Q97UZ9 - SULSO - GREMLIN Contacts

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Q97UZ9 - ABC transporter, permease (Branched chain amino acid)

UniProt:	Q97UZ9	Sequences: MIDPLIINTIVYGSILGLSSLSLTLTYLTTKVPNFAHGIFLLFGSYMTFTIAEVLKQNPYISLPIAFLLGGAIALLQYYGVLLPLSMRGGGLVSQMVATLAFSILLYGGLNAYASYLGYVYNVQSRDVTLGFLDYEIGGIRAVFLISIILAIAFILSLYIFLNKTRLGISIRATVENSSLAESMGINTKLVKAISWFLAGGIASTAGSLYPLQFVFSPTLAYSILLSIFAASVLGGLMSLFGGFIGGFIEGFIEKYIMTELSIYLSPLIGVSPFVINQYSTLVPLIVVAAVLLIAPNGIMGVRVK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	305 (264)
Sequences:	30470 (19835)
Seq/√Len:	1220.8

ECOLI - LIVM LIVH YTFT LSRC YJFF LSRD XYLH RBSC ARAH YPHD MGLC ALSC
BACSU - YUFQ YUFP RBSC
HALSA - Q9HR22 Q9HR23
SULSO - Q97UZ9 Q97UZ8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
67_F	201_G	3.424	1.00
71_G	197_F	3.282	1.00
71_G	201_G	3.032	1.00
178_S	192_K	2.962	1.00
75_L	197_F	2.811	1.00
17_G	151_A	2.677	1.00
171_I	195_S	2.662	1.00
187_N	190_L	2.616	1.00
190_L	194_I	2.442	1.00
51_I	65_I	2.436	1.00
161_F	167_L	2.433	1.00
159_Y	163_N	2.386	1.00
47_M	69_L	2.350	1.00
160_I	164_K	2.325	1.00
83_L	189_K	2.256	1.00
75_L	193_A	2.230	1.00
170_S	191_V	2.229	1.00
58_N	61_I	2.226	1.00
74_A	200_G	2.225	1.00
70_G	204_S	2.221	1.00
24_T	243_G	2.217	1.00
227_S	254_E	2.187	1.00
167_L	194_I	2.185	1.00
79_Y	83_L	2.146	1.00
157_S	161_F	2.088	1.00
77_Q	102_F	2.075	1.00
19_S	228_I	2.030	1.00
60_Y	64_P	2.026	1.00
48_T	66_A	1.939	1.00
156_L	160_I	1.916	1.00
42_L	110_L	1.886	1.00
67_F	205_T	1.871	1.00
48_T	208_S	1.831	1.00
174_T	191_V	1.828	1.00
13_G	251_G	1.810	1.00
70_G	200_G	1.756	1.00
20_S	243_G	1.753	1.00
104_I	107_Y	1.745	1.00
173_A	181_A	1.696	1.00
63_L	208_S	1.670	1.00
78_Y	193_A	1.633	1.00
166_R	170_S	1.619	1.00
17_G	247_G	1.615	1.00
13_G	248_F	1.599	1.00
227_S	284_P	1.587	1.00
29_T	172_R	1.566	1.00
61_I	64_P	1.546	1.00
102_F	106_L	1.529	1.00
167_L	171_I	1.527	1.00
26_T	199_A	1.512	1.00
179_S	182_E	1.504	1.00
239_S	242_G	1.500	1.00
39_I	107_Y	1.482	1.00
32_V	95_Q	1.474	1.00
83_L	193_A	1.471	1.00
194_I	197_F	1.471	1.00
134_D	137_I	1.469	1.00
52_A	62_S	1.462	1.00
178_S	182_E	1.462	1.00
50_T	113_Y	1.450	1.00
155_I	244_F	1.446	1.00
51_I	55_L	1.409	1.00
50_T	54_V	1.396	1.00
19_S	41_L	1.390	1.00
