Q97V32 - SULSO - GREMLIN Contacts

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Q97V32 - Alcohol dehydrogenase (Zn containing) (Adh-12)

UniProt:	Q97V32	Sequences: MMKALTFDKNGIENLKFTDYKNPEIGNHEVLIRVKLAGVNPVDYYTVERLKVNPIPHIPGVEFSGEVVKVGDHVKSVSVGDRVTIYGRIFDGTCDMCMAGYETVCRNGGRIGVDANGGWAEYVAVEEKYVFKLPNEYTWEMGSSLTVAALTAYHALKEAQLSPSQTLVVFGASGNTGMFLVQLGKKFGAKVIAVSRKSWLRGYGADFVVDYNEVEEKVKEITNGKMADVVINSLGEQFWDKSFSVLGVRGKLVTFGTLLGGNVKVDLSQLYSKHISILGVNRGNRKDFIELLDICKDCKVKTWKIFKLEEGKEALKELFSKERDGRIFLYP	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	331 (295)
Sequences:	52626 (36335)
Seq/√Len:	2115.5

ECOLI - YBDR GATD YDJL AHR FRMA ADHP YAHK YPHC YGGP RSPB YJJN TDH QOR1 YDJJ IDND ACUI YCJQ CURA
BACSU - ADHB YJMD YOGA DHSO YYCR TDH ADHA BDHA YHFP YFMJ
HALSA - Q9HP38 Q9HMB6 GLCDH Q9HR85 Q9HQS8
SULSO - Q97V32 Q97WA1 Q7LXK1 ADH Q97YT7 Q97XR4 Q97ZV3 Q97YM2 Q97VV5 Q97VW0 GLCD2 Q97TZ4 GLCD1 Q97W06 GLCD3 Q97UW5 Q97VB8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
310_E	313_E	3.037	1.00
35_K	139_W	2.944	1.00
33_R	68_V	2.874	1.00
35_K	66_E	2.788	1.00
31_L	68_V	2.712	1.00
30_V	130_V	2.626	1.00
138_T	141_M	2.597	1.00
166_T	190_K	2.561	1.00
185_K	206_D	2.540	1.00
82_R	133_L	2.445	1.00
81_D	132_K	2.423	1.00
78_S	81_D	2.417	1.00
306_F	317_E	2.405	1.00
217_K	220_E	2.382	1.00
33_R	66_E	2.273	1.00
162_S	165_Q	2.267	1.00
140_E	305_I	2.245	1.00
22_N	122_Y	2.233	1.00
33_R	122_Y	2.204	1.00
172_A	193_A	2.196	1.00
304_K	317_E	2.180	1.00
190_K	207_F	2.166	1.00
63_F	118_G	2.147	1.00
167_L	184_G	2.146	1.00
76_S	127_E	2.141	1.00
293_D	297_D	2.134	1.00
6_T	18_T	2.131	1.00
197_K	201_R	2.086	1.00
307_K	310_E	2.082	1.00
28_H	73_H	2.037	1.00
198_S	202_G	2.035	1.00
27_N	72_D	2.021	1.00
26_G	29_E	2.015	1.00
136_E	296_K	1.997	1.00
157_K	187_F	1.965	1.00
181_V	205_A	1.965	1.00
63_F	85_I	1.951	1.00
27_N	73_H	1.940	1.00
82_R	139_W	1.922	1.00
64_S	139_W	1.917	1.00
24_E	69_K	1.913	1.00
316_K	320_S	1.891	1.00
198_S	201_R	1.853	1.00
165_Q	251_K	1.851	1.00
149_A	179_F	1.828	1.00
31_L	124_A	1.810	1.00
157_K	290_E	1.791	1.00
48_E	319_F	1.788	1.00
68_V	122_Y	1.771	1.00
313_E	316_K	1.770	1.00
168_V	227_A	1.766	1.00
168_V	194_V	1.749	1.00
306_F	314_A	1.729	1.00
186_K	299_K	1.718	1.00
228_D	247_G	1.713	1.00
133_L	139_W	1.708	1.00
251_K	276_S	1.671	1.00
313_E	317_E	1.666	1.00
