GREMLIN Database
FDHD - Protein FdhD homolog
UniProt: Q97V15 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 257 (241)
Sequences: 2276 (1549)
Seq/√Len: 99.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
25_V228_I3.9351.00
55_E184_L3.9031.00
35_T61_L3.7611.00
210_I236_L3.3551.00
58_L73_V3.3181.00
55_E166_Y3.2881.00
218_C242_L3.2321.00
157_N161_E3.2231.00
195_M209_G2.9261.00
179_V212_A2.6801.00
57_S84_I2.5181.00
67_I73_V2.4991.00
52_D55_E2.4951.00
181_R185_E2.4471.00
46_I56_L2.4381.00
239_I242_L2.4311.00
197_V205_I2.3981.00
164_F181_R2.3911.00
210_I234_A2.3861.00
62_Y183_L2.3561.00
197_V217_I2.1841.00
232_E252_H2.0501.00
182_L190_A2.0371.00
156_F162_L1.9601.00
58_L184_L1.9381.00
164_F178_V1.9371.00
155_L182_L1.8231.00
125_V194_I1.8111.00
23_D248_N1.8111.00
69_S72_D1.8091.00
222_A241_F1.7971.00
74_E87_K1.7391.00
31_L48_R1.7161.00
166_Y181_R1.7071.00
217_I236_L1.7041.00
179_V214_I1.6801.00
155_L193_Y1.6641.00
216_I237_T1.6531.00
175_V195_M1.6261.00
132_S136_K1.5981.00
189_P192_N1.5651.00
225_S229_E1.5621.00
23_D241_F1.5561.00
133_F194_I1.5541.00
54_K184_L1.5521.00
62_Y179_V1.5201.00
33_I57_S1.5031.00
130_I218_C1.4811.00
34_R83_V1.4801.00
195_M214_I1.4761.00
232_E251_T1.4661.00
239_I249_I1.4581.00
52_D166_Y1.4471.00
194_I216_I1.4461.00
153_T197_V1.4401.00
205_I217_I1.4261.00
57_S86_V1.4151.00
68_N72_D1.4061.00
26_A150_L1.4061.00
125_V216_I1.3901.00
201_L219_G1.3870.99
74_E89_N1.3670.99
54_K76_I1.3620.99
73_V86_V1.3550.99
241_F250_Y1.3550.99
154_A162_L1.3500.99
134_P242_L1.3370.99
148_G241_F1.3350.99
13_V247_L1.3170.99
117_N233_E1.3140.99
131_F245_K1.3030.99
156_F194_I1.2970.99
229_E233_E1.2910.99
148_G250_Y1.2900.99
31_L53_D1.2820.99
130_I242_L1.2780.99
23_D250_Y1.2740.99
126_K129_V1.2680.99
157_N163_L1.2650.99
100_I104_S1.2600.99
83_V86_V1.2540.99
153_T174_A1.2420.99
72_D89_N1.2330.99
140_K162_L1.2300.99
73_V76_I1.2230.99
68_N91_P1.2160.99
13_V18_A1.2130.99
48_R53_D1.1850.98
236_L252_H1.1790.98
27_V225_S1.1760.98
82_N86_V1.1730.98
23_D148_G1.1700.98
76_I86_V1.1690.98
129_V132_S1.1620.98
55_E181_R1.1540.98
127_R247_L1.1520.98
228_I238_L1.1310.98
24_F146_I1.1290.98
36_C40_C1.1250.98
41_E96_I1.1120.98
206_V236_L1.0940.97
206_V217_I1.0870.97
40_C85_E1.0760.97
203_Y207_S1.0580.97
54_K84_I1.0560.97
15_D245_K1.0540.97
197_V219_G1.0390.96
142_S165_I1.0380.96
83_V87_K1.0320.96
153_T175_V1.0300.96
219_G240_G1.0270.96
75_D87_K1.0260.96
175_V197_V1.0230.96
239_I256_I1.0180.96
136_K139_E1.0080.96
61_L86_V1.0080.96
240_G250_Y0.9980.95
58_L76_I0.9980.95
43_F99_L0.9970.95
130_I239_I0.9820.95
144_F241_F0.9770.95
44_A60_F0.9740.95
34_R85_E0.9730.95
