GREMLIN Database
Q97V05 - Uncharacterized protein
UniProt: Q97V05 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 233 (218)
Sequences: 2139 (1631)
Seq/√Len: 110.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
78_S88_D3.4911.00
34_G38_I3.2751.00
50_K222_D3.2531.00
170_V173_I3.2241.00
154_T212_Y3.0331.00
214_K218_R2.9951.00
81_T88_D2.7841.00
202_D206_I2.7001.00
80_Q84_S2.5771.00
91_E125_K2.5671.00
41_E60_T2.5331.00
162_A214_K2.4371.00
77_L85_F2.3951.00
40_S107_G2.3481.00
42_Y163_I2.3451.00
90_L122_F2.3111.00
19_V104_I2.1391.00
87_T121_E2.1321.00
17_G58_F2.0911.00
17_G99_L2.0701.00
42_Y46_K2.0391.00
162_A217_L2.0221.00
46_K49_E1.9851.00
17_G93_V1.9671.00
26_Q69_H1.9541.00
27_H156_E1.8541.00
26_Q198_G1.8281.00
161_W170_V1.7971.00
163_I217_L1.7391.00
90_L102_I1.7161.00
61_I85_F1.7091.00
47_A224_L1.6771.00
10_E169_R1.6401.00
71_G192_R1.6361.00
38_I164_G1.6281.00
87_T125_K1.6221.00
66_S69_H1.6141.00
221_V225_I1.6131.00
46_K217_L1.6111.00
75_V89_L1.6071.00
175_E202_D1.6011.00
158_S209_N1.5931.00
30_H157_T1.5851.00
162_A210_E1.5761.00
46_K162_A1.5461.00
218_R222_D1.5151.00
158_S212_Y1.5101.00
50_K221_V1.5041.00
81_T84_S1.4971.00
37_G60_T1.4851.00
48_E57_L1.4781.00
19_V58_F1.4661.00
169_R172_K1.4531.00
159_K217_L1.4411.00
154_T207_R1.4241.00
83_I117_L1.4231.00
174_D197_F1.4221.00
58_F93_V1.4131.00
63_Y75_V1.4041.00
8_R11_I1.3941.00
158_S161_W1.3721.00
132_I227_T1.3671.00
210_E214_K1.3641.00
23_S66_S1.3621.00
84_S88_D1.3341.00
47_A225_I1.3321.00
164_G167_L1.3251.00
149_D153_G1.3221.00
78_S81_T1.3080.99
42_Y45_S1.2980.99
44_A57_L1.2980.99
86_F115_L1.2810.99
94_F129_A1.2630.99
90_L104_I1.2580.99
8_R73_P1.2310.99
61_I89_L1.2240.99
83_I118_V1.2080.99
44_A105_V1.1970.99
50_K218_R1.1950.99
9_E12_R1.1860.99
145_F149_D1.1810.99
47_A221_V1.1810.99
41_E45_S1.1770.99
103_I228_I1.1720.99
46_K218_R1.1660.99
34_G167_L1.1510.99
217_L221_V1.1480.99
161_W208_V1.1450.99
209_N212_Y1.1370.98
18_L228_I1.1350.98
35_T160_I1.1350.98
19_V102_I1.1200.98
18_L57_L1.1150.98
46_K214_K1.0880.98
69_H110_G1.0870.98
222_D226_W1.0850.98
113_Y116_P1.0810.98
175_E205_P1.0800.98
211_E214_K1.0790.98
63_Y89_L1.0780.98
22_G40_S1.0730.98
65_V114_F1.0700.98
226_W229_L1.0670.98
40_S105_V1.0470.97
45_S49_E1.0470.97
101_R130_K1.0380.97
8_R12_R1.0350.97
88_D92_S1.0250.97
38_I160_I1.0240.97
179_Y183_D1.0200.97
26_Q66_S1.0170.97
