GREMLIN Database
Q97V38 - Oxydoreductase, putative
UniProt: Q97V38 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 293 (220)
Sequences: 277 (174)
Seq/√Len: 11.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
112_I228_M4.5901.00
159_Y236_P4.3491.00
50_T111_P3.3680.98
190_E193_P3.2990.97
255_L258_A3.2850.97
228_M234_A2.9130.94
43_K210_L2.8730.94
69_N203_A2.7880.93
118_I237_A2.6120.90
34_V37_A2.4890.88
69_N177_C2.4300.87
228_M236_P2.4140.86
176_H238_S2.4100.86
29_I34_V2.3430.85
134_R141_L2.3090.84
30_R37_A2.1760.80
148_I168_E2.0770.77
47_A124_E2.0350.75
40_F218_I2.0340.75
166_Y230_P2.0250.75
31_Q34_V2.0030.74
151_K164_F2.0000.74
29_I32_G1.9310.71
29_I40_F1.9190.70
159_Y234_A1.8910.69
120_A133_K1.8660.68
192_I219_L1.7890.65
128_V150_T1.7800.64
151_K154_I1.7380.62
121_P144_Y1.7010.61
254_L258_A1.6800.60
252_V258_A1.6590.59
212_P221_Y1.6450.58
134_R137_D1.6320.57
120_A123_T1.5990.56
220_F225_G1.5530.54
29_I35_Q1.5470.53
41_S198_G1.5360.53
91_W94_V1.5340.53
183_D190_E1.5320.53
126_C147_C1.5150.52
126_C153_C1.5150.52
147_C153_C1.5150.52
137_D177_C1.4810.50
133_K140_V1.4770.50
213_T218_I1.4620.49
154_I171_T1.4560.49
54_K211_D1.4480.48
144_Y164_F1.4020.46
140_V150_T1.3870.45
47_A226_F1.3840.45
31_Q35_Q1.3790.45
101_T253_Q1.3740.45
123_T131_T1.3730.45
100_G103_P1.3670.44
160_G193_P1.3590.44
90_F93_R1.3580.44
180_R197_H1.3500.44
139_I148_I1.3300.43
228_M233_G1.3290.43
29_I33_G1.3170.42
225_G241_L1.3150.42
50_T226_F1.2780.40
45_N202_Q1.2600.39
81_N85_E1.2540.39
152_Y155_Y1.2510.39
35_Q42_L1.2250.38
181_I191_R1.2240.38
226_F237_A1.2170.37
229_G246_K1.2140.37
38_P231_E1.2100.37
32_G39_P1.2070.37
48_I151_K1.2060.37
126_C149_G1.1840.36
149_G153_C1.1840.36
69_N175_T1.1810.36
209_I221_Y1.1750.35
33_G37_A1.1720.35
123_T204_R1.1630.35
125_V156_A1.1570.34
86_L166_Y1.1540.34
57_G149_G1.1370.34
68_W164_F1.1160.33
30_R33_G1.1080.32
39_P102_Y1.1010.32
38_P41_S1.0920.32
46_Y145_N1.0910.32
49_I213_T1.0850.31
48_I176_H1.0710.31
222_D225_G1.0670.31
152_Y194_A1.0650.30
113_N238_S1.0590.30
33_G38_P1.0480.30
129_G179_D1.0410.29
30_R34_V1.0400.29
131_T162_R1.0330.29
151_K176_H1.0280.29
29_I37_A1.0110.28
63_M104_Q1.0020.28
98_E145_N1.0000.28
111_P165_D1.0000.28
32_G37_A0.9930.28
50_T203_A0.9930.28
36_H39_P0.9930.28
35_Q39_P0.9870.27
32_G38_P0.9700.27
68_W206_W0.9690.27
137_D175_T0.9660.26
100_G154_I0.9540.26
33_G40_F0.9520.26
121_P170_V0.9500.26
136_E182_Y0.9460.26
