Q97V36 - SULSO - GREMLIN Contacts

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Q97V36 - Uncharacterized protein

UniProt:	Q97V36	Sequences: MEDVIKQAEELLEKGRYNEVLKVLENFESVEVYLLRAEAYLRMNNSKAALVELDKGVQTFPFSYAILSAKAEVLENEGRLEEALENINKALEILPFSSEYRFIKARILFKLERYEEANIELTEVLRLNPNNVDARVMKAFCYYNMGLKLDALSEINRALNVKKEDSSLHELKGKIYFETGFYKLALSEFKIAAHYDPNNPDHYYNAAACYYNLKMYNDALTYMDLALSKGEKANYHILKALILKELNMEFSQEVEEAIKLDPSTKSIIENLFKK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	274 (216)
Sequences:	31501 (27121)
Seq/√Len:	1845.4

ECOLI - LPSRP HEMY NLPI YBEQ YFBP PGAA YJCO BAMD YPHG BCSC YGEH BEPA NRFG
BACSU - YVCD YPIA RAPE RAPB RAPG RAPJ RAPA RAPH RAPK RAPF YRRB RAPI RAPD RAPC YSOA SUNS GUTR
HALSA - Q9HMM8
SULSO - Q97V36 Q97VC4 Q97WM3 Q97ZS3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
181_F	184_L	3.282	1.00
113_R	116_E	3.221	1.00
147_L	150_D	3.167	1.00
215_M	218_D	3.131	1.00
79_R	82_E	3.022	1.00
45_N	48_A	2.961	1.00
203_Y	222_Y	2.801	1.00
169_H	188_E	2.620	1.00
207_A	223_M	2.547	1.00
135_R	154_E	2.452	1.00
105_A	121_L	2.330	1.00
67_L	86_N	2.317	1.00
71_A	87_I	2.300	1.00
139_A	155_I	2.290	1.00
173_G	189_F	2.266	1.00
101_R	120_E	2.222	1.00
172_K	188_E	2.198	1.00
206_A	222_Y	2.098	1.00
104_K	120_E	2.097	1.00
33_Y	52_E	2.049	1.00
37_A	53_L	2.037	1.00
190_K	206_A	2.030	1.00
70_K	86_N	2.020	1.00
54_D	70_K	2.007	1.00
138_K	154_E	1.959	1.00
88_N	104_K	1.933	1.00
36_R	52_E	1.905	1.00
53_L	69_A	1.883	1.00
156_N	172_K	1.877	1.00
210_Y	222_Y	1.852	1.00
122_T	138_K	1.840	1.00
189_F	205_N	1.812	1.00
176_Y	188_E	1.810	1.00
176_Y	184_L	1.760	1.00
40_Y	48_A	1.739	1.00
108_L	116_E	1.706	1.00
108_L	120_E	1.702	1.00
152_L	156_N	1.663	1.00
74_L	86_N	1.655	1.00
142_Y	154_E	1.654	1.00
210_Y	218_D	1.647	1.00
40_Y	52_E	1.645	1.00
155_I	171_L	1.630	1.00
186_L	190_K	1.611	1.00
118_N	122_T	1.546	1.00
142_Y	150_D	1.525	1.00
121_L	137_M	1.495	1.00
87_I	103_I	1.493	1.00
50_L	54_D	1.488	1.00
186_L	210_Y	1.455	1.00
84_L	88_N	1.417	1.00
206_A	210_Y	1.394	1.00
124_V	134_A	1.389	1.00
152_L	179_T	1.360	1.00
152_L	176_Y	1.345	1.00
70_K	74_L	1.324	1.00
74_L	82_E	1.324	1.00
108_L	113_R	1.321	1.00
36_R	40_Y	1.321	1.00
104_K	108_L	1.309	1.00
50_L	74_L	1.305	1.00
186_L	213_L	1.305	1.00
40_Y	45_N	1.297	1.00
176_Y	181_F	1.292	1.00
220_L	224_D	1.288	1.00
158_A	168_L	1.273	1.00
210_Y	215_M	1.257	1.00
172_K	176_Y	1.238	1.00
56_G	66_I	1.238	1.00
118_N	142_Y	1.217	1.00
138_K	142_Y	1.211	1.00
142_Y	147_L	1.183	1.00
218_D	221_T	1.156	1.00
184_L	187_S	1.150	1.00
39_A	43_M	1.147	1.00
196_D	199_N	1.126	1.00
101_R	123_E	1.124	1.00
170_E	205_N	1.123	1.00
203_Y	225_L	1.115	1.00
192_A	202_H	1.110	1.00
207_A	226_A	1.109	1.00
74_L	79_R	1.104	1.00
116_E	119_I	1.097	1.00
90_A	100_Y	1.095	1.00
159_L	169_H	1.094	1.00
102_F	134_A	1.093	1.00
84_L	111_L	1.090	1.00
174_K	205_N	1.088	1.00
38_E	69_A	1.077	1.00
169_H	191_I	1.077	1.00
136_V	168_L	1.064	1.00