18_L	206_A	1.389	1.00
170_S	186_I	1.388	1.00
41_L	210_Y	1.374	1.00
235_G	242_G	1.366	1.00
25_L	158_L	1.355	1.00
30_T	195_S	1.344	1.00
51_I	57_Q	1.333	1.00
22_S	202_I	1.315	1.00
170_S	181_A	1.312	1.00
67_F	208_S	1.299	1.00
17_G	244_F	1.295	1.00
57_Q	65_I	1.293	1.00
131_G	134_D	1.290	1.00
193_A	197_F	1.287	1.00
181_A	186_I	1.284	1.00
32_V	192_K	1.284	1.00
18_L	209_L	1.284	1.00
57_Q	61_I	1.277	1.00
186_I	191_V	1.264	1.00
235_G	246_G	1.257	1.00
174_T	188_T	1.255	1.00
21_L	158_L	1.248	1.00
37_H	203_A	1.236	1.00
66_A	70_G	1.231	1.00
79_Y	193_A	1.227	1.00
159_Y	164_K	1.224	1.00
23_L	228_I	1.213	1.00
64_P	68_L	1.213	1.00
62_S	66_A	1.211	1.00
43_F	73_I	1.191	1.00
25_L	195_S	1.191	1.00
174_T	181_A	1.183	1.00
39_I	106_L	1.180	1.00
32_V	196_W	1.176	1.00
163_N	172_R	1.176	1.00
136_E	139_G	1.173	1.00
47_M	51_I	1.168	1.00
9_T	252_F	1.163	1.00
154_F	202_I	1.162	1.00
23_L	232_S	1.148	1.00
197_F	201_G	1.140	1.00
9_T	251_G	1.129	1.00
5_L	255_K	1.125	1.00
20_S	231_A	1.122	1.00
73_I	106_L	1.114	1.00
194_I	198_L	1.113	1.00
107_Y	111_N	1.107	1.00
40_F	73_I	1.104	1.00
48_T	212_L	1.099	1.00
22_S	37_H	1.097	1.00
182_E	189_K	1.088	1.00
82_L	189_K	1.083	1.00
153_A	157_S	1.081	1.00
254_E	284_P	1.077	1.00
255_K	258_M	1.074	1.00
224_I	227_S	1.068	1.00
13_G	247_G	1.055	1.00
182_E	188_T	1.054	1.00
200_G	204_S	1.054	1.00
198_L	202_I	1.053	1.00
155_I	202_I	1.053	1.00
68_L	71_G	1.046	1.00
156_L	159_Y	1.042	1.00
20_S	232_S	1.041	1.00
66_A	208_S	1.039	1.00
191_V	194_I	1.035	1.00
29_T	238_M	1.031	1.00
171_I	191_V	1.030	1.00
231_A	246_G	1.028	1.00
279_Y	282_L	1.027	1.00
50_T	114_A	1.025	1.00
158_L	198_L	1.023	1.00
231_A	247_G	1.016	1.00
79_Y	84_P	1.006	1.00
207_G	211_P	1.003	1.00
149_I	153_A	1.001	1.00
80_G	98_A	1.000	1.00
82_L	99_T	0.996	1.00
103_S	107_Y	0.992	1.00
71_G	204_S	0.985	1.00
237_L	243_G	0.982	1.00
19_S	206_A	0.976	1.00
46_Y	110_L	0.973	1.00
46_Y	218_P	0.972	1.00
250_E	284_P	0.970	1.00
167_L	191_V	0.969	1.00
64_P	67_F	0.969	1.00
38_G	225_L	0.966	1.00
14_S	148_I	0.961	1.00
241_F	245_I	0.961	1.00
130_L	134_D	0.953	1.00
133_L	136_E	0.952	1.00
84_P	92_L	0.948	1.00
199_A	203_A	0.943	1.00
115_S	118_G	0.942	1.00
135_Y	138_G	0.933	1.00
15_I	206_A	0.931	1.00
12_Y	16_L	0.930	1.00
43_F	47_M	0.928	1.00
