GREMLIN Database
Q97V43 - Acid phosphatase, putative (AcpA)
UniProt: Q97V43 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 511 (435)
Sequences: 944 (559)
Seq/√Len: 26.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
30_V358_I6.9561.00
113_Y118_S4.6981.00
246_G250_N4.6301.00
326_L376_L4.4281.00
46_T152_W4.3651.00
28_R299_S4.1931.00
201_S208_L4.1811.00
179_Y354_L4.1291.00
445_V454_R4.1241.00
32_I179_Y3.7971.00
224_P260_M3.5531.00
27_I301_V3.3721.00
145_Y428_Y3.3191.00
305_T354_L3.1161.00
349_L381_Q3.0471.00
145_Y156_E3.0221.00
115_G118_S2.9491.00
152_W156_E2.9481.00
32_I358_I2.8901.00
151_L306_F2.8311.00
112_P310_G2.8211.00
235_M240_D2.8131.00
256_V358_I2.7331.00
8_T289_N2.7140.99
305_T332_L2.7030.99
224_P261_L2.6500.99
32_I354_L2.6490.99
151_L281_E2.5930.99
11_P289_N2.5820.99
60_L317_I2.5810.99
44_F333_L2.5760.99
223_I229_A2.4960.99
343_Y435_F2.4130.99
301_V383_F2.4050.99
10_L13_L2.3610.99
334_I339_A2.3330.98
446_L457_I2.3250.98
215_Y227_L2.3110.98
262_I269_Y2.2620.98
349_L377_Q2.2110.98
303_F334_I2.1590.97
306_F333_L2.0700.97
10_L14_L2.0540.96
173_E226_P2.0010.96
94_L422_K1.9880.96
17_T388_K1.9780.96
161_A349_L1.9650.95
443_A456_L1.9490.95
179_Y305_T1.9290.95
441_V466_V1.8650.94
66_Y70_E1.8570.94
460_T466_V1.8300.93
347_Y464_F1.8270.93
180_L226_P1.8190.93
48_P432_E1.8050.93
303_F332_L1.7990.93
249_K293_E1.7960.93
68_L71_N1.7950.93
304_I335_I1.7890.92
177_I226_P1.7880.92
444_F459_L1.7830.92
173_E228_D1.7760.92
251_G294_S1.7660.92
441_V458_K1.7480.92
345_D349_L1.7070.91
200_Y203_M1.7000.90
67_G70_E1.6910.90
227_L233_I1.6880.90
185_P191_D1.6860.90
31_I300_T1.6720.90
9_L292_M1.6680.89
156_E428_Y1.6660.89
98_Y141_A1.6610.89
72_Y422_K1.6520.89
193_T196_I1.6510.89
334_I382_A1.6410.89
207_Q212_S1.6390.89
216_F247_D1.6360.89
202_I205_Q1.6330.88
145_Y152_W1.6240.88
222_G270_D1.6160.88
6_I13_L1.5900.87
44_F160_L1.5820.87
24_T357_F1.5780.87
65_P71_N1.5650.86
111_D171_L1.5650.86
345_D382_A1.5560.86
151_L284_I1.5460.85
5_L8_T1.5430.85
180_L260_M1.5380.85
173_E229_A1.5350.85
119_Y328_Q1.5300.85
201_S205_Q1.5130.84
217_V221_N1.4800.83
203_M364_L1.4750.83
31_I248_L1.4730.83
396_T399_N1.4680.82
258_W355_L1.4680.82
118_S171_L1.4630.82
347_Y381_Q1.4630.82
173_E223_I1.4540.82
168_V171_L1.4510.82
225_W233_I1.4350.81
347_Y438_P1.4350.81
303_F339_A1.4270.80
215_Y260_M1.4230.80
114_E310_G1.3960.79
285_A289_N1.3880.79
356_A360_Y1.3870.78
205_Q366_W1.3760.78
19_F389_P1.3750.78
440_D461_F1.3720.78
458_K466_V1.3690.78
6_I10_L1.3530.77
386_S389_P1.3480.76
173_E177_I1.3430.76
121_G130_G1.3350.76
360_Y378_G1.3150.75
116_W120_H1.3050.74
416_A419_P1.2860.73
188_Y191_D1.2840.73
458_K464_F1.2770.72
65_P68_L1.2760.72
454_R459_L1.2750.72
203_M227_L1.2740.72
226_P229_A1.2740.72
111_D119_Y1.2720.72
