GREMLIN Database
Q97V16 - Phosphoenolpyruvate synthase (PpsA-2)
UniProt: Q97V16 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 312 (303)
Sequences: 3193 (2095)
Seq/√Len: 120.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
200_S262_S4.4801.00
183_A275_A4.0071.00
187_H195_Y3.4791.00
278_I299_L3.2921.00
286_I302_V3.1831.00
101_S135_Q3.1651.00
291_A300_L3.0581.00
22_S170_L3.0541.00
185_S275_A2.8911.00
238_K257_E2.8121.00
201_S208_V2.7051.00
230_K265_D2.6831.00
264_S267_D2.5991.00
47_N166_G2.5861.00
76_S155_I2.5851.00
37_K173_T2.4381.00
48_E91_E2.4311.00
51_K54_D2.3291.00
57_I79_I2.3201.00
81_S85_A2.3081.00
97_Y135_Q2.3001.00
292_I297_V2.2591.00
207_S250_S2.1751.00
218_Y262_S2.1701.00
46_V150_F2.1591.00
60_I78_M2.1501.00
40_I168_A2.1271.00
220_V268_A2.1241.00
7_L29_Y2.0891.00
178_V293_E2.0361.00
68_D71_D1.9991.00
27_E281_I1.9691.00
183_A271_I1.9691.00
238_K251_I1.9401.00
267_D292_I1.9311.00
84_I144_R1.9081.00
71_D75_R1.8921.00
185_S288_I1.8551.00
180_A208_V1.8511.00
22_S40_I1.8121.00
140_P143_K1.7921.00
221_S224_T1.7801.00
242_D249_K1.7511.00
17_I44_R1.7421.00
201_S207_S1.7361.00
39_F171_V1.7351.00
254_S257_E1.7341.00
6_L9_E1.7331.00
90_N93_E1.7111.00
186_I193_P1.7001.00
177_P291_A1.6791.00
49_A86_S1.6751.00
18_V40_I1.6251.00
141_S144_R1.6191.00
93_E97_Y1.6191.00
232_I261_E1.6091.00
199_E217_Q1.6091.00
11_S30_K1.5981.00
198_I268_A1.5891.00
23_A27_E1.5501.00
270_R273_N1.5461.00
77_E81_S1.5271.00
34_N296_K1.5201.00
279_E285_N1.5111.00
270_R296_K1.5101.00
161_T164_E1.5081.00
222_K279_E1.4891.00
90_N94_K1.4761.00
54_D58_R1.4751.00
76_S152_P1.4711.00
94_K98_E1.4661.00
257_E260_A1.4631.00
93_E139_I1.4591.00
100_F108_V1.4541.00
230_K261_E1.4361.00
10_V26_G1.4291.00
227_L230_K1.4021.00
239_L250_S1.3931.00
5_Y10_V1.3921.00
200_S218_Y1.3871.00
123_F157_Y1.3841.00
48_E52_D1.3781.00
207_S239_L1.3771.00
179_S262_S1.3661.00
56_E82_M1.3651.00
73_E152_P1.3461.00
159_I162_H1.3421.00
87_K143_K1.3221.00
10_V18_V1.3061.00
44_R48_E1.3021.00
240_T251_I1.2971.00
50_I83_I1.2941.00
273_N277_A1.2781.00
234_E258_A1.2701.00
8_D37_K1.2631.00
206_E210_K1.2480.99
117_P124_A1.2460.99
95_E98_E1.2370.99
179_S267_D1.2330.99
187_H190_T1.2320.99
196_V272_A1.2280.99
202_F235_K1.2260.99
238_K253_L1.2250.99
133_V141_S1.2150.99
130_D144_R1.2150.99
187_H219_V1.2060.99
132_F241_Y1.2000.99
179_S292_I1.1970.99
80_K151_N1.1900.99
216_D235_K1.1860.99
47_N54_D1.1830.99
