Q97V26 - SULSO - GREMLIN Contacts

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Q97V26 - Hydrolase, acetamydase/formamidase related, putative

UniProt:	Q97V26	Sequences: MQYTIHAKTHNKWDNSLPPILTISDGDIITVETKEASDGQVTPSSTEKDLLKLDFSKIHPLTGPIEVKGAEPGDALEVEFLEFRHKGWGWTGVLPGFGFLADEQYTAPIDLQGPALKIWKVDEKYAYAKFGDLNVKVPIYPFPGVIGTGLPFRGKLSTIPPRENGGNMDIKHLTVGTKLYLPVFVNGALLSIGDTHLAQGDGEVCGTAIEAPMEVTVKVRLIKNVGLTQPLFVTKKVKEMEYDEYIAYPGIDSNLWNATKKAIKGIISILSKYMAPVEAYILASVVVNLRVSEVVDVPNWIVTAYLPKNVFDVNVEVL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	318 (289)
Sequences:	1487 (874)
Seq/√Len:	51.4

SULSO - Q97V26

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
24_S	68_K	6.749	1.00
190_L	219_V	5.842	1.00
71_E	186_N	4.716	1.00
31_V	65_I	4.352	1.00
25_D	220_R	4.315	1.00
79_E	218_K	4.082	1.00
82_E	175_V	3.980	1.00
71_E	223_K	3.870	1.00
22_T	68_K	3.659	1.00
81_L	218_K	3.627	1.00
287_V	304_A	3.289	1.00
195_T	213_M	3.226	1.00
77_E	178_K	3.181	1.00
233_V	308_K	3.102	1.00
248_Y	266_I	3.046	1.00
103_E	264_K	2.854	1.00
77_E	222_I	2.758	1.00
66_E	189_L	2.648	1.00
79_E	220_R	2.612	1.00
80_F	146_I	2.590	1.00
77_E	220_R	2.537	1.00
22_T	66_E	2.519	1.00
170_I	292_S	2.484	1.00
146_I	190_L	2.479	1.00
74_D	223_K	2.374	1.00
72_P	186_N	2.366	1.00
76_L	188_A	2.346	1.00
25_D	69_G	2.270	1.00
125_Y	136_K	2.130	1.00
29_I	219_V	2.047	1.00
291_V	302_V	2.043	1.00
25_D	221_L	2.040	1.00
259_T	289_L	2.004	1.00
67_V	219_V	2.003	1.00
89_G	209_I	1.983	1.00
10_H	191_S	1.888	0.99
28_I	81_L	1.877	0.99
23_I	29_I	1.855	0.99
266_I	306_L	1.851	0.99
148_T	188_A	1.843	0.99
79_E	178_K	1.834	0.99
34_K	38_D	1.829	0.99
30_T	216_T	1.827	0.99
143_P	215_V	1.812	0.99
31_V	192_I	1.802	0.99
23_I	219_V	1.785	0.99
19_P	189_L	1.754	0.99
209_I	285_V	1.735	0.99
192_I	217_V	1.695	0.99
100_L	280_Y	1.673	0.98
84_R	214_E	1.644	0.98
245_Y	305_Y	1.597	0.98
165_G	181_L	1.585	0.98
23_I	27_D	1.557	0.97
142_F	199_Q	1.542	0.97
28_I	216_T	1.534	0.97
66_E	187_G	1.479	0.97
259_T	294_V	1.457	0.96
75_A	227_L	1.451	0.96
229_Q	265_G	1.425	0.96
161_P	295_V	1.424	0.96
86_K	212_P	1.416	0.96
149_G	189_L	1.403	0.95
76_L	148_T	1.391	0.95
292_S	303_T	1.388	0.95
80_F	217_V	1.381	0.95
201_D	290_R	1.364	0.95
75_A	225_V	1.362	0.95
192_I	215_V	1.347	0.94
83_F	175_V	1.325	0.94
117_K	278_E	1.315	0.93
271_S	276_P	1.313	0.93
104_Q	276_P	1.292	0.93
67_V	76_L	1.291	0.93
24_S	27_D	1.283	0.93
23_I	65_I	1.278	0.92
256_W	300_W	1.271	0.92
204_V	263_I	1.266	0.92
275_A	278_E	1.262	0.92
78_V	181_L	1.260	0.92
82_E	216_T	1.255	0.92
75_A	180_Y	1.227	0.91
307_P	310_V	1.217	0.90
121_V	211_A	1.212	0.90
131_G	134_N	1.192	0.90
85_H	211_A	1.187	0.89
80_F	215_V	1.184	0.89
289_L	304_A	1.181	0.89
77_E	180_Y	1.171	0.89
25_D	77_E	1.171	0.89
180_Y	222_I	1.170	0.89
76_L	190_L	1.169	0.89