317_E	322_E	1.659	1.00
192_I	227_A	1.652	1.00
197_K	208_V	1.619	1.00
71_G	74_V	1.617	1.00
170_F	242_S	1.599	1.00
246_L	252_L	1.596	1.00
133_L	142_G	1.585	1.00
5_L	311_G	1.568	1.00
77_V	132_K	1.566	1.00
70_V	79_V	1.546	1.00
199_W	202_G	1.546	1.00
29_E	126_E	1.532	1.00
159_A	229_V	1.531	1.00
251_K	278_L	1.524	1.00
246_L	275_I	1.520	1.00
190_K	206_D	1.518	1.00
69_K	79_V	1.491	1.00
207_F	221_I	1.489	1.00
31_L	122_Y	1.479	1.00
119_W	315_L	1.474	1.00
246_L	250_G	1.472	1.00
25_I	124_A	1.469	1.00
34_V	63_F	1.459	1.00
77_V	81_D	1.448	1.00
82_R	135_N	1.445	1.00
28_H	126_E	1.422	1.00
213_E	216_E	1.422	1.00
29_E	124_A	1.410	1.00
66_E	82_R	1.394	1.00
25_I	31_L	1.388	1.00
36_L	140_E	1.384	1.00
230_V	242_S	1.371	1.00
67_V	77_V	1.364	1.00
312_K	316_K	1.355	1.00
230_V	246_L	1.352	1.00
47_V	315_L	1.335	1.00
30_V	77_V	1.314	1.00
181_V	193_A	1.312	1.00
31_L	69_K	1.307	1.00
216_E	220_E	1.294	1.00
293_D	296_K	1.279	1.00
66_E	139_W	1.270	1.00
303_W	317_E	1.260	1.00
4_A	20_Y	1.247	1.00
166_T	192_I	1.245	1.00
180_L	231_I	1.245	1.00
5_L	17_F	1.242	1.00
186_K	294_I	1.236	1.00
153_Y	157_K	1.225	1.00
170_F	194_V	1.210	1.00
161_L	189_A	1.204	1.00
197_K	210_D	1.182	1.00
77_V	130_V	1.178	1.00
35_K	82_R	1.175	1.00
166_T	228_D	1.144	1.00
25_I	29_E	1.142	1.00
22_N	31_L	1.142	1.00
182_Q	301_K	1.138	1.00
201_R	208_V	1.132	1.00
125_V	130_V	1.130	1.00
68_V	79_V	1.118	1.00
290_E	293_D	1.105	1.00
217_K	221_I	1.104	1.00
159_A	253_V	1.102	1.00
285_R	289_I	1.102	1.00
28_H	127_E	1.093	1.00
34_V	123_V	1.085	1.00
213_E	217_K	1.071	1.00
32_I	65_G	1.070	1.00
165_Q	228_D	1.064	1.00
39_V	314_A	1.064	1.00
17_F	309_E	1.062	1.00
141_M	301_K	1.062	1.00
5_L	308_L	1.059	1.00
193_A	205_A	1.055	1.00
137_Y	142_G	1.050	1.00
47_V	319_F	1.048	1.00
244_S	269_Q	1.042	1.00
154_H	287_D	1.040	1.00
157_K	287_D	1.038	1.00
32_I	83_V	1.035	1.00
234_L	238_F	1.032	1.00
36_L	139_W	1.025	1.00
294_I	299_K	1.016	1.00
311_G	329_L	1.010	1.00
152_A	183_L	1.009	1.00
289_I	293_D	1.008	1.00
40_N	62_E	1.001	1.00
10_N	55_I	1.000	1.00
192_I	207_F	0.998	1.00
199_W	324_D	0.997	1.00
35_K	64_S	0.995	1.00
37_A	119_W	0.989	1.00
40_N	61_V	0.989	1.00
152_A	180_L	0.986	1.00
6_T	20_Y	0.985	1.00
6_T	58_I	0.967	1.00
119_W	311_G	0.960	1.00
70_V	74_V	0.957	1.00
149_A	291_L	0.955	1.00
184_G	189_A	0.951	1.00
232_N	235_G	0.940	1.00
215_E	244_S	0.937	1.00
