Q97V35 - SULSO - GREMLIN Contacts

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Q97V35 - Uncharacterized protein

UniProt:	Q97V35	Sequences: MIKMGLFTAPEPGTSFGVQAPIIQINQYPLWGEYVALALYFTEIAGMLMAIIGLMEVTGKYKAFNRRASVAAFIASILALLFFDIDLGRPTAAILAPAEAFFYFAFSWMARGIIFVGGLLLFSFLYMVISLLDVKNRWARGVIAILGVFAGIFSTTYSGFELASTTGIPFWNNGGLPALYLADGVFAASGLGYLIALVGKNEEVMRARVTLTKVLFYSSIAILATWFLFLANVNYLNVFNQVAYEYLLSQVTFYIDIGLSVLTLIISGIGYMSITRFLMFGMRQKAPESAIGQMPVMDLPTVIKYVVVVAAIFALVAGFLARADVLFAGQYAYQLSPMTPFQSVSNQPIPIGSFGWRS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	358 (289)
Sequences:	1659 (1236)
Seq/√Len:	72.7

ECOLI - NRFD HYBB
HALSA - DMSC
SULSO - Q97V35

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
49_M	147_G	3.894	1.00
271_Y	275_T	3.751	1.00
46_G	151_G	3.520	1.00
112_G	157_Y	3.314	1.00
194_L	308_V	3.083	1.00
268_G	275_T	2.906	1.00
84_D	93_A	2.806	1.00
215_L	219_S	2.779	1.00
190_G	311_A	2.720	1.00
273_S	277_F	2.580	1.00
38_A	83_F	2.495	1.00
186_F	314_A	2.477	1.00
280_F	285_K	2.393	1.00
282_M	286_A	2.318	1.00
286_A	317_A	2.290	1.00
274_I	277_F	2.277	1.00
272_M	276_R	2.250	1.00
267_S	271_Y	2.212	1.00
240_N	243_A	2.196	1.00
216_F	221_A	2.133	1.00
262_L	265_I	2.115	1.00
182_A	221_A	2.059	1.00
36_A	323_A	1.972	1.00
68_A	119_L	1.944	1.00
238_V	241_Q	1.930	1.00
38_A	157_Y	1.926	1.00
73_F	124_F	1.905	1.00
239_F	243_A	1.903	1.00
34_Y	85_I	1.900	1.00
73_F	120_L	1.892	1.00
281_G	313_F	1.888	1.00
86_D	158_S	1.886	1.00
259_L	263_T	1.882	1.00
112_G	158_S	1.876	1.00
115_F	153_F	1.847	1.00
237_N	240_N	1.840	1.00
194_L	311_A	1.808	1.00
187_A	318_G	1.803	1.00
36_A	326_L	1.750	1.00
45_A	119_L	1.740	1.00
277_F	280_F	1.734	1.00
50_A	151_G	1.730	1.00
183_D	322_R	1.718	1.00
122_F	150_A	1.706	1.00
312_I	316_V	1.702	1.00
271_Y	274_I	1.701	1.00
84_D	90_P	1.701	1.00
285_K	313_F	1.692	1.00
300_P	306_V	1.690	1.00
94_I	98_A	1.686	1.00
67_R	196_A	1.665	1.00
122_F	146_L	1.650	1.00
270_G	277_F	1.632	0.99
119_L	154_S	1.632	0.99
48_L	72_A	1.605	0.99
71_A	191_L	1.592	0.99
216_F	219_S	1.578	0.99
303_I	306_V	1.576	0.99
156_T	181_L	1.570	0.99
38_A	112_G	1.568	0.99
257_I	260_S	1.538	0.99
211_L	219_S	1.535	0.99
76_S	120_L	1.532	0.99
95_L	98_A	1.521	0.99
316_V	320_L	1.496	0.99
23_I	34_Y	1.489	0.99
