GREMLIN Database
Q97V02 - ABC transporter, binding protein (Branched chain amino acid)
UniProt: Q97V02 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 361 (294)
Sequences: 13099 (9280)
Seq/√Len: 541.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
31_L258_Y3.5751.00
119_N132_V3.4381.00
100_A128_K3.2101.00
8_E23_T3.0471.00
122_F127_G2.9801.00
52_G74_T2.9281.00
260_Y263_L2.8761.00
237_T243_T2.8541.00
231_V235_Q2.8001.00
260_Y264_K2.7651.00
12_T37_S2.7521.00
17_A40_E2.6801.00
11_A16_T2.6731.00
234_D238_Q2.6361.00
285_Y290_Y2.6361.00
283_K290_Y2.5101.00
133_A148_T2.4541.00
119_N123_T2.2231.00
94_Y125_L2.1841.00
121_T124_A2.1821.00
255_F259_F2.1591.00
32_V48_A2.1551.00
105_W134_R2.0871.00
259_F263_L2.0701.00
276_I279_K2.0611.00
230_T234_D2.0121.00
152_T162_K1.9801.00
99_R163_D1.9711.00
253_D286_G1.9621.00
269_N272_A1.9391.00
235_Q238_Q1.9101.00
77_R298_D1.9051.00
102_A131_L1.8611.00
271_T275_S1.8471.00
283_K292_L1.8161.00
52_G271_T1.8111.00
91_N94_Y1.7871.00
264_K276_I1.7481.00
272_A275_S1.7471.00
260_Y280_V1.7441.00
203_G206_V1.7331.00
35_P41_L1.7041.00
8_E20_D1.6991.00
274_K278_P1.6801.00
91_N125_L1.6581.00
38_S62_S1.6551.00
76_F278_P1.6241.00
275_S279_K1.6091.00
181_L184_Q1.5881.00
54_M270_V1.5791.00
120_K124_A1.5521.00
98_I165_V1.5441.00
76_F274_K1.5401.00
87_A121_T1.5371.00
21_L48_A1.4961.00
231_V234_D1.4911.00
236_L240_F1.4861.00
93_M194_Y1.4791.00
227_P231_V1.4611.00
35_P44_I1.4341.00
13_N16_T1.4301.00
8_E24_L1.4201.00
103_V115_V1.4181.00
3_V259_F1.4131.00
116_S120_K1.3921.00
195_G199_T1.3841.00
228_A285_Y1.3821.00
265_V276_I1.3731.00
98_I163_D1.3671.00
135_Y170_V1.3591.00
146_V181_L1.3531.00
92_I216_V1.3521.00
100_A161_G1.3511.00
23_T27_Q1.3511.00
16_T20_D1.3431.00
278_P297_G1.3391.00
257_I277_L1.3371.00
101_I165_V1.3351.00
208_N212_A1.3321.00
49_E73_G1.3321.00
41_L60_S1.3251.00
112_D134_R1.3241.00
86_G90_A1.3241.00
105_W115_V1.3241.00
117_V120_K1.3131.00
256_W259_F1.3101.00
101_I122_F1.2921.00
236_L242_K1.2911.00
21_L32_V1.2851.00
63_P83_T1.2821.00
225_A230_T1.2641.00
35_P55_L1.2601.00
56_F258_Y1.2481.00
25_Y53_I1.2451.00
48_A55_L1.2441.00
10_T40_E1.2401.00
100_A163_D1.2321.00
61_T82_D1.2261.00
213_Q311_K1.2211.00
46_S50_S1.2191.00
74_T274_K1.2161.00
41_L55_L1.2131.00
123_T128_K1.2081.00
138_S174_E1.2051.00
234_D237_T1.1971.00
146_V182_A1.1911.00
258_Y262_V1.1841.00