102_F	137_M	1.051	1.00
177_F	212_N	1.043	1.00
82_E	85_E	1.043	1.00
21_L	25_E	1.038	1.00
84_L	108_L	1.032	1.00
191_I	195_Y	1.007	1.00
183_K	213_L	1.006	1.00
177_F	205_N	1.005	1.00
152_L	172_K	1.004	1.00
41_L	69_A	1.000	1.00
204_Y	208_A	0.997	1.00
193_A	203_Y	0.996	1.00
140_F	171_L	0.992	1.00
170_E	202_H	0.990	1.00
157_R	161_V	0.988	1.00
71_A	83_A	0.986	1.00
67_L	89_K	0.984	1.00
50_L	77_E	0.982	1.00
136_V	171_L	0.979	1.00
211_Y	223_M	0.972	1.00
148_K	175_I	0.957	1.00
101_R	124_V	0.956	1.00
139_A	151_A	0.956	1.00
89_K	93_I	0.950	1.00
173_G	192_A	0.948	1.00
48_A	51_V	0.943	1.00
150_D	153_S	0.937	1.00
57_V	67_L	0.929	1.00
34_L	66_I	0.928	1.00
107_I	111_L	0.922	1.00
149_L	179_T	0.921	1.00
37_A	49_A	0.918	1.00
71_A	90_A	0.917	1.00
118_N	138_K	0.912	1.00
33_Y	55_K	0.912	1.00
139_A	158_A	0.911	1.00
98_S	124_V	0.910	1.00
105_A	124_V	0.909	1.00
118_N	145_M	0.908	1.00
25_E	36_R	0.899	1.00
47_K	77_E	0.895	1.00
191_I	194_H	0.891	1.00
50_L	70_K	0.891	1.00
199_N	202_H	0.889	1.00
170_E	174_K	0.888	1.00
30_V	56_G	0.888	1.00
135_R	157_R	0.887	1.00
186_L	206_A	0.886	1.00
34_L	69_A	0.886	1.00
135_R	158_A	0.884	1.00
106_R	137_M	0.883	1.00
57_V	66_I	0.881	1.00
128_N	131_N	0.876	1.00
33_Y	56_G	0.875	1.00
186_L	209_C	0.870	1.00
169_H	192_A	0.868	1.00
97_S	100_Y	0.865	1.00
41_L	73_V	0.864	1.00
38_E	42_R	0.862	1.00
114_Y	141_C	0.861	1.00
193_A	202_H	0.857	1.00
225_L	229_K	0.855	1.00
205_N	208_A	0.852	1.00
131_N	134_A	0.852	1.00
81_E	111_L	0.845	1.00
208_A	212_N	0.844	1.00
55_K	59_T	0.843	1.00
175_I	179_T	0.832	1.00
72_E	76_N	0.832	1.00
166_S	192_A	0.832	1.00
24_L	35_L	0.830	1.00
68_S	103_I	0.828	1.00
63_S	66_I	0.828	1.00
132_V	158_A	0.826	1.00
72_E	103_I	0.826	1.00
68_S	72_E	0.822	1.00
154_E	157_R	0.821	1.00
182_Y	213_L	0.820	1.00
37_A	56_G	0.816	1.00
143_Y	175_I	0.814	1.00
89_K	92_E	0.811	1.00
125_L	134_A	0.810	1.00
69_A	72_E	0.807	1.00
159_L	168_L	0.807	1.00
120_E	123_E	0.807	1.00
109_F	141_C	0.806	1.00
91_L	101_R	0.805	1.00
34_L	38_E	0.803	1.00
182_Y	209_C	0.803	1.00
105_A	117_A	0.803	1.00
125_L	135_R	0.800	1.00
102_F	106_R	0.797	1.00
84_L	104_K	0.792	1.00
123_E	127_L	0.789	1.00
203_Y	226_A	0.787	1.00
177_F	209_C	0.784	1.00
157_R	160_N	0.784	1.00
103_I	106_R	0.782	1.00
141_C	145_M	0.782	1.00
152_L	175_I	0.773	1.00
173_G	185_A	0.768	1.00
86_N	89_K	0.766	1.00
50_L	73_V	0.765	1.00
80_L	107_I	0.760	1.00
46_S	73_V	0.758	1.00
162_K	165_D	0.758	1.00
94_L	97_S	0.750	1.00
174_K	177_F	0.747	1.00
225_L	228_S	0.741	1.00
177_F	185_A	0.740	1.00
188_E	191_I	0.736	1.00
185_A	209_C	0.734	1.00
165_D	168_L	0.731	1.00
182_Y	212_N	0.730	1.00
222_Y	225_L	0.728	1.00
60_F	63_S	0.725	1.00
118_N	147_L	0.724	1.00
123_E	126_R	0.723	1.00
186_L	215_M	0.718	1.00
136_V	140_F	0.710	1.00
67_L	90_A	0.707	1.00
143_Y	148_K	0.706	1.00
21_L	40_Y	0.702	1.00
115_E	145_M	0.701	1.00
35_L	38_E	0.700	1.00
118_N	141_C	0.699	1.00
207_A	219_A	0.690	1.00
140_F	144_N	0.690	1.00
