GREMLIN Database
Q97V36 - Uncharacterized protein
UniProt: Q97V36 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 274 (216)
Sequences: 31501 (27121)
Seq/√Len: 1845.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
181_F184_L3.2821.00
113_R116_E3.2211.00
147_L150_D3.1671.00
215_M218_D3.1311.00
79_R82_E3.0221.00
45_N48_A2.9611.00
203_Y222_Y2.8011.00
169_H188_E2.6201.00
207_A223_M2.5471.00
135_R154_E2.4521.00
105_A121_L2.3301.00
67_L86_N2.3171.00
71_A87_I2.3001.00
139_A155_I2.2901.00
173_G189_F2.2661.00
101_R120_E2.2221.00
172_K188_E2.1981.00
206_A222_Y2.0981.00
104_K120_E2.0971.00
33_Y52_E2.0491.00
37_A53_L2.0371.00
190_K206_A2.0301.00
70_K86_N2.0201.00
54_D70_K2.0071.00
138_K154_E1.9591.00
88_N104_K1.9331.00
36_R52_E1.9051.00
53_L69_A1.8831.00
156_N172_K1.8771.00
210_Y222_Y1.8521.00
122_T138_K1.8401.00
189_F205_N1.8121.00
176_Y188_E1.8101.00
176_Y184_L1.7601.00
40_Y48_A1.7391.00
108_L116_E1.7061.00
108_L120_E1.7021.00
152_L156_N1.6631.00
74_L86_N1.6551.00
142_Y154_E1.6541.00
210_Y218_D1.6471.00
40_Y52_E1.6451.00
155_I171_L1.6301.00
186_L190_K1.6111.00
118_N122_T1.5461.00
142_Y150_D1.5251.00
121_L137_M1.4951.00
87_I103_I1.4931.00
50_L54_D1.4881.00
186_L210_Y1.4551.00
84_L88_N1.4171.00
206_A210_Y1.3941.00
124_V134_A1.3891.00
152_L179_T1.3601.00
152_L176_Y1.3451.00
70_K74_L1.3241.00
74_L82_E1.3241.00
108_L113_R1.3211.00
36_R40_Y1.3211.00
104_K108_L1.3091.00
50_L74_L1.3051.00
186_L213_L1.3051.00
40_Y45_N1.2971.00
176_Y181_F1.2921.00
220_L224_D1.2881.00
158_A168_L1.2731.00
210_Y215_M1.2571.00
172_K176_Y1.2381.00
56_G66_I1.2381.00
118_N142_Y1.2171.00
138_K142_Y1.2111.00
142_Y147_L1.1831.00
218_D221_T1.1561.00
184_L187_S1.1501.00
39_A43_M1.1471.00
196_D199_N1.1261.00
101_R123_E1.1241.00
170_E205_N1.1231.00
203_Y225_L1.1151.00
192_A202_H1.1101.00
207_A226_A1.1091.00
74_L79_R1.1041.00
116_E119_I1.0971.00
90_A100_Y1.0951.00
159_L169_H1.0941.00
102_F134_A1.0931.00
84_L111_L1.0901.00
174_K205_N1.0881.00
38_E69_A1.0771.00
169_H191_I1.0771.00
136_V168_L1.0641.00
102_F137_M1.0511.00
177_F212_N1.0431.00
82_E85_E1.0431.00
21_L25_E1.0381.00
84_L108_L1.0321.00
191_I195_Y1.0071.00
183_K213_L1.0061.00
177_F205_N1.0051.00
152_L172_K1.0041.00
41_L69_A1.0001.00
204_Y208_A0.9971.00
193_A203_Y0.9961.00
140_F171_L0.9921.00
170_E202_H0.9901.00
157_R161_V0.9881.00
71_A83_A0.9861.00
67_L89_K0.9841.00
50_L77_E0.9821.00
136_V171_L0.9791.00
211_Y223_M0.9721.00
148_K175_I0.9571.00
101_R124_V0.9561.00
139_A151_A0.9561.00
89_K93_I0.9501.00
173_G192_A0.9481.00
48_A51_V0.9431.00
150_D153_S0.9371.00
57_V67_L0.9291.00
34_L66_I0.9281.00
107_I111_L0.9221.00
149_L179_T0.9211.00
37_A49_A0.9181.00
71_A90_A0.9171.00
118_N138_K0.9121.00
33_Y55_K0.9121.00
139_A158_A0.9111.00
98_S124_V0.9101.00
105_A124_V0.9091.00
118_N145_M0.9081.00
25_E36_R0.8991.00
47_K77_E0.8951.00
191_I194_H0.8911.00
50_L70_K0.8911.00
199_N202_H0.8891.00
170_E174_K0.8881.00
30_V56_G0.8881.00
135_R157_R0.8871.00
186_L206_A0.8861.00
34_L69_A0.8861.00
135_R158_A0.8841.00
106_R137_M0.8831.00
57_V66_I0.8811.00
128_N131_N0.8761.00
33_Y56_G0.8751.00
186_L209_C0.8701.00
169_H192_A0.8681.00
97_S100_Y0.8651.00
41_L73_V0.8641.00
38_E42_R0.8621.00
114_Y141_C0.8611.00
193_A202_H0.8571.00
225_L229_K0.8551.00
205_N208_A0.8521.00
131_N134_A0.8521.00
81_E111_L0.8451.00
208_A212_N0.8441.00
55_K59_T0.8431.00
175_I179_T0.8321.00
72_E76_N0.8321.00
166_S192_A0.8321.00
24_L35_L0.8301.00
68_S103_I0.8281.00
63_S66_I0.8281.00
132_V158_A0.8261.00
72_E103_I0.8261.00
68_S72_E0.8221.00
154_E157_R0.8211.00
182_Y213_L0.8201.00