58_C177_C0.9340.25
30_R40_F0.9340.25
46_Y139_I0.9270.25
214_D217_T0.9230.25
156_A246_K0.9200.25
233_G236_P0.9150.25
35_Q40_F0.9060.24
139_I233_G0.9010.24
54_K225_G0.9000.24
30_R39_P0.9000.24
164_F233_G0.8930.24
253_Q257_E0.8920.24
121_P156_A0.8920.24
150_T156_A0.8870.24
94_V103_P0.8850.23
136_E141_L0.8850.23
146_E160_G0.8840.23
161_N204_R0.8790.23
121_P131_T0.8710.23
31_Q36_H0.8690.23
252_V255_L0.8680.23
46_Y170_V0.8660.23
122_C157_C0.8620.23
173_K199_C0.8620.23
173_K195_C0.8620.23
122_C195_C0.8620.23
122_C173_K0.8620.23
122_C199_C0.8620.23
114_C122_C0.8620.23
195_C199_C0.8620.23
114_C117_C0.8620.23
114_C157_C0.8620.23
114_C173_K0.8620.23
114_C195_C0.8620.23
114_C199_C0.8620.23
117_C122_C0.8620.23
117_C157_C0.8620.23
117_C173_K0.8620.23
117_C195_C0.8620.23
117_C199_C0.8620.23
157_C199_C0.8620.23
55_C61_C0.8620.23
55_C117_C0.8620.23
55_C122_C0.8620.23
61_C173_K0.8620.23
61_C157_C0.8620.23
55_C114_C0.8620.23
55_C157_C0.8620.23
61_C122_C0.8620.23
61_C117_C0.8620.23
61_C195_C0.8620.23
157_C195_C0.8620.23
61_C199_C0.8620.23
55_C199_C0.8620.23
157_C173_K0.8620.23
55_C173_K0.8620.23
55_C195_C0.8620.23
61_C114_C0.8620.23
82_P238_S0.8490.22
130_A180_R0.8490.22
52_L159_Y0.8470.22
124_E167_V0.8450.22
81_N91_W0.8340.22
29_I42_L0.8320.22
66_K136_E0.8310.22
134_R230_P0.8290.22
48_I164_F0.8290.22
50_T217_T0.8280.21
34_V39_P0.8230.21
169_G220_F0.8170.21
52_L111_P0.8160.21
193_P196_I0.8100.21
33_G39_P0.8060.21
120_A196_I0.8060.21
44_A136_E0.8050.21
125_V152_Y0.8010.21
68_W179_D0.7930.20
208_N214_D0.7890.20
215_P218_I0.7880.20
134_R178_F0.7830.20
138_G207_A0.7800.20
99_V108_Y0.7800.20
209_I217_T0.7750.20
249_E252_V0.7750.20
70_T144_Y0.7750.20
53_N152_Y0.7730.20
37_A104_Q0.7730.20
140_V156_A0.7690.20
130_A138_G0.7660.19
68_W166_Y0.7660.19
146_E165_D0.7610.19
52_L226_F0.7600.19
60_G241_L0.7580.19
49_I225_G0.7550.19
208_N211_D0.7540.19
111_P159_Y0.7520.19
43_K221_Y0.7520.19
30_R35_Q0.7500.19
69_N75_G0.7500.19
118_I169_G0.7480.19
139_I181_I0.7330.18
151_K166_Y0.7120.18
142_V163_F0.7110.18
64_S82_P0.7090.18
68_W144_Y0.7090.18
151_K172_K0.7050.18
197_H232_T0.7040.18
30_R38_P0.7020.18
115_F240_Y0.6970.17
244_R249_E0.6950.17
29_I39_P0.6930.17
34_V38_P0.6910.17
67_E105_T0.6810.17
128_V152_Y0.6800.17
48_I146_E0.6710.17
69_N179_D0.6650.17
253_Q256_S0.6640.16
44_A214_D0.6640.16
29_I104_Q0.6630.16
94_V107_V0.6600.16
51_D154_I0.6600.16
250_S253_Q0.6590.16
