GREMLIN Database
Q97V06 - AAA family ATPase
UniProt: Q97V06 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 585 (459)
Sequences: 4496 (2280)
Seq/√Len: 106.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
63_P67_W5.6021.00
60_I119_A5.5581.00
349_E352_E4.7011.00
254_S257_F4.3081.00
58_P121_F4.2671.00
500_Q513_I3.9041.00
496_E514_S3.5231.00
148_E195_R3.3261.00
229_E251_A3.1611.00
232_R251_A3.1311.00
324_W331_E3.1091.00
361_G450_M3.0391.00
126_S181_I2.9731.00
463_G481_F2.9701.00
492_K518_E2.9611.00
318_G321_N2.9211.00
86_I222_I2.8681.00
320_P335_R2.7721.00
376_A462_V2.7661.00
319_I382_D2.7151.00
59_K64_N2.7041.00
228_D231_S2.7031.00
234_E237_K2.6581.00
322_I325_N2.6391.00
52_T55_S2.5621.00
70_V114_N2.5371.00
271_S275_S2.4861.00
233_E247_Y2.4811.00
131_K135_E2.3991.00
248_S252_K2.3751.00
509_N512_I2.3741.00
491_D494_G2.3121.00
83_I222_I2.2741.00
328_G501_V2.2501.00
128_I143_F2.2471.00
96_I160_L2.2421.00
51_N55_S2.2061.00
64_N69_E2.1991.00
365_Y465_T2.1261.00
326_D378_A2.0891.00
288_Y292_I2.0731.00
334_K375_I2.0681.00
364_L462_V2.0591.00
289_K292_I2.0581.00
301_E304_A2.0361.00
145_D149_I2.0261.00
60_I63_P2.0201.00
271_S274_N1.9921.00
288_Y293_Q1.9771.00
304_A308_E1.8961.00
322_I382_D1.8911.00
63_P66_R1.8741.00
398_A433_N1.8681.00
250_L253_K1.8621.00
71_Y90_G1.8571.00
320_P342_V1.8461.00
164_A212_F1.7801.00
414_A459_V1.7571.00
250_L266_A1.7551.00
259_P263_K1.7471.00
296_T304_A1.7241.00
145_D148_E1.7231.00
515_K519_L1.7201.00
297_I304_A1.7031.00
349_E353_K1.7011.00
508_I512_I1.6941.00
326_D381_N1.6921.00
349_E355_G1.6811.00
53_T142_S1.6771.00
363_L481_F1.6681.00
352_E355_G1.6651.00
231_S234_E1.6591.00
52_T146_Q1.6281.00
502_L505_D1.6281.00
229_E233_E1.6161.00
288_Y294_L1.6091.00
492_K514_S1.6041.00
259_P267_D1.5951.00
326_D374_S1.5941.00
291_S294_L1.5851.00
332_E488_P1.5821.00
250_L254_S1.5741.00
259_P262_I1.5711.00
363_L427_I1.4951.00
66_R119_A1.4921.00
297_I303_I1.4891.00
253_K257_F1.4831.00
53_T146_Q1.4761.00
508_I513_I1.4671.00
386_N417_N1.4601.00
258_S262_I1.4581.00
256_R259_P1.4581.00
262_I269_V1.4541.00
272_K275_S1.4501.00
301_E308_E1.4501.00
289_K293_Q1.4361.00
225_A417_N1.4251.00
503_I508_I1.4201.00
303_I308_E1.4191.00
296_T303_I1.4161.00
318_G322_I1.4151.00
260_A267_D1.4141.00
488_P494_G1.4141.00
229_E255_E1.4141.00
229_E252_K1.4101.00
297_I301_E1.4061.00
248_S251_A1.4001.00
296_T300_F1.3971.00
259_P264_N1.3961.00
260_A264_N1.3911.00
