GREMLIN Database
Q97V45 - Membrane protein, putative
UniProt: Q97V45 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 194 (184)
Sequences: 7180 (5039)
Seq/√Len: 371.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
63_I130_I3.3381.00
46_S49_L3.1261.00
185_I189_I3.0091.00
55_T142_T2.8351.00
63_I134_L2.5341.00
19_I64_I2.4901.00
59_L138_F2.4491.00
101_Y104_M2.4181.00
40_S153_Y2.3981.00
129_K132_K2.3311.00
51_V146_I2.3241.00
183_I187_W2.3241.00
103_N132_K2.3051.00
186_L190_F2.3011.00
107_F139_L2.3001.00
15_F57_G2.1781.00
87_D90_K2.1501.00
95_H99_L2.0901.00
53_V57_G2.0281.00
54_G145_D1.9801.00
150_L154_Q1.9661.00
103_N136_F1.9591.00
47_L150_L1.9221.00
6_Q10_G1.8931.00
51_V149_A1.8541.00
70_Y127_Q1.7991.00
74_L95_H1.7971.00
18_M57_G1.6941.00
88_E92_E1.6311.00
11_Y46_S1.6261.00
130_I134_L1.6151.00
47_L51_V1.6151.00
67_I71_K1.6001.00
19_I60_V1.5981.00
15_F53_V1.5861.00
36_V50_G1.5841.00
171_N175_I1.5751.00
180_I184_Y1.5081.00
172_Y176_L1.5001.00
33_M149_A1.4491.00
184_Y188_R1.4441.00
14_L54_G1.4191.00
47_L149_A1.4131.00
11_Y49_L1.4021.00
104_M108_G1.3971.00
163_I167_E1.3781.00
62_S110_R1.3581.00
92_E96_N1.3511.00
9_G13_I1.3501.00
21_E29_S1.3471.00
11_Y53_V1.3421.00
67_I130_I1.3211.00
131_L135_G1.3181.00
69_G125_I1.3101.00
78_K88_E1.3061.00
59_L141_H1.3051.00
89_G93_A1.3041.00
49_L53_V1.2971.00
15_F56_L1.2951.00
111_F143_I1.2591.00
81_G84_I1.2421.00
92_E95_H1.2351.00
168_K172_Y1.2331.00
50_G149_A1.2271.00
40_S47_L1.2031.00
165_Q168_K1.2011.00
109_F119_I1.1891.00
160_N164_T1.1861.00
177_V180_I1.1801.00
107_F143_I1.1781.00
95_H126_G1.1731.00
186_L189_I1.1691.00
71_K75_A1.1661.00
33_M54_G1.1641.00
45_I50_G1.1501.00
181_I185_I1.1501.00
59_L134_L1.1481.00
48_Y150_L1.1441.00
167_E171_N1.1401.00
184_Y187_W1.1401.00
106_V128_M1.1381.00
181_I184_Y1.1371.00
48_Y52_I1.1161.00
37_G152_G1.1151.00
73_G77_L1.1071.00
65_A121_Y1.0731.00
96_N100_R1.0681.00
183_I186_L1.0681.00
75_A79_R1.0641.00
166_A169_L1.0411.00
52_I56_L1.0391.00
74_L78_K1.0341.00
67_I70_Y1.0251.00
161_F164_T1.0141.00
77_L86_I1.0121.00
174_F178_I1.0051.00
41_Y153_Y0.9991.00
11_Y45_I0.9901.00
63_I67_I0.9891.00
33_M37_G0.9821.00
37_G149_A0.9791.00
137_T141_H0.9771.00
161_F165_Q0.9701.00
165_Q169_L0.9651.00
55_T59_L0.9521.00
169_L172_Y0.9511.00
54_G149_A0.9471.00
98_F123_A0.9371.00
90_K93_A0.9321.00
24_G65_A0.9271.00
94_L126_G0.9251.00
55_T145_D0.9241.00
51_V150_L0.9201.00
20_G25_L0.9151.00
66_Y130_I0.9121.00
170_G174_F0.9091.00
51_V55_T0.9091.00
81_G86_I0.8981.00
77_L91_I0.8981.00
52_I55_T0.8951.00
158_Q161_F0.8951.00
116_R144_W0.8931.00
58_S141_H0.8911.00
15_F60_V0.8851.00
102_G128_M0.8771.00
41_Y157_N0.8761.00
182_V186_L0.8751.00
120_S137_T0.8731.00
143_I146_I0.8721.00
76_F79_R0.8711.00
131_L134_L0.8701.00
135_G139_L0.8591.00
9_G12_I0.8541.00
18_M145_D0.8531.00
163_I166_A0.8471.00
97_W105_A0.8441.00
176_L180_I0.8421.00
62_S137_T0.8321.00
164_T168_K0.8311.00
68_I72_L0.8301.00
49_L52_I0.8251.00
30_E116_R0.8021.00
48_Y51_V0.7981.00
173_L177_V0.7981.00
187_W190_F0.7971.00
146_I150_L0.7911.00