240_D	244_S	0.935	1.00
74_V	127_E	0.935	1.00
4_A	58_I	0.934	1.00
155_A	255_F	0.930	1.00
172_A	195_S	0.927	1.00
317_E	327_I	0.926	1.00
75_K	127_E	0.924	1.00
22_N	69_K	0.923	1.00
37_A	118_G	0.921	1.00
316_K	319_F	0.918	1.00
201_R	207_F	0.917	1.00
161_L	165_Q	0.916	1.00
44_Y	318_L	0.915	1.00
169_V	180_L	0.912	1.00
183_L	291_L	0.910	1.00
222_T	226_M	0.910	1.00
181_V	191_V	0.908	1.00
57_H	116_N	0.902	1.00
33_R	121_E	0.896	1.00
153_Y	290_E	0.894	1.00
24_E	31_L	0.893	1.00
169_V	184_G	0.890	1.00
78_S	132_K	0.889	1.00
178_M	199_W	0.887	1.00
28_H	71_G	0.887	1.00
170_F	230_V	0.887	1.00
194_V	211_Y	0.884	1.00
168_V	245_V	0.883	1.00
269_Q	273_K	0.883	1.00
215_E	219_K	0.882	1.00
145_L	295_C	0.878	1.00
241_K	244_S	0.873	1.00
38_G	62_E	0.869	1.00
172_A	181_V	0.865	1.00
166_T	227_A	0.857	1.00
202_G	301_K	0.854	1.00
155_A	231_I	0.852	1.00
165_Q	229_V	0.849	1.00
5_L	15_L	0.847	1.00
20_Y	116_N	0.846	1.00
286_K	290_E	0.846	1.00
249_R	274_H	0.845	1.00
63_F	123_V	0.844	1.00
22_N	68_V	0.844	1.00
318_L	327_I	0.840	1.00
119_W	329_L	0.840	1.00
215_E	241_K	0.836	1.00
84_T	292_L	0.836	1.00
270_L	277_I	0.829	1.00
195_S	208_V	0.824	1.00
36_L	328_F	0.824	1.00
222_T	225_K	0.811	1.00
135_N	296_K	0.811	1.00
290_E	294_I	0.810	1.00
5_L	312_K	0.809	1.00
150_L	287_D	0.807	1.00
172_A	200_L	0.804	1.00
28_H	72_D	0.803	1.00
218_V	227_A	0.801	1.00
193_A	200_L	0.801	1.00
192_I	209_V	0.799	1.00
196_R	324_D	0.795	1.00
156_L	184_G	0.791	1.00
183_L	294_I	0.790	1.00
39_V	318_L	0.788	1.00
152_A	179_F	0.785	1.00
306_F	310_E	0.779	1.00
40_N	43_D	0.779	1.00
215_E	245_V	0.778	1.00
187_F	290_E	0.773	1.00
155_A	180_L	0.773	1.00
17_F	308_L	0.769	1.00
213_E	241_K	0.765	1.00
152_A	176_T	0.765	1.00
286_K	289_I	0.761	1.00
26_G	124_A	0.760	1.00
270_L	275_I	0.758	1.00
242_S	252_L	0.756	1.00
197_K	200_L	0.756	1.00
42_V	61_V	0.754	1.00
7_F	14_N	0.752	1.00
157_K	183_L	0.750	1.00
195_S	200_L	0.748	1.00
137_Y	295_C	0.747	1.00
39_V	119_W	0.746	1.00
223_N	226_M	0.745	1.00
83_V	130_V	0.745	1.00
230_V	252_L	0.745	1.00
294_I	297_D	0.745	1.00
167_L	189_A	0.745	1.00
85_I	125_V	0.744	1.00
160_Q	251_K	0.740	1.00
161_L	229_V	0.735	1.00
214_V	241_K	0.733	1.00
70_V	78_S	0.732	1.00
40_N	147_V	0.732	1.00
200_L	205_A	0.728	1.00
154_H	274_H	0.728	1.00
294_I	298_C	0.725	1.00
266_D	269_Q	0.724	1.00
197_K	211_Y	0.723	1.00