231_A238_L0.9710.95
30_P45_I0.9710.95
79_V85_E0.9690.95
129_V160_G0.9680.95
26_A143_V0.9680.95
241_F248_N0.9670.95
154_A196_Q0.9650.94
60_F99_L0.9630.94
54_K78_Q0.9560.94
33_I86_V0.9500.94
249_I256_I0.9460.94
137_L198_S0.9360.93
237_T255_R0.9340.93
162_L165_I0.9340.93
14_K246_S0.9330.93
142_S146_I0.9320.93
58_L70_I0.9280.93
35_T86_V0.9260.93
31_L57_S0.9250.93
32_N42_D0.9190.93
155_L178_V0.9160.93
141_Q152_A0.9110.93
41_E93_G0.9060.92
67_I183_L0.9030.92
67_I76_I0.9020.92
29_E82_N0.9020.92
147_S241_F0.9010.92
170_G173_N0.9010.92
78_Q84_I0.8950.92
42_D98_E0.8930.92
163_L193_Y0.8900.92
111_A115_T0.8900.92
23_D147_S0.8900.92
70_I186_D0.8900.92
182_L193_Y0.8890.92
140_K165_I0.8890.92
52_D181_R0.8740.91
235_G252_H0.8740.91
62_Y67_I0.8720.91
158_P161_E0.8710.91
148_G222_A0.8660.91
12_R21_D0.8580.90
58_L67_I0.8570.90
175_V205_I0.8570.90
176_D208_K0.8560.90
70_I183_L0.8530.90
48_R56_L0.8510.90
201_L241_F0.8500.90
194_I218_C0.8490.90
197_V236_L0.8460.90
178_V195_M0.8450.89
35_T88_L0.8380.89
151_H200_R0.8370.89
136_K161_E0.8360.89
196_Q218_C0.8340.89
152_A198_S0.8340.89
121_S192_N0.8310.89
205_I224_T0.8300.89
70_I184_L0.8270.88
47_M107_V0.8190.88
23_D198_S0.8190.88
130_I247_L0.8150.88
23_D144_F0.8140.88
119_L122_D0.8130.88
96_I111_A0.8090.87
129_V133_F0.8050.87
104_S109_G0.8010.87
169_V224_T0.7990.87
123_L216_I0.7980.87
201_L240_G0.7970.87
151_H171_R0.7910.86
196_Q242_L0.7870.86
23_D240_G0.7860.86
201_L227_A0.7810.85
14_K17_E0.7750.85
229_E232_E0.7710.85
58_L183_L0.7670.84
71_H186_D0.7660.84
46_I101_V0.7640.84
13_V249_I0.7530.83
43_F66_V0.7530.83
95_R111_A0.7490.83
171_R200_R0.7430.82
111_A114_Y0.7420.82
148_G198_S0.7410.82
148_G246_S0.7390.82
105_C108_C0.7360.82
240_G248_N0.7310.81
32_N45_I0.7270.81
138_R145_N0.7250.81
104_S197_V0.7190.80
50_P177_K0.7180.80
125_V218_C0.7170.80
144_F248_N0.7170.80
137_L149_G0.7150.80
135_E138_R0.7090.79
100_I110_R0.7070.79
216_I255_R0.7040.79
149_G241_F0.7000.79
136_K140_K0.7000.79
143_V149_G0.7000.79
71_H89_N0.6960.78
144_F149_G0.6950.78
230_I233_E0.6870.77
47_M141_Q0.6860.77
97_R108_C0.6770.76
155_L214_I0.6750.76
108_C141_Q0.6700.75
201_L206_V0.6680.75
12_R19_Y0.6670.75
55_E164_F0.6650.75
175_V202_G0.6650.75
91_P94_I0.6640.75
147_S222_A0.6550.74
18_A247_L0.6520.73
215_P235_G0.6520.73
144_F148_G0.6510.73
129_V156_F0.6500.73
47_M104_S0.6500.73
239_I247_L0.6480.73
15_D145_N0.6450.73
209_G214_I0.6450.73
235_G251_T0.6440.73
123_L158_P0.6440.73
119_L236_L0.6430.72
20_K128_E0.6410.72
148_G240_G0.6400.72
83_V89_N0.6350.72
197_V201_L0.6310.71
92_I96_I0.6220.70
195_M212_A0.6200.70
195_M217_I0.6180.69
143_V150_L0.6170.69
