GREMLIN Database
Q97V25 - Transposase ISC1316
UniProt: Q97V25 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 411 (354)
Sequences: 4519 (2910)
Seq/√Len: 154.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
261_D265_K5.5151.00
283_H286_Q4.3421.00
335_A365_N4.2851.00
315_L322_L3.6391.00
278_V374_A3.0331.00
308_R324_L2.9701.00
202_L307_L2.9701.00
279_M311_L2.8831.00
268_K272_E2.7781.00
345_S348_D2.7651.00
306_E310_V2.7401.00
162_V174_I2.5311.00
288_V300_S2.4811.00
221_L297_R2.4681.00
306_E309_D2.4181.00
333_T340_V2.3721.00
329_Y332_K2.3241.00
271_A315_L2.3171.00
312_K324_L2.2951.00
307_L311_L2.2821.00
325_V370_I2.2691.00
373_G376_S2.2001.00
227_L244_A2.1281.00
36_W40_Y2.1221.00
264_M313_Y2.1181.00
277_V315_L2.1161.00
332_K344_L2.0841.00
352_V359_I2.0771.00
337_C356_C2.0691.00
160_K179_E2.0681.00
279_M322_L2.0641.00
13_D16_T2.0461.00
264_M310_V2.0391.00
39_I97_F2.0161.00
334_C337_C2.0151.00
330_T370_I2.0131.00
293_R296_R2.0101.00
220_A258_L1.9871.00
267_G310_V1.9031.00
260_S306_E1.8941.00
349_R362_R1.8881.00
202_L262_L1.8871.00
337_C353_C1.8791.00
34_L80_A1.8641.00
353_C356_C1.8421.00
334_C356_C1.8271.00
312_K316_E1.8261.00
263_Y310_V1.8241.00
244_A248_L1.8111.00
51_Q55_R1.7961.00
52_T55_R1.7901.00
275_D320_K1.7871.00
21_K172_I1.7861.00
336_R358_W1.7751.00
264_M267_G1.7591.00
264_M314_Q1.7501.00
51_Q81_D1.7311.00
239_N242_F1.7251.00
334_C353_C1.7011.00
351_F360_A1.6911.00
35_R83_Y1.6831.00
22_A70_Q1.6631.00
279_M324_L1.6281.00
9_R171_R1.6151.00
195_I203_L1.6081.00
138_L174_I1.5951.00
263_Y306_E1.5751.00
344_L348_D1.5701.00
281_G324_L1.5651.00
82_R110_V1.5491.00
230_E234_K1.5431.00
29_K67_E1.5331.00
20_L172_I1.5321.00
234_K244_A1.5261.00
242_F245_K1.5071.00
89_R95_A1.5031.00
231_L245_K1.5011.00
18_R22_A1.5001.00
279_M308_R1.4941.00
267_G313_Y1.4931.00
346_L349_R1.4791.00
74_Q112_T1.4761.00
341_K351_F1.4661.00
17_L21_K1.4541.00
351_F358_W1.4491.00
350_V359_I1.4471.00
74_Q113_Q1.4401.00
341_K344_L1.4321.00
52_T56_Q1.4181.00
280_E327_P1.4091.00
204_V364_Y1.3991.00
368_L372_K1.3891.00
192_V371_L1.3831.00
84_Y88_K1.3681.00
201_K204_V1.3591.00
267_G314_Q1.3521.00
193_V205_T1.3401.00
51_Q80_A1.3361.00
237_L241_W1.3341.00
88_K92_E1.3321.00
205_T209_E1.3261.00
24_L172_I1.3261.00
312_K322_L1.3221.00
34_L83_Y1.3111.00
224_V248_L1.3081.00
5_G175_T1.2971.00
171_R253_E1.2931.00
227_L230_E1.2901.00
223_K227_L1.2701.00
169_S253_E1.2681.00
267_G307_L1.2621.00
299_L304_F1.2601.00
339_Y354_P1.2571.00
220_A255_L1.2521.00
87_K97_F1.2481.00
335_A368_L1.2281.00
346_L362_R1.2241.00
39_I43_Q1.2151.00
253_E257_N1.2131.00
224_V252_Y1.2051.00
195_I205_T1.1931.00
269_W273_H1.1911.00
271_A318_Y1.1881.00
231_L248_L1.1851.00
193_V274_Y1.1791.00
227_L251_A1.1761.00
14_E17_L1.1741.00
55_R81_D1.1721.00
55_R80_A1.1711.00
50_T53_E1.1691.00
