3801.00
309_K319_L1.3581.00
234_L238_W1.3571.00
264_G304_L1.3571.00
264_G310_Y1.3521.00
224_L227_E1.3411.00
336_Y351_S1.3331.00
93_G96_R1.3051.00
264_G311_Q1.2971.00
198_K201_V1.2961.00
34_L83_Y1.2861.00
87_R97_F1.2851.00
250_E254_N1.2851.00
343_L346_R1.2831.00
277_E324_P1.2751.00
287_K290_R1.2741.00
329_K339_E1.2601.00
164_T167_E1.2571.00
217_A252_L1.2491.00
361_Y365_L1.2401.00
332_A365_L1.2311.00
168_R250_E1.2211.00
39_I43_Q1.2161.00
220_K224_L1.2101.00
50_T53_E1.2101.00
338_K351_S1.2101.00
190_V271_Y1.2091.00
24_L169_I1.2051.00
221_V245_L1.2051.00
166_S250_E1.2031.00
78_Q112_P1.1921.00
268_A315_Y1.1871.00
111_Y114_Y1.1821.00
257_T307_L1.1781.00
37_A57_L1.1691.00
55_R81_D1.1661.00
88_Q92_E1.1661.00
221_V249_Y1.1611.00
296_L301_F1.1601.00
189_V273_V1.1531.00
14_E17_L1.1491.00
58_A80_A1.1461.00
266_W270_H1.1401.00
224_L248_A1.1401.00
357_A365_L1.1391.00
55_R80_A1.1361.00
343_L359_R1.1171.00
192_I202_T1.1121.00
322_V370_G1.1111.00
136_K142_V1.1071.00
194_V301_F1.1001.00
27_A79_I1.0991.00
306_D309_K1.0960.99
78_Q81_D1.0950.99
260_Y304_L1.0940.99
85_E89_R1.0870.99
225_H229_S1.0830.99
332_A357_A1.0720.99
186_T272_D1.0690.99
194_V305_R1.0670.99
162_K172_T1.0560.99
265_K315_Y1.0550.99
280_H324_P1.0460.99
51_Q80_A1.0460.99
329_K337_V1.0440.99
196_V299_V1.0400.99
329_K340_D1.0400.99
228_L245_L1.0370.99
191_A368_L1.0340.99
228_L241_A1.0290.99
134_T142_V1.0280.99
40_Y44_R1.0270.99
327_T370_G1.0190.99
164_T168_R1.0150.99
264_G308_I1.0100.99
260_Y264_G1.0100.99
287_K291_S1.0080.99
253_K257_T1.0040.99
268_A317_K1.0040.99
311_Q314_K1.0030.99
8_F171_I1.0020.99
6_F175_V1.0000.99
38_D54_L0.9910.99
198_K209_P0.9900.99
278_D324_P0.9890.99
307_L310_Y0.9870.99
110_V158_R0.9870.99
82_R160_V0.9850.99
207_Y358_D0.9840.99
31_Y79_I0.9830.99
189_V372_G0.9830.99
117_K136_K0.9790.99
269_E315_Y0.9790.99
330_T370_G0.9720.99
357_A361_Y0.9710.99
62_R76_V0.9680.99
72_Y75_V0.9660.99
225_H245_L0.9660.99
221_V229_S0.9650.99
322_V371_S0.9610.99
90_F97_F0.9580.99
89_R93_G0.9570.99
198_K207_Y0.9570.99
56_Q59_L0.9560.99
117_K120_Q0.9550.99
238_W242_K0.9500.99
203_S207_Y0.9460.98
116_W120_Q0.9370.98
74_Q114_Y0.9350.98
12_T16_T0.9320.98
267_F274_V0.9300.98
164_T250_E0.9270.98
275_V367_I0.9220.98
29_E33_T0.9180.98
285_I293_R0.9170.98
341_L348_F0.9170.98
39_I87_R0.9170.98
137_L161_V0.9150.98
336_Y352_N0.9150.98
268_A274_V0.9070.98
89_R94_L0.9040.98
248_A252_L0.9040.98
332_A363_A0.9030.98
224_L245_L0.9020.98
217_A221_V0.9020.98
26_L67_E0.8990.98
338_K342_S0.8940.98
34_L54_L0.8940.98
312_L317_K0.8940.98
77_Q81_D0.8930.98
35_R87_R0.8930.98
347_V357_A0.8920.98
222_K225_H0.8920.98
89_R92_E0.8900.98
332_A355_W0.8890.98
224_L244_K0.8890.98
332_A369_R0.8880.98
115_G138_S0.8860.98
365_L368_L0.8830.98
12_T20_L0.8800.98
251_H255_L0.8780.98
74_Q78_Q0.8760.98
281_V302_S0.8740.97
78_Q110_V0.8710.97
260_Y300_A0.8700.97
225_H249_Y0.8680.97
31_Y83_Y0.8660.97
190_V274_V0.8630.97
201_V207_Y0.8620.97
25_K28_C0.8620.97
273_V318_K0.8610.97
213_P255_L0.8600.97
68_Y76_V0.8560.97