142_S145_N0.6150.69
159_Q191_S0.6130.69
58_L185_E0.6120.69
81_N85_E0.6120.69
197_V228_I0.6080.68
207_S230_I0.6060.68
166_Y219_G0.6060.68
147_S150_L0.6050.68
30_P106_G0.6050.68
151_H170_G0.6040.68
151_H172_H0.6030.68
35_T43_F0.6010.67
63_S211_K0.6010.67
107_V141_Q0.6000.67
198_S248_N0.5990.67
33_I46_I0.5980.67
65_G211_K0.5980.67
64_E105_C0.5950.67
82_N89_N0.5950.67
152_A167_E0.5940.66
120_K123_L0.5920.66
190_A212_A0.5910.66
175_V178_V0.5900.66
139_E145_N0.5890.66
185_E188_I0.5870.66
198_S220_I0.5830.65
109_G141_Q0.5820.65
153_T195_M0.5820.65
242_L247_L0.5800.65
60_F63_S0.5790.64
61_L67_I0.5790.64
44_A63_S0.5780.64
149_G182_L0.5770.64
164_F188_I0.5760.64
146_I163_L0.5750.64
99_L110_R0.5750.64
95_R118_I0.5750.64
182_L198_S0.5740.64
63_S100_I0.5740.64
47_M105_C0.5720.64
134_P218_C0.5700.63
69_S186_D0.5660.63
123_L192_N0.5640.62
172_H200_R0.5640.62
143_V147_S0.5640.62
135_E244_G0.5630.62
86_V89_N0.5630.62
54_K79_V0.5630.62
60_F153_T0.5610.62
144_F220_I0.5600.62
106_G109_G0.5590.62
203_Y227_A0.5590.62
65_G228_I0.5580.62
173_N215_P0.5580.62
121_S215_P0.5570.62
95_R115_T0.5550.61
31_L84_I0.5550.61
222_A226_L0.5540.61
164_F182_L0.5540.61
122_D191_S0.5530.61
175_V209_G0.5530.61
198_S241_F0.5520.61
30_P105_C0.5490.60
170_G176_D0.5490.60
89_N92_I0.5490.60
28_E170_G0.5490.60
182_L186_D0.5480.60
155_L198_S0.5460.60
119_L256_I0.5450.60
157_N188_I0.5410.59
137_L169_V0.5410.59
108_C207_S0.5380.59
190_A193_Y0.5370.59
47_M225_S0.5370.59
101_V199_G0.5360.59
26_A56_L0.5360.59
47_M109_G0.5360.59
70_I73_V0.5350.58
14_K245_K0.5340.58
47_M106_G0.5330.58
12_R133_F0.5320.58
167_E238_L0.5310.58
182_L189_P0.5290.58
201_L220_I0.5280.57
58_L86_V0.5270.57
102_N105_C0.5260.57
42_D104_S0.5220.57
104_S110_R0.5220.57
15_D22_S0.5210.56
61_L199_G0.5210.56
101_V104_S0.5200.56
135_E245_K0.5180.56
36_C88_L0.5180.56
47_M167_E0.5140.55
46_I53_D0.5120.55
116_L207_S0.5110.55
137_L196_Q0.5100.55
74_E93_G0.5090.55
50_P223_P0.5060.54
63_S179_V0.5050.54
206_V227_A0.5050.54
77_K80_E0.5050.54
203_Y220_I0.5040.54
49_T143_V0.5020.54
30_P47_M0.5010.54
62_Y224_T0.5000.53
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pdeA 2 0.8988 100 0.09 Contact Map
2pw9A 2 0.8988 100 0.126 Contact Map
2fp4A 1 0.5253 39.7 0.959 Contact Map
2yv1A 1 0.4864 36.8 0.959 Contact Map
1oi7A 1 0.5136 32.4 0.961 Contact Map
3mtjA 3 0.537 31.5 0.961 Contact Map
2yv2A 1 0.4942 29.2 0.962 Contact Map
2duwA 1 0.4942 21.6 0.964 Contact Map
3i23A 2 0.4942 21.5 0.964 Contact Map
3oqbA 4 0.5292 21.2 0.964 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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