GREMLIN Database
Q97V08 - Uncharacterized protein
UniProt: Q97V08 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 291 (247)
Sequences: 11634 (8494)
Seq/√Len: 540.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
281_D285_W3.7781.00
57_G96_L3.5441.00
221_N282_K3.5181.00
152_S163_I3.3621.00
167_S177_K3.1111.00
228_K232_N3.0291.00
249_G256_A2.9491.00
224_L278_G2.9011.00
222_D287_L2.8031.00
283_A287_L2.7011.00
283_A286_E2.6651.00
234_F275_L2.5451.00
150_A163_I2.4601.00
225_N229_A2.4551.00
248_T258_T2.4361.00
251_N256_A2.4081.00
211_Q254_T2.3461.00
127_Q131_Q2.3171.00
154_I161_P2.2921.00
209_P258_T2.1271.00
229_A233_D2.1001.00
226_L283_A2.0911.00
273_L277_N2.0871.00
227_A280_F2.0831.00
229_A283_A2.0511.00
224_L228_K2.0461.00
168_K175_E1.9971.00
279_A282_K1.9771.00
150_A165_E1.9661.00
190_A194_N1.9661.00
209_P256_A1.9491.00
222_D225_N1.9271.00
226_L287_L1.8811.00
222_D226_L1.8611.00
221_N278_G1.7641.00
152_S199_K1.7571.00
211_Q256_A1.7531.00
247_F255_N1.7161.00
275_L279_A1.7101.00
167_S183_V1.6831.00
282_K286_E1.6521.00
178_T184_I1.6431.00
233_D279_A1.6401.00
142_S172_L1.6391.00
230_Y283_A1.6301.00
152_S197_F1.6261.00
230_Y279_A1.5911.00
261_L276_I1.5871.00
212_L223_L1.5701.00
152_S161_P1.5481.00
69_Y85_K1.5391.00
231_I259_V1.5081.00
207_V258_T1.4971.00
128_T131_Q1.4751.00
154_I195_T1.4571.00
226_L229_A1.4571.00
150_A179_I1.4561.00
65_Q89_D1.4511.00
223_L257_F1.4501.00
217_D222_D1.4451.00
162_I195_T1.4131.00
50_V104_L1.4101.00
145_I174_T1.4081.00
225_N228_K1.3981.00
175_E183_V1.3851.00
120_I123_G1.3741.00
174_T188_N1.3541.00
184_I197_F1.3511.00
210_Y280_F1.3391.00
234_F279_A1.3301.00
233_D283_A1.3221.00
154_I194_N1.3211.00
271_G275_L1.3181.00
212_L216_A1.3171.00
59_Y63_I1.3051.00
238_E241_Q1.2981.00
265_D268_Q1.2951.00
149_D201_E1.2801.00
151_V166_I1.2751.00
213_L216_A1.2671.00
263_F272_I1.2661.00
92_F96_L1.2631.00
236_S275_L1.2601.00
278_G282_K1.2601.00
229_A232_N1.2491.00
164_G176_V1.2441.00
221_N225_N1.2411.00
243_P246_Y1.2401.00
57_G61_I1.2361.00
211_Q253_G1.2291.00
54_A58_F1.2271.00
35_P38_S1.2211.00
182_N197_F1.1981.00
50_V100_I1.1941.00
146_R201_E1.1861.00
214_V250_K1.1731.00
211_Q251_N1.1711.00
190_A193_G1.1501.00
178_T182_N1.1471.00
46_T49_T1.1411.00
284_Y289_K1.1341.00
236_S268_Q1.1271.00
114_G117_V1.1241.00
215_N281_D1.1161.00
209_P249_G1.1121.00
183_V201_E1.1011.00
211_Q214_V1.1011.00
110_G113_V1.0901.00
206_L261_L1.0841.00
89_D93_Y1.0841.00
65_Q85_K1.0841.00
252_G256_A1.0781.00
279_A283_A1.0771.00
100_I104_L1.0761.00
101_L106_V1.0721.00
216_A223_L1.0711.00
153_L191_F1.0591.00
227_A259_V1.0581.00
220_A257_F1.0511.00
190_A195_T1.0361.00
232_N239_K1.0261.00
211_Q252_G1.0251.00
228_K245_I1.0091.00