18_L44_A1.0130.97
35_T38_I0.9910.96
169_R173_I0.9910.96
191_S195_N0.9880.96
69_H198_G0.9790.96
79_F114_F0.9730.96
161_W210_E0.9710.96
50_K225_I0.9690.96
44_A48_E0.9590.96
211_E215_K0.9540.96
43_I220_L0.9540.96
137_F140_E0.9540.96
91_E126_H0.9530.96
225_I229_L0.9520.95
42_Y217_L0.9490.95
38_I167_L0.9370.95
180_E184_G0.9370.95
21_V82_A0.9340.95
9_E13_G0.9310.95
158_S208_V0.9220.95
69_H109_G0.9150.94
58_F63_Y0.9120.94
81_T85_F0.9120.94
26_Q74_F0.9080.94
70_K76_S0.9070.94
136_T220_L0.9060.94
18_L48_E0.9020.94
179_Y184_G0.9010.94
15_L100_R0.8990.94
68_E110_G0.8990.94
81_T92_S0.8910.94
20_P40_S0.8840.93
208_V213_G0.8820.93
22_G44_A0.8730.93
46_K50_K0.8700.93
40_S60_T0.8650.93
27_H36_D0.8590.92
80_Q121_E0.8530.92
173_I206_I0.8400.91
65_V79_F0.8340.91
21_V115_L0.8330.91
66_S111_N0.8270.91
179_Y185_V0.8270.91
87_T118_V0.8250.91
51_L225_I0.8230.91
22_G63_Y0.8230.91
35_T156_E0.8220.91
43_I224_L0.8150.90
77_L82_A0.8090.90
32_P35_T0.8080.90
43_I221_V0.8050.90
39_I136_T0.8010.89
129_A132_I0.7980.89
94_F100_R0.7960.89
165_K210_E0.7940.89
84_S87_T0.7940.89
70_K97_L0.7940.89
31_L168_V0.7900.89
45_S57_L0.7890.89
39_I107_G0.7820.88
40_S44_A0.7820.88
183_D186_F0.7790.88
36_D156_E0.7780.88
68_E109_G0.7760.88
22_G107_G0.7760.88
67_L200_L0.7740.88
128_D131_V0.7680.87
223_K226_W0.7680.87
76_S92_S0.7630.87
106_N111_N0.7630.87
37_G66_S0.7630.87
83_I121_E0.7570.87
39_I159_K0.7570.87
25_E108_H0.7550.86
182_R185_V0.7500.86
181_V184_G0.7490.86
43_I217_L0.7430.86
35_T111_N0.7420.85
104_I131_V0.7320.85
37_G40_S0.7310.85
37_G62_Y0.7300.85
92_S95_N0.7280.84
209_N213_G0.7250.84
47_A105_V0.7200.84
154_T158_S0.7200.84
190_S193_E0.7190.84
201_N205_P0.7160.83
16_V101_R0.7160.83
219_D223_K0.7150.83
94_F126_H0.7100.83
102_I129_A0.7080.83
170_V209_N0.7080.83
161_W168_V0.7030.82
142_K215_K0.7000.82
19_V86_F0.6930.81
123_N189_Y0.6920.81
28_G199_V0.6900.81
226_W230_N0.6900.81
90_L94_F0.6860.81
29_P199_V0.6830.80
11_I14_D0.6810.80
43_I107_G0.6800.80
176_I197_F0.6780.80
119_Q131_V0.6780.80
68_E153_G0.6760.80
106_N109_G0.6720.79
80_Q83_I0.6710.79
181_V185_V0.6700.79
10_E13_G0.6640.79
43_I137_F0.6620.78
70_K95_N0.6610.78
134_F138_G0.6590.78
15_L56_L0.6580.78
66_S198_G0.6580.78
27_H35_T0.6560.78
107_G136_T0.6550.78
93_V97_L0.6540.77
35_T40_S0.6530.77
43_I47_A0.6520.77
144_L147_V0.6510.77
159_K216_I0.6490.77
71_G152_A0.6480.77