174_T	177_T	1.169	0.89
293_E	301_I	1.156	0.88
74_D	183_V	1.152	0.88
162_R	299_N	1.140	0.87
252_D	261_K	1.135	0.87
137_V	198_A	1.134	0.87
197_L	211_A	1.133	0.87
14_D	155_K	1.129	0.87
147_G	164_N	1.128	0.87
254_N	257_N	1.125	0.87
28_I	218_K	1.118	0.86
190_L	217_V	1.104	0.86
72_P	183_V	1.090	0.85
83_F	143_P	1.081	0.84
97_F	206_G	1.065	0.83
29_I	65_I	1.057	0.83
21_L	29_I	1.055	0.83
164_N	184_F	1.040	0.82
179_L	232_F	1.038	0.82
232_F	249_P	1.038	0.82
115_A	278_E	1.032	0.81
230_P	234_T	1.019	0.81
257_N	260_K	1.018	0.81
283_A	307_P	1.015	0.80
171_K	288_N	1.003	0.80
32_E	214_E	1.003	0.80
41_V	45_S	0.991	0.79
40_Q	54_D	0.983	0.78
75_A	222_I	0.975	0.78
173_L	179_L	0.974	0.78
94_L	205_C	0.964	0.77
172_H	247_A	0.957	0.76
119_W	209_I	0.957	0.76
208_A	301_I	0.956	0.76
266_I	283_A	0.954	0.76
290_R	305_Y	0.953	0.76
246_I	269_I	0.953	0.76
148_T	184_F	0.951	0.76
78_V	188_A	0.946	0.75
65_I	219_V	0.945	0.75
31_V	190_L	0.945	0.75
54_D	57_K	0.941	0.75
70_A	221_L	0.940	0.75
35_E	60_P	0.937	0.75
206_G	285_V	0.928	0.74
167_N	203_E	0.924	0.74
19_P	66_E	0.922	0.74
140_Y	174_T	0.919	0.73
31_V	219_V	0.918	0.73
255_L	294_V	0.910	0.73
78_V	179_L	0.909	0.72
128_A	209_I	0.909	0.72
15_N	154_G	0.907	0.72
244_E	308_K	0.906	0.72
25_D	219_V	0.900	0.72
252_D	257_N	0.900	0.72
268_S	276_P	0.900	0.72
10_H	13_W	0.892	0.71
267_I	280_Y	0.886	0.71
130_F	135_V	0.869	0.69
170_I	249_P	0.866	0.69
83_F	195_T	0.865	0.69
31_V	217_V	0.862	0.68
11_N	59_H	0.855	0.68
248_Y	306_L	0.855	0.68
59_H	145_V	0.852	0.67
101_A	206_G	0.850	0.67
83_F	213_M	0.849	0.67
287_V	306_L	0.848	0.67
208_A	250_G	0.848	0.67
180_Y	233_V	0.847	0.67
122_D	125_Y	0.847	0.67
143_P	195_T	0.847	0.67
119_W	128_A	0.846	0.67
123_E	126_A	0.846	0.67
156_L	164_N	0.845	0.67
115_A	277_V	0.842	0.67
61_L	145_V	0.840	0.66
81_L	216_T	0.839	0.66
59_H	62_T	0.838	0.66
268_S	272_K	0.838	0.66
14_D	17_L	0.835	0.66
13_W	17_L	0.832	0.66
235_K	244_E	0.832	0.66
41_V	118_I	0.828	0.65
140_Y	171_K	0.824	0.65
90_W	116_L	0.822	0.65
69_G	221_L	0.815	0.64
135_V	274_M	0.812	0.64
195_T	215_V	0.808	0.63
245_Y	307_P	0.807	0.63
102_D	260_K	0.806	0.63
23_I	67_V	0.805	0.63
231_L	273_Y	0.799	0.62
251_I	301_I	0.796	0.62
13_W	205_C	0.796	0.62
248_Y	265_G	0.796	0.62
29_I	78_V	0.792	0.62
178_K	220_R	0.790	0.62
202_G	230_P	0.789	0.61
231_L	269_I	0.789	0.61
37_S	90_W	0.786	0.61
80_F	143_P	0.784	0.61
159_I	206_G	0.783	0.61
27_D	219_V	0.782	0.61
178_K	222_I	0.782	0.61
99_F	294_V	0.780	0.61
293_E	303_T	0.779	0.60
146_I	219_V	0.778	0.60
198_A	285_V	0.774	0.60
163_E	184_F	0.772	0.60
161_P	296_D	0.771	0.60
23_I	31_V	0.770	0.60
205_C	281_I	0.762	0.59
174_T	235_K	0.759	0.58
248_Y	269_I	0.754	0.58
20_I	65_I	0.752	0.58
8_K	60_P	0.750	0.58
134_N	275_A	0.750	0.58
192_I	219_V	0.749	0.57
70_A	223_K	0.744	0.57
7_A	291_V	0.739	0.56