70_E92_P1.2690.72
354_L376_L1.2640.72
183_F368_T1.2620.71
180_L281_E1.2560.71
30_V211_V1.2550.71
171_L274_P1.2550.71
405_P408_Y1.2540.71
248_L291_V1.2510.71
123_Y169_L1.2500.71
66_Y92_P1.2480.71
187_F190_D1.2480.71
462_L465_V1.2470.71
462_L466_V1.2370.70
226_P260_M1.2300.69
347_Y356_A1.2190.69
345_D381_Q1.2080.68
97_A144_S1.2080.68
205_Q367_L1.2020.68
123_Y165_F1.1990.67
50_G344_I1.1870.67
23_T26_P1.1850.67
15_I292_M1.1770.66
434_A437_L1.1760.66
201_S365_P1.1760.66
178_A324_Y1.1730.66
15_I298_N1.1710.66
19_F388_K1.1670.65
160_L344_I1.1650.65
169_L328_Q1.1630.65
405_P414_Y1.1600.65
18_T28_R1.1540.64
413_G419_P1.1470.64
123_Y320_S1.1460.64
448_F455_T1.1440.64
70_E94_L1.1380.63
460_T465_V1.1300.63
132_V140_L1.1210.62
123_Y313_Y1.1160.62
185_P188_Y1.1120.62
158_Y297_W1.1100.61
263_G274_P1.1100.61
222_G263_G1.1050.61
124_W129_K1.1030.61
96_I147_Q1.1020.61
122_D281_E1.0990.61
184_S324_Y1.0980.61
245_F249_K1.0950.60
261_L283_M1.0950.60
443_A458_K1.0920.60
159_V341_E1.0920.60
151_L333_L1.0880.60
447_L455_T1.0810.59
57_N60_L1.0650.58
359_D373_D1.0580.58
304_I333_L1.0560.57
99_S299_S1.0520.57
51_Y55_L1.0510.57
221_N270_D1.0500.57
262_I282_I1.0490.57
161_A377_Q1.0480.57
9_L15_I1.0480.57
404_L407_Q1.0440.57
199_N231_N1.0410.56
147_Q370_Y1.0310.56
43_L271_M1.0250.55
174_P351_G1.0250.55
111_D114_E1.0210.55
242_K246_G1.0200.55
221_N224_P1.0150.54
42_N370_Y1.0140.54
301_V385_F1.0140.54
442_I461_F1.0130.54
154_Y351_G1.0110.54
349_L438_P0.9990.53
195_V198_F0.9950.53
398_S402_Y0.9870.52
447_L450_S0.9780.52
7_L457_I0.9740.51
47_Y155_A0.9730.51
99_S103_Y0.9720.51
160_L165_F0.9690.51
156_E433_M0.9690.51
444_F457_I0.9680.51
171_L174_P0.9680.51
173_E224_P0.9580.50
192_A196_I0.9520.50
260_M305_T0.9520.50
292_M302_I0.9500.50
446_L455_T0.9500.50
59_T244_F0.9490.49
62_L68_L0.9480.49
244_F292_M0.9430.49
108_S112_P0.9360.49
59_T69_Y0.9300.48
340_K389_P0.9270.48
301_V334_I0.9240.48
119_Y169_L0.9200.47
130_G133_Y0.9130.47
438_P464_F0.9130.47
436_L440_D0.9130.47
269_Y283_M0.9080.46
243_N246_G0.9080.46
215_Y223_I0.9050.46
345_D437_L0.9040.46
112_P312_Y0.9030.46
245_F286_N0.9010.46
246_G249_K0.9000.46
251_G299_S0.8960.46
17_T386_S0.8940.45
392_P396_T0.8940.45
223_I260_M0.8930.45
62_L69_Y0.8920.45
167_P181_T0.8910.45
5_L251_G0.8910.45
183_F201_S0.8890.45
48_P428_Y0.8890.45
226_P354_L0.8870.45
118_S136_G0.8850.45
437_L456_L0.8820.44
223_I226_P0.8790.44
160_L444_F0.8780.44
197_P368_T0.8770.44
456_L462_L0.8760.44
47_Y152_W0.8740.44
181_T202_I0.8720.44
318_P350_S0.8720.44
165_F316_V0.8690.44
62_L72_Y0.8650.43
451_F457_I0.8640.43
121_G136_G0.8640.43
348_T376_L0.8580.43
5_L174_P0.8540.42
161_A381_Q0.8530.42
179_Y226_P0.8530.42
461_F466_V0.8520.42
447_L453_K0.8520.42
269_Y282_I0.8490.42
53_P204_Y0.8470.42