58_F62_R1.0091.00
276_I280_F1.0001.00
248_T256_A0.9931.00
269_L273_L0.9921.00
221_N224_L0.9831.00
266_I269_L0.9671.00
118_G122_I0.9571.00
61_I89_D0.9511.00
112_L116_A0.9461.00
274_N278_G0.9421.00
220_A224_L0.9291.00
53_I103_A0.9281.00
173_F185_K0.9281.00
58_F93_Y0.9261.00
214_V253_G0.9241.00
205_S262_H0.9231.00
250_K255_N0.9221.00
61_I65_Q0.9141.00
82_S86_V0.9081.00
240_I243_P0.9081.00
226_L230_Y0.9071.00
45_F49_T0.9011.00
228_K243_P0.8841.00
53_I96_L0.8771.00
170_S175_E0.8761.00
96_L100_I0.8731.00
212_L257_F0.8721.00
212_L220_A0.8681.00
131_Q189_S0.8671.00
231_I261_L0.8671.00
85_K89_D0.8611.00
177_K183_V0.8601.00
126_V134_L0.8551.00
143_R146_R0.8541.00
264_N268_Q0.8481.00
166_I176_V0.8461.00
209_P248_T0.8451.00
125_A130_A0.8441.00
216_A220_A0.8421.00
57_G92_F0.8411.00
212_L284_Y0.8401.00
162_I184_I0.8401.00
206_L273_L0.8381.00
251_N254_T0.8371.00
41_T45_F0.8371.00
247_F277_N0.8351.00
250_K277_N0.8351.00
181_G262_H0.8321.00
245_I259_V0.8311.00
224_L274_N0.8301.00
204_H269_L0.8251.00
117_V126_V0.8221.00
246_Y274_N0.8201.00
223_L284_Y0.8191.00
61_I92_F0.8111.00
165_E177_K0.8111.00
246_Y258_T0.8111.00
236_S272_I0.8071.00
268_Q271_G0.8021.00
129_I135_S0.8001.00
135_S192_L0.7911.00
43_D47_A0.7911.00
227_A284_Y0.7901.00
102_A107_N0.7871.00
216_A222_D0.7871.00
270_N274_N0.7861.00
230_Y276_I0.7861.00
151_V176_V0.7851.00
138_L192_L0.7821.00
37_I40_Y0.7821.00
154_I190_A0.7751.00
142_S173_F0.7731.00
223_L226_L0.7681.00
214_V255_N0.7681.00
231_I234_F0.7671.00
223_L227_A0.7661.00
249_G277_N0.7661.00
227_A231_I0.7651.00
226_L289_K0.7641.00
49_T103_A0.7631.00
114_G118_G0.7621.00
42_S46_T0.7581.00
234_F276_I0.7521.00
118_G121_V0.7521.00
207_V260_I0.7511.00
232_N242_L0.7501.00
67_L71_Q0.7471.00
210_Y227_A0.7431.00
236_S271_G0.7401.00
230_Y234_F0.7401.00
228_K231_I0.7401.00
36_Q40_Y0.7381.00
275_L278_G0.7341.00
48_I52_I0.7221.00
113_V116_A0.7161.00
206_L263_F0.7151.00
43_D46_T0.7101.00
94_T98_L0.7091.00
226_L286_E0.7051.00
248_T273_L0.7041.00
242_L246_Y0.7031.00
61_I96_L0.7031.00
93_Y97_V0.7011.00
177_K181_G0.7011.00
214_V252_G0.6961.00
78_K81_A0.6891.00
230_Y233_D0.6871.00
225_N232_N0.6861.00
259_V280_F0.6831.00
39_T43_D0.6811.00
114_G119_G0.6781.00
220_A255_N0.6781.00
115_G119_G0.6761.00
141_S144_T0.6761.00
39_T42_S0.6741.00
255_N281_D0.6731.00
208_Y277_N0.6721.00
183_V202_S0.6721.00
68_I71_Q0.6721.00
96_L99_V0.6701.00
99_V103_A0.6661.00
231_I237_K0.6641.00
244_E260_I0.6641.00
250_K281_D0.6611.00
177_K202_S0.6591.00
122_I130_A0.6551.00
109_T113_V0.6491.00
170_S173_F0.6481.00
250_K280_F0.6471.00
226_L284_Y0.6461.00
180_N205_S0.6461.00
231_I276_I0.6441.00
153_L162_I0.6401.00
52_I56_G0.6401.00
153_L186_I0.6391.00
132_N189_S0.6331.00