50_L	53_L	0.736	0.56
252_D	299_N	0.734	0.56
222_I	225_V	0.732	0.56
186_N	221_L	0.732	0.56
85_H	213_M	0.729	0.55
143_P	192_I	0.727	0.55
119_W	285_V	0.727	0.55
247_A	290_R	0.727	0.55
229_Q	261_K	0.722	0.55
12_K	155_K	0.722	0.55
65_I	192_I	0.721	0.55
271_S	279_A	0.720	0.55
98_G	284_S	0.712	0.54
83_F	215_V	0.712	0.54
267_I	283_A	0.710	0.53
209_I	227_L	0.709	0.53
267_I	276_P	0.707	0.53
205_C	280_Y	0.707	0.53
48_K	51_L	0.700	0.52
206_G	300_W	0.699	0.52
228_T	268_S	0.699	0.52
87_G	123_E	0.699	0.52
292_S	301_I	0.698	0.52
215_V	258_A	0.698	0.52
148_T	181_L	0.697	0.52
265_G	268_S	0.688	0.51
207_T	284_S	0.687	0.51
11_N	38_D	0.686	0.51
25_D	70_A	0.685	0.51
172_H	290_R	0.684	0.51
137_V	285_V	0.683	0.51
37_S	58_I	0.682	0.51
26_G	29_I	0.680	0.50
36_A	208_A	0.679	0.50
80_F	177_T	0.676	0.50
257_N	261_K	0.675	0.50
89_G	302_V	0.674	0.50
183_V	219_V	0.674	0.50
128_A	139_I	0.673	0.50
33_T	83_F	0.672	0.50
282_L	310_V	0.670	0.49
156_L	162_R	0.669	0.49
293_E	296_D	0.666	0.49
91_T	119_W	0.666	0.49
209_I	250_G	0.665	0.49
145_V	293_E	0.664	0.49
96_G	114_P	0.663	0.49
8_K	11_N	0.663	0.49
27_D	220_R	0.660	0.48
98_G	101_A	0.660	0.48
143_P	217_V	0.658	0.48
78_V	219_V	0.654	0.48
177_T	232_F	0.653	0.48
41_V	92_G	0.653	0.48
143_P	190_L	0.652	0.47
49_D	53_L	0.649	0.47
269_I	273_Y	0.648	0.47
113_G	177_T	0.648	0.47
126_A	130_F	0.648	0.47
199_Q	208_A	0.648	0.47
251_I	292_S	0.647	0.47
142_F	208_A	0.646	0.47
32_E	86_K	0.646	0.47
94_L	97_F	0.645	0.47
83_F	179_L	0.645	0.47
214_E	221_L	0.644	0.47
124_K	228_T	0.642	0.46
86_K	214_E	0.641	0.46
270_L	273_Y	0.639	0.46
116_L	119_W	0.639	0.46
35_E	59_H	0.639	0.46
21_L	27_D	0.639	0.46
218_K	264_K	0.635	0.46
127_Y	136_K	0.635	0.46
262_A	304_A	0.633	0.45
75_A	226_G	0.632	0.45
70_A	183_V	0.632	0.45
173_L	232_F	0.630	0.45
88_W	118_I	0.630	0.45
249_P	292_S	0.629	0.45
9_T	38_D	0.628	0.45
117_K	130_F	0.628	0.45
9_T	34_K	0.627	0.45
183_V	223_K	0.627	0.45
95_P	98_G	0.627	0.45
122_D	126_A	0.626	0.45
99_F	256_W	0.624	0.45
49_D	52_K	0.621	0.44
260_K	300_W	0.620	0.44
47_E	51_L	0.619	0.44
140_Y	198_A	0.618	0.44
71_E	221_L	0.618	0.44
46_T	49_D	0.616	0.44
59_H	158_T	0.613	0.43
93_V	277_V	0.613	0.43
289_L	302_V	0.613	0.43
29_I	217_V	0.612	0.43
288_N	293_E	0.612	0.43
33_T	62_T	0.611	0.43
20_I	286_V	0.610	0.43
261_K	265_G	0.610	0.43
129_K	133_L	0.609	0.43
31_V	246_I	0.608	0.43
96_G	102_D	0.608	0.43
279_A	289_L	0.607	0.43
10_H	35_E	0.606	0.43
117_K	281_I	0.605	0.43
115_A	281_I	0.601	0.42
36_A	60_P	0.601	0.42
36_A	145_V	0.601	0.42
161_P	294_V	0.601	0.42
66_E	69_G	0.600	0.42
38_D	57_K	0.599	0.42
255_L	291_V	0.599	0.42
80_F	192_I	0.598	0.42
168_M	197_L	0.597	0.42
29_I	190_L	0.597	0.42
42_T	45_S	0.594	0.42
18_P	312_D	0.592	0.41
13_W	191_S	0.592	0.41
65_I	190_L	0.592	0.41
59_H	142_F	0.591	0.41
