GREMLIN Database
Q97V26 - Hydrolase, acetamydase/formamidase related, putative
UniProt: Q97V26 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 318 (289)
Sequences: 1487 (874)
Seq/√Len: 51.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
24_S68_K6.7491.00
190_L219_V5.8421.00
71_E186_N4.7161.00
31_V65_I4.3521.00
25_D220_R4.3151.00
79_E218_K4.0821.00
82_E175_V3.9801.00
71_E223_K3.8701.00
22_T68_K3.6591.00
81_L218_K3.6271.00
287_V304_A3.2891.00
195_T213_M3.2261.00
77_E178_K3.1811.00
233_V308_K3.1021.00
248_Y266_I3.0461.00
103_E264_K2.8541.00
77_E222_I2.7581.00
66_E189_L2.6481.00
79_E220_R2.6121.00
80_F146_I2.5901.00
77_E220_R2.5371.00
22_T66_E2.5191.00
170_I292_S2.4841.00
146_I190_L2.4791.00
74_D223_K2.3741.00
72_P186_N2.3661.00
76_L188_A2.3461.00
25_D69_G2.2701.00
125_Y136_K2.1301.00
29_I219_V2.0471.00
291_V302_V2.0431.00
25_D221_L2.0401.00
259_T289_L2.0041.00
67_V219_V2.0031.00
89_G209_I1.9831.00
10_H191_S1.8880.99
28_I81_L1.8770.99
23_I29_I1.8550.99
266_I306_L1.8510.99
148_T188_A1.8430.99
79_E178_K1.8340.99
34_K38_D1.8290.99
30_T216_T1.8270.99
143_P215_V1.8120.99
31_V192_I1.8020.99
23_I219_V1.7850.99
19_P189_L1.7540.99
209_I285_V1.7350.99
192_I217_V1.6950.99
100_L280_Y1.6730.98
84_R214_E1.6440.98
245_Y305_Y1.5970.98
165_G181_L1.5850.98
23_I27_D1.5570.97
142_F199_Q1.5420.97
28_I216_T1.5340.97
66_E187_G1.4790.97
259_T294_V1.4570.96
75_A227_L1.4510.96
229_Q265_G1.4250.96
161_P295_V1.4240.96
86_K212_P1.4160.96
149_G189_L1.4030.95
76_L148_T1.3910.95
292_S303_T1.3880.95
80_F217_V1.3810.95
201_D290_R1.3640.95
75_A225_V1.3620.95
192_I215_V1.3470.94
83_F175_V1.3250.94
117_K278_E1.3150.93
271_S276_P1.3130.93
104_Q276_P1.2920.93
67_V76_L1.2910.93
24_S27_D1.2830.93
23_I65_I1.2780.92
256_W300_W1.2710.92
204_V263_I1.2660.92
275_A278_E1.2620.92
78_V181_L1.2600.92
82_E216_T1.2550.92
75_A180_Y1.2270.91
307_P310_V1.2170.90
121_V211_A1.2120.90
131_G134_N1.1920.90
85_H211_A1.1870.89
80_F215_V1.1840.89
289_L304_A1.1810.89
77_E180_Y1.1710.89
25_D77_E1.1710.89
180_Y222_I1.1700.89
76_L190_L1.1690.89
174_T177_T1.1690.89
293_E301_I1.1560.88
74_D183_V1.1520.88
162_R299_N1.1400.87
252_D261_K1.1350.87
137_V198_A1.1340.87
197_L211_A1.1330.87
14_D155_K1.1290.87
147_G164_N1.1280.87
254_N257_N1.1250.87
28_I218_K1.1180.86
190_L217_V1.1040.86
72_P183_V1.0900.85
83_F143_P1.0810.84
97_F206_G1.0650.83
29_I65_I1.0570.83
21_L29_I1.0550.83
164_N184_F1.0400.82
179_L232_F1.0380.82
232_F249_P1.0380.82
115_A278_E1.0320.81
230_P234_T1.0190.81
257_N260_K1.0180.81
283_A307_P1.0150.80
171_K288_N1.0030.80
32_E214_E1.0030.80
41_V45_S0.9910.79
40_Q54_D0.9830.78
75_A222_I0.9750.78
173_L179_L0.9740.78
94_L205_C0.9640.77
172_H247_A0.9570.76
119_W209_I0.9570.76
208_A301_I0.9560.76
266_I283_A0.9540.76
290_R305_Y0.9530.76
246_I269_I0.9530.76
148_T184_F0.9510.76
78_V188_A0.9460.75
65_I219_V0.9450.75
31_V190_L0.9450.75
54_D57_K0.9410.75
70_A221_L0.9400.75
35_E60_P0.9370.75
206_G285_V0.9280.74
167_N203_E0.9240.74
19_P66_E0.9220.74
140_Y174_T0.9190.73
31_V219_V0.9180.73
255_L294_V0.9100.73
78_V179_L0.9090.72
128_A209_I0.9090.72
15_N154_G0.9070.72