216_E	219_K	0.720	1.00
166_T	225_K	0.720	1.00
170_F	238_F	0.720	1.00
134_P	296_K	0.717	1.00
62_E	147_V	0.716	1.00
304_K	313_E	0.715	1.00
317_E	320_S	0.715	1.00
36_L	305_I	0.714	1.00
20_Y	58_I	0.712	1.00
11_G	14_N	0.709	1.00
306_F	329_L	0.708	1.00
131_F	289_I	0.707	1.00
25_I	69_K	0.707	1.00
192_I	221_I	0.706	1.00
233_S	255_F	0.706	1.00
225_K	247_G	0.704	1.00
84_T	133_L	0.704	1.00
304_K	327_I	0.702	1.00
195_S	210_D	0.700	1.00
254_T	277_I	0.698	1.00
192_I	218_V	0.697	1.00
229_V	253_V	0.695	1.00
184_G	191_V	0.694	1.00
13_E	316_K	0.692	1.00
227_A	230_V	0.692	1.00
237_Q	241_K	0.692	1.00
82_R	136_E	0.691	1.00
118_G	123_V	0.690	1.00
64_S	143_S	0.688	1.00
219_K	226_M	0.688	1.00
30_V	127_E	0.687	1.00
323_R	327_I	0.686	1.00
25_I	71_G	0.685	1.00
219_K	222_T	0.677	1.00
270_L	279_G	0.676	1.00
248_V	273_K	0.675	1.00
152_A	156_L	0.675	1.00
153_Y	291_L	0.671	1.00
61_V	147_V	0.671	1.00
127_E	130_V	0.667	1.00
131_F	288_F	0.665	1.00
10_N	14_N	0.665	1.00
76_S	132_K	0.664	1.00
189_A	229_V	0.664	1.00
181_V	203_Y	0.664	1.00
169_V	193_A	0.662	1.00
199_W	203_Y	0.660	1.00
151_T	176_T	0.658	1.00
191_V	206_D	0.658	1.00
32_I	85_I	0.657	1.00
195_S	211_Y	0.656	1.00
64_S	133_L	0.653	1.00
23_P	124_A	0.651	1.00
160_Q	278_L	0.651	1.00
159_A	251_K	0.651	1.00
292_L	296_K	0.651	1.00
30_V	67_V	0.651	1.00
131_F	292_L	0.649	1.00
185_K	191_V	0.645	1.00
36_L	64_S	0.645	1.00
40_N	148_A	0.645	1.00
84_T	146_T	0.644	1.00
239_W	252_L	0.643	1.00
153_Y	294_I	0.643	1.00
148_A	175_N	0.642	1.00
41_P	45_Y	0.639	1.00
306_F	327_I	0.636	1.00
227_A	245_V	0.636	1.00
81_D	135_N	0.636	1.00
182_Q	203_Y	0.635	1.00
76_S	285_R	0.635	1.00
42_V	46_T	0.630	1.00
240_D	262_N	0.630	1.00
194_V	209_V	0.627	1.00
28_H	128_K	0.627	1.00
147_V	151_T	0.625	1.00
218_V	245_V	0.625	1.00
315_L	319_F	0.625	1.00
158_E	276_S	0.624	1.00
64_S	82_R	0.618	1.00
34_V	37_A	0.618	1.00
263_V	266_D	0.615	1.00
160_Q	276_S	0.613	1.00
232_N	252_L	0.611	1.00
76_S	79_V	0.609	1.00
167_L	229_V	0.606	1.00
144_S	328_F	0.604	1.00
23_P	122_Y	0.601	1.00
238_F	242_S	0.600	1.00
183_L	187_F	0.592	1.00
22_N	25_I	0.590	1.00
240_D	269_Q	0.590	1.00
230_V	245_V	0.585	1.00
229_V	251_K	0.584	1.00
232_N	256_G	0.582	1.00
138_T	142_G	0.582	1.00
86_Y	131_F	0.581	1.00
23_P	31_L	0.580	1.00
85_I	130_V	0.579	1.00
25_I	73_H	0.579	1.00
60_G	119_W	0.579	1.00