231_L	265_G	0.588	0.41
39_G	50_L	0.588	0.41
26_G	70_A	0.587	0.41
224_N	272_K	0.587	0.41
274_M	282_L	0.587	0.41
90_W	118_I	0.585	0.41
13_W	147_G	0.585	0.41
244_E	247_A	0.583	0.40
47_E	50_L	0.583	0.40
96_G	100_L	0.582	0.40
263_I	283_A	0.580	0.40
88_W	205_C	0.574	0.39
164_N	191_S	0.574	0.39
30_T	214_E	0.573	0.39
14_D	197_L	0.573	0.39
150_L	156_L	0.572	0.39
76_L	221_L	0.571	0.39
167_N	295_V	0.571	0.39
283_A	287_V	0.570	0.39
104_Q	267_I	0.567	0.39
263_I	292_S	0.566	0.39
30_T	65_I	0.564	0.39
277_V	281_I	0.564	0.39
125_Y	151_P	0.563	0.38
102_D	159_I	0.563	0.38
168_M	303_T	0.563	0.38
251_I	303_T	0.561	0.38
146_I	181_L	0.560	0.38
75_A	148_T	0.557	0.38
137_V	310_V	0.557	0.38
11_N	57_K	0.556	0.38
159_I	207_T	0.555	0.38
178_K	312_D	0.554	0.38
33_T	143_P	0.554	0.38
67_V	222_I	0.553	0.37
15_N	178_K	0.552	0.37
87_G	120_K	0.552	0.37
100_L	306_L	0.552	0.37
74_D	221_L	0.551	0.37
162_R	184_F	0.548	0.37
262_A	289_L	0.548	0.37
160_P	295_V	0.547	0.37
170_I	251_I	0.546	0.37
59_H	303_T	0.546	0.37
172_H	305_Y	0.546	0.37
121_V	126_A	0.542	0.36
58_I	145_V	0.541	0.36
286_V	310_V	0.540	0.36
199_Q	203_E	0.539	0.36
60_P	145_V	0.538	0.36
267_I	271_S	0.537	0.36
118_I	121_V	0.537	0.36
159_I	208_A	0.536	0.36
113_G	277_V	0.536	0.36
128_A	131_G	0.534	0.36
114_P	121_V	0.532	0.35
172_H	292_S	0.531	0.35
78_V	311_F	0.531	0.35
35_E	119_W	0.529	0.35
66_E	186_N	0.529	0.35
78_V	190_L	0.528	0.35
174_T	234_T	0.528	0.35
13_W	145_V	0.528	0.35
23_I	28_I	0.528	0.35
151_P	184_F	0.527	0.35
91_T	205_C	0.526	0.35
76_L	219_V	0.524	0.35
11_N	35_E	0.523	0.35
59_H	301_I	0.522	0.34
244_E	309_N	0.521	0.34
39_G	206_G	0.520	0.34
39_G	215_V	0.519	0.34
124_K	268_S	0.517	0.34
147_G	203_E	0.517	0.34
180_Y	308_K	0.515	0.34
129_K	291_V	0.515	0.34
259_T	262_A	0.515	0.34
286_V	306_L	0.514	0.34
87_G	311_F	0.513	0.34
71_E	127_Y	0.512	0.34
24_S	186_N	0.510	0.33
66_E	188_A	0.509	0.33
70_A	188_A	0.509	0.33
160_P	299_N	0.508	0.33
167_N	293_E	0.507	0.33
121_V	128_A	0.507	0.33
147_G	185_V	0.507	0.33
52_K	84_R	0.505	0.33
87_G	305_Y	0.505	0.33
142_F	283_A	0.504	0.33
252_D	300_W	0.503	0.33
203_E	295_V	0.502	0.33
58_I	159_I	0.502	0.33
210_E	295_V	0.502	0.33
251_I	293_E	0.501	0.33
12_K	17_L	0.501	0.33
138_P	198_A	0.500	0.32
34_K	221_L	0.500	0.32

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2ii1A	2	0.9277	100	0.118	Contact Map
3tkkA	2	0.9277	100	0.118	Contact Map
2f4lA	2	0.8648	100	0.124	Contact Map
3b9tA	4	0.9371	100	0.174	Contact Map
2wknA	5	0.9686	100	0.187	Contact Map
1yezA	1	0.2138	53.1	0.965	Contact Map
1yvcA	1	0.2201	41.5	0.967	Contact Map
1id2A	1	0.2767	31.3	0.969	Contact Map
3c75A	1	0.2767	25.5	0.971	Contact Map
4kzsA	1	0.217	21.6	0.972	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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