GREMLIN Database
Q97V40 - Uncharacterized protein
UniProt: Q97V40 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 498 (445)
Sequences: 144 (114)
Seq/√Len: 5.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
101_Y105_V5.5050.99
210_I214_Y5.1000.98
125_R128_L4.9600.98
125_R129_K4.5230.96
124_R128_L4.2750.94
100_A105_V4.2010.93
157_S187_S3.9000.91
101_Y123_S3.6970.88
100_A123_S3.5510.86
334_L477_Q3.4980.85
365_K412_A3.3480.82
100_A109_D3.3190.81
101_Y109_D3.3040.81
97_L100_A3.3040.81
100_A107_L3.2250.79
124_R127_L3.1950.79
100_A104_R3.1680.78
124_R130_L3.1520.78
123_S127_L3.0890.76
123_S128_L3.0330.75
123_S129_K2.9590.73
100_A103_L2.9320.72
96_T100_A2.8690.70
211_V214_Y2.8340.69
160_Q179_S2.7950.68
190_L399_I2.7550.67
125_R130_L2.7480.67
100_A114_V2.7250.66
438_R467_Q2.7180.66
420_K427_K2.6870.65
101_Y104_R2.6860.65
124_R129_K2.6840.65
101_Y125_R2.6540.64
123_S130_L2.5920.62
101_Y107_L2.5910.62
100_A125_R2.5670.61
32_Y35_E2.4120.56
90_S430_N2.3690.55
109_D123_S2.3600.54
201_D205_S2.3450.54
109_D114_V2.3050.53
206_F214_Y2.2890.52
102_S107_L2.2750.52
127_L130_L2.2470.51
149_R165_K2.2390.50
114_V118_P2.1880.49
149_R152_N2.1490.47
100_A120_S2.1200.46
100_A124_R2.0720.45
102_S105_V2.0540.44
82_P85_W2.0540.44
101_Y124_R2.0410.44
206_F210_I2.0270.43
100_A118_P2.0260.43
45_N333_L2.0060.43
107_L114_V1.9720.41
101_Y120_S1.9380.40
104_R109_D1.9280.40
105_V109_D1.9200.40
223_F415_V1.9010.39
432_A448_R1.8840.39
275_A278_R1.8680.38
101_Y106_E1.8640.38
447_E480_L1.8620.38
268_K272_R1.8600.38
454_D470_D1.8210.37
208_N211_V1.8170.36
165_K291_F1.7910.36
30_L39_Y1.7870.36
218_Q225_D1.7720.35
101_Y127_L1.7400.34
106_E115_Q1.7270.34
102_S109_D1.7250.34
97_L114_V1.7070.33
100_A128_L1.6950.33
97_L101_Y1.6940.33
101_Y108_M1.6800.32
101_Y116_P1.6750.32
435_S470_D1.6660.32
105_V123_S1.6600.32
187_S387_S1.6420.31
100_A119_T1.6380.31
262_I375_A1.5830.29
54_L81_I1.5810.29
219_A234_G1.5810.29
102_S124_R1.5740.29
378_M421_I1.5630.29
30_L187_S1.5480.29
39_Y339_E1.5450.28
210_I462_F1.5390.28
56_S83_P1.5320.28
171_S451_N1.5290.28
100_A129_K1.5290.28
101_Y119_T1.5270.28
135_Y140_V1.5230.28
435_S451_N1.5100.27
395_I418_Y1.4990.27
64_M68_D1.4970.27
108_M127_L1.4810.27
105_V117_T1.4790.27
107_L124_R1.4780.27
109_D128_L1.4660.26
371_V396_P1.4640.26
108_M123_S1.4570.26
240_M333_L1.4560.26
108_M111_A1.4480.26
446_S462_F1.4460.26
120_S124_R1.4440.26
108_M128_L1.4330.25
35_E40_V1.4300.25
385_G462_F1.4230.25
100_A127_L1.4150.25
121_S129_K1.4030.25
282_L287_P1.4010.25
232_P335_I1.3990.25
120_S123_S1.3960.25
379_L397_Y1.3910.24
102_S123_S1.3870.24
101_Y129_K1.3870.24
206_F211_V1.3840.24
117_T120_S1.3830.24
60_K385_G1.3770.24
172_V290_N1.3650.24
248_D356_V1.3640.24
100_A121_S1.3630.24
144_E450_K1.3620.24
108_M120_S1.3560.24
101_Y121_S1.3400.23
96_T114_V1.3240.23
104_R128_L1.3230.23