220_F239_G0.6550.16
140_V143_D0.6520.16
151_K222_D0.6500.16
166_Y238_S0.6480.16
137_D237_A0.6410.16
175_T206_W0.6380.16
137_D181_I0.6380.16
54_K209_I0.6370.16
155_Y165_D0.6370.16
146_E193_P0.6370.16
127_P169_G0.6300.16
209_I227_V0.6270.15
90_F167_V0.6230.15
61_C65_C0.6180.15
65_C122_C0.6180.15
65_C199_C0.6180.15
65_C157_C0.6180.15
65_C114_C0.6180.15
65_C195_C0.6180.15
65_C173_K0.6180.15
55_C65_C0.6180.15
65_C117_C0.6180.15
150_T171_T0.6100.15
118_I238_S0.6090.15
117_C158_P0.6020.15
55_C158_P0.6020.15
61_C158_P0.6020.15
122_C158_P0.6020.15
114_C158_P0.6020.15
158_P199_C0.6020.15
158_P195_C0.6020.15
158_P173_K0.6020.15
125_V155_Y0.6000.15
212_P244_R0.5950.15
29_I38_P0.5940.15
144_Y172_K0.5930.15
33_G116_H0.5930.15
114_C174_C0.5910.15
61_C174_C0.5910.15
55_C174_C0.5910.15
174_C199_C0.5910.15
174_C195_C0.5910.15
157_C174_C0.5910.15
122_C174_C0.5910.15
117_C174_C0.5910.15
208_N230_P0.5910.15
32_G218_I0.5870.14
89_M150_T0.5870.14
37_A218_I0.5830.14
180_R249_E0.5810.14
92_L140_V0.5800.14
111_P216_G0.5780.14
121_P125_V0.5770.14
113_N156_A0.5720.14
127_P153_C0.5690.14
127_P147_C0.5690.14
150_T155_Y0.5680.14
100_G107_V0.5660.14
62_Q81_N0.5650.14
61_C138_G0.5650.14
55_C138_G0.5650.14
138_G157_C0.5650.14
114_C138_G0.5650.14
122_C138_G0.5650.14
117_C138_G0.5650.14
138_G199_C0.5650.14
138_G195_C0.5650.14
138_G173_K0.5650.14
90_F107_V0.5640.14
142_V162_R0.5640.14
155_Y161_N0.5630.14
112_I163_F0.5610.14
30_R36_H0.5600.14
165_D172_K0.5590.14
53_N246_K0.5580.14
101_T202_Q0.5520.14
47_A137_D0.5490.14
35_Q38_P0.5470.14
67_E211_D0.5470.14
238_S249_E0.5420.13
182_Y234_A0.5410.13
32_G40_F0.5360.13
46_Y137_D0.5330.13
111_P162_R0.5330.13
32_G35_Q0.5320.13
136_E243_W0.5300.13
102_Y222_D0.5270.13
83_Y160_G0.5260.13
216_G219_L0.5250.13
42_L81_N0.5230.13
50_T206_W0.5140.13
33_G36_H0.5070.13
219_L225_G0.5050.13
33_G42_L0.5050.13
115_F125_V0.5020.13
57_G203_A0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ivfB 1 0.8362 100 0.516 Contact Map
1ti6B 2 0.7918 100 0.566 Contact Map
1q16B 2 0.8464 100 0.587 Contact Map
1kqfB 3 0.8805 100 0.596 Contact Map
1h0hB 1 0.6997 100 0.608 Contact Map
2vpzB 2 0.6553 100 0.628 Contact Map
4z3xE 2 0.5768 100 0.738 Contact Map
3mm5B 2 0.884 99.7 0.818 Contact Map
3i9v9 1 0.4642 99.4 0.861 Contact Map
1jnrB 1 0.4676 99.2 0.869 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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