Q97V45 - SULSO - GREMLIN Contacts

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Q97V45 - Membrane protein, putative

UniProt:	Q97V45	Sequences: MVYVFQGIGGYIILFLLMIGEGIGLPLPSEVIMPLVGYYSYLGSISLYLGVIVGTLGSLVGSIIAYIIGYKLGLAFLKRYGKYILIDEGKIEALHNWFLRYGNMAVFGFRFIPGLRALISYPAGIGQMKILKFLGFTFLGHTIWDIVLALIGYQLANQINFVITQAEKLGNYLFILVIVIIVIYILWRIFWKRK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	194 (184)
Sequences:	7180 (5039)
Seq/√Len:	371.5

ECOLI - YABI YQJA YGHB DEDA YOHD YDJZ YDJX
BACSU - YNGC YKOX YBFM YHJE YQED YTXB
SULSO - Q97V45

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
63_I	130_I	3.338	1.00
46_S	49_L	3.126	1.00
185_I	189_I	3.009	1.00
55_T	142_T	2.835	1.00
63_I	134_L	2.534	1.00
19_I	64_I	2.490	1.00
59_L	138_F	2.449	1.00
101_Y	104_M	2.418	1.00
40_S	153_Y	2.398	1.00
129_K	132_K	2.331	1.00
51_V	146_I	2.324	1.00
183_I	187_W	2.324	1.00
103_N	132_K	2.305	1.00
186_L	190_F	2.301	1.00
107_F	139_L	2.300	1.00
15_F	57_G	2.178	1.00
87_D	90_K	2.150	1.00
95_H	99_L	2.090	1.00
53_V	57_G	2.028	1.00
54_G	145_D	1.980	1.00
150_L	154_Q	1.966	1.00
103_N	136_F	1.959	1.00
47_L	150_L	1.922	1.00
6_Q	10_G	1.893	1.00
51_V	149_A	1.854	1.00
70_Y	127_Q	1.799	1.00
74_L	95_H	1.797	1.00
18_M	57_G	1.694	1.00
88_E	92_E	1.631	1.00
11_Y	46_S	1.626	1.00
130_I	134_L	1.615	1.00
47_L	51_V	1.615	1.00
67_I	71_K	1.600	1.00
19_I	60_V	1.598	1.00
15_F	53_V	1.586	1.00
36_V	50_G	1.584	1.00
171_N	175_I	1.575	1.00
180_I	184_Y	1.508	1.00
172_Y	176_L	1.500	1.00
33_M	149_A	1.449	1.00
184_Y	188_R	1.444	1.00
14_L	54_G	1.419	1.00
47_L	149_A	1.413	1.00
11_Y	49_L	1.402	1.00
104_M	108_G	1.397	1.00
163_I	167_E	1.378	1.00
62_S	110_R	1.358	1.00
92_E	96_N	1.351	1.00
9_G	13_I	1.350	1.00
21_E	29_S	1.347	1.00
11_Y	53_V	1.342	1.00
67_I	130_I	1.321	1.00
131_L	135_G	1.318	1.00
69_G	125_I	1.310	1.00
78_K	88_E	1.306	1.00
59_L	141_H	1.305	1.00
89_G	93_A	1.304	1.00
49_L	53_V	1.297	1.00
15_F	56_L	1.295	1.00
111_F	143_I	1.259	1.00
81_G	84_I	1.242	1.00
92_E	95_H	1.235	1.00
168_K	172_Y	1.233	1.00
50_G	149_A	1.227	1.00
40_S	47_L	1.203	1.00
165_Q	168_K	1.201	1.00
109_F	119_I	1.189	1.00
160_N	164_T	1.186	1.00
177_V	180_I	1.180	1.00
107_F	143_I	1.178	1.00
95_H	126_G	1.173	1.00
186_L	189_I	1.169	1.00
71_K	75_A	1.166	1.00
33_M	54_G	1.164	1.00
45_I	50_G	1.150	1.00
181_I	185_I	1.150	1.00
59_L	134_L	1.148	1.00
48_Y	150_L	1.144	1.00
167_E	171_N	1.140	1.00
184_Y	187_W	1.140	1.00
106_V	128_M	1.138	1.00
181_I	184_Y	1.137	1.00