38_D54_L1.1611.00
341_K354_P1.1601.00
332_K342_N1.1541.00
283_H327_P1.1501.00
37_A57_L1.1491.00
58_A80_A1.1381.00
263_Y307_L1.1361.00
360_A368_L1.1301.00
78_Q112_T1.1301.00
310_V313_Y1.1261.00
197_V304_F1.1191.00
192_V276_V1.1110.99
167_T171_R1.1100.99
268_K318_Y1.1090.99
85_E89_R1.1090.99
167_T170_E1.1090.99
314_Q317_K1.1040.99
199_V302_V1.0970.99
231_L244_A1.0940.99
260_S310_V1.0920.99
189_T275_D1.0880.99
335_A360_A1.0870.99
137_T145_T1.0850.99
78_Q81_D1.0840.99
27_A79_I1.0840.99
12_T16_T1.0780.99
345_S349_R1.0730.99
332_K340_V1.0710.99
325_V373_G1.0680.99
364_Y368_L1.0660.99
267_G311_L1.0650.99
62_R76_V1.0590.99
263_Y267_G1.0580.99
330_T373_G1.0540.99
345_S362_R1.0520.99
140_L164_V1.0480.99
288_V296_R1.0470.99
90_F97_F1.0460.99
228_H232_S1.0460.99
165_K175_T1.0380.99
210_Y361_D1.0360.99
56_Q59_L1.0350.99
194_A371_L1.0350.99
272_E318_Y1.0270.99
271_A277_V1.0270.99
271_A320_K1.0260.99
241_W245_K1.0160.99
332_K343_D1.0140.99
31_Y79_I1.0110.99
72_Y75_V0.9950.99
284_A305_G0.9840.99
6_F178_V0.9830.99
58_A77_Q0.9780.99
26_L67_E0.9780.99
197_V308_R0.9770.99
309_D312_K0.9770.99
333_T373_G0.9750.99
167_T253_E0.9680.99
360_A364_Y0.9630.99
335_A358_W0.9570.98
344_L351_F0.9550.98
111_Y114_S0.9510.98
227_L248_L0.9500.98
117_K139_K0.9480.98
110_V161_R0.9470.98
278_V370_I0.9360.98
89_R94_L0.9360.98
25_K28_C0.9340.98
206_P210_Y0.9320.98
349_R361_D0.9320.98
197_V203_L0.9310.98
325_V374_A0.9290.98
35_R87_K0.9240.98
335_A366_A0.9230.98
150_V153_D0.9180.98
281_G327_P0.9160.98
89_R92_E0.9160.98
256_K260_S0.9120.98
82_R163_V0.9100.98
201_K210_Y0.9100.98
41_F45_D0.9090.98
192_V375_G0.9060.98
348_D362_R0.9050.98
339_Y355_N0.9000.98
31_Y83_Y0.8980.98
315_L320_K0.8940.98
227_L247_K0.8940.98
231_L241_W0.8930.98
29_K33_T0.8910.98
31_Y86_A0.8870.98
77_Q81_D0.8870.98
228_H248_L0.8820.97
348_D351_F0.8800.97
117_K120_H0.8790.97
8_F174_I0.8740.97
263_Y303_G0.8730.97
224_V255_L0.8720.97
251_A255_L0.8690.97
341_K345_S0.8660.97
254_H258_L0.8650.97
344_L362_R0.8630.97
270_F277_V0.8620.97
295_L299_L0.8610.97
74_Q78_Q0.8580.97
139_K145_T0.8580.97
116_W120_H0.8560.97
42_Y87_K0.8550.97
350_V360_A0.8510.97
234_K240_N0.8500.97
164_V174_I0.8480.97
247_K250_R0.8450.97
224_V232_S0.8440.97
327_P330_T0.8440.97
78_Q110_V0.8410.97
41_F49_L0.8400.97
228_H252_Y0.8400.97
36_W100_E0.8370.96
12_T20_L0.8360.96
39_I87_K0.8360.96
276_V321_K0.8360.96
201_K212_P0.8340.96
226_H230_E0.8340.96
163_V175_T0.8330.96
40_Y44_R0.8330.96
34_L58_A0.8330.96
335_A372_K0.8330.96
68_Y76_V0.8310.96
373_G377_E0.8270.96
225_K228_H0.8220.96
216_P258_L0.8180.96
351_F362_R0.8170.96
17_L172_I0.8170.96
192_V278_V0.8170.96
281_G308_R0.8130.96
368_L371_L0.8120.96
33_T37_A0.8110.96
199_V288_V0.8090.96
110_V163_V0.8080.96
323_I374_A0.8070.96
232_S248_L0.8070.96
203_L266_L0.8060.96
34_L54_L0.8060.96