206_F326_Q1.3210.23
282_L285_H1.3190.23
101_Y128_L1.3160.23
344_K420_K1.3140.23
252_L390_E1.3120.22
105_V114_V1.3120.22
211_V259_I1.3060.22
96_T107_L1.3050.22
100_A108_M1.3040.22
333_L340_E1.2930.22
132_T218_Q1.2890.22
446_S473_N1.2740.22
54_L102_S1.2720.22
194_E469_T1.2680.21
81_I207_I1.2600.21
102_S120_S1.2580.21
106_E121_S1.2540.21
96_T118_P1.2490.21
152_N480_L1.2440.21
360_E416_T1.2430.21
101_Y111_A1.2430.21
48_E422_S1.2400.21
387_S479_I1.2360.21
120_S125_R1.2260.21
100_A106_E1.2210.20
99_T105_V1.2020.20
217_K236_F1.2010.20
436_K443_P1.1960.20
70_K342_S1.1950.20
171_S218_Q1.1910.20
62_R66_D1.1900.20
44_I48_E1.1880.20
104_R123_S1.1840.20
99_T107_L1.1780.19
171_S288_G1.1700.19
250_F330_R1.1620.19
84_K88_G1.1610.19
335_I374_R1.1510.19
185_S460_Y1.1490.19
483_I486_E1.1410.19
120_S128_L1.1310.19
120_S127_L1.1310.19
44_I474_E1.1150.18
254_S469_T1.1140.18
207_I257_A1.1140.18
268_K271_S1.1110.18
81_I99_T1.1090.18
91_K293_I1.1070.18
140_V234_G1.1020.18
119_T123_S1.0940.18
111_A123_S1.0930.18
42_D46_N1.0860.18
262_I288_G1.0780.17
117_T121_S1.0700.17
102_S125_R1.0690.17
105_V111_A1.0610.17
385_G390_E1.0570.17
210_I213_H1.0570.17
192_Y367_V1.0530.17
381_P471_V1.0500.17
202_Q362_D1.0500.17
98_L103_L1.0500.17
54_L83_P1.0490.17
109_D129_K1.0470.17
455_T458_I1.0460.17
252_L453_V1.0450.17
169_G449_I1.0450.17
30_L339_E1.0420.17
96_T99_T1.0410.17
133_Y441_G1.0300.17
317_S452_K1.0280.16
36_M359_V1.0240.16
445_G449_I1.0230.16
60_K359_V1.0220.16
294_S469_T1.0190.16
204_L210_I1.0170.16
206_F462_F1.0150.16
112_Y115_Q1.0140.16
101_Y114_V1.0130.16
61_E66_D1.0090.16
99_T103_L1.0080.16
218_Q240_M1.0000.16
72_G91_K0.9900.16
56_S415_V0.9840.16
377_Q476_K0.9800.16
211_V236_F0.9800.16
63_W244_A0.9770.16
350_D354_P0.9760.16
359_V441_G0.9730.15
344_K407_N0.9650.15
65_E416_T0.9630.15
276_L280_D0.9610.15
62_R208_N0.9550.15
109_D125_R0.9540.15
194_E481_T0.9520.15
120_S129_K0.9520.15
247_H471_V0.9510.15
185_S194_E0.9510.15
216_D347_L0.9500.15
104_R125_R0.9480.15
101_Y117_T0.9480.15
222_L333_L0.9420.15
108_M125_R0.9390.15
107_L120_S0.9330.15
102_S130_L0.9300.15
105_V120_S0.9300.15
140_V153_K0.9290.15
63_W207_I0.9230.15
54_L209_T0.9190.15
217_K240_M0.9180.15
186_A422_S0.9180.15
282_L419_A0.9180.15
244_A412_A0.9170.15
60_K83_P0.9120.14
61_E223_F0.9090.14
131_K356_V0.9080.14
102_S108_M0.9060.14
109_D116_P0.8980.14
361_V391_L0.8960.14
107_L119_T0.8960.14
72_G98_L0.8940.14
217_K234_G0.8920.14
155_I432_A0.8910.14
109_D124_R0.8860.14
185_S203_V0.8850.14
143_D434_V0.8820.14
174_Y359_V0.8780.14
315_S411_K0.8760.14
32_Y36_M0.8750.14
135_Y193_L0.8730.14
187_S371_V0.8630.14
370_G374_R0.8620.14
278_R284_S0.8610.14
160_Q487_R0.8610.14
121_S124_R0.8580.14
167_P247_H0.8570.14
175_P467_Q0.8520.13
208_N214_Y0.8510.13
104_R124_R0.8490.13
177_K294_S0.8460.13
30_L150_E0.8440.13
