GREMLIN Database
Q97V20 - 2-oxoacid--ferredoxin oxidoreductase, beta chain
UniProt: Q97V20 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 316 (269)
Sequences: 2406 (1221)
Seq/√Len: 74.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
121_D197_K5.5321.00
123_T200_A5.1201.00
164_I237_V4.0661.00
178_G186_L3.8891.00
115_A122_L2.9471.00
218_E221_D2.7441.00
126_V201_M2.7381.00
50_V86_I2.7281.00
193_A202_I2.6841.00
195_K242_E2.6591.00
191_K195_K2.6321.00
178_G189_I2.5941.00
17_V61_I2.5541.00
116_G167_A2.3421.00
32_L98_N2.2681.00
52_V86_I2.1831.00
79_A97_V2.1301.00
83_A97_V2.0961.00
97_V122_L2.0961.00
143_L147_V2.0911.00
35_E190_I2.0651.00
128_N203_D1.9911.00
125_I204_V1.9701.00
185_H189_I1.9501.00
285_S288_D1.9481.00
283_S287_L1.9161.00
162_N165_A1.9071.00
116_G199_L1.8191.00
190_I202_I1.7971.00
177_R203_D1.7771.00
173_T196_H1.7691.00
258_G261_I1.7671.00
99_G124_V1.7631.00
104_Q124_V1.7331.00
284_P288_D1.7311.00
261_I264_G1.7281.00
35_E98_N1.7131.00
225_Y228_D1.6901.00
224_V228_D1.6881.00
213_D264_G1.6791.00
28_N127_H1.6711.00
130_G160_D1.6481.00
185_H263_I1.6301.00
197_K277_Q1.6171.00
123_T194_I1.6010.99
96_I123_T1.5890.99
99_G104_Q1.5690.99
167_A201_M1.5620.99
226_K229_E1.5550.99
125_I190_I1.5540.99
33_S37_Q1.5330.99
178_G190_I1.5330.99
83_A95_V1.5290.99
32_L61_I1.5230.99
124_V199_L1.5180.99
192_K268_Q1.5160.99
178_G185_H1.4960.99
145_L159_S1.4760.99
32_L127_H1.4720.99
144_K147_V1.4560.99
49_V94_E1.4480.99
74_T82_F1.4430.99
195_K240_P1.4370.99
282_R285_S1.4320.99
90_N93_L1.4130.99
285_S289_N1.4130.99
50_V95_V1.4120.99
96_I194_I1.4090.99
216_T227_L1.3890.98
164_I175_V1.3730.98
31_I206_Q1.3650.98
53_S71_G1.3230.98
243_M248_S1.3210.98
52_V83_A1.3170.98
240_P243_M1.3080.98
287_L290_P1.3040.98
94_E194_I1.3030.98
86_I95_V1.2920.98
55_I73_H1.2910.98
119_N199_L1.2860.97
287_L291_P1.2730.97
207_P219_Y1.2730.97
264_G267_Y1.2720.97
167_A175_V1.2720.97
281_E284_P1.2710.97
129_N133_G1.2650.97
186_L190_I1.2620.97
50_V90_N1.2600.97
35_E125_I1.2560.97
178_G204_V1.2560.97
265_I268_Q1.2490.97
267_Y276_E1.2450.97
126_V163_P1.2450.97
72_V82_F1.2450.97
279_I283_S1.2360.97
113_V161_I1.2270.97
224_V227_L1.2210.97
48_K92_S1.2060.96
278_R281_E1.2050.96
125_I202_I1.1960.96
188_E191_K1.1870.96
280_A284_P1.1860.96
55_I60_K1.1820.96
87_K91_P1.1710.96
157_I282_R1.1700.96
128_N160_D1.1690.96
188_E192_K1.1640.95
164_I201_M1.1600.95
216_T220_Y1.1590.95
263_I291_P1.1550.95
84_I120_V1.1510.95
87_K120_V1.1500.95
59_G73_H1.1450.95
270_E274_T1.1450.95
39_I194_I1.1440.95
254_S258_G1.1320.95
215_H218_E1.1260.95
37_Q187_K1.1210.94
32_L36_Q1.1180.94
34_A183_V1.1160.94
176_A189_I1.1150.94
192_K265_I1.1100.94
247_M250_A1.1090.94
55_I59_G1.1030.94
225_Y260_R1.0970.94
22_W29_F1.0920.94
257_W260_R1.0850.93
105_L126_V1.0830.93
232_S253_K1.0820.93
224_V268_Q1.0790.93
80_L124_V1.0720.93
262_P266_F1.0680.93
238_K241_E1.0600.93
196_H200_A1.0590.93
125_I193_A1.0570.92