8_E27_Q1.1831.00
57_S60_S1.1771.00
165_V194_Y1.1741.00
25_Y47_Y1.1741.00
102_A162_K1.1681.00
264_K279_K1.1681.00
143_S181_L1.1661.00
146_V185_Y1.1651.00
26_S51_N1.1651.00
148_T152_T1.1561.00
115_V132_V1.1551.00
257_I293_F1.1541.00
42_R64_A1.1501.00
121_T125_L1.1401.00
114_L169_D1.1371.00
76_F293_F1.1361.00
89_I167_V1.1361.00
107_G136_D1.1351.00
115_V119_N1.1351.00
181_L185_Y1.1331.00
264_K280_V1.1321.00
102_A133_A1.1301.00
122_F129_V1.1271.00
232_F248_S1.1261.00
139_T145_Y1.1261.00
213_Q312_T1.1191.00
100_A130_M1.1171.00
64_A67_T1.0961.00
227_P230_T1.0941.00
22_Q26_S1.0891.00
58_P251_T1.0871.00
107_G112_D1.0821.00
266_G269_N1.0781.00
235_Q239_H1.0731.00
253_D288_S1.0721.00
206_V209_P1.0691.00
272_A276_I1.0591.00
205_I209_P1.0571.00
118_V122_F1.0561.00
147_S151_N1.0561.00
102_A149_L1.0471.00
76_F277_L1.0441.00
147_S185_Y1.0441.00
253_D287_A1.0391.00
21_L44_I1.0341.00
277_L280_V1.0311.00
6_V27_Q1.0231.00
24_L29_V1.0231.00
66_A77_R1.0211.00
35_P48_A1.0141.00
91_N95_Q1.0041.00
251_T255_F0.9981.00
16_T19_S0.9971.00
104_I178_I0.9961.00
182_A193_W0.9911.00
90_A118_V0.9881.00
233_Y237_T0.9851.00
78_D257_I0.9841.00
216_V308_I0.9781.00
25_Y51_N0.9741.00
150_A185_Y0.9731.00
294_D298_D0.9721.00
189_T192_K0.9721.00
55_L75_I0.9691.00
57_S75_I0.9641.00
29_V32_V0.9641.00
18_L22_Q0.9621.00
263_L266_G0.9591.00
177_S181_L0.9571.00
3_V255_F0.9511.00
267_S272_A0.9471.00
33_I254_I0.9451.00
31_L273_I0.9451.00
228_A231_V0.9411.00
230_T233_Y0.9411.00
130_M162_K0.9351.00
91_N121_T0.9261.00
112_D116_S0.9261.00
18_L47_Y0.9261.00
10_T35_P0.9231.00
74_T271_T0.9171.00
212_A215_A0.9161.00
257_I284_F0.9081.00
92_I96_Q0.9041.00
30_K270_V0.9031.00
256_W284_F0.9021.00
274_K277_L0.9011.00
54_M274_K0.8971.00
25_Y48_A0.8971.00
256_W260_Y0.8961.00
265_V272_A0.8921.00
61_T79_V0.8911.00
45_M75_I0.8871.00
238_Q241_N0.8861.00
106_R111_G0.8861.00
226_A229_H0.8841.00
168_Y178_I0.8801.00
102_A130_M0.8801.00
236_L244_L0.8771.00
170_V178_I0.8761.00
136_D139_T0.8761.00
65_L75_I0.8701.00
21_L25_Y0.8601.00
113_G116_S0.8551.00
105_W132_V0.8521.00
229_H233_Y0.8471.00
237_T241_N0.8441.00
214_V308_I0.8401.00
53_I270_V0.8371.00
210_V213_Q0.8361.00
104_I145_Y0.8351.00
90_A122_F0.8321.00
90_A125_L0.8311.00
143_S184_Q0.8291.00
226_A230_T0.8271.00
205_I309_V0.8271.00
64_A68_P0.8231.00
135_Y174_E0.8201.00
131_L152_T0.8201.00
131_L148_T0.8171.00