342_S346_R0.8530.97
90_F98_P0.8530.97
41_F45_D0.8500.97
110_V160_V0.8500.97
221_V252_L0.8430.97
10_A171_I0.8370.97
59_L62_R0.8350.97
265_K311_Q0.8330.97
188_K272_D0.8300.97
31_Y86_A0.8290.97
147_V150_D0.8240.96
333_R365_L0.8230.96
42_Y46_G0.8230.96
17_L169_I0.8230.96
104_H107_Y0.8220.96
228_L231_K0.8190.96
206_E266_W0.8180.96
33_T37_A0.8170.96
58_A77_Q0.8170.96
345_D359_R0.8160.96
259_L263_L0.8140.96
231_K237_N0.8140.96
60_D64_Q0.8130.96
42_Y87_R0.8110.96
278_D305_R0.8100.96
228_L238_W0.8090.96
189_V275_V0.8080.96
223_H227_E0.8010.96
292_L296_L0.8000.96
302_S306_D0.7990.96
346_R358_D0.7990.96
342_S359_R0.7970.96
326_Y370_G0.7970.96
275_V320_I0.7970.96
200_L263_L0.7960.96
362_N366_N0.7920.96
324_P327_T0.7900.95
348_F359_R0.7890.95
160_V172_T0.7890.95
363_A366_N0.7880.95
196_V285_I0.7860.95
345_D348_F0.7850.95
194_V200_L0.7690.95
34_L58_A0.7660.95
201_V208_F0.7650.95
208_F263_L0.7650.95
158_R174_V0.7650.95
229_S245_L0.7640.95
38_D87_R0.7630.95
275_V368_L0.7620.94
273_V320_I0.7610.94
30_V79_I0.7600.94
279_I324_P0.7560.94
185_N188_K0.7560.94
161_V171_I0.7550.94
244_K247_R0.7510.94
267_F271_Y0.7500.94
8_F149_R0.7500.94
23_Q27_A0.7480.94
208_F259_L0.7440.94
71_V74_Q0.7440.94
320_I371_S0.7430.94
36_W100_E0.7420.94
222_K226_R0.7410.94
263_L266_W0.7390.94
19_A23_Q0.7380.93
119_L136_K0.7380.93
196_V295_R0.7380.93
290_R297_S0.7370.93
59_L63_K0.7360.93
74_Q77_Q0.7360.93
78_Q82_R0.7360.93
53_E56_Q0.7340.93
26_L29_E0.7340.93
190_V203_S0.7310.93
25_K29_E0.7300.93
361_Y364_S0.7280.93
55_R59_L0.7280.93
81_D112_P0.7260.93
340_D345_D0.7260.93
197_E201_V0.7190.93
37_A40_Y0.7140.92
38_D84_Y0.7130.92
26_L68_Y0.7120.92
14_E18_R0.7080.92
329_K338_K0.7060.92
242_K246_A0.7010.92
108_S160_V0.7000.92
188_K204_D0.6990.92
214_L218_L0.6990.92
41_F49_L0.6980.91
207_Y361_Y0.6960.91
109_L113_Q0.6950.91
330_T366_N0.6950.91
168_R254_N0.6920.91
111_Y137_L0.6900.91
132_L137_L0.6860.91
281_V301_F0.6850.91
330_T339_E0.6850.91
221_V225_H0.6840.91
120_Q133_I0.6820.90
134_T144_K0.6790.90
210_N299_V0.6780.90
135_L138_S0.6780.90
217_A248_A0.6770.90
203_S361_Y0.6760.90
155_K176_E0.6750.90
326_Y330_T0.6740.90
145_V148_H0.6700.90
193_D360_D0.6690.90
187_G272_D0.6690.90
227_E230_R0.6680.90
9_R170_Y0.6680.90
195_G201_V0.6670.90
73_S112_P0.6670.90
200_L208_F0.6670.90
252_L298_D0.6660.89
37_A54_L0.6660.89
19_A22_A0.6650.89
213_P217_A0.6640.89
256_R298_D0.6630.89
357_A362_N0.6620.89
37_A41_F0.6580.89
227_E241_A0.6550.89
199_L299_V0.6530.89
237_N240_K0.6510.88
87_R90_F0.6510.88
26_L71_V0.6510.88
21_K164_T0.6500.88
80_A84_Y0.6490.88
136_K140_L0.6490.88
87_R91_F0.6460.88
326_Y337_V0.6440.88
59_L73_S0.6410.88
191_A275_V0.6410.88
269_E273_V0.6410.88
12_T17_L0.6390.87
134_T137_L0.6380.87
226_R229_S0.6370.87
234_L239_F0.6360.87
204_D271_Y0.6360.87
341_L359_R0.6360.87
62_R65_D0.6350.87
274_V308_I0.6350.87
7_R162_K0.6300.87
5_G174_V0.6290.87
312_L315_Y0.6270.86
83_Y87_R0.6270.86
193_D328_S0.6240.86
351_S359_R0.6240.86
22_A26_L0.6190.86
215_E218_L0.6170.86
369_R372_G0.6170.86
59_L80_A0.6150.85