298_I304_A1.3901.00
246_D253_K1.3891.00
260_A263_K1.3871.00
273_N276_L1.3861.00
301_E305_R1.3691.00
326_D384_R1.3611.00
336_I485_I1.3571.00
263_K267_D1.3511.00
130_S143_F1.3511.00
259_P269_V1.3440.99
233_E248_S1.3300.99
73_L80_L1.3290.99
82_E85_K1.3250.99
310_S318_G1.3140.99
108_I224_V1.3080.99
388_I420_A1.3070.99
125_P128_I1.3060.99
247_Y266_A1.2950.99
414_A422_I1.2930.99
290_P293_Q1.2810.99
258_S261_D1.2770.99
300_F304_A1.2750.99
285_I292_I1.2750.99
243_E246_D1.2740.99
60_I121_F1.2710.99
383_L460_I1.2660.99
513_I516_V1.2450.99
144_F185_R1.2350.99
496_E510_R1.2290.99
254_S258_S1.2270.99
223_Y417_N1.2230.99
285_I288_Y1.2230.99
253_K259_P1.2220.99
262_I267_D1.2110.99
160_L200_G1.2100.99
246_D250_L1.2080.99
257_F263_K1.2050.99
282_L292_I1.2030.99
324_W334_K1.1980.99
237_K244_D1.1960.99
140_L143_F1.1950.99
254_S261_D1.1880.99
49_I52_T1.1830.99
264_N267_D1.1790.99
512_I517_A1.1780.99
296_T301_E1.1780.99
494_G497_K1.1670.99
168_Q175_T1.1660.99
305_R308_E1.1590.98
259_P270_I1.1560.98
290_P294_L1.1550.98
396_S444_T1.1530.98
424_I449_Q1.1370.98
449_Q461_V1.1370.98
266_A269_V1.1320.98
281_F284_E1.1320.98
256_R267_D1.1300.98
303_I307_Y1.1300.98
65_I70_V1.1280.98
297_I305_R1.1230.98
302_N308_E1.1210.98
282_L286_E1.1170.98
387_F421_I1.1110.98
396_S433_N1.1010.98
62_I65_I1.1000.98
250_L257_F1.0990.98
257_F267_D1.0960.98
285_I293_Q1.0930.98
246_D259_P1.0930.98
251_A259_P1.0900.98
319_I338_R1.0870.98
348_K353_K1.0860.98
282_L295_S1.0840.98
83_I97_L1.0840.98
496_E500_Q1.0820.98
82_E268_K1.0810.98
55_S63_P1.0720.97
388_I414_A1.0720.97
256_R260_A1.0670.97
43_F47_M1.0660.97
147_V155_V1.0660.97
263_K269_V1.0630.97
100_P204_V1.0600.97
253_K261_D1.0560.97
267_D270_I1.0550.97
284_E288_Y1.0540.97
240_I244_D1.0540.97
514_S517_A1.0520.97
253_K256_R1.0480.97
254_S259_P1.0430.97
288_Y291_S1.0360.97
246_D257_F1.0320.97
282_L289_K1.0320.97
512_I515_K1.0270.97
77_K115_K1.0240.97
251_A254_S1.0220.97
259_P266_A1.0190.97
250_L258_S1.0140.96
282_L288_Y1.0110.96
285_I289_K1.0100.96
350_F353_K1.0090.96
98_F221_V1.0080.96
265_V297_I1.0050.96
229_E232_R1.0050.96
253_K263_K1.0050.96
311_K314_I1.0030.96
150_N153_A1.0030.96
446_L449_Q1.0010.96
305_R309_R0.9990.96
256_R262_I0.9950.96
256_R264_N0.9930.96
292_I295_S0.9890.96
246_D251_A0.9890.96
497_K500_Q0.9880.96
258_S263_K0.9880.96
83_I109_A0.9840.96
302_N305_R0.9840.96
250_L269_V0.9830.96
258_S264_N0.9810.96
251_A257_F0.9780.96
