Q97V02 - SULSO - GREMLIN Contacts

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Q97V02 - ABC transporter, binding protein (Branched chain amino acid)

UniProt:	Q97V02	Sequences: MQVQVVIEDTATNPQTALSDLQTLYSQGVKLVIGPFSSGELRQIMSYAESNGIMLFSPSSTSPALATPDRINGTIFRDVPNDTYQGAVIANIMYQQGIRAIAVIWRGDTYGDGLVSVVNKTFTALGGKVMLVARYDPSTTDFSSYVSTLANTISQLINQYGKDHVAVYDVSFEEGASILQLASQYPQLTEVKWYGSDGTAGVGSIVQNPVAAQVAVETLFLNPIAAPAHTVFYDQLTQHFNKTLQAYSYITYDIFWIYFYSVLKVGSDNVTAIKSILPKVAAKFYGASGYHLFDKYGDRVSGIYQLQIVNKTASGYEWTIYGVYDVTTHTLTIGFPPAAQPPQGYLYPDDPQAMSKLSSIS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	361 (294)
Sequences:	13099 (9280)
Seq/√Len:	541.2

ECOLI - LIVK LIVJ
HALSA - Q9HP09
SULSO - Q97V02

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
31_L	258_Y	3.575	1.00
119_N	132_V	3.438	1.00
100_A	128_K	3.210	1.00
8_E	23_T	3.047	1.00
122_F	127_G	2.980	1.00
52_G	74_T	2.928	1.00
260_Y	263_L	2.876	1.00
237_T	243_T	2.854	1.00
231_V	235_Q	2.800	1.00
260_Y	264_K	2.765	1.00
12_T	37_S	2.752	1.00
17_A	40_E	2.680	1.00
11_A	16_T	2.673	1.00
234_D	238_Q	2.636	1.00
285_Y	290_Y	2.636	1.00
283_K	290_Y	2.510	1.00
133_A	148_T	2.454	1.00
119_N	123_T	2.223	1.00
94_Y	125_L	2.184	1.00
121_T	124_A	2.182	1.00
255_F	259_F	2.159	1.00
32_V	48_A	2.155	1.00
105_W	134_R	2.087	1.00
259_F	263_L	2.070	1.00
276_I	279_K	2.061	1.00
230_T	234_D	2.012	1.00
152_T	162_K	1.980	1.00
99_R	163_D	1.971	1.00
253_D	286_G	1.962	1.00
269_N	272_A	1.939	1.00
235_Q	238_Q	1.910	1.00
77_R	298_D	1.905	1.00
102_A	131_L	1.861	1.00
271_T	275_S	1.847	1.00
283_K	292_L	1.816	1.00
52_G	271_T	1.811	1.00
91_N	94_Y	1.787	1.00
264_K	276_I	1.748	1.00
272_A	275_S	1.747	1.00
260_Y	280_V	1.744	1.00
203_G	206_V	1.733	1.00
35_P	41_L	1.704	1.00
8_E	20_D	1.699	1.00
274_K	278_P	1.680	1.00
91_N	125_L	1.658	1.00
38_S	62_S	1.655	1.00
76_F	278_P	1.624	1.00
275_S	279_K	1.609	1.00
181_L	184_Q	1.588	1.00
54_M	270_V	1.579	1.00
120_K	124_A	1.552	1.00
98_I	165_V	1.544	1.00
76_F	274_K	1.540	1.00
87_A	121_T	1.537	1.00
21_L	48_A	1.496	1.00
231_V	234_D	1.491	1.00
236_L	240_F	1.486	1.00
93_M	194_Y	1.479	1.00
227_P	231_V	1.461	1.00
35_P	44_I	1.434	1.00
13_N	16_T	1.430	1.00
8_E	24_L	1.420	1.00
103_V	115_V	1.418	1.00
3_V	259_F	1.413	1.00
116_S	120_K	1.392	1.00
195_G	199_T	1.384	1.00
228_A	285_Y	1.382	1.00