224_V229_E1.0570.92
263_I284_P1.0570.92
98_N127_H1.0570.92
61_I127_H1.0550.92
55_I78_R1.0540.92
59_G62_P1.0430.92
242_E245_D1.0430.92
277_Q280_A1.0400.92
263_I266_F1.0320.92
160_D177_R1.0220.91
275_Y283_S1.0120.91
253_K256_E1.0090.91
223_R226_K1.0000.90
257_W261_I0.9990.90
180_A186_L0.9960.90
263_I267_Y0.9930.90
48_K94_E0.9920.90
62_P66_R0.9920.90
262_P290_P0.9850.90
187_K191_K0.9820.89
59_G78_R0.9800.89
52_V97_V0.9720.89
221_D224_V0.9720.89
249_K252_L0.9720.89
243_M252_L0.9710.89
189_I238_K0.9670.89
60_K73_H0.9570.88
179_Y205_L0.9550.88
31_I204_V0.9530.88
174_F265_I0.9530.88
105_L142_T0.9490.88
84_I118_R0.9470.88
166_L169_S0.9390.87
104_Q126_V0.9350.87
55_I71_G0.9350.87
164_I177_R0.9300.87
131_V210_T0.9290.87
116_G201_M0.9230.86
282_R286_Y0.9200.86
87_K95_V0.9190.86
276_E279_I0.9170.86
127_H206_Q0.9150.86
280_A283_S0.9030.85
72_V86_I0.9030.85
215_H219_Y0.9020.85
94_E121_D0.8970.85
112_F124_V0.8960.85
283_S290_P0.8950.84
261_I291_P0.8810.84
30_G34_A0.8790.83
63_H66_R0.8750.83
276_E280_A0.8710.83
158_N172_Y0.8650.82
179_Y223_R0.8610.82
57_C107_I0.8450.81
143_L149_T0.8360.80
265_I269_N0.8340.80
240_P252_L0.8300.80
260_R263_I0.8300.80
113_V170_S0.8220.79
283_S286_Y0.8170.79
35_E61_I0.8160.79
75_L78_R0.8120.78
259_D264_G0.8100.78
279_I282_R0.8100.78
186_L204_V0.8000.77
235_P239_K0.8000.77
112_F167_A0.7970.77
243_M246_K0.7930.77
284_P287_L0.7910.76
58_S127_H0.7870.76
240_P245_D0.7860.76
74_T78_R0.7860.76
250_A254_S0.7850.76
216_T219_Y0.7840.76
40_Q47_K0.7810.75
91_P120_V0.7800.75
123_T190_I0.7800.75
273_S277_Q0.7790.75
250_A253_K0.7760.75
56_G78_R0.7670.74
259_D266_F0.7600.74
88_L171_G0.7580.73
225_Y229_E0.7550.73
117_R139_A0.7500.73
110_G113_V0.7490.72
172_Y175_V0.7470.72
165_A168_I0.7440.72
259_D263_I0.7430.72
288_D291_P0.7400.72
143_L155_P0.7380.71
51_L69_A0.7380.71
35_E96_I0.7330.71
189_I265_I0.7330.71
136_K174_F0.7320.71
83_A122_L0.7270.70
218_E227_L0.7250.70
130_G144_K0.7210.70
115_A199_L0.7200.69
163_P201_M0.7180.69
124_V167_A0.7020.67
223_R227_L0.6980.67
189_I202_I0.6980.67
119_N172_Y0.6970.67
154_K157_I0.6970.67
105_L203_D0.6970.67
123_T193_A0.6960.67
148_K275_Y0.6960.67
20_N29_F0.6940.67
23_C26_C0.6920.66
274_T278_R0.6900.66
51_L65_I0.6890.66
192_K240_P0.6890.66
261_I265_I0.6870.66
55_I76_H0.6830.65
275_Y286_Y0.6820.65
267_Y287_L0.6800.65
286_Y290_P0.6780.65
164_I266_F0.6760.65
86_I90_N0.6740.64
192_K241_E0.6740.64
112_F201_M0.6740.64
244_D251_I0.6720.64
171_G175_V0.6700.64
57_C208_C0.6660.63
163_P175_V0.6640.63
53_S62_P0.6640.63
80_L115_A0.6630.63
20_N73_H0.6620.63
105_L163_P0.6570.62
248_S252_L0.6550.62
216_T226_K0.6540.62
277_Q281_E0.6540.62
80_L97_V0.6480.61
139_A152_L0.6480.61
80_L104_Q0.6470.61
39_I49_V0.6460.61
39_I96_I0.6460.61
76_H107_I0.6450.61
259_D265_I0.6440.61
50_V93_L0.6440.61
88_L120_V0.6440.61
265_I271_L0.6400.60
105_L141_P0.6400.60
235_P238_K0.6370.60
107_I110_G0.6340.60
94_E123_T0.6330.60
262_P265_I0.6330.60