446_L459_L0.8440.42
114_E309_G0.8420.42
107_Y110_R0.8410.41
357_F361_N0.8380.41
15_I18_T0.8370.41
161_A341_E0.8310.41
169_L320_S0.8290.41
21_A25_T0.8210.40
215_Y226_P0.8200.40
19_F298_N0.8180.40
30_V357_F0.8170.40
244_F294_S0.8150.40
175_N308_E0.8150.40
6_I14_L0.8150.40
200_Y205_Q0.8130.39
69_Y72_Y0.8090.39
458_K463_L0.8090.39
30_V256_V0.8060.39
205_Q365_P0.8060.39
64_Y70_E0.8060.39
440_D445_V0.8030.39
166_S309_G0.7990.38
202_I356_A0.7980.38
454_R462_L0.7970.38
448_F451_F0.7970.38
18_T21_A0.7960.38
109_T143_F0.7960.38
446_L461_F0.7950.38
456_L465_V0.7930.38
446_L458_K0.7910.38
291_V302_I0.7890.38
72_Y80_N0.7880.38
255_A361_N0.7870.38
168_V358_I0.7870.38
397_P402_Y0.7860.38
108_S276_N0.7850.37
395_L429_P0.7840.37
287_I302_I0.7830.37
451_F455_T0.7830.37
221_N228_D0.7810.37
234_N259_V0.7810.37
116_W425_A0.7810.37
193_T198_F0.7790.37
127_T387_T0.7780.37
177_I198_F0.7760.37
62_L66_Y0.7740.37
168_V335_I0.7740.37
458_K462_L0.7740.37
200_Y366_W0.7730.37
7_L392_P0.7710.36
104_S326_L0.7710.36
447_L454_R0.7710.36
429_P451_F0.7700.36
72_Y211_V0.7700.36
161_A382_A0.7650.36
122_D126_D0.7640.36
404_L408_Y0.7620.36
32_I215_Y0.7610.36
186_N191_D0.7590.36
399_N402_Y0.7550.35
454_R466_V0.7550.35
104_S107_Y0.7530.35
107_Y169_L0.7530.35
180_L261_L0.7510.35
414_Y419_P0.7510.35
203_M366_W0.7500.35
248_L296_Y0.7490.35
104_S276_N0.7480.35
292_M362_W0.7430.35
225_W371_V0.7370.34
184_S229_A0.7360.34
35_E55_L0.7360.34
177_I184_S0.7350.34
49_F52_P0.7330.34
369_K374_S0.7330.34
43_L385_F0.7330.34
411_H414_Y0.7330.34
184_S191_D0.7320.34
32_I121_G0.7310.34
454_R457_I0.7300.34
15_I241_L0.7290.34
152_W428_Y0.7220.33
125_F211_V0.7150.33
173_E220_L0.7150.33
332_L434_A0.7150.33
43_L164_Y0.7130.33
450_S453_K0.7130.33
4_V463_L0.7110.32
244_F251_G0.7100.32
112_P279_A0.7100.32
183_F190_D0.7090.32
420_N455_T0.7080.32
214_G414_Y0.7080.32
72_Y91_I0.7070.32
405_P411_H0.7050.32
34_I167_P0.7040.32
276_N279_A0.7040.32
103_Y160_L0.7030.32
192_A195_V0.7030.32
228_D243_N0.6990.32
251_G259_V0.6990.32
449_I461_F0.6990.32
112_P148_T0.6960.31
326_L348_T0.6940.31
432_E464_F0.6920.31
119_Y132_V0.6910.31
442_I464_F0.6900.31
203_M367_L0.6890.31
454_R464_F0.6890.31
116_W215_Y0.6880.31
357_F380_L0.6870.31
51_Y346_N0.6870.31
442_I458_K0.6870.31
25_T463_L0.6850.31
62_L71_N0.6840.31
164_Y351_G0.6840.31
445_V458_K0.6830.31
142_Y423_G0.6820.31
14_L445_V0.6810.30
360_Y459_L0.6810.30
450_S454_R0.6800.30
107_Y290_A0.6790.30
223_I228_D0.6780.30
33_I228_D0.6760.30
108_S113_Y0.6760.30
223_I241_L0.6750.30
197_P332_L0.6740.30
110_R259_V0.6700.30
49_F341_E0.6690.30
104_S108_S0.6680.30
143_F171_L0.6680.30
431_P441_V0.6680.30
202_I366_W0.6670.30
226_P233_I0.6660.30
451_F463_L0.6650.29
10_L461_F0.6640.29
447_L451_F0.6630.29
107_Y151_L0.6620.29