37_A56_G0.8161.00
143_Y175_I0.8141.00
89_K92_E0.8111.00
125_L134_A0.8101.00
69_A72_E0.8071.00
159_L168_L0.8071.00
120_E123_E0.8071.00
109_F141_C0.8061.00
91_L101_R0.8051.00
34_L38_E0.8031.00
182_Y209_C0.8031.00
105_A117_A0.8031.00
125_L135_R0.8001.00
102_F106_R0.7971.00
84_L104_K0.7921.00
123_E127_L0.7891.00
203_Y226_A0.7871.00
177_F209_C0.7841.00
157_R160_N0.7841.00
103_I106_R0.7821.00
141_C145_M0.7821.00
152_L175_I0.7731.00
173_G185_A0.7681.00
86_N89_K0.7661.00
50_L73_V0.7651.00
80_L107_I0.7601.00
46_S73_V0.7581.00
162_K165_D0.7581.00
94_L97_S0.7501.00
174_K177_F0.7471.00
225_L228_S0.7411.00
177_F185_A0.7401.00
188_E191_I0.7361.00
185_A209_C0.7341.00
165_D168_L0.7311.00
182_Y212_N0.7301.00
222_Y225_L0.7281.00
60_F63_S0.7251.00
118_N147_L0.7241.00
123_E126_R0.7231.00
186_L215_M0.7181.00
136_V140_F0.7101.00
67_L90_A0.7071.00
143_Y148_K0.7061.00
21_L40_Y0.7021.00
115_E145_M0.7011.00
35_L38_E0.7001.00
118_N141_C0.6991.00
207_A219_A0.6901.00
140_F144_N0.6901.00
23_V26_N0.6891.00
109_F114_Y0.6871.00
68_S100_Y0.6861.00
177_F189_F0.6831.00
143_Y171_L0.6801.00
211_Y216_Y0.6791.00
106_R110_K0.6751.00
52_E55_K0.6731.00
116_E120_E0.6711.00
109_F144_N0.6691.00
189_F209_C0.6661.00
169_H195_Y0.6631.00
82_E86_N0.6601.00
75_E103_I0.6601.00
148_K178_E0.6561.00
91_L100_Y0.6551.00
41_L46_S0.6491.00
90_A93_I0.6471.00
125_L138_K0.6461.00
19_E22_K0.6461.00
114_Y145_M0.6451.00
208_A211_Y0.6451.00
67_L93_I0.6411.00
200_P226_A0.6411.00
119_I123_E0.6401.00
218_D222_Y0.6371.00
41_L53_L0.6331.00
75_E107_I0.6331.00
34_L63_S0.6321.00
51_V55_K0.6301.00
140_F143_Y0.6281.00
84_L113_R0.6251.00
135_R161_V0.6201.00
171_L174_K0.6161.00
46_S76_N0.6041.00
174_K178_E0.6031.00
73_V77_E0.6001.00
117_A141_C0.5971.00
114_Y144_N0.5961.00
109_F137_M0.5961.00
224_D228_S0.5951.00
137_M140_F0.5941.00
177_F182_Y0.5931.00
56_G59_T0.5921.00
209_C213_L0.5921.00
84_L107_I0.5901.00
190_K218_D0.5851.00
102_F131_N0.5821.00
156_N188_E0.5811.00
204_Y207_A0.5721.00
158_A161_V0.5721.00
33_Y59_T0.5661.00
174_K189_F0.5661.00
143_Y155_I0.5661.00
55_K58_Q0.5641.00
190_K194_H0.5641.00
57_V70_K0.5611.00
210_Y213_L0.5611.00
30_V34_L0.5611.00
142_Y145_M0.5611.00
143_Y151_A0.5611.00
23_V27_F0.5601.00
221_T224_D0.5601.00
81_E85_E0.5561.00
90_A94_L0.5551.00
187_S191_I0.5521.00
216_Y220_L0.5501.00
64_Y90_A0.5501.00
98_S128_N0.5501.00
176_Y179_T0.5481.00
29_S32_V0.5471.00
156_N160_N0.5461.00
221_T225_L0.5431.00
41_L49_A0.5431.00
153_S157_R0.5421.00
88_N92_E0.5411.00
98_S131_N0.5411.00
166_S196_D0.5401.00
101_R127_L0.5401.00
86_N90_A0.5391.00
20_V24_L0.5391.00
75_E87_I0.5361.00
190_K210_Y0.5361.00
156_N184_L0.5351.00
143_Y178_E0.5341.00
140_F155_I0.5331.00
184_L188_E0.5321.00
189_F206_A0.5311.00
106_R109_F0.5301.00
68_S97_S0.5301.00
187_S190_K0.5291.00
109_F121_L0.5281.00
91_L104_K0.5281.00
21_L36_R0.5281.00
109_F117_A0.5271.00
211_Y219_A0.5201.00
153_S156_N0.5201.00
72_E75_E0.5151.00
75_E80_L0.5141.00
148_K179_T0.5081.00
224_D227_L0.5081.00
182_Y186_L0.5061.00
200_P230_G0.5021.00
48_A52_E0.5011.00
80_L84_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3dssA 1 0.9307 100 0.187 Contact Map
1w3bA 2 0.9051 100 0.19 Contact Map
4l9pA 1 0.9051 100 0.206 Contact Map
2h6fA 1 0.9051 100 0.211 Contact Map
2xpiA 2 0.8905 100 0.213 Contact Map
4rg9A 2 0.6898 100 0.219 Contact Map
3q7aA 1 0.8613 100 0.22 Contact Map
4ui9C 2 0.9964 100 0.225 Contact Map
3draA 1 0.8905 100 0.228 Contact Map
4r7sA 1 0.8942 100 0.23 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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