265_V	276_I	1.373	1.00
98_I	163_D	1.367	1.00
135_Y	170_V	1.359	1.00
146_V	181_L	1.353	1.00
92_I	216_V	1.352	1.00
100_A	161_G	1.351	1.00
23_T	27_Q	1.351	1.00
16_T	20_D	1.343	1.00
278_P	297_G	1.339	1.00
257_I	277_L	1.337	1.00
101_I	165_V	1.335	1.00
208_N	212_A	1.332	1.00
49_E	73_G	1.332	1.00
41_L	60_S	1.325	1.00
112_D	134_R	1.324	1.00
86_G	90_A	1.324	1.00
105_W	115_V	1.324	1.00
117_V	120_K	1.313	1.00
256_W	259_F	1.310	1.00
101_I	122_F	1.292	1.00
236_L	242_K	1.291	1.00
21_L	32_V	1.285	1.00
63_P	83_T	1.282	1.00
225_A	230_T	1.264	1.00
35_P	55_L	1.260	1.00
56_F	258_Y	1.248	1.00
25_Y	53_I	1.245	1.00
48_A	55_L	1.244	1.00
10_T	40_E	1.240	1.00
100_A	163_D	1.232	1.00
61_T	82_D	1.226	1.00
213_Q	311_K	1.221	1.00
46_S	50_S	1.219	1.00
74_T	274_K	1.216	1.00
41_L	55_L	1.213	1.00
123_T	128_K	1.208	1.00
138_S	174_E	1.205	1.00
234_D	237_T	1.197	1.00
146_V	182_A	1.191	1.00
258_Y	262_V	1.184	1.00
8_E	27_Q	1.183	1.00
57_S	60_S	1.177	1.00
165_V	194_Y	1.174	1.00
25_Y	47_Y	1.174	1.00
102_A	162_K	1.168	1.00
264_K	279_K	1.168	1.00
143_S	181_L	1.166	1.00
146_V	185_Y	1.165	1.00
26_S	51_N	1.165	1.00
148_T	152_T	1.156	1.00
115_V	132_V	1.155	1.00
257_I	293_F	1.154	1.00
42_R	64_A	1.150	1.00
121_T	125_L	1.140	1.00
114_L	169_D	1.137	1.00
76_F	293_F	1.136	1.00
89_I	167_V	1.136	1.00
107_G	136_D	1.135	1.00
115_V	119_N	1.135	1.00
181_L	185_Y	1.133	1.00
264_K	280_V	1.132	1.00
102_A	133_A	1.130	1.00
122_F	129_V	1.127	1.00
232_F	248_S	1.126	1.00
139_T	145_Y	1.126	1.00
213_Q	312_T	1.119	1.00
100_A	130_M	1.117	1.00
64_A	67_T	1.096	1.00
227_P	230_T	1.094	1.00
22_Q	26_S	1.089	1.00
58_P	251_T	1.087	1.00
107_G	112_D	1.082	1.00
266_G	269_N	1.078	1.00
235_Q	239_H	1.073	1.00
253_D	288_S	1.072	1.00
206_V	209_P	1.069	1.00
272_A	276_I	1.059	1.00
205_I	209_P	1.057	1.00
118_V	122_F	1.056	1.00
147_S	151_N	1.056	1.00
102_A	149_L	1.047	1.00
76_F	277_L	1.044	1.00
147_S	185_Y	1.044	1.00
253_D	287_A	1.039	1.00
21_L	44_I	1.034	1.00
277_L	280_V	1.031	1.00
6_V	27_Q	1.023	1.00
24_L	29_V	1.023	1.00
66_A	77_R	1.021	1.00
35_P	48_A	1.014	1.00
91_N	95_Q	1.004	1.00
251_T	255_F	0.998	1.00
16_T	19_S	0.997	1.00
104_I	178_I	0.996	1.00
182_A	193_W	0.991	1.00
90_A	118_V	0.988	1.00
233_Y	237_T	0.985	1.00
78_D	257_I	0.984	1.00
216_V	308_I	0.978	1.00
25_Y	51_N	0.974	1.00