244_E308_K0.9060.72
25_D219_V0.9000.72
252_D257_N0.9000.72
268_S276_P0.9000.72
10_H13_W0.8920.71
267_I280_Y0.8860.71
130_F135_V0.8690.69
170_I249_P0.8660.69
83_F195_T0.8650.69
31_V217_V0.8620.68
11_N59_H0.8550.68
248_Y306_L0.8550.68
59_H145_V0.8520.67
101_A206_G0.8500.67
83_F213_M0.8490.67
287_V306_L0.8480.67
208_A250_G0.8480.67
180_Y233_V0.8470.67
122_D125_Y0.8470.67
143_P195_T0.8470.67
119_W128_A0.8460.67
123_E126_A0.8460.67
156_L164_N0.8450.67
115_A277_V0.8420.67
61_L145_V0.8400.66
81_L216_T0.8390.66
59_H62_T0.8380.66
268_S272_K0.8380.66
14_D17_L0.8350.66
13_W17_L0.8320.66
235_K244_E0.8320.66
41_V118_I0.8280.65
140_Y171_K0.8240.65
90_W116_L0.8220.65
69_G221_L0.8150.64
135_V274_M0.8120.64
195_T215_V0.8080.63
245_Y307_P0.8070.63
102_D260_K0.8060.63
23_I67_V0.8050.63
231_L273_Y0.7990.62
251_I301_I0.7960.62
13_W205_C0.7960.62
248_Y265_G0.7960.62
29_I78_V0.7920.62
178_K220_R0.7900.62
202_G230_P0.7890.61
231_L269_I0.7890.61
37_S90_W0.7860.61
80_F143_P0.7840.61
159_I206_G0.7830.61
27_D219_V0.7820.61
178_K222_I0.7820.61
99_F294_V0.7800.61
293_E303_T0.7790.60
146_I219_V0.7780.60
198_A285_V0.7740.60
163_E184_F0.7720.60
161_P296_D0.7710.60
23_I31_V0.7700.60
205_C281_I0.7620.59
174_T235_K0.7590.58
248_Y269_I0.7540.58
20_I65_I0.7520.58
8_K60_P0.7500.58
134_N275_A0.7500.58
192_I219_V0.7490.57
70_A223_K0.7440.57
7_A291_V0.7390.56
50_L53_L0.7360.56
252_D299_N0.7340.56
222_I225_V0.7320.56
186_N221_L0.7320.56
85_H213_M0.7290.55
143_P192_I0.7270.55
119_W285_V0.7270.55
247_A290_R0.7270.55
229_Q261_K0.7220.55
12_K155_K0.7220.55
65_I192_I0.7210.55
271_S279_A0.7200.55
98_G284_S0.7120.54
83_F215_V0.7120.54
267_I283_A0.7100.53
209_I227_L0.7090.53
267_I276_P0.7070.53
205_C280_Y0.7070.53
48_K51_L0.7000.52
206_G300_W0.6990.52
228_T268_S0.6990.52
87_G123_E0.6990.52
292_S301_I0.6980.52
215_V258_A0.6980.52
148_T181_L0.6970.52
265_G268_S0.6880.51
207_T284_S0.6870.51
11_N38_D0.6860.51
25_D70_A0.6850.51
172_H290_R0.6840.51
137_V285_V0.6830.51
37_S58_I0.6820.51
26_G29_I0.6800.50
36_A208_A0.6790.50
80_F177_T0.6760.50
257_N261_K0.6750.50
89_G302_V0.6740.50
183_V219_V0.6740.50
128_A139_I0.6730.50
33_T83_F0.6720.50
282_L310_V0.6700.49
156_L162_R0.6690.49
293_E296_D0.6660.49
91_T119_W0.6660.49
209_I250_G0.6650.49
145_V293_E0.6640.49
96_G114_P0.6630.49
8_K11_N0.6630.49
27_D220_R0.6600.48
98_G101_A0.6600.48
143_P217_V0.6580.48
78_V219_V0.6540.48
177_T232_F0.6530.48
41_V92_G0.6530.48
143_P190_L0.6520.47
49_D53_L0.6490.47
269_I273_Y0.6480.47
113_G177_T0.6480.47
126_A130_F0.6480.47
199_Q208_A0.6480.47
251_I292_S0.6470.47
142_F208_A0.6460.47
32_E86_K0.6460.47
94_L97_F0.6450.47
83_F179_L0.6450.47
214_E221_L0.6440.47
124_K228_T0.6420.46
86_K214_E0.6410.46
270_L273_Y0.6390.46
116_L119_W0.6390.46
35_E59_H0.6390.46
21_L27_D0.6390.46
218_K264_K0.6350.46
127_Y136_K0.6350.46
262_A304_A0.6330.45
75_A226_G0.6320.45
70_A183_V0.6320.45
173_L232_F0.6300.45
88_W118_I0.6300.45
249_P292_S0.6290.45
9_T38_D0.6280.45
117_K130_F0.6280.45
9_T34_K0.6270.45
183_V223_K0.6270.45
95_P98_G0.6270.45
122_D126_A0.6260.45
99_F256_W0.6240.45
49_D52_K0.6210.44