88_L139_I1.1770.99
60_I75_R1.1770.99
263_L267_D1.1750.99
142_I146_I1.1560.99
71_D74_K1.1500.99
202_F253_L1.1490.99
100_F138_L1.1490.99
11_S14_M1.1460.99
277_A280_S1.1420.99
58_R62_S1.1400.99
183_A288_I1.1400.99
186_I308_L1.1360.99
181_G290_W1.1350.99
142_I169_I1.1340.99
237_M250_S1.1310.99
278_I288_I1.1270.99
186_I305_I1.1260.99
49_A89_P1.1180.99
177_P180_A1.1150.99
305_I308_L1.1060.99
48_E92_M1.1060.99
7_L10_V1.0990.99
127_Y154_A1.0910.99
220_V272_A1.0890.99
137_N141_S1.0880.98
74_K78_M1.0850.98
192_E195_Y1.0830.98
126_E131_L1.0740.98
52_D90_N1.0740.98
274_M299_L1.0660.98
140_P144_R1.0600.98
84_I147_A1.0580.98
34_N274_M1.0530.98
88_L92_M1.0520.98
112_A117_P1.0460.98
225_R269_I1.0440.98
49_A143_K1.0390.98
108_V138_L1.0370.98
182_T201_S1.0330.98
178_V267_D1.0320.98
182_T209_T1.0280.98
97_Y139_I1.0270.98
197_V219_V1.0270.98
100_F103_L1.0260.98
233_S261_E1.0260.98
79_I83_I1.0200.98
6_L102_Q1.0180.98
89_P92_M1.0050.97
288_I299_L1.0050.97
7_L22_S1.0010.97
56_E59_G0.9990.97
278_I302_V0.9940.97
183_A196_V0.9920.97
109_A131_L0.9920.97
53_L82_M0.9850.97
238_K254_S0.9840.97
242_D246_K0.9780.97
41_I169_I0.9750.97
160_L165_A0.9740.97
55_D58_R0.9650.97
96_I142_I0.9630.97
56_E60_I0.9560.97
48_E51_K0.9560.97
60_I63_S0.9550.97
253_L257_E0.9420.96
154_A158_R0.9380.96
207_S237_M0.9340.96
40_I170_L0.9320.96
12_L27_E0.9310.96
268_A272_A0.9240.96
55_D59_G0.9120.96
175_I291_A0.9060.95
180_A207_S0.9030.95
197_V217_Q0.9030.95
209_T287_N0.9010.95
135_Q138_L0.8990.95
261_E265_D0.8910.95
200_S290_W0.8900.95
142_I172_Q0.8840.95
58_R163_N0.8830.95
179_S263_L0.8810.95
227_L268_A0.8810.95
270_R297_V0.8770.94
106_K173_T0.8770.94
255_K259_L0.8760.94
180_A210_K0.8660.94
24_Y286_I0.8640.94
53_L56_E0.8590.94
97_Y136_E0.8580.94
5_Y9_E0.8550.94
185_S286_I0.8540.94
76_S79_I0.8510.94
235_K262_S0.8510.94
130_D141_S0.8500.93
208_V215_P0.8470.93
53_L57_I0.8460.93
20_R157_Y0.8450.93
7_L38_G0.8440.93
234_E259_L0.8380.93
218_Y268_A0.8380.93
179_S200_S0.8370.93
232_I235_K0.8330.93
253_L258_A0.8280.93
133_V247_K0.8220.92
127_Y167_M0.8220.92
98_E102_Q0.8150.92
54_D57_I0.8090.92
185_S196_V0.8090.92
46_V83_I0.8040.91
107_Y134_T0.8000.91
52_D86_S0.7970.91
118_L127_Y0.7960.91
88_L143_K0.7920.91
218_Y263_L0.7910.91
218_Y261_E0.7850.90
116_S165_A0.7760.90
118_L160_L0.7750.90
6_L99_R0.7740.90
239_L248_I0.7730.90
80_K152_P0.7730.90
28_L278_I0.7730.90
115_T118_L0.7730.90
195_Y221_S0.7680.90
12_L15_V0.7680.90