258_S267_D0.9750.96
288_Y295_S0.9740.96
297_I308_E0.9740.96
324_W335_R0.9690.95
515_K518_E0.9680.95
331_E494_G0.9610.95
247_Y250_L0.9580.95
257_F264_N0.9580.95
297_I300_F0.9570.95
277_K282_L0.9560.95
256_R261_D0.9550.95
260_A266_A0.9540.95
253_K262_I0.9500.95
304_A307_Y0.9460.95
350_F355_G0.9450.95
283_R286_E0.9450.95
245_I248_S0.9440.95
499_L513_I0.9430.95
157_I198_I0.9400.95
256_R263_K0.9400.95
257_F260_A0.9310.94
264_N270_I0.9290.94
323_S327_L0.9250.94
296_T308_E0.9220.94
246_D256_R0.9220.94
253_K267_D0.9190.94
260_A269_V0.9170.94
284_E290_P0.9170.94
246_D263_K0.9160.94
243_E247_Y0.9160.94
260_A270_I0.9160.94
40_W47_M0.9150.94
486_Y489_P0.9150.94
298_I303_I0.9150.94
40_W43_F0.9110.94
261_D267_D0.9100.94
125_P163_L0.9090.94
72_D239_Y0.9080.94
264_N269_V0.9070.94
254_S265_V0.9060.94
44_S50_G0.9050.93
300_F303_I0.9040.93
296_T305_R0.9030.93
512_I516_V0.9020.93
289_K294_L0.9010.93
314_I317_Y0.8990.93
263_K266_A0.8990.93
246_D269_V0.8980.93
245_I251_A0.8970.93
116_L120_Y0.8950.93
495_R517_A0.8930.93
243_E253_K0.8930.93
237_K240_I0.8900.93
237_K248_S0.8900.93
90_G242_R0.8890.93
298_I308_E0.8870.93
130_S140_L0.8820.93
62_I70_V0.8810.93
247_Y253_K0.8800.93
509_N513_I0.8770.92
246_D261_D0.8730.92
258_S269_V0.8700.92
500_Q504_K0.8690.92
81_E299_K0.8690.92
77_K231_S0.8670.92
246_D262_I0.8660.92
508_I511_N0.8650.92
257_F262_I0.8650.92
261_D264_N0.8640.92
37_L41_I0.8640.92
364_L487_V0.8640.92
335_R339_E0.8640.92
378_A381_N0.8630.92
97_L224_V0.8600.92
300_F308_E0.8600.92
511_N514_S0.8600.92
324_W494_G0.8580.92
257_F261_D0.8560.91
349_E354_L0.8560.91
245_I253_K0.8550.91
38_I42_Y0.8550.91
237_K247_Y0.8520.91
170_D175_T0.8510.91
300_F307_Y0.8510.91
156_F201_A0.8450.91
420_A459_V0.8450.91
245_I250_L0.8450.91
499_L517_A0.8440.91
44_S47_M0.8440.91
244_D257_F0.8420.91
272_K276_L0.8360.90
243_E251_A0.8340.90
247_Y251_A0.8330.90
350_F354_L0.8330.90
169_S176_H0.8310.90
320_P324_W0.8290.90
239_Y242_R0.8290.90
246_D258_S0.8280.90
51_N121_F0.8240.90
298_I301_E0.8240.90
278_T285_I0.8240.90
78_M299_K0.8240.90
253_K258_S0.8220.90
284_E289_K0.8210.90
286_E290_P0.8210.90
263_K270_I0.8200.90
246_D249_L0.8190.90
264_N268_K0.8160.89
284_E294_L0.8160.89
414_A456_I0.8150.89
244_D253_K0.8130.89
261_D269_V0.8110.89
320_P338_R0.8110.89
247_Y262_I0.8100.89
243_E257_F0.8080.89
297_I302_N0.8070.89
187_Q196_V0.8030.89
428_D474_A0.7970.88
333_V485_I0.7970.88
423_F464_A0.7940.88
