GREMLIN Database
Q97V35 - Uncharacterized protein
UniProt: Q97V35 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 358 (289)
Sequences: 1659 (1236)
Seq/√Len: 72.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
49_M147_G3.8941.00
271_Y275_T3.7511.00
46_G151_G3.5201.00
112_G157_Y3.3141.00
194_L308_V3.0831.00
268_G275_T2.9061.00
84_D93_A2.8061.00
215_L219_S2.7791.00
190_G311_A2.7201.00
273_S277_F2.5801.00
38_A83_F2.4951.00
186_F314_A2.4771.00
280_F285_K2.3931.00
282_M286_A2.3181.00
286_A317_A2.2901.00
274_I277_F2.2771.00
272_M276_R2.2501.00
267_S271_Y2.2121.00
240_N243_A2.1961.00
216_F221_A2.1331.00
262_L265_I2.1151.00
182_A221_A2.0591.00
36_A323_A1.9721.00
68_A119_L1.9441.00
238_V241_Q1.9301.00
38_A157_Y1.9261.00
73_F124_F1.9051.00
239_F243_A1.9031.00
34_Y85_I1.9001.00
73_F120_L1.8921.00
281_G313_F1.8881.00
86_D158_S1.8861.00
259_L263_T1.8821.00
112_G158_S1.8761.00
115_F153_F1.8471.00
237_N240_N1.8401.00
194_L311_A1.8081.00
187_A318_G1.8031.00
36_A326_L1.7501.00
45_A119_L1.7401.00
277_F280_F1.7341.00
50_A151_G1.7301.00
183_D322_R1.7181.00
122_F150_A1.7061.00
312_I316_V1.7021.00
271_Y274_I1.7011.00
84_D90_P1.7011.00
285_K313_F1.6921.00
300_P306_V1.6901.00
94_I98_A1.6861.00
67_R196_A1.6651.00
122_F146_L1.6501.00
270_G277_F1.6320.99
119_L154_S1.6320.99
48_L72_A1.6050.99
71_A191_L1.5920.99
216_F219_S1.5780.99
303_I306_V1.5760.99
156_T181_L1.5700.99
38_A112_G1.5680.99
257_I260_S1.5380.99
211_L219_S1.5350.99
76_S120_L1.5320.99
95_L98_A1.5210.99
316_V320_L1.4960.99
23_I34_Y1.4890.99
213_K221_A1.4810.99
90_P93_A1.4750.99
279_M283_R1.4690.99
115_F154_S1.4680.99
44_I75_A1.4510.99
256_D260_S1.4460.99
37_L319_F1.4450.99
218_S221_A1.4440.99
112_G116_V1.4250.99
80_L116_V1.4250.99
48_L192_G1.4220.99
223_L226_W1.4170.99
242_V276_R1.3960.98
87_L93_A1.3910.98
215_L222_I1.3910.98
48_L119_L1.3740.98
260_S263_T1.3650.98
305_Y309_V1.3560.98
180_Y325_V1.3400.98
219_S222_I1.3170.98
35_V38_A1.3070.98
263_T267_S1.3000.97
72_A123_S1.2800.97
212_T216_F1.2790.97
151_G188_A1.2690.97
197_L308_V1.2660.97
69_S130_S1.2650.97
107_S177_P1.2620.97
179_L322_R1.2460.97
333_Y339_T1.2380.97
274_I278_L1.2380.97
89_R92_A1.2270.96
71_A315_L1.2250.96
45_A76_S1.2140.96
44_I191_L1.2110.96
260_S265_I1.2100.96
194_L315_L1.1980.96
111_R115_F1.1930.96
216_F220_I1.1740.95
77_I80_L1.1720.95
160_F177_P1.1690.95
159_G176_L1.1640.95
47_M188_A1.1600.95
207_A210_T1.1480.95
118_G150_A1.1440.95
303_I308_V1.1430.95
155_T181_L1.1410.95
282_M313_F1.1350.94
212_T215_L1.1350.94
41_F78_L1.1240.94
103_Y110_A1.1220.94
23_I27_Q1.1190.94
95_L99_E1.1180.94
259_L266_I1.1170.94
276_R281_G1.1160.94
138_W141_G1.1100.94
291_I302_V1.1100.94
300_P303_I1.1090.94
45_A72_A1.1090.94
284_Q309_V1.1090.94
260_S264_L1.1090.94
39_L112_G1.1070.94
281_G284_Q1.1040.94
239_F242_V1.1010.93
49_M69_S1.0920.93
38_A159_G1.0920.93
54_L185_V1.0880.93
57_V141_G1.0870.93
80_L84_D1.0840.93
83_F112_G1.0730.93
73_F81_L1.0700.92
29_P327_F1.0610.92
306_V310_A1.0560.92
119_L155_T1.0500.92
112_G321_A1.0490.92
154_S158_S1.0480.92
119_L123_S1.0460.92
83_F90_P1.0460.92
265_I274_I1.0410.91
155_T184_G1.0330.91
