GREMLIN Database
Q97V46 - Uncharacterized protein
UniProt: Q97V46 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 205 (166)
Sequences: 9835 (7099)
Seq/√Len: 551.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
61_G99_A4.2141.00
155_N160_D4.0091.00
164_E174_L3.8031.00
153_N160_D3.3981.00
187_M191_N2.8591.00
130_Q134_G2.7401.00
165_D172_T2.4321.00
155_N196_K2.3311.00
153_N176_A2.2931.00
155_N194_Y2.2051.00
153_N162_I2.1611.00
175_K181_V2.1321.00
73_Y89_R2.1221.00
145_A169_L2.1201.00
181_V194_Y1.9071.00
159_E192_K1.8471.00
47_S50_S1.8301.00
131_Q134_G1.7971.00
157_V192_K1.7761.00
155_N158_S1.7481.00
54_I107_A1.7271.00
152_D198_T1.7051.00
172_T180_R1.6881.00
164_E180_R1.6761.00
69_S93_R1.6711.00
179_T194_Y1.6661.00
171_T185_N1.6551.00
123_I126_G1.6331.00
175_K179_T1.6311.00
95_I99_A1.6301.00
117_L120_F1.5721.00
44_H48_Y1.5531.00
93_R96_G1.5471.00
113_A116_A1.5331.00
187_M192_K1.5181.00
41_F44_H1.4971.00
156_I188_I1.4731.00
62_Y96_G1.4521.00
103_S107_A1.4431.00
161_G173_I1.4361.00
63_L67_G1.4121.00
115_V119_G1.3871.00
58_L62_Y1.3831.00
148_F171_T1.3781.00
54_I103_S1.3451.00
154_V163_V1.3401.00
157_V191_N1.3261.00
187_M190_G1.3251.00
39_P42_N1.3191.00
46_V49_E1.3051.00
65_V93_R1.2761.00
86_A90_N1.2501.00
69_S89_R1.2481.00
180_R198_T1.2461.00
61_G65_V1.2341.00
149_K198_T1.2151.00
57_A99_A1.2101.00
40_S43_I1.2101.00
104_I109_A1.2011.00
148_F188_I1.1761.00
129_S137_V1.1591.00
89_R93_R1.1481.00
99_A103_S1.1451.00
68_I92_M1.1371.00
57_A106_G1.1341.00
145_A170_F1.1021.00
167_S172_T1.0961.00
45_A48_Y1.0581.00
45_A50_S1.0551.00
134_G186_N1.0551.00
121_I125_I1.0491.00
135_Q186_N1.0461.00
65_V95_I1.0331.00
50_S53_Q1.0331.00
75_S78_P1.0291.00
128_A133_L1.0281.00
132_V138_A1.0231.00
174_L180_R1.0231.00
162_I174_L1.0141.00
163_V173_I1.0041.00
112_A116_A0.9921.00
62_Y66_S0.9891.00
44_H47_S0.9861.00
180_R199_E0.9761.00
141_F189_I0.9751.00
53_Q106_G0.9731.00
46_V50_S0.9641.00
170_F182_L0.9581.00
44_H49_E0.9521.00
179_T196_K0.9501.00
154_V173_I0.9411.00
97_I101_A0.9321.00
174_L178_G0.9241.00
121_I124_V0.9211.00
174_L199_E0.9161.00
57_A61_G0.9131.00
38_L41_F0.9081.00
83_P87_A0.9061.00
146_R149_K0.8981.00
162_I176_A0.8981.00
102_A106_G0.8961.00
36_S39_P0.8921.00
138_A189_I0.8921.00
156_I159_E0.8891.00
127_F130_Q0.8891.00
134_G190_G0.8751.00
117_L122_G0.8681.00
59_A63_L0.8521.00
63_L66_S0.8491.00
100_L104_I0.8481.00
157_V187_M0.8431.00
45_A49_E0.8291.00
56_L60_F0.8291.00
138_A186_N0.8231.00
61_G95_I0.8221.00
69_S73_Y0.8201.00
38_L42_N0.8171.00
172_T182_L0.8161.00
125_I133_L0.8141.00
159_E181_V0.8111.00
36_S40_S0.8111.00
164_E199_E0.8101.00
118_G122_G0.8031.00
59_A62_Y0.8021.00
73_Y77_L0.7961.00
148_F154_V0.7961.00
73_Y85_A0.7931.00
40_S44_H0.7931.00
132_V189_I0.7921.00
131_Q190_G0.7911.00
37_L41_F0.7891.00