231_L234_K0.8050.96
10_A174_I0.8020.96
336_R368_L0.7980.95
137_T140_L0.7970.95
30_I79_I0.7940.95
204_V210_Y0.7910.95
217_L220_A0.7910.95
59_L62_R0.7910.95
203_L211_F0.7910.95
333_T369_N0.7860.95
59_L73_S0.7850.95
268_K314_Q0.7840.95
293_R300_S0.7830.95
262_L266_L0.7820.95
193_V206_P0.7820.95
366_A369_N0.7820.95
216_P220_A0.7820.95
365_N369_N0.7750.95
190_G275_D0.7680.94
199_V298_R0.7670.94
115_G141_S0.7650.94
329_Y373_G0.7630.94
339_Y342_N0.7610.94
8_F152_R0.7610.94
90_F98_P0.7590.94
282_I327_P0.7590.94
203_L307_L0.7580.94
211_F262_L0.7560.94
111_Y116_W0.7560.94
245_K249_A0.7540.94
209_E269_W0.7540.94
200_E204_V0.7530.94
364_Y367_S0.7520.94
278_V371_L0.7520.94
71_L74_Q0.7480.94
266_L269_W0.7450.93
161_R177_V0.7450.93
72_Y111_Y0.7440.93
38_D84_Y0.7440.93
305_G309_D0.7430.93
55_R59_L0.7420.93
278_V323_I0.7410.93
93_G96_R0.7370.93
193_V277_V0.7370.93
104_H107_Y0.7360.93
74_Q114_S0.7340.93
213_N302_V0.7290.93
277_V311_L0.7290.93
23_Q27_A0.7270.93
19_A23_Q0.7250.92
286_Q327_P0.7240.92
78_Q82_R0.7200.92
276_V323_I0.7180.92
332_K341_K0.7160.92
25_K29_K0.7140.92
5_G177_V0.7110.92
26_L29_K0.7100.92
220_A251_A0.7100.92
114_S117_K0.7100.92
9_R173_Y0.7070.92
37_A54_L0.7040.91
188_N191_K0.7030.91
59_L63_K0.6960.91
83_Y87_K0.6960.91
332_K345_S0.6930.91
80_A84_Y0.6920.91
191_K275_D0.6920.91
139_K143_L0.6910.91
74_Q77_Q0.6890.90
284_A304_F0.6890.90
272_E276_V0.6860.90
213_N216_P0.6860.90
220_A254_H0.6850.90
343_D348_D0.6850.90
158_K179_E0.6840.90
196_D363_D0.6840.90
138_L162_V0.6840.90
230_E233_R0.6840.90
7_R165_K0.6810.90
225_K229_R0.6790.90
135_L140_L0.6790.90
206_P364_Y0.6780.90
329_Y333_T0.6780.90
26_L71_L0.6740.89
22_A26_L0.6710.89
315_L318_Y0.6700.89
53_E56_Q0.6690.89
111_Y140_L0.6660.89
311_L322_L0.6650.89
202_L302_V0.6640.89
341_K362_R0.6640.89
344_L349_R0.6610.89
346_L361_D0.6600.88
109_L113_Q0.6590.88
329_Y340_V0.6590.88
225_K232_S0.6580.88
79_I83_Y0.6550.88
255_L301_D0.6550.88
38_D87_K0.6530.88
42_Y46_G0.6510.88
148_V151_H0.6500.88
20_L24_L0.6500.88
140_L146_F0.6490.88
270_F274_Y0.6480.88
87_K91_F0.6480.88
26_L68_Y0.6460.87
186_L189_T0.6440.87
224_V228_H0.6430.87
230_E244_A0.6410.87
229_R232_S0.6410.87
259_R301_D0.6390.87
191_K207_D0.6380.87
71_L76_V0.6370.87
87_K90_F0.6370.87
120_H136_I0.6370.87
331_S345_S0.6350.87
207_D274_Y0.6330.86
60_D64_Q0.6330.86
370_I373_G0.6330.86
23_Q71_L0.6300.86
374_A378_R0.6290.86
218_E221_L0.6270.86
51_Q54_L0.6270.86
144_G147_K0.6260.86
313_Y317_K0.6220.85
288_V293_R0.6210.85
19_A22_A0.6210.85
274_Y277_V0.6190.85
372_K377_E0.6190.85
74_Q115_G0.6180.85
217_L221_L0.6150.85
15_Q18_R0.6150.85
14_E18_R0.6140.85
12_T146_F0.6120.84
11_Y149_I0.6110.84
37_A40_Y0.6110.84
37_A41_F0.6110.84
336_R360_A0.6110.84
278_V373_G0.6100.84
286_Q299_L0.6100.84
37_A61_L0.6080.84
331_S344_L0.6030.84
12_T17_L0.6010.83