257_I263_T1.0280.91
84_D161_E1.0260.91
218_S222_I1.0240.91
96_A113_I1.0140.90
265_I272_M1.0130.90
43_E183_D1.0110.90
68_A153_F0.9940.89
97_P117_G0.9930.89
277_F281_G0.9870.89
214_V222_I0.9840.89
273_S320_L0.9820.89
281_G285_K0.9810.89
163_A177_P0.9800.89
39_L162_L0.9710.88
327_F330_Q0.9680.88
238_V243_A0.9650.88
59_G62_K0.9640.88
40_Y315_L0.9640.88
185_V197_L0.9610.88
109_M161_E0.9570.88
270_G274_I0.9470.87
76_S154_S0.9460.87
39_L80_L0.9360.86
258_G262_L0.9330.86
84_D116_V0.9260.86
183_D321_A0.9210.85
39_L157_Y0.9170.85
290_A293_Q0.9000.84
161_E183_D0.8980.84
22_I25_I0.8960.84
32_G88_G0.8910.84
198_V202_E0.8910.84
285_K316_V0.8910.84
170_F262_L0.8900.83
155_T161_E0.8870.83
86_D116_V0.8840.83
74_I285_K0.8830.83
32_G86_D0.8820.83
217_Y222_I0.8790.83
264_L269_I0.8760.82
40_Y54_L0.8750.82
87_L97_P0.8750.82
49_M119_L0.8750.82
272_M279_M0.8730.82
200_K205_M0.8720.82
219_S227_F0.8700.82
34_Y38_A0.8650.82
129_I132_L0.8650.82
155_T158_S0.8620.81
209_V213_K0.8570.81
288_E312_I0.8570.81
220_I312_I0.8530.81
219_S223_L0.8530.81
151_G155_T0.8520.81
210_T220_I0.8510.81
83_F157_Y0.8500.81
43_E158_S0.8460.80
84_D87_L0.8410.80
37_L159_G0.8390.80
258_G265_I0.8360.79
220_I225_T0.8360.79
22_I121_L0.8360.79
258_G261_V0.8340.79
256_D279_M0.8310.79
217_Y220_I0.8310.79
113_I117_G0.8260.79
29_P330_Q0.8250.79
31_W109_M0.8230.78
49_M123_S0.8140.78
222_I225_T0.8140.78
276_R313_F0.8120.77
97_P113_I0.8090.77
169_P172_N0.8070.77
285_K293_Q0.8030.77
208_R212_T0.8020.77
168_I330_Q0.8020.77
287_P290_A0.8000.76
210_T213_K0.7990.76
211_L304_K0.7980.76
39_L161_E0.7950.76
77_I120_L0.7940.76
219_S285_K0.7930.76
266_I269_I0.7870.75
148_V191_L0.7850.75
211_L217_Y0.7770.74
301_T307_V0.7770.74
138_W288_E0.7760.74
216_F222_I0.7740.74
160_F163_A0.7730.74
336_S339_T0.7710.74
87_L99_E0.7710.74
80_L109_M0.7640.73
126_Y144_A0.7640.73
215_L314_A0.7630.73
56_E144_A0.7620.73
193_Y311_A0.7610.73
266_I285_K0.7580.72
194_L312_I0.7580.72
53_G58_T0.7570.72
122_F125_L0.7560.72
257_I261_V0.7540.72
309_V313_F0.7530.72
257_I266_I0.7520.72
46_G155_T0.7510.72
111_R126_Y0.7500.72
262_L281_G0.7480.71
265_I271_Y0.7450.71
79_A322_R0.7440.71
262_L274_I0.7440.71
262_L277_F0.7410.71
43_E112_G0.7380.70
278_L281_G0.7370.70
50_A148_V0.7350.70
112_G155_T0.7350.70
279_M282_M0.7280.69
165_T171_W0.7270.69
80_L117_G0.7260.69
208_R211_L0.7240.69
42_T160_F0.7220.69
275_T278_L0.7220.69
142_V146_L0.7210.69
92_A171_W0.7200.68
33_E36_A0.7190.68
207_A213_K0.7190.68
182_A218_S0.7170.68
289_S306_V0.7160.68
45_A75_A0.7150.68
179_L183_D0.7150.68
218_S225_T0.7140.68
177_P322_R0.7100.67
160_F164_S0.7090.67
148_V181_L0.7070.67
176_L325_V0.7040.67
175_G182_A0.7000.66
87_L330_Q0.7000.66
211_L225_T0.6970.66
88_G108_W0.6960.66
261_V265_I0.6940.66
30_L105_A0.6930.66
124_F285_K0.6910.65
265_I269_I0.6900.65
282_M317_A0.6900.65
222_I226_W0.6890.65
45_A154_S0.6820.64
116_V157_Y0.6810.64
174_G178_A0.6810.64
56_E65_N0.6780.64
40_Y282_M0.6770.64
69_S126_Y0.6760.64
221_A225_T0.6750.64
116_V158_S0.6720.63
126_Y154_S0.6710.63
223_L312_I0.6700.63
254_Y257_I0.6690.63
37_L104_F0.6630.62
265_I277_F0.6610.62
267_S276_R0.6610.62