176_N293_E0.7650.89
162_H165_A0.7640.89
65_N68_D0.7630.89
38_G211_G0.7620.89
182_T287_N0.7610.89
52_D91_E0.7600.89
218_Y230_K0.7590.89
222_K276_I0.7570.89
274_M297_V0.7520.89
233_S239_L0.7510.88
201_S262_S0.7480.88
7_L37_K0.7480.88
70_T74_K0.7430.88
112_A124_A0.7350.87
184_F305_I0.7340.87
266_N269_I0.7340.87
255_K258_A0.7340.87
287_N303_R0.7320.87
42_S45_G0.7290.87
91_E95_E0.7270.87
184_F287_N0.7270.87
103_L108_V0.7240.87
180_A205_G0.7220.86
172_Q184_F0.7200.86
184_F306_R0.7200.86
111_R117_P0.7180.86
29_Y37_K0.7180.86
52_D89_P0.7170.86
269_I273_N0.7160.86
8_D106_K0.7130.86
41_I96_I0.7120.86
112_A287_N0.7100.86
111_R125_G0.7080.85
212_M239_L0.7050.85
87_K93_E0.7030.85
242_D245_E0.7020.85
225_R276_I0.7010.85
282_F286_I0.7010.85
261_E268_A0.7000.85
49_A53_L0.6990.85
270_R274_M0.6990.85
20_R114_A0.6990.85
244_A247_K0.6970.84
26_G38_G0.6970.84
4_T99_R0.6970.84
25_L181_G0.6940.84
34_N270_R0.6940.84
66_L159_I0.6940.84
18_V22_S0.6930.84
293_E296_K0.6880.84
115_T165_A0.6870.84
97_Y101_S0.6870.84
80_K128_E0.6840.83
45_G92_M0.6780.83
18_V168_A0.6770.83
38_G215_P0.6760.83
150_F163_N0.6710.82
63_S75_R0.6710.82
150_F187_H0.6670.82
138_L169_I0.6670.82
49_A146_I0.6660.82
110_V117_P0.6650.82
76_S80_K0.6640.81
75_R79_I0.6640.81
5_Y8_D0.6590.81
80_K83_I0.6570.81
287_N301_E0.6520.80
251_I254_S0.6490.80
216_D220_V0.6470.80
59_G62_S0.6450.80
196_V222_K0.6440.79
282_F302_V0.6440.79
173_T293_E0.6420.79
148_S209_T0.6400.79
157_Y184_F0.6390.79
110_V138_L0.6390.79
62_S163_N0.6390.79
94_K135_Q0.6370.79
219_V229_S0.6360.79
27_E282_F0.6360.79
131_L174_M0.6350.79
158_R162_H0.6350.79
116_S127_Y0.6330.78
289_E301_E0.6320.78
112_A122_S0.6310.78
114_A127_Y0.6290.78
127_Y162_H0.6290.78
5_Y42_S0.6280.78
201_S239_L0.6280.78
24_Y282_F0.6260.78
78_M81_S0.6230.77
88_L146_I0.6210.77
196_V275_A0.6190.77
86_S143_K0.6190.77
81_S101_S0.6180.77
127_Y165_A0.6120.76
215_P233_S0.6120.76
81_S94_K0.6110.76
294_D298_Y0.6100.76
56_E78_M0.6070.75
121_A127_Y0.6060.75
111_R129_T0.6060.75
116_S119_S0.6040.75
108_V142_I0.6040.75
43_S47_N0.6030.75
9_E102_Q0.6020.75
90_N98_E0.6020.75
48_E164_E0.6010.75
182_T208_V0.6000.75
183_A198_I0.5990.74
64_V75_R0.5990.74
136_E144_R0.5980.74
278_I286_I0.5970.74
18_V26_G0.5970.74
20_R113_T0.5960.74
23_A26_G0.5960.74
113_T117_P0.5960.74
214_T234_E0.5960.74
21_K301_E0.5960.74
244_A249_K0.5920.74
55_D60_I0.5920.74
24_Y302_V0.5900.73
209_T301_E0.5870.73
