GREMLIN Database
Q97V32 - Alcohol dehydrogenase (Zn containing) (Adh-12)
UniProt: Q97V32 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 331 (295)
Sequences: 52626 (36335)
Seq/√Len: 2115.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
310_E313_E3.0371.00
35_K139_W2.9441.00
33_R68_V2.8741.00
35_K66_E2.7881.00
31_L68_V2.7121.00
30_V130_V2.6261.00
138_T141_M2.5971.00
166_T190_K2.5611.00
185_K206_D2.5401.00
82_R133_L2.4451.00
81_D132_K2.4231.00
78_S81_D2.4171.00
306_F317_E2.4051.00
217_K220_E2.3821.00
33_R66_E2.2731.00
162_S165_Q2.2671.00
140_E305_I2.2451.00
22_N122_Y2.2331.00
33_R122_Y2.2041.00
172_A193_A2.1961.00
304_K317_E2.1801.00
190_K207_F2.1661.00
63_F118_G2.1471.00
167_L184_G2.1461.00
76_S127_E2.1411.00
293_D297_D2.1341.00
6_T18_T2.1311.00
197_K201_R2.0861.00
307_K310_E2.0821.00
28_H73_H2.0371.00
198_S202_G2.0351.00
27_N72_D2.0211.00
26_G29_E2.0151.00
136_E296_K1.9971.00
157_K187_F1.9651.00
181_V205_A1.9651.00
63_F85_I1.9511.00
27_N73_H1.9401.00
82_R139_W1.9221.00
64_S139_W1.9171.00
24_E69_K1.9131.00
316_K320_S1.8911.00
198_S201_R1.8531.00
165_Q251_K1.8511.00
149_A179_F1.8281.00
31_L124_A1.8101.00
157_K290_E1.7911.00
48_E319_F1.7881.00
68_V122_Y1.7711.00
313_E316_K1.7701.00
168_V227_A1.7661.00
168_V194_V1.7491.00
306_F314_A1.7291.00
186_K299_K1.7181.00
228_D247_G1.7131.00
133_L139_W1.7081.00
251_K276_S1.6711.00
313_E317_E1.6661.00
317_E322_E1.6591.00
192_I227_A1.6521.00
197_K208_V1.6191.00
71_G74_V1.6171.00
170_F242_S1.5991.00
246_L252_L1.5961.00
133_L142_G1.5851.00
5_L311_G1.5681.00
77_V132_K1.5661.00
70_V79_V1.5461.00
199_W202_G1.5461.00
29_E126_E1.5321.00
159_A229_V1.5311.00
251_K278_L1.5241.00
246_L275_I1.5201.00
190_K206_D1.5181.00
69_K79_V1.4911.00
207_F221_I1.4891.00
31_L122_Y1.4791.00
119_W315_L1.4741.00
246_L250_G1.4721.00
25_I124_A1.4691.00
34_V63_F1.4591.00
77_V81_D1.4481.00
82_R135_N1.4451.00
28_H126_E1.4221.00
213_E216_E1.4221.00
29_E124_A1.4101.00
66_E82_R1.3941.00
25_I31_L1.3881.00
36_L140_E1.3841.00
230_V242_S1.3711.00
67_V77_V1.3641.00
312_K316_K1.3551.00
230_V246_L1.3521.00
47_V315_L1.3351.00
30_V77_V1.3141.00
181_V193_A1.3121.00
31_L69_K1.3071.00
216_E220_E1.2941.00
293_D296_K1.2791.00
66_E139_W1.2701.00
303_W317_E1.2601.00
4_A20_Y1.2471.00
166_T192_I1.2451.00
180_L231_I1.2451.00
5_L17_F1.2421.00
186_K294_I1.2361.00
153_Y157_K1.2251.00
170_F194_V1.2101.00
161_L189_A1.2041.00
197_K210_D1.1821.00
77_V130_V1.1781.00
35_K82_R1.1751.00
166_T228_D1.1441.00
25_I29_E1.1421.00
22_N31_L1.1421.00
182_Q301_K1.1381.00
201_R208_V1.1321.00
125_V130_V1.1301.00
68_V79_V1.1181.00
290_E293_D1.1051.00
217_K221_I1.1041.00
159_A253_V1.1021.00
285_R289_I1.1021.00
28_H127_E1.0931.00
34_V123_V1.0851.00
213_E217_K1.0711.00
32_I65_G1.0701.00
165_Q228_D1.0641.00
39_V314_A1.0641.00
17_F309_E1.0621.00
141_M301_K1.0621.00
5_L308_L1.0591.00
193_A205_A1.0551.00
137_Y142_G1.0501.00
47_V319_F1.0481.00
244_S269_Q1.0421.00
154_H287_D1.0401.00
157_K287_D1.0381.00
32_I83_V1.0351.00
234_L238_F1.0321.00
36_L139_W1.0251.00
294_I299_K1.0161.00
311_G329_L1.0101.00
152_A183_L1.0091.00
289_I293_D1.0081.00
40_N62_E1.0011.00
10_N55_I1.0001.00
192_I207_F0.9981.00