148_T151_N0.8141.00
175_G199_T0.8141.00
252_Y256_W0.8131.00
115_V134_R0.8131.00
33_I56_F0.8121.00
261_S277_L0.8101.00
219_L307_Q0.8081.00
291_H299_R0.8081.00
275_S278_P0.8071.00
116_S119_N0.8051.00
12_T40_E0.8031.00
20_D24_L0.8021.00
101_I127_G0.8011.00
37_S40_E0.8001.00
22_Q51_N0.7971.00
202_V206_V0.7961.00
249_Y287_A0.7951.00
292_L300_V0.7921.00
82_D113_G0.7901.00
86_G114_L0.7891.00
20_D23_T0.7871.00
276_I280_V0.7861.00
87_A91_N0.7861.00
66_A298_D0.7861.00
178_I182_A0.7851.00
262_V273_I0.7761.00
179_L193_W0.7751.00
221_L229_H0.7711.00
41_L65_L0.7681.00
163_D191_V0.7671.00
102_A152_T0.7531.00
203_G207_Q0.7491.00
6_V29_V0.7481.00
284_F291_H0.7441.00
119_N129_V0.7431.00
103_V129_V0.7421.00
180_Q184_Q0.7401.00
149_L152_T0.7381.00
236_L239_H0.7371.00
225_A229_H0.7371.00
22_Q47_Y0.7371.00
265_V269_N0.7351.00
232_F236_L0.7341.00
42_R65_L0.7331.00
183_S210_V0.7301.00
73_G274_K0.7291.00
59_S247_Y0.7261.00
120_K123_T0.7251.00
57_S65_L0.7231.00
108_D111_G0.7191.00
237_T242_K0.7151.00
45_M72_N0.7131.00
103_V118_V0.7131.00
139_T142_F0.7101.00
142_F181_L0.7041.00
78_D254_I0.7031.00
89_I218_T0.7021.00
56_F277_L0.7021.00
21_L51_N0.6961.00
31_L56_F0.6941.00
90_A121_T0.6931.00
56_F78_D0.6881.00
93_M98_I0.6871.00
98_I192_K0.6811.00
277_L284_F0.6791.00
33_I258_Y0.6721.00
130_M152_T0.6681.00
44_I48_A0.6651.00
107_G134_R0.6641.00
152_T161_G0.6621.00
30_K53_I0.6611.00
280_V284_F0.6591.00
261_S265_V0.6541.00
205_I208_N0.6531.00
150_A161_G0.6531.00
166_A191_V0.6531.00
118_V167_V0.6521.00
108_D137_P0.6521.00
103_V119_N0.6511.00
261_S273_I0.6491.00
117_V121_T0.6471.00
80_P220_F0.6441.00
74_T270_V0.6431.00
273_I276_I0.6421.00
87_A124_A0.6421.00
176_A208_N0.6421.00
213_Q310_N0.6411.00
199_T203_G0.6401.00
63_P113_G0.6381.00
141_D144_S0.6361.00
21_L47_Y0.6341.00
218_T223_P0.6341.00
122_F125_L0.6331.00
143_S185_Y0.6331.00
146_V150_A0.6331.00
170_V175_G0.6321.00
133_A145_Y0.6301.00
262_V268_D0.6301.00
17_A44_I0.6291.00
63_P117_V0.6281.00
286_G289_G0.6271.00
221_L224_I0.6271.00
25_Y32_V0.6241.00
129_V132_V0.6231.00
111_G169_D0.6231.00
260_Y284_F0.6231.00
294_D300_V0.6171.00
68_P72_N0.6151.00
299_R302_G0.6151.00
85_Q197_D0.6141.00
193_W196_S0.6131.00
280_V283_K0.6121.00
294_D297_G0.6111.00
199_T204_S0.6111.00
63_P82_D0.6111.00
60_S65_L0.6091.00
235_Q242_K0.6081.00
30_K262_V0.6071.00
228_A256_W0.6061.00
146_V178_I0.6061.00