150_A	185_Y	0.973	1.00
294_D	298_D	0.972	1.00
189_T	192_K	0.972	1.00
55_L	75_I	0.969	1.00
57_S	75_I	0.964	1.00
29_V	32_V	0.964	1.00
18_L	22_Q	0.962	1.00
263_L	266_G	0.959	1.00
177_S	181_L	0.957	1.00
3_V	255_F	0.951	1.00
267_S	272_A	0.947	1.00
33_I	254_I	0.945	1.00
31_L	273_I	0.945	1.00
228_A	231_V	0.941	1.00
230_T	233_Y	0.941	1.00
130_M	162_K	0.935	1.00
91_N	121_T	0.926	1.00
112_D	116_S	0.926	1.00
18_L	47_Y	0.926	1.00
10_T	35_P	0.923	1.00
74_T	271_T	0.917	1.00
212_A	215_A	0.916	1.00
257_I	284_F	0.908	1.00
92_I	96_Q	0.904	1.00
30_K	270_V	0.903	1.00
256_W	284_F	0.902	1.00
274_K	277_L	0.901	1.00
54_M	274_K	0.897	1.00
25_Y	48_A	0.897	1.00
256_W	260_Y	0.896	1.00
265_V	272_A	0.892	1.00
61_T	79_V	0.891	1.00
45_M	75_I	0.887	1.00
238_Q	241_N	0.886	1.00
106_R	111_G	0.886	1.00
226_A	229_H	0.884	1.00
168_Y	178_I	0.880	1.00
102_A	130_M	0.880	1.00
236_L	244_L	0.877	1.00
170_V	178_I	0.876	1.00
136_D	139_T	0.876	1.00
65_L	75_I	0.870	1.00
21_L	25_Y	0.860	1.00
113_G	116_S	0.855	1.00
105_W	132_V	0.852	1.00
229_H	233_Y	0.847	1.00
237_T	241_N	0.844	1.00
214_V	308_I	0.840	1.00
53_I	270_V	0.837	1.00
210_V	213_Q	0.836	1.00
104_I	145_Y	0.835	1.00
90_A	122_F	0.832	1.00
90_A	125_L	0.831	1.00
143_S	184_Q	0.829	1.00
226_A	230_T	0.827	1.00
205_I	309_V	0.827	1.00
64_A	68_P	0.823	1.00
135_Y	174_E	0.820	1.00
131_L	152_T	0.820	1.00
131_L	148_T	0.817	1.00
148_T	151_N	0.814	1.00
175_G	199_T	0.814	1.00
252_Y	256_W	0.813	1.00
115_V	134_R	0.813	1.00
33_I	56_F	0.812	1.00
261_S	277_L	0.810	1.00
219_L	307_Q	0.808	1.00
291_H	299_R	0.808	1.00
275_S	278_P	0.807	1.00
116_S	119_N	0.805	1.00
12_T	40_E	0.803	1.00
20_D	24_L	0.802	1.00
101_I	127_G	0.801	1.00
37_S	40_E	0.800	1.00
22_Q	51_N	0.797	1.00
202_V	206_V	0.796	1.00
249_Y	287_A	0.795	1.00
292_L	300_V	0.792	1.00
82_D	113_G	0.790	1.00
86_G	114_L	0.789	1.00
20_D	23_T	0.787	1.00
276_I	280_V	0.786	1.00
87_A	91_N	0.786	1.00
66_A	298_D	0.786	1.00
178_I	182_A	0.785	1.00
262_V	273_I	0.776	1.00
179_L	193_W	0.775	1.00
221_L	229_H	0.771	1.00
41_L	65_L	0.768	1.00
163_D	191_V	0.767	1.00
102_A	152_T	0.753	1.00
203_G	207_Q	0.749	1.00
6_V	29_V	0.748	1.00
284_F	291_H	0.744	1.00
119_N	129_V	0.743	1.00
103_V	129_V	0.742	1.00
180_Q	184_Q	0.740	1.00
149_L	152_T	0.738	1.00
236_L	239_H	0.737	1.00
225_A	229_H	0.737	1.00
22_Q	47_Y	0.737	1.00