6_Q13_I0.7881.00
112_I115_L0.7851.00
104_M136_F0.7851.00
151_I154_Q0.7811.00
147_V150_L0.7781.00
72_L75_A0.7741.00
177_V181_I0.7741.00
14_L50_G0.7741.00
22_G110_R0.7721.00
40_S50_G0.7691.00
38_Y41_Y0.7551.00
59_L137_T0.7541.00
7_G10_G0.7531.00
105_A108_G0.7531.00
134_L138_F0.7511.00
10_G13_I0.7491.00
162_V165_Q0.7461.00
89_G92_E0.7431.00
56_L60_V0.7401.00
8_I12_I0.7381.00
96_N99_L0.7371.00
14_L36_V0.7301.00
79_R82_K0.7291.00
63_I137_T0.7231.00
155_L159_I0.7171.00
123_A128_M0.7151.00
75_A78_K0.7090.99
35_L39_Y0.7060.99
15_F19_I0.7060.99
37_G50_G0.7060.99
72_L76_F0.6990.99
90_K94_L0.6990.99
110_R116_R0.6940.99
40_S149_A0.6930.99
178_I181_I0.6770.99
155_L158_Q0.6770.99
135_G138_F0.6770.99
175_I178_I0.6770.99
98_F105_A0.6740.99
35_L38_Y0.6730.99
174_F177_V0.6720.99
180_I183_I0.6720.99
62_S130_I0.6690.99
29_S137_T0.6670.99
145_D149_A0.6660.99
178_I182_V0.6640.99
66_Y124_G0.6610.99
35_L166_A0.6580.99
80_Y84_I0.6560.99
20_G24_G0.6480.99
58_S110_R0.6450.99
105_A119_I0.6390.99
82_K86_I0.6370.99
76_F80_Y0.6340.99
38_Y159_I0.6340.99
65_A117_A0.6330.99
179_V183_I0.6320.99
106_V123_A0.6320.99
171_N174_F0.6300.99
142_T146_I0.6240.99
77_L81_G0.6210.99
160_N163_I0.6150.99
66_Y127_Q0.6090.98
64_I67_I0.6080.98
6_Q9_G0.6060.98
161_F169_L0.6060.98
29_S113_P0.6040.98
41_Y44_S0.6040.98
18_M117_A0.6000.98
22_G137_T0.5960.98
93_A97_W0.5960.98
107_F111_F0.5940.98
22_G117_A0.5920.98
27_L117_A0.5880.98
21_E110_R0.5870.98
143_I147_V0.5860.98
151_I155_L0.5840.98
80_Y88_E0.5760.98
18_M140_G0.5730.98
110_R137_T0.5720.98
93_A96_N0.5720.98
171_N189_I0.5710.98
47_L146_I0.5710.98
7_G44_S0.5690.98
181_I188_R0.5670.98
74_L77_L0.5670.98
10_G45_I0.5670.98
14_L53_V0.5640.97
60_V64_I0.5630.97
153_Y157_N0.5620.97
113_P117_A0.5600.97
132_K136_F0.5570.97
77_L80_Y0.5550.97
107_F136_F0.5540.97
158_Q162_V0.5530.97
104_M122_P0.5520.97
21_E117_A0.5510.97
23_I64_I0.5500.97
34_P38_Y0.5480.97
116_R141_H0.5470.97
61_G65_A0.5410.97
167_E170_G0.5360.97
17_L32_I0.5360.97
172_Y175_I0.5360.97
116_R137_T0.5360.97
133_F137_T0.5340.97
139_L142_T0.5340.97
155_L161_F0.5340.97
175_I179_V0.5300.96
124_G127_Q0.5300.96
97_W101_Y0.5290.96
36_V45_I0.5250.96
30_E148_L0.5250.96
80_Y86_I0.5240.96
81_G88_E0.5230.96
88_E91_I0.5230.96
66_Y123_A0.5210.96
58_S62_S0.5210.96
185_I188_R0.5200.96
94_L118_L0.5190.96
74_L127_Q0.5180.96
97_W100_R0.5160.96
77_L125_I0.5150.96
22_G62_S0.5130.96
138_F142_T0.5130.96
11_Y40_S0.5110.96
30_E140_G0.5070.95
132_K135_G0.5050.95
41_Y156_A0.5030.95
154_Q158_Q0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2m20A 2 0.1753 26.2 0.926 Contact Map
2kv5A 1 0.1701 23.3 0.928 Contact Map
2jwaA 2 0.2216 22.8 0.928 Contact Map
2l2tA 2 0.1959 22.2 0.929 Contact Map
2kluA 1 0.1959 21.1 0.93 Contact Map
2ks1B 1 0.2165 17.5 0.932 Contact Map
4dx5A 3 0.8041 10.2 0.939 Contact Map
5a63D 1 0.4845 9.9 0.939 Contact Map
3qnqA 2 0.4175 8.9 0.941 Contact Map
1fftB 1 0.2371 7.8 0.942 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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