122_I134_L0.6331.00
220_A247_F0.6301.00
131_Q193_G0.6281.00
162_I197_F0.6281.00
107_N110_G0.6251.00
64_L88_L0.6191.00
55_I59_Y0.6161.00
145_I191_F0.6151.00
214_V254_T0.6131.00
205_S260_I0.6121.00
212_L289_K0.6111.00
235_F238_E0.6111.00
64_L92_F0.6091.00
220_A282_K0.6091.00
95_I99_V0.6051.00
112_L121_V0.6031.00
208_Y261_L0.6031.00
145_I151_V0.6001.00
220_A281_D0.5991.00
222_D229_A0.5991.00
117_V121_V0.5971.00
142_S175_E0.5971.00
163_I199_K0.5951.00
154_I162_I0.5931.00
61_I93_Y0.5921.00
231_I243_P0.5911.00
53_I57_G0.5901.00
152_S162_I0.5891.00
36_Q39_T0.5891.00
175_E185_K0.5881.00
59_Y62_R0.5881.00
228_K242_L0.5881.00
72_L81_A0.5881.00
217_D285_W0.5870.99
127_Q189_S0.5860.99
82_S168_K0.5840.99
229_A287_L0.5840.99
65_Q69_Y0.5840.99
129_I192_L0.5810.99
124_L127_Q0.5790.99
240_I246_Y0.5750.99
62_R66_G0.5750.99
128_T193_G0.5750.99
128_T189_S0.5720.99
211_Q255_N0.5720.99
237_K272_I0.5710.99
90_I94_T0.5710.99
38_S42_S0.5650.99
186_I195_T0.5640.99
69_Y73_L0.5640.99
71_Q74_T0.5640.99
151_V191_F0.5620.99
79_S140_T0.5600.99
120_I128_T0.5600.99
224_L245_I0.5600.99
139_V145_I0.5580.99
210_Y250_K0.5580.99
217_D282_K0.5570.99
238_E264_N0.5560.99
112_L117_V0.5540.99
52_I55_I0.5520.99
230_Y287_L0.5510.99
214_V251_N0.5510.99
77_E146_R0.5500.99
35_P40_Y0.5480.99
47_A51_I0.5480.99
264_N267_K0.5460.99
116_A119_G0.5450.99
86_V89_D0.5450.99
211_Q250_K0.5450.99
266_I270_N0.5440.99
135_S189_S0.5430.99
117_V120_I0.5430.99
272_I275_L0.5410.99
246_Y260_I0.5400.99
182_N199_K0.5400.99
221_N228_K0.5360.99
40_Y43_D0.5350.99
277_N280_F0.5310.99
215_N285_W0.5300.99
119_G125_A0.5290.99
247_F250_K0.5260.99
180_N207_V0.5260.99
224_L257_F0.5240.99
223_L283_A0.5240.99
79_S83_S0.5230.99
216_A255_N0.5220.99
62_R65_Q0.5210.99
86_V90_I0.5210.99
55_I58_F0.5200.99
237_K241_Q0.5200.99
237_K261_L0.5190.99
124_L129_I0.5180.99
234_F237_K0.5180.99
118_G125_A0.5170.99
42_S45_F0.5150.99
227_A245_I0.5150.99
50_V54_A0.5140.99
231_I245_I0.5130.99
258_T274_N0.5120.99
86_V168_K0.5110.99
270_N273_L0.5070.99
138_L172_L0.5070.99
108_L114_G0.5060.99
78_K82_S0.5060.99
44_T48_I0.5060.99
81_A85_K0.5050.99
51_I62_R0.5040.98
189_S193_G0.5010.98
226_L231_I0.5010.98
267_K270_N0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
5ajiA 3 0.8522 100 0.186 Contact Map
4hw9A 3 0.8247 100 0.19 Contact Map
3udcA 3 0.8282 100 0.221 Contact Map
1nz9A 1 0.1821 48.6 0.933 Contact Map
2e6zA 1 0.1924 36.9 0.938 Contact Map
2mi6A 1 0.1959 27 0.942 Contact Map
3cnrA 1 0.2921 26.4 0.942 Contact Map
2qn6B 1 0.2955 24.7 0.943 Contact Map
3ghfA 2 0.244 18 0.946 Contact Map
4hczA 1 0.1924 15.4 0.948 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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