79_V250_I0.6051.00
54_M58_P0.6031.00
179_L204_S0.6031.00
58_P254_I0.6011.00
5_V255_F0.6001.00
88_V304_Y0.6001.00
15_Q19_S0.5991.00
110_Y114_L0.5991.00
191_V195_G0.5981.00
191_V194_Y0.5981.00
54_M74_T0.5961.00
33_I58_P0.5951.00
43_Q46_S0.5951.00
93_M167_V0.5941.00
90_A127_G0.5921.00
73_G271_T0.5911.00
41_L75_I0.5891.00
40_E44_I0.5891.00
271_T274_K0.5860.99
33_I255_F0.5830.99
85_Q218_T0.5810.99
101_I118_V0.5800.99
44_I55_L0.5790.99
297_G300_V0.5780.99
183_S211_A0.5760.99
41_L45_M0.5760.99
179_L182_A0.5740.99
204_S212_A0.5730.99
103_V132_V0.5700.99
262_V267_S0.5700.99
18_L43_Q0.5700.99
22_Q50_S0.5690.99
67_T296_Y0.5650.99
177_S180_Q0.5620.99
92_I306_L0.5600.99
104_I166_A0.5590.99
141_D181_L0.5560.99
109_T112_D0.5560.99
180_Q209_P0.5550.99
200_A217_E0.5520.99
92_I95_Q0.5520.99
235_Q240_F0.5490.99
49_E72_N0.5420.99
168_Y175_G0.5400.99
49_E74_T0.5400.99
145_Y148_T0.5390.99
130_M133_A0.5380.99
46_S49_E0.5380.99
42_R45_M0.5370.99
55_L65_L0.5370.99
147_S150_A0.5370.99
149_L162_K0.5360.99
270_V274_K0.5320.99
289_G299_R0.5320.99
36_F59_S0.5300.99
144_S147_S0.5300.99
35_P58_P0.5290.99
41_L57_S0.5290.99
108_D171_S0.5290.99
279_K283_K0.5280.99
31_L54_M0.5270.99
47_Y50_S0.5270.99
10_T17_A0.5240.99
249_Y288_S0.5240.99
96_Q216_V0.5230.99
145_Y149_L0.5230.99
143_S147_S0.5230.99
140_T177_S0.5220.99
19_S22_Q0.5220.99
257_I280_V0.5220.99
54_M273_I0.5190.99
193_W215_A0.5180.99
288_S291_H0.5170.99
56_F254_I0.5170.99
253_D256_W0.5160.99
35_P60_S0.5120.99
93_M101_I0.5120.99
182_A189_T0.5110.99
236_L241_N0.5100.99
252_Y287_A0.5100.99
266_G272_A0.5090.99
142_F145_Y0.5080.99
101_I129_V0.5080.99
166_A193_W0.5080.99
47_Y51_N0.5080.99
218_T221_L0.5060.99
199_T202_V0.5050.99
96_Q165_V0.5040.98
83_T87_A0.5020.98
258_Y273_I0.5020.98
231_V252_Y0.5020.98
261_S276_I0.5020.98
73_G278_P0.5000.98
239_H243_T0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2e4uA 2 0.9418 100 0.254 Contact Map
4ms4B 1 0.9058 100 0.262 Contact Map
1dp4A 2 0.9529 100 0.263 Contact Map
4ms4A 1 0.9169 100 0.274 Contact Map
3sm9A 2 0.8892 100 0.287 Contact Map
4xaqA 2 0.8947 100 0.288 Contact Map
1jdpA 2 0.8532 100 0.317 Contact Map
3ks9A 2 0.8975 100 0.317 Contact Map
4tllA 1 0.8864 100 0.325 Contact Map
5c5cA 1 0.867 100 0.352 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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