298_I305_R0.7900.88
69_E195_R0.7890.88
37_L42_Y0.7890.88
282_L290_P0.7890.88
101_P213_L0.7890.88
249_L254_S0.7880.88
42_Y48_M0.7860.88
450_M461_V0.7840.87
507_I511_N0.7810.87
251_A258_S0.7800.87
64_N67_W0.7790.87
424_I463_G0.7790.87
52_T121_F0.7780.87
332_E335_R0.7750.87
128_I155_V0.7750.87
447_L474_A0.7740.87
296_T302_N0.7740.87
62_I119_A0.7740.87
253_K269_V0.7710.87
38_I41_I0.7700.86
52_T56_R0.7700.86
299_K303_I0.7670.86
130_S133_Y0.7660.86
277_K280_D0.7630.86
338_R342_V0.7610.86
287_N292_I0.7610.86
273_N277_K0.7580.86
279_E282_L0.7570.86
398_A444_T0.7570.86
56_R130_S0.7520.85
390_L469_W0.7520.85
232_R258_S0.7520.85
286_E291_S0.7510.85
280_D284_E0.7490.85
475_I481_F0.7490.85
314_I318_G0.7490.85
285_I290_P0.7480.85
300_F305_R0.7480.85
253_K264_N0.7460.85
233_E258_S0.7450.85
80_L111_A0.7450.85
278_T281_F0.7450.85
170_D176_H0.7420.84
49_I55_S0.7390.84
39_F47_M0.7380.84
261_D270_I0.7360.84
374_S378_A0.7260.83
47_M50_G0.7250.83
244_D248_S0.7200.83
316_T342_V0.7190.82
483_K486_Y0.7190.82
485_I488_P0.7180.82
247_Y257_F0.7170.82
42_Y47_M0.7150.82
496_E513_I0.7140.82
266_A270_I0.7140.82
323_S378_A0.7120.82
395_V409_E0.7120.82
136_S178_L0.7120.82
246_D260_A0.7120.82
249_L253_K0.7080.82
336_I483_K0.7080.82
249_L261_D0.7080.82
279_E283_R0.7070.81
245_I249_L0.7070.81
251_A264_N0.7050.81
262_I270_I0.7050.81
252_K255_E0.7030.81
253_K260_A0.7030.81
334_K338_R0.7020.81
277_K281_F0.7010.81
278_T292_I0.7000.81
287_N290_P0.6970.80
259_P265_V0.6960.80
281_F289_K0.6950.80
85_K299_K0.6940.80
177_R180_N0.6940.80
244_D251_A0.6940.80
246_D267_D0.6940.80
390_L422_I0.6930.80
279_E289_K0.6930.80
246_D254_S0.6910.80
513_I517_A0.6910.80
307_Y311_K0.6860.79
281_F288_Y0.6830.79
37_L48_M0.6830.79
303_I306_K0.6810.79
387_F420_A0.6780.79
278_T282_L0.6780.79
324_W488_P0.6780.79
304_A311_K0.6770.79
331_E335_R0.6770.79
324_W328_G0.6770.79
257_F269_V0.6760.78
250_L259_P0.6750.78
119_A150_N0.6740.78
286_E293_Q0.6740.78
43_F51_N0.6740.78
120_Y199_I0.6720.78
286_E292_I0.6710.78
101_P210_E0.6690.78
109_A199_I0.6690.78
285_I295_S0.6670.78
280_D290_P0.6670.78
59_K148_E0.6650.77
283_R287_N0.6640.77
327_L378_A0.6640.77
251_A260_A0.6640.77
284_E293_Q0.6640.77
249_L252_K0.6630.77
298_I302_N0.6630.77
396_S445_E0.6610.77
280_D286_E0.6610.77
517_A522_N0.6590.77
281_F285_I0.6580.77
400_P403_A0.6580.77
54_K143_F0.6580.77
251_A261_D0.6570.76
337_I485_I0.6550.76
74_K238_G0.6550.76
360_K365_Y0.6540.76