65_V69_S0.7891.00
120_F129_S0.7861.00
65_V99_A0.7801.00
142_L148_F0.7761.00
130_Q186_N0.7721.00
159_E194_Y0.7711.00
186_N190_G0.7681.00
110_G113_A0.7661.00
160_D196_K0.7651.00
118_G121_I0.7631.00
105_A110_G0.7601.00
96_G100_L0.7591.00
156_I183_I0.7591.00
42_N46_V0.7551.00
76_L85_A0.7511.00
131_Q186_N0.7471.00
176_A196_K0.7441.00
68_I71_I0.7421.00
53_Q57_A0.7421.00
132_V141_F0.7381.00
58_L61_G0.7381.00
167_S170_F0.7361.00
54_I58_L0.7291.00
116_A119_G0.7261.00
65_V96_G0.7251.00
39_P44_H0.7191.00
71_I75_S0.7121.00
86_A165_D0.7101.00
120_F124_V0.7081.00
43_I46_V0.7061.00
160_D176_A0.7051.00
121_I128_A0.7051.00
119_G123_I0.7051.00
153_N196_K0.7041.00
84_T87_A0.7041.00
105_A111_G0.7011.00
144_V147_P0.7001.00
82_H86_A0.6991.00
76_L79_K0.6941.00
52_V56_L0.6921.00
156_I192_K0.6881.00
81_G146_R0.6881.00
178_G200_Q0.6851.00
81_G84_T0.6841.00
54_I62_Y0.6831.00
72_F75_S0.6761.00
42_N45_A0.6741.00
82_H85_A0.6681.00
55_L66_S0.6671.00
56_L59_A0.6671.00
83_P86_A0.6651.00
42_N50_S0.6651.00
101_A105_A0.6641.00
141_F145_A0.6621.00
99_A102_A0.6601.00
145_A172_T0.6561.00
90_N165_D0.6551.00
37_L40_S0.6521.00
60_F63_L0.6501.00
90_N93_R0.6451.00
109_A113_A0.6441.00
36_S42_N0.6431.00
175_K194_Y0.6421.00
102_A105_A0.6421.00
57_A60_F0.6351.00
83_P143_L0.6311.00
142_L185_N0.6301.00
53_Q66_S0.6261.00
123_I131_Q0.6251.00
41_F45_A0.6191.00
74_Y77_L0.6171.00
54_I65_V0.6111.00
51_Y55_L0.6101.00
121_I126_G0.6091.00
141_F169_L0.6091.00
117_L124_V0.6051.00
81_G85_A0.5991.00
49_E52_V0.5951.00
115_V124_V0.5911.00
43_I47_S0.5871.00
66_S70_L0.5861.00
83_P149_K0.5851.00
68_I72_F0.5750.99
52_V55_L0.5750.99
44_H50_S0.5730.99
60_F64_I0.5680.99
125_I137_V0.5670.99
154_V188_I0.5660.99
159_E183_I0.5650.99
67_G70_L0.5640.99
122_G128_A0.5620.99
117_L121_I0.5620.99
68_I95_I0.5600.99
131_Q135_Q0.5570.99
57_A102_A0.5570.99
71_I74_Y0.5530.99
58_L103_S0.5510.99
104_I108_V0.5470.99
75_S79_K0.5450.99
98_G102_A0.5450.99
82_H150_V0.5440.99
176_A201_Q0.5430.99
67_G71_I0.5400.99
55_L59_A0.5370.99
86_A89_R0.5340.99
120_F123_I0.5260.99
148_F198_T0.5200.99
132_V178_G0.5180.99
184_P187_M0.5160.99
111_G114_G0.5140.99
151_N162_I0.5140.99
155_N159_E0.5130.99
156_I191_N0.5120.99
74_Y78_P0.5110.99
150_V165_D0.5110.99
171_T188_I0.5050.99
119_G130_Q0.5020.99
81_G149_K0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
5ajiA 3 0.8146 100 0.248 Contact Map
4hw9A 3 0.7707 100 0.264 Contact Map
3udcA 3 0.7805 100 0.299 Contact Map
3mlqE 1 0.1902 30.3 0.927 Contact Map
3askA 1 0.2683 29.8 0.927 Contact Map
1nz9A 1 0.2341 23.6 0.93 Contact Map
4lz6A 1 0.6829 18 0.934 Contact Map
4l5gA 1 0.3024 15.9 0.936 Contact Map
2mi6A 1 0.2537 14.5 0.937 Contact Map
4kbmB 1 0.2829 12.1 0.939 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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