260_K300_W0.6200.44
47_E51_L0.6190.44
140_Y198_A0.6180.44
71_E221_L0.6180.44
46_T49_D0.6160.44
59_H158_T0.6130.43
93_V277_V0.6130.43
289_L302_V0.6130.43
29_I217_V0.6120.43
288_N293_E0.6120.43
33_T62_T0.6110.43
20_I286_V0.6100.43
261_K265_G0.6100.43
129_K133_L0.6090.43
31_V246_I0.6080.43
96_G102_D0.6080.43
279_A289_L0.6070.43
10_H35_E0.6060.43
117_K281_I0.6050.43
115_A281_I0.6010.42
36_A60_P0.6010.42
36_A145_V0.6010.42
161_P294_V0.6010.42
66_E69_G0.6000.42
38_D57_K0.5990.42
255_L291_V0.5990.42
80_F192_I0.5980.42
168_M197_L0.5970.42
29_I190_L0.5970.42
42_T45_S0.5940.42
18_P312_D0.5920.41
13_W191_S0.5920.41
65_I190_L0.5920.41
59_H142_F0.5910.41
231_L265_G0.5880.41
39_G50_L0.5880.41
26_G70_A0.5870.41
224_N272_K0.5870.41
274_M282_L0.5870.41
90_W118_I0.5850.41
13_W147_G0.5850.41
244_E247_A0.5830.40
47_E50_L0.5830.40
96_G100_L0.5820.40
263_I283_A0.5800.40
88_W205_C0.5740.39
164_N191_S0.5740.39
30_T214_E0.5730.39
14_D197_L0.5730.39
150_L156_L0.5720.39
76_L221_L0.5710.39
167_N295_V0.5710.39
283_A287_V0.5700.39
104_Q267_I0.5670.39
263_I292_S0.5660.39
30_T65_I0.5640.39
277_V281_I0.5640.39
125_Y151_P0.5630.38
102_D159_I0.5630.38
168_M303_T0.5630.38
251_I303_T0.5610.38
146_I181_L0.5600.38
75_A148_T0.5570.38
137_V310_V0.5570.38
11_N57_K0.5560.38
159_I207_T0.5550.38
178_K312_D0.5540.38
33_T143_P0.5540.38
67_V222_I0.5530.37
15_N178_K0.5520.37
87_G120_K0.5520.37
100_L306_L0.5520.37
74_D221_L0.5510.37
162_R184_F0.5480.37
262_A289_L0.5480.37
160_P295_V0.5470.37
170_I251_I0.5460.37
59_H303_T0.5460.37
172_H305_Y0.5460.37
121_V126_A0.5420.36
58_I145_V0.5410.36
286_V310_V0.5400.36
199_Q203_E0.5390.36
60_P145_V0.5380.36
267_I271_S0.5370.36
118_I121_V0.5370.36
159_I208_A0.5360.36
113_G277_V0.5360.36
128_A131_G0.5340.36
114_P121_V0.5320.35
172_H292_S0.5310.35
78_V311_F0.5310.35
35_E119_W0.5290.35
66_E186_N0.5290.35
78_V190_L0.5280.35
174_T234_T0.5280.35
13_W145_V0.5280.35
23_I28_I0.5280.35
151_P184_F0.5270.35
91_T205_C0.5260.35
76_L219_V0.5240.35
11_N35_E0.5230.35
59_H301_I0.5220.34
244_E309_N0.5210.34
39_G206_G0.5200.34
39_G215_V0.5190.34
124_K268_S0.5170.34
147_G203_E0.5170.34
180_Y308_K0.5150.34
129_K291_V0.5150.34
259_T262_A0.5150.34
286_V306_L0.5140.34
87_G311_F0.5130.34
71_E127_Y0.5120.34
24_S186_N0.5100.33
66_E188_A0.5090.33
70_A188_A0.5090.33
160_P299_N0.5080.33
167_N293_E0.5070.33
121_V128_A0.5070.33
147_G185_V0.5070.33
52_K84_R0.5050.33
87_G305_Y0.5050.33
142_F283_A0.5040.33
252_D300_W0.5030.33
203_E295_V0.5020.33
58_I159_I0.5020.33
210_E295_V0.5020.33
251_I293_E0.5010.33
12_K17_L0.5010.33
138_P198_A0.5000.32
34_K221_L0.5000.32
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ii1A 2 0.9277 100 0.118 Contact Map
3tkkA 2 0.9277 100 0.118 Contact Map
2f4lA 2 0.8648 100 0.124 Contact Map
3b9tA 4 0.9371 100 0.174 Contact Map
2wknA 5 0.9686 100 0.187 Contact Map
1yezA 1 0.2138 53.1 0.965 Contact Map
1yvcA 1 0.2201 41.5 0.967 Contact Map
1id2A 1 0.2767 31.3 0.969 Contact Map
3c75A 1 0.2767 25.5 0.971 Contact Map
4kzsA 1 0.217 21.6 0.972 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0103 seconds.