109_A114_N0.6530.76
250_L263_K0.6530.76
163_L212_F0.6500.76
280_D288_Y0.6480.75
256_R269_V0.6470.75
377_K452_G0.6470.75
271_S295_S0.6460.75
123_L147_V0.6450.75
98_F204_V0.6450.75
405_K408_A0.6440.75
321_N325_N0.6420.75
57_K139_L0.6410.75
41_I47_M0.6400.75
398_A404_P0.6400.75
325_N381_N0.6390.74
284_E291_S0.6380.74
77_K81_E0.6380.74
62_I120_Y0.6360.74
413_I417_N0.6350.74
110_K188_D0.6350.74
485_I489_P0.6350.74
61_H70_V0.6340.74
301_E307_Y0.6320.74
204_V223_Y0.6320.74
446_L450_M0.6320.74
40_W44_S0.6300.73
165_M177_R0.6290.73
278_T288_Y0.6290.73
262_I266_A0.6280.73
365_Y467_R0.6270.73
283_R288_Y0.6270.73
90_G93_Y0.6250.73
368_P477_R0.6250.73
327_L389_E0.6250.73
492_K517_A0.6240.73
389_E451_D0.6230.73
256_R266_A0.6230.73
374_S502_L0.6230.73
188_D195_R0.6220.72
286_E289_K0.6210.72
258_S265_V0.6210.72
246_D266_A0.6210.72
65_I90_G0.6200.72
250_L261_D0.6200.72
258_S266_A0.6180.72
122_E160_L0.6180.72
254_S267_D0.6170.72
117_G152_P0.6170.72
510_R513_I0.6160.72
279_E286_E0.6150.72
287_N294_L0.6140.72
243_E270_I0.6140.72
65_I114_N0.6140.72
250_L262_I0.6140.72
254_S264_N0.6140.72
507_I510_R0.6140.72
244_D247_Y0.6130.71
281_F290_P0.6120.71
72_D242_R0.6120.71
61_H122_E0.6110.71
147_V150_N0.6110.71
159_E206_Q0.6110.71
125_P176_H0.6100.71
342_V386_N0.6090.71
427_I463_G0.6090.71
41_I44_S0.6060.71
251_A256_R0.6050.70
291_S295_S0.6050.70
88_Q271_S0.6040.70
147_V153_A0.6030.70
382_D501_V0.6030.70
269_V296_T0.6030.70
256_R270_I0.6020.70
136_S167_R0.6010.70
290_P295_S0.6000.70
179_V469_W0.6000.70
214_R217_R0.5990.70
144_F181_I0.5970.69
500_Q508_I0.5970.69
37_L43_F0.5960.69
250_L267_D0.5950.69
36_P42_Y0.5950.69
254_S263_K0.5950.69
42_Y51_N0.5940.69
118_W197_I0.5940.69
321_N324_W0.5940.69
507_I513_I0.5940.69
296_T299_K0.5930.69
389_E447_L0.5920.69
284_E287_N0.5910.69
138_L142_S0.5910.69
38_I47_M0.5910.69
514_S518_E0.5910.69
188_D201_A0.5900.69
58_P128_I0.5900.69
83_I224_V0.5890.68
432_R443_L0.5880.68
43_F46_R0.5880.68
389_E474_A0.5870.68
140_L413_I0.5860.68
289_K295_S0.5850.68
493_D496_E0.5840.68
281_F293_Q0.5830.68
263_K268_K0.5830.68
273_N282_L0.5820.67
499_L508_I0.5810.67
253_K266_A0.5800.67
80_L83_I0.5790.67
316_T320_P0.5790.67
43_F48_M0.5780.67
98_F223_Y0.5770.67
433_N444_T0.5760.67
96_I213_L0.5740.66
271_S282_L0.5740.66
261_D266_A0.5740.66
159_E217_R0.5740.66
44_S48_M0.5730.66
48_M51_N0.5720.66
258_S270_I0.5700.66
254_S260_A0.5700.66
163_L179_V0.5680.66