99_T111_A0.8400.13
38_D137_P0.8300.13
172_V185_S0.8280.13
38_D45_N0.8260.13
97_L106_E0.8260.13
347_L362_D0.8250.13
151_I154_A0.8220.13
362_D466_A0.8180.13
232_P374_R0.8150.13
102_S114_V0.8140.13
191_G331_R0.8110.13
100_A117_T0.8110.13
279_L285_H0.8110.13
35_E49_L0.8060.13
100_A116_P0.8060.13
215_R433_N0.8040.13
181_C445_G0.8030.13
133_Y172_V0.7990.13
53_L447_E0.7990.13
72_G428_I0.7980.13
169_G179_S0.7970.13
104_R118_P0.7960.13
102_S127_L0.7950.13
216_D438_R0.7930.13
380_V401_S0.7930.13
105_V125_R0.7910.13
151_I189_Y0.7910.13
44_I353_V0.7900.13
103_L121_S0.7890.13
76_L102_S0.7880.13
362_D454_D0.7870.12
59_G397_Y0.7860.12
76_L98_L0.7840.12
42_D477_Q0.7830.12
36_M91_K0.7780.12
172_V193_L0.7770.12
354_P439_F0.7760.12
314_L452_K0.7740.12
243_T452_K0.7740.12
202_Q205_S0.7720.12
179_S432_A0.7710.12
280_D411_K0.7700.12
114_V124_R0.7700.12
411_K467_Q0.7590.12
164_V225_D0.7590.12
56_S81_I0.7540.12
234_G336_W0.7540.12
152_N186_A0.7520.12
120_S130_L0.7510.12
85_W412_A0.7490.12
411_K473_N0.7460.12
332_A394_N0.7450.12
118_P122_V0.7430.12
299_D306_L0.7430.12
241_P348_N0.7410.12
205_S210_I0.7410.12
34_A43_D0.7400.12
40_V338_I0.7340.12
104_R107_L0.7330.12
154_A188_S0.7300.12
31_S273_D0.7300.12
70_K277_K0.7300.12
109_D120_S0.7290.12
48_E304_K0.7290.12
91_K405_V0.7290.12
364_N456_L0.7260.12
189_Y401_S0.7250.12
189_Y380_V0.7250.12
106_E277_K0.7240.12
97_L107_L0.7220.12
135_Y245_G0.7200.12
447_E456_L0.7180.12
107_L129_K0.7160.11
224_T227_I0.7140.11
55_V81_I0.7140.11
411_K429_V0.7140.11
99_T109_D0.7140.11
143_D400_G0.7110.11
97_L118_P0.7100.11
208_N356_V0.7090.11
72_G297_R0.7070.11
202_Q212_R0.7060.11
255_Y321_L0.7030.11
203_V427_K0.7020.11
439_F467_Q0.7010.11
172_V253_A0.7010.11
464_G483_I0.6990.11
188_S401_S0.6940.11
188_S380_V0.6940.11
36_M44_I0.6900.11
327_R359_V0.6890.11
185_S200_T0.6880.11
342_S403_R0.6880.11
267_S270_E0.6880.11
97_L109_D0.6850.11
194_E460_Y0.6840.11
107_L118_P0.6840.11
247_H381_P0.6840.11
38_D149_R0.6830.11
157_S452_K0.6830.11
354_P482_K0.6830.11
154_A401_S0.6830.11
154_A380_V0.6830.11
400_G459_Q0.6820.11
193_L340_E0.6800.11
453_V480_L0.6790.11
123_S126_S0.6790.11
201_D445_G0.6780.11
203_V483_I0.6770.11
97_L102_S0.6750.11
32_Y63_W0.6740.11
477_Q481_T0.6740.11
147_A187_S0.6730.11
38_D238_F0.6710.11
92_E290_N0.6710.11
154_A162_L0.6700.11
238_F296_V0.6700.11
223_F244_A0.6660.11
438_R469_T0.6650.11
41_I83_P0.6640.11
44_I73_I0.6630.11
75_P172_V0.6620.11
104_R127_L0.6610.11
59_G84_K0.6610.11
375_A407_N0.6600.11
144_E379_L0.6600.11
248_D390_E0.6580.11
55_V342_S0.6560.11
72_G308_Y0.6540.11
370_G397_Y0.6530.11
151_I162_L0.6520.11
151_I401_S0.6520.11
151_I380_V0.6520.11
77_A290_N0.6520.11
232_P384_K0.6510.11
53_L201_D0.6490.11
238_F392_S0.6470.11
87_I132_T0.6460.11
449_I453_V0.6460.11
200_T486_E0.6460.11
107_L125_R0.6460.11
99_T114_V0.6450.11