144_S	302_T	0.577	1.00
317_E	323_R	0.577	1.00
180_L	255_F	0.576	1.00
22_N	124_A	0.575	1.00
75_K	78_S	0.574	1.00
295_C	302_T	0.573	1.00
56_P	60_G	0.572	1.00
240_D	264_K	0.570	1.00
153_Y	287_D	0.569	1.00
151_T	255_F	0.569	1.00
41_P	174_G	0.568	1.00
274_H	284_N	0.567	1.00
131_F	285_R	0.564	1.00
148_A	179_F	0.563	1.00
44_Y	319_F	0.562	1.00
42_V	45_Y	0.561	1.00
192_I	222_T	0.559	1.00
64_S	142_G	0.555	1.00
156_L	183_L	0.553	1.00
14_N	312_K	0.552	1.00
158_E	287_D	0.552	1.00
181_V	200_L	0.551	1.00
201_R	205_A	0.550	1.00
70_V	81_D	0.550	1.00
34_V	118_G	0.549	1.00
77_V	127_E	0.549	1.00
163_P	188_G	0.549	1.00
295_C	300_V	0.548	1.00
209_V	217_K	0.545	1.00
210_D	213_E	0.544	1.00
205_A	208_V	0.544	1.00
168_V	230_V	0.543	1.00
209_V	221_I	0.543	1.00
179_F	183_L	0.541	1.00
155_A	280_V	0.540	1.00
237_Q	240_D	0.539	1.00
214_V	218_V	0.538	1.00
126_E	129_Y	0.537	1.00
21_K	24_E	0.537	1.00
298_C	301_K	0.536	1.00
32_I	130_V	0.536	1.00
306_F	313_E	0.534	1.00
34_V	85_I	0.533	1.00
17_F	311_G	0.532	1.00
253_V	280_V	0.532	1.00
185_K	205_A	0.530	1.00
10_N	16_K	0.530	1.00
200_L	208_V	0.529	1.00
23_P	29_E	0.529	1.00
154_H	158_E	0.529	1.00
54_P	57_H	0.528	1.00
178_M	203_Y	0.528	1.00
196_R	322_E	0.525	1.00
207_F	210_D	0.524	1.00
262_N	266_D	0.523	1.00
207_F	217_K	0.523	1.00
15_L	315_L	0.522	1.00
182_Q	300_V	0.521	1.00
138_T	305_I	0.521	1.00
37_A	329_L	0.521	1.00
14_N	47_V	0.521	1.00
58_I	117_G	0.518	1.00
44_Y	48_E	0.515	1.00
153_Y	187_F	0.514	1.00
287_D	290_E	0.514	1.00
304_K	310_E	0.513	1.00
196_R	200_L	0.511	1.00
160_Q	165_Q	0.509	1.00
85_I	123_V	0.508	1.00
261_G	264_K	0.508	1.00
209_V	214_V	0.508	1.00
146_T	288_F	0.507	1.00
32_I	63_F	0.506	1.00
271_Y	279_G	0.506	1.00
25_I	28_H	0.505	1.00
164_S	189_A	0.503	1.00
169_V	181_V	0.502	1.00
242_S	246_L	0.501	1.00
208_V	211_Y	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1h2bA	4	0.9849	100	0.169	Contact Map
4gi2A	2	1	100	0.174	Contact Map
2h6eA	4	0.9215	100	0.181	Contact Map
3jv7A	4	0.9849	100	0.182	Contact Map
4ej6A	1	0.9789	100	0.186	Contact Map
4jbgA	4	0.9728	100	0.186	Contact Map
4cpdA	2	0.9819	100	0.186	Contact Map
1rjwA	4	0.9849	100	0.187	Contact Map
4c4oA	4	0.9728	100	0.187	Contact Map
2eihA	4	0.997	100	0.189	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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