32_P167_L0.6470.77
78_S91_E0.6440.76
21_V86_F0.6410.76
51_L229_L0.6400.76
113_Y120_R0.6350.75
179_Y182_R0.6340.75
47_A57_L0.6320.75
23_S26_Q0.6300.75
180_E186_F0.6270.74
157_T205_P0.6240.74
9_E49_E0.6240.74
31_L160_I0.6200.74
121_E125_K0.6180.73
36_D64_G0.6110.73
68_E191_S0.6080.72
116_P120_R0.6070.72
154_T201_N0.6060.72
157_T199_V0.6060.72
189_Y193_E0.6040.72
51_L55_T0.6030.72
82_A114_F0.6010.71
74_F198_G0.5970.71
26_Q68_E0.5950.71
22_G60_T0.5860.69
111_N136_T0.5810.69
47_A50_K0.5800.69
215_K219_D0.5790.69
106_N115_L0.5790.69
44_A107_G0.5780.68
21_V61_I0.5760.68
158_S213_G0.5720.68
131_V134_F0.5680.67
27_H31_L0.5660.67
41_E62_Y0.5650.67
79_F83_I0.5620.66
61_I77_L0.5610.66
35_T110_G0.5600.66
103_I134_F0.5590.66
18_L51_L0.5580.66
24_I62_Y0.5580.66
49_E226_W0.5560.65
12_R73_P0.5550.65
26_Q72_F0.5540.65
115_L133_V0.5540.65
136_T139_E0.5530.65
178_N185_V0.5530.65
220_L223_K0.5520.65
42_Y164_G0.5510.65
70_K190_S0.5500.65
42_Y221_V0.5500.65
106_N156_E0.5500.65
93_V125_K0.5500.65
91_E95_N0.5490.64
103_I227_T0.5470.64
104_I119_Q0.5470.64
68_E188_Y0.5460.64
175_E206_I0.5450.64
152_A199_V0.5440.64
178_N182_R0.5380.63
136_T159_K0.5370.63
43_I76_S0.5350.63
50_K229_L0.5350.63
14_D100_R0.5350.63
102_I131_V0.5340.62
86_F118_V0.5340.62
100_R222_D0.5340.62
31_L157_T0.5330.62
69_H199_V0.5310.62
82_A85_F0.5310.62
15_L101_R0.5290.62
66_S110_G0.5280.62
178_N186_F0.5280.62
107_G137_F0.5270.61
26_Q76_S0.5250.61
110_G149_D0.5240.61
46_K163_I0.5240.61
12_R89_L0.5210.60
143_I146_N0.5150.60
26_Q37_G0.5130.59
181_V186_F0.5120.59
18_L50_K0.5110.59
50_K211_E0.5110.59
61_I82_A0.5100.59
212_Y216_I0.5100.59
120_R124_M0.5080.59
16_V142_K0.5080.59
75_V93_V0.5080.59
159_K220_L0.5070.58
134_F161_W0.5050.58
58_F75_V0.5040.58
17_G75_V0.5040.58
86_F104_I0.5020.58
144_L148_N0.5010.58
172_K223_K0.5000.57
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3no4A 5 0.97 100 0.12 Contact Map
3lubA 4 0.9785 100 0.122 Contact Map
1v7zA 5 0.9785 100 0.14 Contact Map
2zqeA 1 0.3305 23.9 0.956 Contact Map
3ei9A 2 0.3906 22.7 0.956 Contact Map
3f7xA 2 0.4893 16 0.959 Contact Map
3gr7A 3 0.7597 12.4 0.961 Contact Map
3hgjA 2 0.7597 12.4 0.961 Contact Map
4od6A 1 0.3305 12.1 0.961 Contact Map
4oe7A 3 0.7725 11.5 0.961 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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