199_W324_D0.9971.00
35_K64_S0.9951.00
37_A119_W0.9891.00
40_N61_V0.9891.00
152_A180_L0.9861.00
6_T20_Y0.9851.00
6_T58_I0.9671.00
119_W311_G0.9601.00
70_V74_V0.9571.00
149_A291_L0.9551.00
184_G189_A0.9511.00
232_N235_G0.9401.00
215_E244_S0.9371.00
240_D244_S0.9351.00
74_V127_E0.9351.00
4_A58_I0.9341.00
155_A255_F0.9301.00
172_A195_S0.9271.00
317_E327_I0.9261.00
75_K127_E0.9241.00
22_N69_K0.9231.00
37_A118_G0.9211.00
316_K319_F0.9181.00
201_R207_F0.9171.00
161_L165_Q0.9161.00
44_Y318_L0.9151.00
169_V180_L0.9121.00
183_L291_L0.9101.00
222_T226_M0.9101.00
181_V191_V0.9081.00
57_H116_N0.9021.00
33_R121_E0.8961.00
153_Y290_E0.8941.00
24_E31_L0.8931.00
169_V184_G0.8901.00
78_S132_K0.8891.00
178_M199_W0.8871.00
28_H71_G0.8871.00
170_F230_V0.8871.00
194_V211_Y0.8841.00
168_V245_V0.8831.00
269_Q273_K0.8831.00
215_E219_K0.8821.00
145_L295_C0.8781.00
241_K244_S0.8731.00
38_G62_E0.8691.00
172_A181_V0.8651.00
166_T227_A0.8571.00
202_G301_K0.8541.00
155_A231_I0.8521.00
165_Q229_V0.8491.00
5_L15_L0.8471.00
20_Y116_N0.8461.00
286_K290_E0.8461.00
249_R274_H0.8451.00
63_F123_V0.8441.00
22_N68_V0.8441.00
318_L327_I0.8401.00
119_W329_L0.8401.00
215_E241_K0.8361.00
84_T292_L0.8361.00
270_L277_I0.8291.00
195_S208_V0.8241.00
36_L328_F0.8241.00
222_T225_K0.8111.00
135_N296_K0.8111.00
290_E294_I0.8101.00
5_L312_K0.8091.00
150_L287_D0.8071.00
172_A200_L0.8041.00
28_H72_D0.8031.00
218_V227_A0.8011.00
193_A200_L0.8011.00
192_I209_V0.7991.00
196_R324_D0.7951.00
156_L184_G0.7911.00
183_L294_I0.7901.00
39_V318_L0.7881.00
152_A179_F0.7851.00
306_F310_E0.7791.00
40_N43_D0.7791.00
215_E245_V0.7781.00
187_F290_E0.7731.00
155_A180_L0.7731.00
17_F308_L0.7691.00
213_E241_K0.7651.00
152_A176_T0.7651.00
286_K289_I0.7611.00
26_G124_A0.7601.00
270_L275_I0.7581.00
242_S252_L0.7561.00
197_K200_L0.7561.00
42_V61_V0.7541.00
7_F14_N0.7521.00
157_K183_L0.7501.00
195_S200_L0.7481.00
137_Y295_C0.7471.00
39_V119_W0.7461.00
223_N226_M0.7451.00
83_V130_V0.7451.00
230_V252_L0.7451.00
294_I297_D0.7451.00
167_L189_A0.7451.00
85_I125_V0.7441.00
160_Q251_K0.7401.00
161_L229_V0.7351.00
214_V241_K0.7331.00
70_V78_S0.7321.00
40_N147_V0.7321.00
200_L205_A0.7281.00
154_H274_H0.7281.00
294_I298_C0.7251.00
266_D269_Q0.7241.00
197_K211_Y0.7231.00
216_E219_K0.7201.00
166_T225_K0.7201.00
170_F238_F0.7201.00
134_P296_K0.7171.00
62_E147_V0.7161.00
304_K313_E0.7151.00
317_E320_S0.7151.00
36_L305_I0.7141.00
20_Y58_I0.7121.00
11_G14_N0.7091.00
306_F329_L0.7081.00
131_F289_I0.7071.00
25_I69_K0.7071.00
192_I221_I0.7061.00
233_S255_F0.7061.00
225_K247_G0.7041.00
84_T133_L0.7041.00
304_K327_I0.7021.00
195_S210_D0.7001.00
254_T277_I0.6981.00
192_I218_V0.6971.00
229_V253_V0.6951.00
184_G191_V0.6941.00
13_E316_K0.6921.00
227_A230_V0.6921.00
237_Q241_K0.6921.00
82_R136_E0.6911.00
118_G123_V0.6901.00
64_S143_S0.6881.00
219_K226_M0.6881.00
30_V127_E0.6871.00
323_R327_I0.6861.00
25_I71_G0.6851.00
219_K222_T0.6771.00
270_L279_G0.6761.00
248_V273_K0.6751.00
152_A156_L0.6751.00
153_Y291_L0.6711.00
61_V147_V0.6711.00
127_E130_V0.6671.00
131_F288_F0.6651.00
10_N14_N0.6651.00
76_S132_K0.6641.00
189_A229_V0.6641.00
181_V203_Y0.6641.00
169_V193_A0.6621.00