213_K	221_A	1.481	0.99
90_P	93_A	1.475	0.99
279_M	283_R	1.469	0.99
115_F	154_S	1.468	0.99
44_I	75_A	1.451	0.99
256_D	260_S	1.446	0.99
37_L	319_F	1.445	0.99
218_S	221_A	1.444	0.99
112_G	116_V	1.425	0.99
80_L	116_V	1.425	0.99
48_L	192_G	1.422	0.99
223_L	226_W	1.417	0.99
242_V	276_R	1.396	0.98
87_L	93_A	1.391	0.98
215_L	222_I	1.391	0.98
48_L	119_L	1.374	0.98
260_S	263_T	1.365	0.98
305_Y	309_V	1.356	0.98
180_Y	325_V	1.340	0.98
219_S	222_I	1.317	0.98
35_V	38_A	1.307	0.98
263_T	267_S	1.300	0.97
72_A	123_S	1.280	0.97
212_T	216_F	1.279	0.97
151_G	188_A	1.269	0.97
197_L	308_V	1.266	0.97
69_S	130_S	1.265	0.97
107_S	177_P	1.262	0.97
179_L	322_R	1.246	0.97
333_Y	339_T	1.238	0.97
274_I	278_L	1.238	0.97
89_R	92_A	1.227	0.96
71_A	315_L	1.225	0.96
45_A	76_S	1.214	0.96
44_I	191_L	1.211	0.96
260_S	265_I	1.210	0.96
194_L	315_L	1.198	0.96
111_R	115_F	1.193	0.96
216_F	220_I	1.174	0.95
77_I	80_L	1.172	0.95
160_F	177_P	1.169	0.95
159_G	176_L	1.164	0.95
47_M	188_A	1.160	0.95
207_A	210_T	1.148	0.95
118_G	150_A	1.144	0.95
303_I	308_V	1.143	0.95
155_T	181_L	1.141	0.95
282_M	313_F	1.135	0.94
212_T	215_L	1.135	0.94
41_F	78_L	1.124	0.94
103_Y	110_A	1.122	0.94
23_I	27_Q	1.119	0.94
95_L	99_E	1.118	0.94
259_L	266_I	1.117	0.94
276_R	281_G	1.116	0.94
138_W	141_G	1.110	0.94
291_I	302_V	1.110	0.94
300_P	303_I	1.109	0.94
45_A	72_A	1.109	0.94
284_Q	309_V	1.109	0.94
260_S	264_L	1.109	0.94
39_L	112_G	1.107	0.94
281_G	284_Q	1.104	0.94
239_F	242_V	1.101	0.93
49_M	69_S	1.092	0.93
38_A	159_G	1.092	0.93
54_L	185_V	1.088	0.93
57_V	141_G	1.087	0.93
80_L	84_D	1.084	0.93
83_F	112_G	1.073	0.93
73_F	81_L	1.070	0.92
29_P	327_F	1.061	0.92
306_V	310_A	1.056	0.92
119_L	155_T	1.050	0.92
112_G	321_A	1.049	0.92
154_S	158_S	1.048	0.92
119_L	123_S	1.046	0.92
83_F	90_P	1.046	0.92
265_I	274_I	1.041	0.91
155_T	184_G	1.033	0.91
257_I	263_T	1.028	0.91
84_D	161_E	1.026	0.91
218_S	222_I	1.024	0.91
96_A	113_I	1.014	0.90
265_I	272_M	1.013	0.90
43_E	183_D	1.011	0.90
68_A	153_F	0.994	0.89
97_P	117_G	0.993	0.89
277_F	281_G	0.987	0.89
214_V	222_I	0.984	0.89
273_S	320_L	0.982	0.89
281_G	285_K	0.981	0.89
163_A	177_P	0.980	0.89
39_L	162_L	0.971	0.88
327_F	330_Q	0.968	0.88
238_V	243_A	0.965	0.88
59_G	62_K	0.964	0.88
40_Y	315_L	0.964	0.88