198_G204_V0.6000.83
360_A365_N0.5990.83
242_F246_V0.5980.83
42_Y45_D0.5970.83
240_N243_K0.5960.83
238_S241_W0.5950.83
288_V294_S0.5950.83
139_K142_N0.5950.83
76_V79_I0.5890.82
200_E349_R0.5890.82
186_L320_K0.5890.82
333_T351_F0.5870.82
266_L307_L0.5870.82
6_F152_R0.5870.82
111_Y115_G0.5860.82
20_L109_L0.5850.82
341_K348_D0.5840.82
260_S264_M0.5830.82
308_R312_K0.5820.81
210_Y364_Y0.5820.81
23_Q111_Y0.5820.81
226_H229_R0.5810.81
218_E297_R0.5800.81
202_L267_G0.5770.81
296_R300_S0.5760.81
48_G84_Y0.5750.81
21_K167_T0.5750.81
252_Y256_K0.5730.80
252_Y259_R0.5710.80
287_L299_L0.5700.80
344_L347_S0.5680.80
92_E95_A0.5680.80
211_F269_W0.5660.80
7_R260_S0.5640.79
81_D112_T0.5640.79
45_D48_G0.5620.79
62_R65_D0.5620.79
75_V109_L0.5610.79
218_E298_R0.5600.79
116_W141_S0.5600.79
229_R233_R0.5590.79
211_F266_L0.5570.79
263_Y266_L0.5570.79
10_A148_V0.5570.79
57_L61_L0.5570.79
194_A367_S0.5570.79
286_Q295_L0.5570.79
72_Y113_Q0.5560.78
171_R257_N0.5550.78
49_L54_L0.5550.78
194_A206_P0.5550.78
15_Q19_A0.5540.78
220_A224_V0.5540.78
86_A98_P0.5530.78
33_T67_E0.5530.78
310_V314_Q0.5530.78
72_Y112_T0.5520.78
7_R173_Y0.5520.78
333_T338_G0.5510.78
43_Q46_G0.5500.78
288_V299_L0.5490.78
36_W39_I0.5480.77
42_Y91_F0.5470.77
59_L80_A0.5470.77
202_L263_Y0.5460.77
47_K53_E0.5460.77
140_L143_L0.5460.77
73_S112_T0.5460.77
5_G165_K0.5430.77
339_Y351_F0.5430.77
119_L139_K0.5410.76
38_D41_F0.5410.76
170_E253_E0.5400.76
8_F150_V0.5390.76
33_T61_L0.5360.76
197_V284_A0.5350.76
333_T342_N0.5340.76
257_N260_S0.5330.75
326_N329_Y0.5320.75
23_Q72_Y0.5320.75
51_Q56_Q0.5300.75
198_G201_K0.5290.75
303_G306_E0.5290.75
22_A25_K0.5270.75
115_G118_I0.5260.74
38_D48_G0.5240.74
200_E361_D0.5230.74
268_K271_A0.5220.74
7_R175_T0.5220.74
72_Y109_L0.5220.74
75_V111_Y0.5200.74
31_Y87_K0.5200.74
230_E247_K0.5170.73
351_F354_P0.5150.73
150_V154_F0.5150.73
102_K105_K0.5150.73
191_K274_Y0.5120.73
112_T116_W0.5120.73
196_D331_S0.5120.73
225_K293_R0.5110.72
136_I150_V0.5110.72
22_A71_L0.5110.72
38_D42_Y0.5110.72
372_K375_G0.5090.72
23_Q109_L0.5070.72
352_V358_W0.5070.72
30_I76_V0.5060.72
237_L242_F0.5050.72
48_G54_L0.5040.71
328_A332_K0.5040.71
295_L298_R0.5030.71
217_L297_R0.5030.71
331_S341_K0.5020.71
278_V375_G0.5020.71
232_S244_A0.5000.71
241_W244_A0.5000.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1nu0A 1 0.3163 92.3 0.938 Contact Map
1vhxA 2 0.3333 91.7 0.939 Contact Map
4aybP 1 0.1046 88.1 0.943 Contact Map
1iv0A 1 0.236 87.2 0.944 Contact Map
1ffkW 1 0.1752 86.3 0.945 Contact Map
1qypA 1 0.1119 84.3 0.946 Contact Map
2k4xA 1 0.1338 83.7 0.947 Contact Map
1vq8Z 1 0.1606 80.8 0.948 Contact Map
3j20Y 1 0.1217 80.3 0.949 Contact Map
1vd4A 1 0.1363 78.1 0.95 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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