146_I	149_I	0.927	1.00
7_I	11_V	0.926	1.00
6_I	256_Y	0.923	1.00
257_I	283_V	0.923	1.00
132_F	136_E	0.922	1.00
72_A	75_L	0.919	1.00
114_A	117_L	0.919	1.00
39_I	103_S	0.916	1.00
142_A	149_I	0.915	1.00
109_G	113_Y	0.914	1.00
81_V	98_A	0.910	1.00
45_S	220_L	0.903	1.00
34_N	37_H	0.902	1.00
190_L	193_A	0.896	1.00
151_A	155_I	0.895	1.00
152_I	156_L	0.895	1.00
147_S	209_L	0.892	1.00
68_L	72_A	0.890	1.00
27_Y	232_S	0.890	1.00
290_A	294_I	0.890	1.00
44_G	70_G	0.890	1.00
159_Y	241_F	0.885	1.00
61_I	65_I	0.884	1.00
41_L	224_I	0.880	1.00
17_G	155_I	0.872	1.00
169_I	172_R	0.871	1.00
80_G	84_P	0.869	1.00
30_T	171_I	0.865	1.00
112_A	279_Y	0.865	1.00
20_S	247_G	0.846	1.00
18_L	151_A	0.846	1.00
189_K	192_K	0.845	1.00
40_F	203_A	0.843	1.00
180_L	184_M	0.838	1.00
44_G	66_A	0.837	1.00
51_I	62_S	0.836	1.00
145_L	149_I	0.829	1.00
45_S	211_P	0.827	1.00
19_S	37_H	0.826	1.00
67_F	204_S	0.823	1.00
162_L	171_I	0.822	1.00
174_T	195_S	0.821	1.00
29_T	163_N	0.819	1.00
49_F	53_E	0.816	1.00
148_I	152_I	0.816	1.00
48_T	52_A	0.816	1.00
45_S	216_F	0.816	1.00
18_L	154_F	0.813	1.00
24_T	238_M	0.811	1.00
223_S	227_S	0.810	1.00
108_G	111_N	0.806	1.00
21_L	154_F	0.805	1.00
117_L	120_V	0.800	1.00
203_A	207_G	0.800	1.00
25_L	162_L	0.798	1.00
24_T	232_S	0.792	1.00
178_S	188_T	0.791	1.00
177_N	180_L	0.788	1.00
21_L	243_G	0.787	1.00
119_Y	123_V	0.786	1.00
47_M	50_T	0.786	1.00
24_T	27_Y	0.783	1.00
44_G	207_G	0.782	1.00
188_T	192_K	0.780	1.00
157_S	160_I	0.779	1.00
161_F	164_K	0.778	1.00
49_F	216_F	0.777	1.00
286_I	290_A	0.776	1.00
40_F	70_G	0.774	1.00
174_T	192_K	0.773	1.00
239_S	243_G	0.771	1.00
41_L	221_A	0.770	1.00
141_R	149_I	0.766	1.00
130_L	133_L	0.763	1.00
230_A	288_V	0.758	1.00
95_Q	196_W	0.756	1.00
139_G	142_A	0.755	1.00
46_Y	114_A	0.755	1.00
23_L	37_H	0.753	1.00
201_G	204_S	0.752	1.00
189_K	193_A	0.751	1.00
281_T	284_P	0.743	1.00
201_G	205_T	0.742	1.00
118_G	121_Y	0.742	1.00
24_T	237_L	0.739	1.00
146_I	150_L	0.731	1.00
76_L	80_G	0.731	1.00
16_L	227_S	0.728	1.00
134_D	139_G	0.727	1.00
134_D	138_G	0.725	1.00
232_S	237_L	0.720	1.00
22_S	203_A	0.720	1.00
243_G	247_G	0.719	1.00
41_L	206_A	0.718	1.00
26_T	34_N	0.716	1.00
75_L	79_Y	0.713	1.00
78_Y	83_L	0.710	1.00
170_S	187_N	0.707	1.00
19_S	22_S	0.702	1.00