197_T412_A0.6450.11
357_Y444_L0.6440.11
367_V401_S0.6430.11
367_V380_V0.6430.11
190_L378_M0.6430.11
419_A464_G0.6390.10
177_K336_W0.6370.10
32_Y73_I0.6360.10
249_S340_E0.6340.10
104_R108_M0.6340.10
172_V289_T0.6330.10
164_V238_F0.6320.10
286_F342_S0.6310.10
65_E308_Y0.6300.10
126_S325_L0.6300.10
151_I188_S0.6280.10
281_E285_H0.6280.10
150_E406_K0.6270.10
69_Q414_I0.6260.10
240_M416_T0.6250.10
253_A457_L0.6230.10
301_E316_R0.6230.10
325_L336_W0.6210.10
371_V422_S0.6200.10
240_M427_K0.6200.10
119_T125_R0.6190.10
371_V473_N0.6160.10
121_S127_L0.6160.10
60_K166_A0.6150.10
213_H424_L0.6130.10
153_K157_S0.6130.10
333_L465_T0.6130.10
356_V390_E0.6120.10
55_V93_Y0.6120.10
201_D296_V0.6120.10
100_A130_L0.6100.10
133_Y156_E0.6100.10
69_Q362_D0.6040.10
104_R147_A0.6040.10
134_E177_K0.6030.10
138_Y327_R0.6030.10
62_R348_N0.5990.10
275_A281_E0.5960.10
268_K335_I0.5960.10
87_I335_I0.5930.10
58_N135_Y0.5930.10
205_S214_Y0.5930.10
406_K447_E0.5920.10
332_A469_T0.5920.10
301_E305_T0.5920.10
154_A189_Y0.5910.10
290_N442_K0.5910.10
257_A336_W0.5910.10
72_G90_S0.5890.10
291_F420_K0.5880.10
187_S251_V0.5880.10
237_P475_C0.5880.10
99_T102_S0.5860.10
72_G305_T0.5840.10
201_D240_M0.5820.10
143_D459_Q0.5810.10
81_I138_Y0.5790.10
55_V61_E0.5790.10
209_T213_H0.5780.10
143_D395_I0.5770.10
429_V463_A0.5730.10
264_H329_R0.5720.10
189_Y367_V0.5700.10
118_P125_R0.5660.10
114_V305_T0.5650.10
119_T124_R0.5640.10
162_L188_S0.5630.10
46_N72_G0.5620.10
183_Y206_F0.5610.10
251_V446_S0.5610.10
157_S209_T0.5590.09
400_G434_V0.5580.09
293_I362_D0.5580.09
294_S297_R0.5550.09
114_V128_L0.5550.09
162_L401_S0.5550.09
162_L380_V0.5550.09
103_L112_Y0.5550.09
149_R153_K0.5540.09
57_E89_K0.5540.09
278_R362_D0.5520.09
167_P355_G0.5520.09
239_L430_N0.5520.09
185_S486_E0.5510.09
162_L192_Y0.5510.09
230_D281_E0.5490.09
203_V292_I0.5490.09
163_I456_L0.5470.09
143_D389_L0.5470.09
69_Q466_A0.5440.09
122_V128_L0.5440.09
305_T345_V0.5440.09
99_T120_S0.5440.09
165_K430_N0.5430.09
381_P453_V0.5430.09
105_V129_K0.5430.09
100_A111_A0.5430.09
188_S367_V0.5420.09
117_T126_S0.5410.09
152_N436_K0.5400.09
194_E453_V0.5400.09
154_A192_Y0.5400.09
86_F480_L0.5390.09
203_V274_I0.5390.09
108_M124_R0.5380.09
39_Y204_L0.5340.09
253_A458_I0.5340.09
102_S128_L0.5330.09
321_L346_K0.5330.09
147_A318_E0.5310.09
32_Y40_V0.5310.09
214_Y364_N0.5300.09
62_R73_I0.5290.09
86_F249_S0.5270.09
305_T318_E0.5270.09
151_I192_Y0.5270.09
115_Q360_E0.5260.09
282_L337_S0.5260.09
204_L455_T0.5260.09
154_A367_V0.5250.09
162_L189_Y0.5240.09
190_L439_F0.5240.09
109_D118_P0.5230.09
134_E171_S0.5220.09
82_P412_A0.5220.09
241_P407_N0.5210.09
385_G423_D0.5210.09
261_P339_E0.5210.09
353_V407_N0.5150.09
82_P375_A0.5140.09
262_I478_K0.5110.09
146_H375_A0.5110.09
97_L105_V0.5110.09
142_F254_S0.5110.09
80_T245_G0.5100.09
400_G461_G0.5090.09