48_Y	52_I	1.116	1.00
37_G	152_G	1.115	1.00
73_G	77_L	1.107	1.00
65_A	121_Y	1.073	1.00
96_N	100_R	1.068	1.00
183_I	186_L	1.068	1.00
75_A	79_R	1.064	1.00
166_A	169_L	1.041	1.00
52_I	56_L	1.039	1.00
74_L	78_K	1.034	1.00
67_I	70_Y	1.025	1.00
161_F	164_T	1.014	1.00
77_L	86_I	1.012	1.00
174_F	178_I	1.005	1.00
41_Y	153_Y	0.999	1.00
11_Y	45_I	0.990	1.00
63_I	67_I	0.989	1.00
33_M	37_G	0.982	1.00
37_G	149_A	0.979	1.00
137_T	141_H	0.977	1.00
161_F	165_Q	0.970	1.00
165_Q	169_L	0.965	1.00
55_T	59_L	0.952	1.00
169_L	172_Y	0.951	1.00
54_G	149_A	0.947	1.00
98_F	123_A	0.937	1.00
90_K	93_A	0.932	1.00
24_G	65_A	0.927	1.00
94_L	126_G	0.925	1.00
55_T	145_D	0.924	1.00
51_V	150_L	0.920	1.00
20_G	25_L	0.915	1.00
66_Y	130_I	0.912	1.00
170_G	174_F	0.909	1.00
51_V	55_T	0.909	1.00
81_G	86_I	0.898	1.00
77_L	91_I	0.898	1.00
52_I	55_T	0.895	1.00
158_Q	161_F	0.895	1.00
116_R	144_W	0.893	1.00
58_S	141_H	0.891	1.00
15_F	60_V	0.885	1.00
102_G	128_M	0.877	1.00
41_Y	157_N	0.876	1.00
182_V	186_L	0.875	1.00
120_S	137_T	0.873	1.00
143_I	146_I	0.872	1.00
76_F	79_R	0.871	1.00
131_L	134_L	0.870	1.00
135_G	139_L	0.859	1.00
9_G	12_I	0.854	1.00
18_M	145_D	0.853	1.00
163_I	166_A	0.847	1.00
97_W	105_A	0.844	1.00
176_L	180_I	0.842	1.00
62_S	137_T	0.832	1.00
164_T	168_K	0.831	1.00
68_I	72_L	0.830	1.00
49_L	52_I	0.825	1.00
30_E	116_R	0.802	1.00
48_Y	51_V	0.798	1.00
173_L	177_V	0.798	1.00
187_W	190_F	0.797	1.00
146_I	150_L	0.791	1.00
6_Q	13_I	0.788	1.00
112_I	115_L	0.785	1.00
104_M	136_F	0.785	1.00
151_I	154_Q	0.781	1.00
147_V	150_L	0.778	1.00
72_L	75_A	0.774	1.00
177_V	181_I	0.774	1.00
14_L	50_G	0.774	1.00
22_G	110_R	0.772	1.00
40_S	50_G	0.769	1.00
38_Y	41_Y	0.755	1.00
59_L	137_T	0.754	1.00
7_G	10_G	0.753	1.00
105_A	108_G	0.753	1.00
134_L	138_F	0.751	1.00
10_G	13_I	0.749	1.00
162_V	165_Q	0.746	1.00
89_G	92_E	0.743	1.00
56_L	60_V	0.740	1.00
8_I	12_I	0.738	1.00
96_N	99_L	0.737	1.00
14_L	36_V	0.730	1.00
79_R	82_K	0.729	1.00
63_I	137_T	0.723	1.00
155_L	159_I	0.717	1.00
123_A	128_M	0.715	1.00
75_A	78_K	0.709	0.99
35_L	39_Y	0.706	0.99
15_F	19_I	0.706	0.99
37_G	50_G	0.706	0.99
72_L	76_F	0.699	0.99
90_K	94_L	0.699	0.99
110_R	116_R	0.694	0.99
40_S	149_A	0.693	0.99
178_I	181_I	0.677	0.99
155_L	158_Q	0.677	0.99
135_G	138_F	0.677	0.99
175_I	178_I	0.677	0.99
98_F	105_A	0.674	0.99
35_L	38_Y	0.673	0.99
174_F	177_V	0.672	0.99
180_I	183_I	0.672	0.99
62_S	130_I	0.669	0.99
29_S	137_T	0.667	0.99
145_D	149_A	0.666	0.99