122_F143_I0.6600.62
262_L266_I0.6580.62
113_I158_S0.6560.61
47_M154_S0.6560.61
201_N307_V0.6520.61
292_G310_A0.6520.61
124_F135_K0.6510.61
112_G154_S0.6510.61
304_K308_V0.6500.61
74_I186_F0.6500.61
284_Q288_E0.6490.60
193_Y307_V0.6470.60
109_M188_A0.6470.60
262_L271_Y0.6470.60
261_V264_L0.6450.60
80_L115_F0.6440.60
116_V123_S0.6440.60
43_E322_R0.6440.60
271_Y284_Q0.6420.60
65_N130_S0.6400.59
190_G315_L0.6340.59
88_G117_G0.6320.58
191_L315_L0.6320.58
147_G224_A0.6290.58
171_W314_A0.6280.58
137_R146_L0.6270.58
211_L224_A0.6250.58
39_L83_F0.6240.57
42_T162_L0.6240.57
23_I38_A0.6220.57
288_E292_G0.6200.57
96_A110_A0.6190.57
207_A221_A0.6180.57
161_E176_L0.6180.57
108_W165_T0.6150.56
169_P322_R0.6130.56
88_G180_Y0.6130.56
183_D222_I0.6130.56
49_M151_G0.6100.56
168_I329_G0.6060.55
103_Y188_A0.6050.55
308_V311_A0.6030.55
80_L154_S0.6020.55
280_F288_E0.6010.55
271_Y277_F0.5990.54
52_I111_R0.5980.54
83_F87_L0.5950.54
40_Y192_G0.5950.54
29_P168_I0.5910.53
217_Y225_T0.5880.53
276_R287_P0.5870.53
276_R280_F0.5860.53
128_V316_V0.5860.53
135_K141_G0.5840.53
292_G305_Y0.5810.52
98_A169_P0.5810.52
63_A66_R0.5810.52
34_Y112_G0.5800.52
167_G308_V0.5790.52
193_Y214_V0.5780.52
53_G121_L0.5770.52
29_P46_G0.5690.51
78_L82_F0.5690.51
122_F147_G0.5690.51
39_L158_S0.5690.51
38_A322_R0.5680.51
109_M112_G0.5660.50
85_I145_I0.5660.50
22_I87_L0.5640.50
158_S161_E0.5630.50
274_I279_M0.5610.50
98_A104_F0.5610.50
40_Y319_F0.5600.50
213_K220_I0.5600.50
135_K139_A0.5580.49
64_F191_L0.5570.49
51_I134_V0.5560.49
127_M154_S0.5560.49
319_F323_A0.5550.49
124_F173_N0.5550.49
22_I93_A0.5530.49
270_G275_T0.5520.49
254_Y259_L0.5450.48
38_A42_T0.5450.48
162_L283_R0.5440.48
42_T155_T0.5430.48
29_P151_G0.5410.47
86_D168_I0.5390.47
126_Y147_G0.5390.47
79_A163_A0.5380.47
254_Y260_S0.5370.47
255_I261_V0.5360.47
43_E161_E0.5360.47
151_G157_Y0.5350.47
188_A191_L0.5350.47
210_T217_Y0.5350.47
31_W171_W0.5340.46
35_V326_L0.5340.46
35_V161_E0.5340.46
280_F313_F0.5320.46
37_L115_F0.5320.46
48_L191_L0.5300.46
34_Y140_R0.5290.46
111_R157_Y0.5290.46
37_L153_F0.5270.46
152_I262_L0.5260.45
38_A158_S0.5260.45
108_W112_G0.5260.45
25_I32_G0.5210.45
270_G273_S0.5210.45
25_I38_A0.5200.45
305_Y308_V0.5200.45
213_K216_F0.5200.45
211_L222_I0.5200.45
261_V266_I0.5200.45
256_D259_L0.5190.45
44_I123_S0.5170.44
311_A314_A0.5160.44
46_G188_A0.5160.44
144_A184_G0.5110.44
28_Y181_L0.5100.43
55_M70_V0.5100.43
114_I117_G0.5080.43
91_T150_A0.5080.43
197_L201_N0.5070.43
283_R287_P0.5070.43
218_S224_A0.5060.43
137_R140_R0.5020.43
168_I177_P0.5020.43
272_M277_F0.5010.42
87_L152_I0.5000.42
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2vpzC 2 0.6899 100 0.456 Contact Map
4l35A 3 0.257 7.7 0.967 Contact Map
4o6yA 2 0.5251 7.4 0.967 Contact Map
2cfqA 1 0.514 7.1 0.968 Contact Map
2kncA 1 0.1341 7.1 0.968 Contact Map
4i0uA 4 0.1648 5.9 0.969 Contact Map
4ev6A 3 0.1704 5.5 0.969 Contact Map
4fbzA 3 0.257 4.9 0.97 Contact Map
4hyjA 2 0.2654 4.4 0.971 Contact Map
2wswA 3 0.3408 3.2 0.973 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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