23_V	26_N	0.689	1.00
109_F	114_Y	0.687	1.00
68_S	100_Y	0.686	1.00
177_F	189_F	0.683	1.00
143_Y	171_L	0.680	1.00
211_Y	216_Y	0.679	1.00
106_R	110_K	0.675	1.00
52_E	55_K	0.673	1.00
116_E	120_E	0.671	1.00
109_F	144_N	0.669	1.00
189_F	209_C	0.666	1.00
169_H	195_Y	0.663	1.00
82_E	86_N	0.660	1.00
75_E	103_I	0.660	1.00
148_K	178_E	0.656	1.00
91_L	100_Y	0.655	1.00
41_L	46_S	0.649	1.00
90_A	93_I	0.647	1.00
125_L	138_K	0.646	1.00
19_E	22_K	0.646	1.00
114_Y	145_M	0.645	1.00
208_A	211_Y	0.645	1.00
67_L	93_I	0.641	1.00
200_P	226_A	0.641	1.00
119_I	123_E	0.640	1.00
218_D	222_Y	0.637	1.00
41_L	53_L	0.633	1.00
75_E	107_I	0.633	1.00
34_L	63_S	0.632	1.00
51_V	55_K	0.630	1.00
140_F	143_Y	0.628	1.00
84_L	113_R	0.625	1.00
135_R	161_V	0.620	1.00
171_L	174_K	0.616	1.00
46_S	76_N	0.604	1.00
174_K	178_E	0.603	1.00
73_V	77_E	0.600	1.00
117_A	141_C	0.597	1.00
114_Y	144_N	0.596	1.00
109_F	137_M	0.596	1.00
224_D	228_S	0.595	1.00
137_M	140_F	0.594	1.00
177_F	182_Y	0.593	1.00
56_G	59_T	0.592	1.00
209_C	213_L	0.592	1.00
84_L	107_I	0.590	1.00
190_K	218_D	0.585	1.00
102_F	131_N	0.582	1.00
156_N	188_E	0.581	1.00
204_Y	207_A	0.572	1.00
158_A	161_V	0.572	1.00
33_Y	59_T	0.566	1.00
174_K	189_F	0.566	1.00
143_Y	155_I	0.566	1.00
55_K	58_Q	0.564	1.00
190_K	194_H	0.564	1.00
57_V	70_K	0.561	1.00
210_Y	213_L	0.561	1.00
30_V	34_L	0.561	1.00
142_Y	145_M	0.561	1.00
143_Y	151_A	0.561	1.00
23_V	27_F	0.560	1.00
221_T	224_D	0.560	1.00
81_E	85_E	0.556	1.00
90_A	94_L	0.555	1.00
187_S	191_I	0.552	1.00
216_Y	220_L	0.550	1.00
64_Y	90_A	0.550	1.00
98_S	128_N	0.550	1.00
176_Y	179_T	0.548	1.00
29_S	32_V	0.547	1.00
156_N	160_N	0.546	1.00
221_T	225_L	0.543	1.00
41_L	49_A	0.543	1.00
153_S	157_R	0.542	1.00
88_N	92_E	0.541	1.00
98_S	131_N	0.541	1.00
166_S	196_D	0.540	1.00
101_R	127_L	0.540	1.00
86_N	90_A	0.539	1.00
20_V	24_L	0.539	1.00
75_E	87_I	0.536	1.00
190_K	210_Y	0.536	1.00
156_N	184_L	0.535	1.00
143_Y	178_E	0.534	1.00
140_F	155_I	0.533	1.00
184_L	188_E	0.532	1.00
189_F	206_A	0.531	1.00
106_R	109_F	0.530	1.00
68_S	97_S	0.530	1.00
187_S	190_K	0.529	1.00
109_F	121_L	0.528	1.00
91_L	104_K	0.528	1.00
21_L	36_R	0.528	1.00
109_F	117_A	0.527	1.00
211_Y	219_A	0.520	1.00
153_S	156_N	0.520	1.00
72_E	75_E	0.515	1.00
75_E	80_L	0.514	1.00
148_K	179_T	0.508	1.00
224_D	227_L	0.508	1.00
182_Y	186_L	0.506	1.00
200_P	230_G	0.502	1.00
48_A	52_E	0.501	1.00
80_L	84_L	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3dssA	1	0.9307	100	0.187	Contact Map
1w3bA	2	0.9051	100	0.19	Contact Map
4l9pA	1	0.9051	100	0.206	Contact Map
2h6fA	1	0.9051	100	0.211	Contact Map
2xpiA	2	0.8905	100	0.213	Contact Map
4rg9A	2	0.6898	100	0.219	Contact Map
3q7aA	1	0.8613	100	0.22	Contact Map
4ui9C	2	0.9964	100	0.225	Contact Map
3draA	1	0.8905	100	0.228	Contact Map
4r7sA	1	0.8942	100	0.23	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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