178_I	182_V	0.664	0.99
66_Y	124_G	0.661	0.99
35_L	166_A	0.658	0.99
80_Y	84_I	0.656	0.99
20_G	24_G	0.648	0.99
58_S	110_R	0.645	0.99
105_A	119_I	0.639	0.99
82_K	86_I	0.637	0.99
76_F	80_Y	0.634	0.99
38_Y	159_I	0.634	0.99
65_A	117_A	0.633	0.99
179_V	183_I	0.632	0.99
106_V	123_A	0.632	0.99
171_N	174_F	0.630	0.99
142_T	146_I	0.624	0.99
77_L	81_G	0.621	0.99
160_N	163_I	0.615	0.99
66_Y	127_Q	0.609	0.98
64_I	67_I	0.608	0.98
6_Q	9_G	0.606	0.98
161_F	169_L	0.606	0.98
29_S	113_P	0.604	0.98
41_Y	44_S	0.604	0.98
18_M	117_A	0.600	0.98
22_G	137_T	0.596	0.98
93_A	97_W	0.596	0.98
107_F	111_F	0.594	0.98
22_G	117_A	0.592	0.98
27_L	117_A	0.588	0.98
21_E	110_R	0.587	0.98
143_I	147_V	0.586	0.98
151_I	155_L	0.584	0.98
80_Y	88_E	0.576	0.98
18_M	140_G	0.573	0.98
110_R	137_T	0.572	0.98
93_A	96_N	0.572	0.98
171_N	189_I	0.571	0.98
47_L	146_I	0.571	0.98
7_G	44_S	0.569	0.98
181_I	188_R	0.567	0.98
74_L	77_L	0.567	0.98
10_G	45_I	0.567	0.98
14_L	53_V	0.564	0.97
60_V	64_I	0.563	0.97
153_Y	157_N	0.562	0.97
113_P	117_A	0.560	0.97
132_K	136_F	0.557	0.97
77_L	80_Y	0.555	0.97
107_F	136_F	0.554	0.97
158_Q	162_V	0.553	0.97
104_M	122_P	0.552	0.97
21_E	117_A	0.551	0.97
23_I	64_I	0.550	0.97
34_P	38_Y	0.548	0.97
116_R	141_H	0.547	0.97
61_G	65_A	0.541	0.97
167_E	170_G	0.536	0.97
17_L	32_I	0.536	0.97
172_Y	175_I	0.536	0.97
116_R	137_T	0.536	0.97
133_F	137_T	0.534	0.97
139_L	142_T	0.534	0.97
155_L	161_F	0.534	0.97
175_I	179_V	0.530	0.96
124_G	127_Q	0.530	0.96
97_W	101_Y	0.529	0.96
36_V	45_I	0.525	0.96
30_E	148_L	0.525	0.96
80_Y	86_I	0.524	0.96
81_G	88_E	0.523	0.96
88_E	91_I	0.523	0.96
66_Y	123_A	0.521	0.96
58_S	62_S	0.521	0.96
185_I	188_R	0.520	0.96
94_L	118_L	0.519	0.96
74_L	127_Q	0.518	0.96
97_W	100_R	0.516	0.96
77_L	125_I	0.515	0.96
22_G	62_S	0.513	0.96
138_F	142_T	0.513	0.96
11_Y	40_S	0.511	0.96
30_E	140_G	0.507	0.95
132_K	135_G	0.505	0.95
41_Y	156_A	0.503	0.95
154_Q	158_Q	0.500	0.95

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2m20A	2	0.1753	26.2	0.926	Contact Map
2kv5A	1	0.1701	23.3	0.928	Contact Map
2jwaA	2	0.2216	22.8	0.928	Contact Map
2l2tA	2	0.1959	22.2	0.929	Contact Map
2kluA	1	0.1959	21.1	0.93	Contact Map
2ks1B	1	0.2165	17.5	0.932	Contact Map
4dx5A	3	0.8041	10.2	0.939	Contact Map
5a63D	1	0.4845	9.9	0.939	Contact Map
3qnqA	2	0.4175	8.9	0.941	Contact Map
1fftB	1	0.2371	7.8	0.942	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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