109_A129_T0.5870.73
120_G164_E0.5870.73
242_D247_K0.5850.73
117_P129_T0.5840.73
114_A149_Y0.5840.73
235_K258_A0.5820.72
39_F103_L0.5820.72
112_A126_E0.5810.72
112_A301_E0.5800.72
52_D87_K0.5760.72
149_Y158_R0.5750.71
117_P125_G0.5750.71
236_V252_E0.5730.71
41_I142_I0.5710.71
10_V27_E0.5710.71
114_A129_T0.5700.71
301_E304_G0.5680.71
124_A304_G0.5680.71
102_Q105_S0.5670.70
240_T249_K0.5660.70
115_T149_Y0.5650.70
84_I141_S0.5650.70
134_T245_E0.5640.70
62_S280_S0.5630.70
12_L284_R0.5620.70
43_S115_T0.5600.69
236_V258_A0.5600.69
83_I147_A0.5590.69
121_A129_T0.5580.69
136_E139_I0.5570.69
10_V29_Y0.5560.69
14_M27_E0.5550.69
111_R124_A0.5550.69
24_Y153_R0.5550.69
8_D105_S0.5550.69
202_F216_D0.5510.68
201_S235_K0.5510.68
181_G211_G0.5510.68
227_L265_D0.5500.68
199_E215_P0.5500.68
20_R24_Y0.5490.68
210_K239_L0.5480.68
129_T300_L0.5430.67
114_A167_M0.5410.67
149_Y306_R0.5410.67
124_A129_T0.5380.66
104_G138_L0.5360.66
8_D48_E0.5340.66
11_S27_E0.5340.66
191_E305_I0.5310.65
98_E101_S0.5300.65
44_R130_D0.5270.65
92_M96_I0.5260.65
254_S258_A0.5260.65
216_D263_L0.5260.65
178_V295_K0.5260.65
190_T222_K0.5240.64
43_S168_A0.5240.64
69_T73_E0.5230.64
125_G129_T0.5210.64
216_D262_S0.5200.64
96_I139_I0.5180.63
14_M17_I0.5160.63
109_A157_Y0.5160.63
192_E222_K0.5160.63
155_I290_W0.5150.63
48_E89_P0.5150.63
69_T74_K0.5150.63
153_R206_E0.5150.63
31_M34_N0.5150.63
97_Y138_L0.5140.63
49_A87_K0.5140.63
236_V240_T0.5140.63
215_P279_E0.5130.63
128_E153_R0.5130.63
127_Y158_R0.5130.63
79_I84_I0.5130.63
68_D83_I0.5130.63
156_A159_I0.5120.63
115_T121_A0.5110.62
201_S213_V0.5110.62
47_N51_K0.5110.62
39_F99_R0.5100.62
142_I171_V0.5090.62
95_E229_S0.5090.62
20_R287_N0.5090.62
87_K129_T0.5080.62
22_S29_Y0.5080.62
124_A287_N0.5070.62
200_S216_D0.5030.61
130_D145_V0.5030.61
193_P285_N0.5030.61
230_K235_K0.5020.61
245_E249_K0.5010.61
195_Y219_V0.5000.61
224_T228_V0.5000.61
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2olsA 2 0.9519 100 0.144 Contact Map
2x0sA 2 0.9391 100 0.381 Contact Map
1vbgA 2 0.8718 100 0.396 Contact Map
1kblA 2 0.8718 100 0.423 Contact Map
1a9xA 3 0.6699 93.3 0.935 Contact Map
2i87A 2 0.6218 83.7 0.946 Contact Map
3jrxA 1 0.6635 82.8 0.947 Contact Map
3u9tA 3 0.5962 82 0.947 Contact Map
1wr2A 1 0.6474 81.3 0.947 Contact Map
3va7A 1 0.4968 80 0.948 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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