185_V	197_L	0.961	0.88
109_M	161_E	0.957	0.88
270_G	274_I	0.947	0.87
76_S	154_S	0.946	0.87
39_L	80_L	0.936	0.86
258_G	262_L	0.933	0.86
84_D	116_V	0.926	0.86
183_D	321_A	0.921	0.85
39_L	157_Y	0.917	0.85
290_A	293_Q	0.900	0.84
161_E	183_D	0.898	0.84
22_I	25_I	0.896	0.84
32_G	88_G	0.891	0.84
198_V	202_E	0.891	0.84
285_K	316_V	0.891	0.84
170_F	262_L	0.890	0.83
155_T	161_E	0.887	0.83
86_D	116_V	0.884	0.83
74_I	285_K	0.883	0.83
32_G	86_D	0.882	0.83
217_Y	222_I	0.879	0.83
264_L	269_I	0.876	0.82
40_Y	54_L	0.875	0.82
87_L	97_P	0.875	0.82
49_M	119_L	0.875	0.82
272_M	279_M	0.873	0.82
200_K	205_M	0.872	0.82
219_S	227_F	0.870	0.82
34_Y	38_A	0.865	0.82
129_I	132_L	0.865	0.82
155_T	158_S	0.862	0.81
209_V	213_K	0.857	0.81
288_E	312_I	0.857	0.81
220_I	312_I	0.853	0.81
219_S	223_L	0.853	0.81
151_G	155_T	0.852	0.81
210_T	220_I	0.851	0.81
83_F	157_Y	0.850	0.81
43_E	158_S	0.846	0.80
84_D	87_L	0.841	0.80
37_L	159_G	0.839	0.80
258_G	265_I	0.836	0.79
220_I	225_T	0.836	0.79
22_I	121_L	0.836	0.79
258_G	261_V	0.834	0.79
256_D	279_M	0.831	0.79
217_Y	220_I	0.831	0.79
113_I	117_G	0.826	0.79
29_P	330_Q	0.825	0.79
31_W	109_M	0.823	0.78
49_M	123_S	0.814	0.78
222_I	225_T	0.814	0.78
276_R	313_F	0.812	0.77
97_P	113_I	0.809	0.77
169_P	172_N	0.807	0.77
285_K	293_Q	0.803	0.77
208_R	212_T	0.802	0.77
168_I	330_Q	0.802	0.77
287_P	290_A	0.800	0.76
210_T	213_K	0.799	0.76
211_L	304_K	0.798	0.76
39_L	161_E	0.795	0.76
77_I	120_L	0.794	0.76
219_S	285_K	0.793	0.76
266_I	269_I	0.787	0.75
148_V	191_L	0.785	0.75
211_L	217_Y	0.777	0.74
301_T	307_V	0.777	0.74
138_W	288_E	0.776	0.74
216_F	222_I	0.774	0.74
160_F	163_A	0.773	0.74
336_S	339_T	0.771	0.74
87_L	99_E	0.771	0.74
80_L	109_M	0.764	0.73
126_Y	144_A	0.764	0.73
215_L	314_A	0.763	0.73
56_E	144_A	0.762	0.73
193_Y	311_A	0.761	0.73
266_I	285_K	0.758	0.72
194_L	312_I	0.758	0.72
53_G	58_T	0.757	0.72
122_F	125_L	0.756	0.72
257_I	261_V	0.754	0.72
309_V	313_F	0.753	0.72
257_I	266_I	0.752	0.72
46_G	155_T	0.751	0.72
111_R	126_Y	0.750	0.72
262_L	281_G	0.748	0.71
265_I	271_Y	0.745	0.71
79_A	322_R	0.744	0.71
262_L	274_I	0.744	0.71
262_L	277_F	0.741	0.71
43_E	112_G	0.738	0.70
278_L	281_G	0.737	0.70
50_A	148_V	0.735	0.70
112_G	155_T	0.735	0.70
279_M	282_M	0.728	0.69
165_T	171_W	0.727	0.69