106_E172_V0.5060.09
366_C369_C0.5050.09
366_C372_C0.5050.09
366_C376_C0.5050.09
366_C398_C0.5050.09
366_C404_C0.5050.09
366_C408_C0.5050.09
366_C410_E0.5050.09
366_C437_C0.5050.09
178_C184_C0.5050.09
369_C404_C0.5050.09
184_C437_C0.5050.09
182_G472_C0.5050.09
178_C404_C0.5050.09
440_C472_C0.5050.09
398_C472_C0.5050.09
398_C440_C0.5050.09
398_C437_C0.5050.09
184_C410_E0.5050.09
398_C410_E0.5050.09
184_C366_C0.5050.09
398_C408_C0.5050.09
178_C182_G0.5050.09
398_C404_C0.5050.09
366_C440_C0.5050.09
366_C472_C0.5050.09
372_C398_C0.5050.09
372_C404_C0.5050.09
372_C408_C0.5050.09
372_C410_E0.5050.09
372_C437_C0.5050.09
372_C440_C0.5050.09
372_C472_C0.5050.09
376_C398_C0.5050.09
376_C404_C0.5050.09
376_C408_C0.5050.09
376_C410_E0.5050.09
376_C437_C0.5050.09
376_C440_C0.5050.09
372_C376_C0.5050.09
184_C372_C0.5050.09
178_C366_C0.5050.09
369_C372_C0.5050.09
184_C376_C0.5050.09
369_C376_C0.5050.09
369_C398_C0.5050.09
369_C408_C0.5050.09
369_C410_E0.5050.09
369_C437_C0.5050.09
369_C440_C0.5050.09
369_C472_C0.5050.09
178_C369_C0.5050.09
178_C372_C0.5050.09
178_C376_C0.5050.09
376_C472_C0.5050.09
184_C398_C0.5050.09
158_C372_C0.5050.09
182_G372_C0.5050.09
408_C440_C0.5050.09
437_C440_C0.5050.09
408_C437_C0.5050.09
182_G398_C0.5050.09
158_C408_C0.5050.09
158_C437_C0.5050.09
184_C404_C0.5050.09
158_C366_C0.5050.09
182_G376_C0.5050.09
178_C440_C0.5050.09
182_G369_C0.5050.09
158_C369_C0.5050.09
184_C472_C0.5050.09
158_C376_C0.5050.09
410_E472_C0.5050.09
178_C472_C0.5050.09
158_C398_C0.5050.09
158_C404_C0.5050.09
410_E440_C0.5050.09
410_E437_C0.5050.09
182_G366_C0.5050.09
408_C472_C0.5050.09
182_G404_C0.5050.09
178_C408_C0.5050.09
437_C472_C0.5050.09
404_C410_E0.5050.09
182_G440_C0.5050.09
158_C182_G0.5050.09
182_G408_C0.5050.09
182_G410_E0.5050.09
184_C408_C0.5050.09
178_C398_C0.5050.09
182_G437_C0.5050.09
158_C178_C0.5050.09
158_C184_C0.5050.09
404_C408_C0.5050.09
158_C440_C0.5050.09
404_C472_C0.5050.09
404_C440_C0.5050.09
158_C410_E0.5050.09
184_C440_C0.5050.09
178_C437_C0.5050.09
184_C369_C0.5050.09
178_C410_E0.5050.09
158_C472_C0.5050.09
404_C437_C0.5050.09
136_K199_T0.5050.09
80_T458_I0.5040.09
248_D338_I0.5040.09
133_Y484_W0.5030.09
126_S129_K0.5030.09
33_V60_K0.5020.09
69_Q450_K0.5010.09
54_L272_R0.5010.09
481_T485_L0.5010.09
114_V120_S0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4z3xE 2 0.3293 99.5 0.919 Contact Map
1h0hB 1 0.3273 99.5 0.921 Contact Map
1q16B 2 0.5622 99.5 0.921 Contact Map
2ivfB 1 0.3815 99.4 0.923 Contact Map
1hfeL 2 0.3293 99.4 0.924 Contact Map
2vpzB 2 0.3333 99.3 0.925 Contact Map
3gyxB 1 0.241 99.2 0.929 Contact Map
1xerA 2 0.1928 99.2 0.929 Contact Map
1bc6A 1 0.1546 99.2 0.931 Contact Map
1h98A 1 0.1546 99.1 0.932 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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