204_Y233_I0.6620.29
407_Q410_I0.6610.29
18_T27_I0.6610.29
440_D463_L0.6600.29
11_P457_I0.6590.29
222_G260_M0.6590.29
240_D448_F0.6590.29
416_A432_E0.6590.29
35_E42_N0.6580.29
35_E161_A0.6570.29
340_K358_I0.6570.29
202_I227_L0.6550.29
139_S306_F0.6530.29
72_Y81_G0.6520.29
28_R252_S0.6520.29
142_Y232_Q0.6510.29
289_N292_M0.6490.28
183_F235_M0.6490.28
352_Y356_A0.6490.28
9_L298_N0.6490.28
15_I23_T0.6480.28
111_D328_Q0.6470.28
445_V457_I0.6470.28
5_L101_P0.6450.28
285_A326_L0.6410.28
249_K294_S0.6410.28
244_F302_I0.6400.28
301_V357_F0.6380.28
410_I414_Y0.6370.28
302_I335_I0.6370.28
9_L69_Y0.6370.28
178_A184_S0.6360.28
176_R308_E0.6360.28
10_L442_I0.6360.28
22_N26_P0.6340.28
459_L463_L0.6330.28
112_P137_P0.6330.28
397_P400_W0.6320.27
408_Y412_Y0.6310.27
48_P142_Y0.6310.27
14_L355_L0.6280.27
91_I132_V0.6280.27
245_F287_I0.6260.27
362_W396_T0.6260.27
11_P285_A0.6250.27
169_L260_M0.6240.27
180_L224_P0.6220.27
161_A332_L0.6220.27
113_Y122_D0.6210.27
65_P69_Y0.6190.27
100_H104_S0.6190.27
185_P199_N0.6160.27
377_Q381_Q0.6160.27
134_Y310_G0.6150.26
415_I455_T0.6140.26
136_G335_I0.6110.26
288_T339_A0.6100.26
321_I384_N0.6100.26
187_F191_D0.6090.26
224_P263_G0.6090.26
27_I299_S0.6070.26
432_E438_P0.6050.26
280_G285_A0.6050.26
424_Y455_T0.6050.26
117_D181_T0.6040.26
7_L153_D0.6040.26
460_T464_F0.6030.26
440_D458_K0.6030.26
134_Y313_Y0.6010.26
263_G275_H0.5990.26
47_Y211_V0.5990.26
453_K464_F0.5980.25
144_S152_W0.5980.25
458_K465_V0.5980.25
154_Y319_P0.5970.25
278_T285_A0.5970.25
234_N287_I0.5960.25
410_I413_G0.5950.25
257_S340_K0.5950.25
288_T291_V0.5940.25
406_L412_Y0.5940.25
160_L168_V0.5900.25
449_I464_F0.5890.25
244_F286_N0.5890.25
448_F453_K0.5890.25
167_P330_I0.5860.25
62_L382_A0.5850.25
104_S413_G0.5850.25
5_L440_D0.5840.25
178_A183_F0.5830.25
5_L347_Y0.5830.25
303_F357_F0.5810.25
106_A332_L0.5810.25
108_S275_H0.5800.24
98_Y241_L0.5800.24
293_E296_Y0.5780.24
447_L457_I0.5780.24
223_I306_F0.5770.24
120_H320_S0.5770.24
180_L283_M0.5740.24
309_G313_Y0.5740.24
441_V459_L0.5720.24
245_F291_V0.5700.24
244_F328_Q0.5700.24
394_I400_W0.5700.24
395_L398_S0.5700.24
172_T176_R0.5700.24
447_L459_L0.5690.24
345_D442_I0.5690.24
218_Y241_L0.5680.24
391_A396_T0.5670.24
174_P345_D0.5670.24
22_N271_M0.5660.24
400_W463_L0.5660.24
319_P362_W0.5650.24
59_T81_G0.5650.24
186_N190_D0.5650.24
450_S466_V0.5640.24
112_P309_G0.5640.24
244_F340_K0.5640.24
181_T426_E0.5640.24
154_Y335_I0.5620.23
150_I310_G0.5620.23
30_V440_D0.5620.23
366_W371_V0.5620.23
405_P409_P0.5600.23
72_Y335_I0.5600.23
173_E263_G0.5590.23
184_S234_N0.5580.23
111_D224_P0.5580.23
11_P361_N0.5580.23
398_S401_T0.5580.23
6_I440_D0.5570.23
110_R113_Y0.5570.23
333_L339_A0.5570.23
230_F354_L0.5560.23
215_Y243_N0.5560.23
448_F456_L0.5560.23