80_L	117_G	0.726	0.69
208_R	211_L	0.724	0.69
42_T	160_F	0.722	0.69
275_T	278_L	0.722	0.69
142_V	146_L	0.721	0.69
92_A	171_W	0.720	0.68
33_E	36_A	0.719	0.68
207_A	213_K	0.719	0.68
182_A	218_S	0.717	0.68
289_S	306_V	0.716	0.68
45_A	75_A	0.715	0.68
179_L	183_D	0.715	0.68
218_S	225_T	0.714	0.68
177_P	322_R	0.710	0.67
160_F	164_S	0.709	0.67
148_V	181_L	0.707	0.67
176_L	325_V	0.704	0.67
175_G	182_A	0.700	0.66
87_L	330_Q	0.700	0.66
211_L	225_T	0.697	0.66
88_G	108_W	0.696	0.66
261_V	265_I	0.694	0.66
30_L	105_A	0.693	0.66
124_F	285_K	0.691	0.65
265_I	269_I	0.690	0.65
282_M	317_A	0.690	0.65
222_I	226_W	0.689	0.65
45_A	154_S	0.682	0.64
116_V	157_Y	0.681	0.64
174_G	178_A	0.681	0.64
56_E	65_N	0.678	0.64
40_Y	282_M	0.677	0.64
69_S	126_Y	0.676	0.64
221_A	225_T	0.675	0.64
116_V	158_S	0.672	0.63
126_Y	154_S	0.671	0.63
223_L	312_I	0.670	0.63
254_Y	257_I	0.669	0.63
37_L	104_F	0.663	0.62
265_I	277_F	0.661	0.62
267_S	276_R	0.661	0.62
122_F	143_I	0.660	0.62
262_L	266_I	0.658	0.62
113_I	158_S	0.656	0.61
47_M	154_S	0.656	0.61
201_N	307_V	0.652	0.61
292_G	310_A	0.652	0.61
124_F	135_K	0.651	0.61
112_G	154_S	0.651	0.61
304_K	308_V	0.650	0.61
74_I	186_F	0.650	0.61
284_Q	288_E	0.649	0.60
193_Y	307_V	0.647	0.60
109_M	188_A	0.647	0.60
262_L	271_Y	0.647	0.60
261_V	264_L	0.645	0.60
80_L	115_F	0.644	0.60
116_V	123_S	0.644	0.60
43_E	322_R	0.644	0.60
271_Y	284_Q	0.642	0.60
65_N	130_S	0.640	0.59
190_G	315_L	0.634	0.59
88_G	117_G	0.632	0.58
191_L	315_L	0.632	0.58
147_G	224_A	0.629	0.58
171_W	314_A	0.628	0.58
137_R	146_L	0.627	0.58
211_L	224_A	0.625	0.58
39_L	83_F	0.624	0.57
42_T	162_L	0.624	0.57
23_I	38_A	0.622	0.57
288_E	292_G	0.620	0.57
96_A	110_A	0.619	0.57
207_A	221_A	0.618	0.57
161_E	176_L	0.618	0.57
108_W	165_T	0.615	0.56
169_P	322_R	0.613	0.56
88_G	180_Y	0.613	0.56
183_D	222_I	0.613	0.56
49_M	151_G	0.610	0.56
168_I	329_G	0.606	0.55
103_Y	188_A	0.605	0.55
308_V	311_A	0.603	0.55
80_L	154_S	0.602	0.55
280_F	288_E	0.601	0.55
271_Y	277_F	0.599	0.54
52_I	111_R	0.598	0.54
83_F	87_L	0.595	0.54
40_Y	192_G	0.595	0.54
29_P	168_I	0.591	0.53
217_Y	225_T	0.588	0.53
276_R	287_P	0.587	0.53
276_R	280_F	0.586	0.53
128_V	316_V	0.586	0.53
135_K	141_G	0.584	0.53
292_G	305_Y	0.581	0.52
98_A	169_P	0.581	0.52