265_V	269_N	0.735	1.00
232_F	236_L	0.734	1.00
42_R	65_L	0.733	1.00
183_S	210_V	0.730	1.00
73_G	274_K	0.729	1.00
59_S	247_Y	0.726	1.00
120_K	123_T	0.725	1.00
57_S	65_L	0.723	1.00
108_D	111_G	0.719	1.00
237_T	242_K	0.715	1.00
45_M	72_N	0.713	1.00
103_V	118_V	0.713	1.00
139_T	142_F	0.710	1.00
142_F	181_L	0.704	1.00
78_D	254_I	0.703	1.00
89_I	218_T	0.702	1.00
56_F	277_L	0.702	1.00
21_L	51_N	0.696	1.00
31_L	56_F	0.694	1.00
90_A	121_T	0.693	1.00
56_F	78_D	0.688	1.00
93_M	98_I	0.687	1.00
98_I	192_K	0.681	1.00
277_L	284_F	0.679	1.00
33_I	258_Y	0.672	1.00
130_M	152_T	0.668	1.00
44_I	48_A	0.665	1.00
107_G	134_R	0.664	1.00
152_T	161_G	0.662	1.00
30_K	53_I	0.661	1.00
280_V	284_F	0.659	1.00
261_S	265_V	0.654	1.00
205_I	208_N	0.653	1.00
150_A	161_G	0.653	1.00
166_A	191_V	0.653	1.00
118_V	167_V	0.652	1.00
108_D	137_P	0.652	1.00
103_V	119_N	0.651	1.00
261_S	273_I	0.649	1.00
117_V	121_T	0.647	1.00
80_P	220_F	0.644	1.00
74_T	270_V	0.643	1.00
273_I	276_I	0.642	1.00
87_A	124_A	0.642	1.00
176_A	208_N	0.642	1.00
213_Q	310_N	0.641	1.00
199_T	203_G	0.640	1.00
63_P	113_G	0.638	1.00
141_D	144_S	0.636	1.00
21_L	47_Y	0.634	1.00
218_T	223_P	0.634	1.00
122_F	125_L	0.633	1.00
143_S	185_Y	0.633	1.00
146_V	150_A	0.633	1.00
170_V	175_G	0.632	1.00
133_A	145_Y	0.630	1.00
262_V	268_D	0.630	1.00
17_A	44_I	0.629	1.00
63_P	117_V	0.628	1.00
286_G	289_G	0.627	1.00
221_L	224_I	0.627	1.00
25_Y	32_V	0.624	1.00
129_V	132_V	0.623	1.00
111_G	169_D	0.623	1.00
260_Y	284_F	0.623	1.00
294_D	300_V	0.617	1.00
68_P	72_N	0.615	1.00
299_R	302_G	0.615	1.00
85_Q	197_D	0.614	1.00
193_W	196_S	0.613	1.00
280_V	283_K	0.612	1.00
294_D	297_G	0.611	1.00
199_T	204_S	0.611	1.00
63_P	82_D	0.611	1.00
60_S	65_L	0.609	1.00
235_Q	242_K	0.608	1.00
30_K	262_V	0.607	1.00
228_A	256_W	0.606	1.00
146_V	178_I	0.606	1.00
79_V	250_I	0.605	1.00
54_M	58_P	0.603	1.00
179_L	204_S	0.603	1.00
58_P	254_I	0.601	1.00
5_V	255_F	0.600	1.00
88_V	304_Y	0.600	1.00
15_Q	19_S	0.599	1.00
110_Y	114_L	0.599	1.00
191_V	195_G	0.598	1.00
191_V	194_Y	0.598	1.00
54_M	74_T	0.596	1.00
33_I	58_P	0.595	1.00
43_Q	46_S	0.595	1.00
93_M	167_V	0.594	1.00
90_A	127_G	0.592	1.00
73_G	271_T	0.591	1.00
41_L	75_I	0.589	1.00
40_E	44_I	0.589	1.00
271_T	274_K	0.586	0.99
33_I	255_F	0.583	0.99
85_Q	218_T	0.581	0.99