92_A264_N0.5680.66
427_I443_L0.5660.65
40_W46_R0.5660.65
38_I45_R0.5660.65
198_I218_F0.5660.65
169_S175_T0.5660.65
337_I364_L0.5650.65
425_D480_R0.5650.65
251_A263_K0.5640.65
120_Y147_V0.5640.65
389_E452_G0.5630.65
495_R499_L0.5620.65
36_P40_W0.5620.65
507_I512_I0.5620.65
247_Y252_K0.5620.65
265_V270_I0.5610.65
91_R138_L0.5610.65
57_K130_S0.5610.65
118_W152_P0.5590.64
246_D264_N0.5590.64
251_A267_D0.5580.64
243_E254_S0.5580.64
37_L40_W0.5570.64
378_A384_R0.5560.64
245_I261_D0.5550.64
244_D264_N0.5550.64
250_L255_E0.5540.64
455_E458_N0.5530.64
283_R292_I0.5520.63
257_F270_I0.5510.63
62_I121_F0.5510.63
40_W45_R0.5510.63
39_F44_S0.5510.63
277_K285_I0.5490.63
500_Q510_R0.5480.63
348_K352_E0.5480.63
277_K290_P0.5460.63
37_L51_N0.5450.62
58_P62_I0.5430.62
274_N278_T0.5420.62
126_S198_I0.5410.62
323_S334_K0.5400.62
244_D261_D0.5390.62
55_S60_I0.5390.62
244_D263_K0.5390.62
42_Y45_R0.5360.61
245_I258_S0.5360.61
165_M180_N0.5360.61
36_P45_R0.5350.61
271_S285_I0.5350.61
285_I294_L0.5350.61
125_P162_S0.5340.61
181_I198_I0.5330.61
281_F294_L0.5330.61
282_L291_S0.5300.60
36_P39_F0.5300.60
38_I48_M0.5280.60
81_E130_S0.5280.60
394_E451_D0.5280.60
101_P470_D0.5270.60
501_V504_K0.5250.60
46_R49_I0.5240.59
47_M51_N0.5240.59
471_L475_I0.5230.59
247_Y258_S0.5210.59
136_S165_M0.5200.59
251_A269_V0.5200.59
36_P44_S0.5190.59
129_L133_Y0.5180.59
281_F292_I0.5170.58
243_E250_L0.5170.58
444_T472_D0.5170.58
37_L47_M0.5150.58
211_A214_R0.5140.58
260_A268_K0.5130.58
251_A255_E0.5130.58
41_I51_N0.5100.57
427_I467_R0.5090.57
351_A355_G0.5090.57
58_P147_V0.5090.57
51_N56_R0.5080.57
262_I265_V0.5070.57
251_A262_I0.5070.57
368_P389_E0.5060.57
247_Y254_S0.5060.57
42_Y46_R0.5050.57
159_E203_N0.5050.57
302_N306_K0.5040.57
233_E237_K0.5030.56
254_S270_I0.5020.56
308_E311_K0.5020.56
493_D497_K0.5010.56
44_S51_N0.5010.56
163_L185_R0.5000.56
325_N504_K0.5000.56
101_P187_Q0.5000.56
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1r6bX 1 0.8718 100 0.454 Contact Map
3cf2A 3 0.8735 100 0.467 Contact Map
1qvrA 3 0.8376 100 0.488 Contact Map
4d2uA 3 0.8376 100 0.494 Contact Map
3pxiA 3 0.8256 100 0.507 Contact Map
4ciuA 1 0.7846 100 0.516 Contact Map
3cmuA 1 0.9333 100 0.63 Contact Map
4cr2J 1 0.6085 100 0.657 Contact Map
3j94A 3 0.7299 100 0.663 Contact Map
4cr2L 1 0.5265 100 0.664 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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