63_A	66_R	0.581	0.52
34_Y	112_G	0.580	0.52
167_G	308_V	0.579	0.52
193_Y	214_V	0.578	0.52
53_G	121_L	0.577	0.52
29_P	46_G	0.569	0.51
78_L	82_F	0.569	0.51
122_F	147_G	0.569	0.51
39_L	158_S	0.569	0.51
38_A	322_R	0.568	0.51
109_M	112_G	0.566	0.50
85_I	145_I	0.566	0.50
22_I	87_L	0.564	0.50
158_S	161_E	0.563	0.50
274_I	279_M	0.561	0.50
98_A	104_F	0.561	0.50
40_Y	319_F	0.560	0.50
213_K	220_I	0.560	0.50
135_K	139_A	0.558	0.49
64_F	191_L	0.557	0.49
51_I	134_V	0.556	0.49
127_M	154_S	0.556	0.49
319_F	323_A	0.555	0.49
124_F	173_N	0.555	0.49
22_I	93_A	0.553	0.49
270_G	275_T	0.552	0.49
254_Y	259_L	0.545	0.48
38_A	42_T	0.545	0.48
162_L	283_R	0.544	0.48
42_T	155_T	0.543	0.48
29_P	151_G	0.541	0.47
86_D	168_I	0.539	0.47
126_Y	147_G	0.539	0.47
79_A	163_A	0.538	0.47
254_Y	260_S	0.537	0.47
255_I	261_V	0.536	0.47
43_E	161_E	0.536	0.47
151_G	157_Y	0.535	0.47
188_A	191_L	0.535	0.47
210_T	217_Y	0.535	0.47
31_W	171_W	0.534	0.46
35_V	326_L	0.534	0.46
35_V	161_E	0.534	0.46
280_F	313_F	0.532	0.46
37_L	115_F	0.532	0.46
48_L	191_L	0.530	0.46
34_Y	140_R	0.529	0.46
111_R	157_Y	0.529	0.46
37_L	153_F	0.527	0.46
152_I	262_L	0.526	0.45
38_A	158_S	0.526	0.45
108_W	112_G	0.526	0.45
25_I	32_G	0.521	0.45
270_G	273_S	0.521	0.45
25_I	38_A	0.520	0.45
305_Y	308_V	0.520	0.45
213_K	216_F	0.520	0.45
211_L	222_I	0.520	0.45
261_V	266_I	0.520	0.45
256_D	259_L	0.519	0.45
44_I	123_S	0.517	0.44
311_A	314_A	0.516	0.44
46_G	188_A	0.516	0.44
144_A	184_G	0.511	0.44
28_Y	181_L	0.510	0.43
55_M	70_V	0.510	0.43
114_I	117_G	0.508	0.43
91_T	150_A	0.508	0.43
197_L	201_N	0.507	0.43
283_R	287_P	0.507	0.43
218_S	224_A	0.506	0.43
137_R	140_R	0.502	0.43
168_I	177_P	0.502	0.43
272_M	277_F	0.501	0.42
87_L	152_I	0.500	0.42

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2vpzC	2	0.6899	100	0.456	Contact Map
4l35A	3	0.257	7.7	0.967	Contact Map
4o6yA	2	0.5251	7.4	0.967	Contact Map
2cfqA	1	0.514	7.1	0.968	Contact Map
2kncA	1	0.1341	7.1	0.968	Contact Map
4i0uA	4	0.1648	5.9	0.969	Contact Map
4ev6A	3	0.1704	5.5	0.969	Contact Map
4fbzA	3	0.257	4.9	0.97	Contact Map
4hyjA	2	0.2654	4.4	0.971	Contact Map
2wswA	3	0.3408	3.2	0.973	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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