174_F192_K0.6330.60
22_W61_I0.6290.59
218_E224_V0.6270.59
276_E284_P0.6260.59
20_N24_P0.6250.59
113_V166_L0.6170.58
197_K274_T0.6170.58
58_S206_Q0.6160.57
179_Y227_L0.6150.57
279_I287_L0.6130.57
130_G143_L0.6130.57
217_K229_E0.6120.57
273_S287_L0.6050.56
276_E283_S0.6040.56
248_S251_I0.6040.56
234_D238_K0.6040.56
17_V32_L0.6030.56
79_A99_G0.6030.56
135_T208_C0.6020.56
131_V137_G0.6010.56
246_K249_K0.6010.56
102_G140_S0.6000.55
34_A37_Q0.5990.55
131_V147_V0.5980.55
227_L236_I0.5980.55
252_L255_M0.5960.55
109_V113_V0.5950.55
87_K121_D0.5920.54
260_R291_P0.5920.54
192_K195_K0.5910.54
63_H136_K0.5910.54
273_S278_R0.5910.54
154_K282_R0.5900.54
95_V196_H0.5900.54
142_T160_D0.5890.54
252_L263_I0.5880.54
18_E21_D0.5870.54
168_I175_V0.5860.54
51_L98_N0.5860.54
220_Y223_R0.5840.53
89_A93_L0.5830.53
243_M247_M0.5830.53
240_P244_D0.5810.53
28_N206_Q0.5790.53
221_D227_L0.5780.53
80_L111_H0.5760.52
116_G124_V0.5750.52
232_S235_P0.5750.52
218_E228_D0.5700.52
220_Y224_V0.5690.52
85_G89_A0.5680.51
55_I77_G0.5650.51
217_K227_L0.5640.51
39_I123_T0.5620.51
219_Y223_R0.5620.51
166_L170_S0.5600.50
168_I239_K0.5590.50
35_E49_V0.5590.50
63_H73_H0.5570.50
177_R235_P0.5550.50
27_G30_G0.5550.50
180_A207_P0.5510.49
177_R237_V0.5480.49
137_G213_D0.5470.49
122_L168_I0.5470.49
23_C208_C0.5470.49
168_I244_D0.5420.48
260_R264_G0.5410.48
239_K242_E0.5410.48
86_I89_A0.5400.48
232_S238_K0.5380.48
60_K63_H0.5360.47
254_S257_W0.5340.47
192_K238_K0.5330.47
278_R283_S0.5310.47
128_N177_R0.5310.47
58_S107_I0.5300.47
145_L289_N0.5300.47
181_Y207_P0.5290.47
149_T162_N0.5280.46
105_L201_M0.5280.46
32_L58_S0.5280.46
35_E186_L0.5270.46
277_Q284_P0.5270.46
22_W28_N0.5250.46
109_V169_S0.5250.46
36_Q69_A0.5250.46
60_K83_A0.5240.46
94_E200_A0.5220.46
235_P251_I0.5210.46
258_G263_I0.5210.46
137_G148_K0.5200.45
256_E259_D0.5190.45
286_Y289_N0.5180.45
54_G99_G0.5180.45
197_K242_E0.5170.45
97_V124_V0.5160.45
56_G155_P0.5160.45
118_R172_Y0.5150.45
251_I254_S0.5150.45
139_A142_T0.5140.45
94_E97_V0.5120.45
87_K122_L0.5100.44
185_H238_K0.5100.44
157_I279_I0.5100.44
242_E252_L0.5100.44
11_Y15_L0.5100.44
79_A142_T0.5090.44
281_E285_S0.5090.44
229_E235_P0.5090.44
145_L282_R0.5080.44
263_I269_N0.5080.44
164_I262_P0.5060.44
260_R266_F0.5050.44
40_Q160_D0.5050.44
115_A124_V0.5030.43
239_K244_D0.5020.43
53_S59_G0.5020.43
60_K106_G0.5020.43
54_G71_G0.5010.43
34_A187_K0.5000.43
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2c42A 2 0.9747 100 0.413 Contact Map
5c4iC 2 0.9082 100 0.552 Contact Map
4kgdA 4 0.7595 99.9 0.767 Contact Map
2panA 3 0.7532 99.9 0.777 Contact Map
1v5eA 4 0.7627 99.9 0.785 Contact Map
1ybhA 4 0.7025 99.9 0.787 Contact Map
2pgnA 4 0.7184 99.9 0.795 Contact Map
4rjjA 5 0.6709 99.9 0.795 Contact Map
1t9bA 2 0.731 99.9 0.796 Contact Map
4k9qA 4 0.6171 99.9 0.796 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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