295_Q362_W0.5560.23
205_Q355_L0.5550.23
224_P232_Q0.5550.23
455_T463_L0.5550.23
406_L409_P0.5520.23
244_F259_V0.5520.23
205_Q364_L0.5520.23
218_Y281_E0.5510.23
219_K283_M0.5510.23
280_G306_F0.5510.23
14_L231_N0.5500.23
105_N109_T0.5500.23
106_A110_R0.5490.23
67_G207_Q0.5490.23
407_Q413_G0.5480.23
255_A362_W0.5480.23
120_H169_L0.5470.23
64_Y92_P0.5470.23
59_T62_L0.5470.23
365_P450_S0.5470.23
167_P350_S0.5460.23
33_I284_I0.5440.23
49_F439_L0.5440.23
438_P441_V0.5440.23
437_L443_A0.5430.22
442_I459_L0.5430.22
243_N303_F0.5420.22
241_L262_I0.5420.22
11_P284_I0.5420.22
39_S309_G0.5420.22
65_P209_N0.5410.22
217_V248_L0.5410.22
116_W247_D0.5400.22
11_P209_N0.5380.22
319_P363_H0.5370.22
32_I256_V0.5370.22
182_G367_L0.5360.22
201_S251_G0.5360.22
168_V304_I0.5340.22
12_L334_I0.5340.22
98_Y138_Q0.5330.22
218_Y283_M0.5320.22
99_S408_Y0.5320.22
106_A312_Y0.5320.22
281_E310_G0.5320.22
104_S109_T0.5310.22
283_M310_G0.5310.22
67_G284_I0.5300.22
110_R284_I0.5300.22
62_L65_P0.5300.22
119_Y306_F0.5300.22
412_Y431_P0.5290.22
165_F249_K0.5290.22
294_S299_S0.5280.22
259_V397_P0.5280.22
24_T271_M0.5270.22
33_I316_V0.5270.22
171_L345_D0.5260.22
27_I242_K0.5260.22
123_Y456_L0.5260.22
13_L18_T0.5240.21
32_I174_P0.5230.21
343_Y436_L0.5220.21
43_L384_N0.5220.21
166_S356_A0.5220.21
450_S459_L0.5210.21
138_Q306_F0.5210.21
32_I226_P0.5210.21
160_L333_L0.5190.21
35_E261_L0.5180.21
10_L142_Y0.5180.21
185_P204_Y0.5170.21
11_P54_I0.5160.21
454_R460_T0.5140.21
47_Y335_I0.5140.21
140_L154_Y0.5140.21
48_P457_I0.5140.21
185_P312_Y0.5120.21
442_I448_F0.5120.21
214_G422_K0.5120.21
47_Y160_L0.5110.21
114_E122_D0.5100.21
220_L263_G0.5100.21
128_D376_L0.5100.21
384_N462_L0.5090.21
407_Q411_H0.5090.21
173_E259_V0.5090.21
100_H282_I0.5090.21
6_I461_F0.5090.21
173_E218_Y0.5080.21
184_S275_H0.5080.21
441_V446_L0.5070.21
211_V454_R0.5070.21
180_L233_I0.5070.21
116_W151_L0.5060.21
79_K451_F0.5050.21
391_A394_I0.5050.21
168_V178_A0.5050.21
310_G367_L0.5050.21
434_A438_P0.5040.20
219_K234_N0.5040.20
381_Q439_L0.5030.20
412_Y417_T0.5030.20
224_P227_L0.5020.20
111_D275_H0.5020.20
156_E430_M0.5020.20
227_L355_L0.5010.20
387_T390_R0.5010.20
214_G368_T0.5010.20
217_V220_L0.5000.20
208_L249_K0.5000.20
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2d1gA 2 0.7339 100 0.388 Contact Map
4kavA 1 0.5225 98.1 0.953 Contact Map
4uorA 3 0.6732 98 0.955 Contact Map
2gsoA 1 0.4951 97.9 0.955 Contact Map
3lxqA 1 0.7104 97.6 0.958 Contact Map
4lr2A 1 0.4971 97.6 0.958 Contact Map
4uopA 2 0.6321 97.5 0.959 Contact Map
2w5vA 2 0.4599 97.3 0.96 Contact Map
3b5qA 1 0.6654 97.3 0.961 Contact Map
4upiA 2 0.7065 97.2 0.961 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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