101_I	118_V	0.580	0.99
44_I	55_L	0.579	0.99
297_G	300_V	0.578	0.99
183_S	211_A	0.576	0.99
41_L	45_M	0.576	0.99
179_L	182_A	0.574	0.99
204_S	212_A	0.573	0.99
103_V	132_V	0.570	0.99
262_V	267_S	0.570	0.99
18_L	43_Q	0.570	0.99
22_Q	50_S	0.569	0.99
67_T	296_Y	0.565	0.99
177_S	180_Q	0.562	0.99
92_I	306_L	0.560	0.99
104_I	166_A	0.559	0.99
141_D	181_L	0.556	0.99
109_T	112_D	0.556	0.99
180_Q	209_P	0.555	0.99
200_A	217_E	0.552	0.99
92_I	95_Q	0.552	0.99
235_Q	240_F	0.549	0.99
49_E	72_N	0.542	0.99
168_Y	175_G	0.540	0.99
49_E	74_T	0.540	0.99
145_Y	148_T	0.539	0.99
130_M	133_A	0.538	0.99
46_S	49_E	0.538	0.99
42_R	45_M	0.537	0.99
55_L	65_L	0.537	0.99
147_S	150_A	0.537	0.99
149_L	162_K	0.536	0.99
270_V	274_K	0.532	0.99
289_G	299_R	0.532	0.99
36_F	59_S	0.530	0.99
144_S	147_S	0.530	0.99
35_P	58_P	0.529	0.99
41_L	57_S	0.529	0.99
108_D	171_S	0.529	0.99
279_K	283_K	0.528	0.99
31_L	54_M	0.527	0.99
47_Y	50_S	0.527	0.99
10_T	17_A	0.524	0.99
249_Y	288_S	0.524	0.99
96_Q	216_V	0.523	0.99
145_Y	149_L	0.523	0.99
143_S	147_S	0.523	0.99
140_T	177_S	0.522	0.99
19_S	22_Q	0.522	0.99
257_I	280_V	0.522	0.99
54_M	273_I	0.519	0.99
193_W	215_A	0.518	0.99
288_S	291_H	0.517	0.99
56_F	254_I	0.517	0.99
253_D	256_W	0.516	0.99
35_P	60_S	0.512	0.99
93_M	101_I	0.512	0.99
182_A	189_T	0.511	0.99
236_L	241_N	0.510	0.99
252_Y	287_A	0.510	0.99
266_G	272_A	0.509	0.99
142_F	145_Y	0.508	0.99
101_I	129_V	0.508	0.99
166_A	193_W	0.508	0.99
47_Y	51_N	0.508	0.99
218_T	221_L	0.506	0.99
199_T	202_V	0.505	0.99
96_Q	165_V	0.504	0.98
83_T	87_A	0.502	0.98
258_Y	273_I	0.502	0.98
231_V	252_Y	0.502	0.98
261_S	276_I	0.502	0.98
73_G	278_P	0.500	0.98
239_H	243_T	0.500	0.98

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
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HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2e4uA	2	0.9418	100	0.254	Contact Map
4ms4B	1	0.9058	100	0.262	Contact Map
1dp4A	2	0.9529	100	0.263	Contact Map
4ms4A	1	0.9169	100	0.274	Contact Map
3sm9A	2	0.8892	100	0.287	Contact Map
4xaqA	2	0.8947	100	0.288	Contact Map
1jdpA	2	0.8532	100	0.317	Contact Map
3ks9A	2	0.8975	100	0.317	Contact Map
4tllA	1	0.8864	100	0.325	Contact Map
5c5cA	1	0.867	100	0.352	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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