199_W203_Y0.6601.00
151_T176_T0.6581.00
191_V206_D0.6581.00
32_I85_I0.6571.00
195_S211_Y0.6561.00
64_S133_L0.6531.00
23_P124_A0.6511.00
160_Q278_L0.6511.00
159_A251_K0.6511.00
292_L296_K0.6511.00
30_V67_V0.6511.00
131_F292_L0.6491.00
185_K191_V0.6451.00
36_L64_S0.6451.00
40_N148_A0.6451.00
84_T146_T0.6441.00
239_W252_L0.6431.00
153_Y294_I0.6431.00
148_A175_N0.6421.00
41_P45_Y0.6391.00
306_F327_I0.6361.00
227_A245_V0.6361.00
81_D135_N0.6361.00
182_Q203_Y0.6351.00
76_S285_R0.6351.00
42_V46_T0.6301.00
240_D262_N0.6301.00
194_V209_V0.6271.00
28_H128_K0.6271.00
147_V151_T0.6251.00
218_V245_V0.6251.00
315_L319_F0.6251.00
158_E276_S0.6241.00
64_S82_R0.6181.00
34_V37_A0.6181.00
263_V266_D0.6151.00
160_Q276_S0.6131.00
232_N252_L0.6111.00
76_S79_V0.6091.00
167_L229_V0.6061.00
144_S328_F0.6041.00
23_P122_Y0.6011.00
238_F242_S0.6001.00
183_L187_F0.5921.00
22_N25_I0.5901.00
240_D269_Q0.5901.00
230_V245_V0.5851.00
229_V251_K0.5841.00
232_N256_G0.5821.00
138_T142_G0.5821.00
86_Y131_F0.5811.00
23_P31_L0.5801.00
85_I130_V0.5791.00
25_I73_H0.5791.00
60_G119_W0.5791.00
144_S302_T0.5771.00
317_E323_R0.5771.00
180_L255_F0.5761.00
22_N124_A0.5751.00
75_K78_S0.5741.00
295_C302_T0.5731.00
56_P60_G0.5721.00
240_D264_K0.5701.00
153_Y287_D0.5691.00
151_T255_F0.5691.00
41_P174_G0.5681.00
274_H284_N0.5671.00
131_F285_R0.5641.00
148_A179_F0.5631.00
44_Y319_F0.5621.00
42_V45_Y0.5611.00
192_I222_T0.5591.00
64_S142_G0.5551.00
156_L183_L0.5531.00
14_N312_K0.5521.00
158_E287_D0.5521.00
181_V200_L0.5511.00
201_R205_A0.5501.00
70_V81_D0.5501.00
34_V118_G0.5491.00
77_V127_E0.5491.00
163_P188_G0.5491.00
295_C300_V0.5481.00
209_V217_K0.5451.00
210_D213_E0.5441.00
205_A208_V0.5441.00
168_V230_V0.5431.00
209_V221_I0.5431.00
179_F183_L0.5411.00
155_A280_V0.5401.00
237_Q240_D0.5391.00
214_V218_V0.5381.00
126_E129_Y0.5371.00
21_K24_E0.5371.00
298_C301_K0.5361.00
32_I130_V0.5361.00
306_F313_E0.5341.00
34_V85_I0.5331.00
17_F311_G0.5321.00
253_V280_V0.5321.00
185_K205_A0.5301.00
10_N16_K0.5301.00
200_L208_V0.5291.00
23_P29_E0.5291.00
154_H158_E0.5291.00
54_P57_H0.5281.00
178_M203_Y0.5281.00
196_R322_E0.5251.00
207_F210_D0.5241.00
262_N266_D0.5231.00
207_F217_K0.5231.00
15_L315_L0.5221.00
182_Q300_V0.5211.00
138_T305_I0.5211.00
37_A329_L0.5211.00
14_N47_V0.5211.00
58_I117_G0.5181.00
44_Y48_E0.5151.00
153_Y187_F0.5141.00
287_D290_E0.5141.00
304_K310_E0.5131.00
196_R200_L0.5111.00
160_Q165_Q0.5091.00
85_I123_V0.5081.00
261_G264_K0.5081.00
209_V214_V0.5081.00
146_T288_F0.5071.00
32_I63_F0.5061.00
271_Y279_G0.5061.00
25_I28_H0.5051.00
164_S189_A0.5031.00
169_V181_V0.5021.00
242_S246_L0.5011.00
208_V211_Y0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1h2bA 4 0.9849 100 0.169 Contact Map
4gi2A 2 1 100 0.174 Contact Map
2h6eA 4 0.9215 100 0.181 Contact Map
3jv7A 4 0.9849 100 0.182 Contact Map
4ej6A 1 0.9789 100 0.186 Contact Map
4jbgA 4 0.9728 100 0.186 Contact Map
4cpdA 2 0.9819 100 0.186 Contact Map
1rjwA 4 0.9849 100 0.187 Contact Map
4c4oA 4 0.9728 100 0.187 Contact Map
2eihA 4 0.997 100 0.189 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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