215_E294_R0.6150.85
71_V76_V0.6150.85
235_S238_W0.6140.85
72_Y111_Y0.6110.85
74_Q115_G0.6090.85
15_Q18_R0.6090.85
11_H146_I0.6080.85
7_R170_Y0.6080.85
37_A61_L0.6070.85
208_F266_W0.6070.85
283_Q324_P0.6050.84
51_Q54_L0.6050.84
217_A251_H0.6050.84
200_L304_L0.6040.84
214_L217_A0.6020.84
42_Y91_F0.6020.84
338_K345_D0.6010.84
226_R230_R0.6010.84
91_F94_L0.6000.84
338_K359_R0.5990.84
36_W39_I0.5990.84
7_R257_T0.5990.84
188_K271_Y0.5990.84
341_L346_R0.5970.84
257_T261_M0.5950.83
227_E244_K0.5930.83
132_L136_K0.5930.83
33_T67_E0.5910.83
215_E295_R0.5900.83
310_Y314_K0.5890.83
38_D41_F0.5880.83
141_G144_K0.5880.83
111_Y116_W0.5870.83
7_R172_T0.5860.83
48_G54_L0.5840.82
38_D42_Y0.5810.82
15_Q19_A0.5810.82
57_L61_L0.5800.82
33_T61_L0.5800.82
330_T335_G0.5770.82
242_K245_L0.5770.82
76_V79_I0.5750.81
80_A83_Y0.5730.81
23_Q71_V0.5730.81
300_A303_E0.5730.81
284_L296_L0.5730.81
333_R357_A0.5720.81
239_F243_V0.5720.81
199_L260_Y0.5710.81
114_Y117_K0.5710.81
79_I83_Y0.5710.81
20_L24_L0.5710.81
210_N213_P0.5680.81
137_L143_F0.5680.81
42_Y45_D0.5650.80
323_N326_Y0.5620.80
115_G118_I0.5620.80
111_Y115_G0.5600.80
23_Q109_L0.5600.80
339_E342_S0.5600.80
222_K290_R0.5590.80
42_Y90_F0.5580.79
254_N258_D0.5570.79
307_L311_Q0.5560.79
271_Y274_V0.5560.79
199_L264_G0.5530.79
367_I370_G0.5520.79
48_G84_Y0.5520.79
343_L358_D0.5520.79
265_K268_A0.5510.79
45_D48_G0.5500.78
328_S341_L0.5490.78
112_P116_W0.5490.78
151_F154_D0.5470.78
343_L347_V0.5460.78
330_T348_F0.5460.78
275_V370_G0.5450.78
23_Q72_Y0.5440.78
254_N257_T0.5430.78
249_Y253_K0.5420.77
220_K223_H0.5420.77
287_K292_L0.5420.77
260_Y263_L0.5420.77
38_D48_G0.5390.77
5_G162_K0.5390.77
40_Y43_Q0.5390.77
12_T143_F0.5370.77
293_R297_S0.5360.77
29_E64_Q0.5360.77
30_V76_V0.5330.76
262_K266_W0.5330.76
193_D277_E0.5330.76
75_V109_L0.5310.76
223_H226_R0.5300.76
328_S342_S0.5300.76
29_E65_D0.5300.76
214_L294_R0.5300.76
53_E57_L0.5280.76
73_S115_G0.5280.76
345_D351_S0.5260.75
137_L159_V0.5240.75
249_Y256_R0.5230.75
224_L228_L0.5230.75
200_L276_M0.5220.75
328_S338_K0.5200.74
167_E250_E0.5200.74
133_I136_K0.5170.74
348_F351_S0.5150.74
183_L317_K0.5150.74
55_R77_Q0.5140.74
135_L159_V0.5140.74
198_K358_D0.5110.73
183_L186_T0.5100.73
145_V150_D0.5100.73
218_L298_D0.5090.73
100_E103_P0.5080.73
282_K302_S0.5080.73
43_Q46_G0.5070.73
24_L27_A0.5060.73
108_S112_P0.5050.72
308_I319_L0.5050.72
20_L109_L0.5040.72
263_L304_L0.5030.72
23_Q111_Y0.5020.72
54_L57_L0.5020.72
111_Y118_I0.5020.72
38_D45_D0.5010.72
281_V297_S0.5010.72
231_K235_S0.5000.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1nu0A 1 0.3233 90.9 0.939 Contact Map
1vhxA 2 0.3409 90.9 0.939 Contact Map
1qypA 1 0.1153 85.8 0.944 Contact Map
4aybP 1 0.1078 85 0.945 Contact Map
1ffkW 1 0.1805 83.1 0.946 Contact Map
3j20Y 1 0.1253 82 0.947 Contact Map
1iv0A 1 0.2406 81.9 0.947 Contact Map
1vd4A 1 0.1404 80.9 0.947 Contact Map
1vq8Z 1 0.183 80.3 0.947 Contact Map
2k4xA 1 0.1378 77.5 0.949 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0118 seconds.