48_T	62_S	0.701	1.00
133_L	138_G	0.694	1.00
278_Q	281_T	0.689	1.00
47_M	73_I	0.687	1.00
158_L	202_I	0.685	1.00
248_F	252_F	0.682	1.00
13_G	17_G	0.678	1.00
72_A	76_L	0.676	1.00
51_I	69_L	0.673	1.00
8_N	12_Y	0.673	1.00
35_F	229_F	0.673	1.00
160_I	163_N	0.673	1.00
40_F	77_Q	0.672	1.00
227_S	281_T	0.666	1.00
116_Y	119_Y	0.664	1.00
140_I	143_V	0.662	1.00
52_A	212_L	0.660	1.00
57_Q	60_Y	0.660	1.00
254_E	280_S	0.659	1.00
116_Y	120_V	0.659	1.00
63_L	67_F	0.658	1.00
38_G	223_S	0.657	1.00
24_T	29_T	0.652	1.00
23_L	27_Y	0.651	1.00
16_L	231_A	0.650	1.00
32_V	178_S	0.648	1.00
51_I	54_V	0.648	1.00
27_Y	229_F	0.645	1.00
43_F	70_G	0.644	1.00
40_F	44_G	0.642	1.00
167_L	198_L	0.642	1.00
107_Y	225_L	0.641	1.00
113_Y	116_Y	0.640	1.00
40_F	106_L	0.640	1.00
158_L	162_L	0.637	1.00
247_G	251_G	0.635	1.00
116_Y	121_Y	0.634	1.00
44_G	69_L	0.633	1.00
9_T	13_G	0.632	1.00
275_V	279_Y	0.630	1.00
105_L	109_G	0.629	1.00
59_P	63_L	0.626	1.00
44_G	203_A	0.625	1.00
10_I	14_S	0.624	1.00
59_P	212_L	0.622	1.00
141_R	144_F	0.619	1.00
155_I	159_Y	0.617	1.00
204_S	208_S	0.616	1.00
67_F	71_G	0.613	1.00
77_Q	106_L	0.608	1.00
14_S	151_A	0.608	1.00
110_L	113_Y	0.607	1.00
122_N	125_S	0.606	1.00
40_F	200_G	0.604	1.00
70_G	74_A	0.602	1.00
16_L	224_I	0.597	1.00
77_Q	81_V	0.594	1.00
22_S	26_T	0.592	1.00
257_I	275_V	0.592	1.00
49_F	119_Y	0.591	1.00
230_A	284_P	0.591	1.00
144_F	149_I	0.588	1.00
25_L	198_L	0.588	1.00
30_T	192_K	0.588	1.00
231_A	243_G	0.587	1.00
154_F	205_T	0.587	1.00
48_T	207_G	0.586	1.00
117_L	121_Y	0.584	1.00
30_T	174_T	0.583	1.00
36_A	77_Q	0.581	1.00
99_T	103_S	0.581	1.00
161_F	194_I	0.580	1.00
81_V	196_W	0.580	1.00
9_T	255_K	0.579	1.00
92_L	189_K	0.578	1.00
282_L	286_I	0.574	1.00
198_L	201_G	0.573	1.00
77_Q	98_A	0.572	1.00
234_L	246_G	0.572	1.00
21_L	155_I	0.569	1.00
104_I	108_G	0.569	1.00
115_S	120_V	0.568	1.00
16_L	247_G	0.568	1.00
50_T	55_L	0.567	1.00
103_S	225_L	0.565	1.00
200_G	203_A	0.565	1.00
24_T	240_L	0.564	1.00
159_Y	239_S	0.562	1.00
161_F	165_T	0.558	1.00
8_N	255_K	0.557	1.00
15_I	210_Y	0.557	1.00
188_T	191_V	0.552	1.00
210_Y	224_I	0.552	1.00
47_M	70_G	0.551	1.00
136_E	140_I	0.551	1.00
120_V	124_Q	0.550	1.00
181_A	188_T	0.550	1.00
42_L	220_L	0.546	1.00
192_K	195_S	0.544	1.00
115_S	119_Y	0.542	1.00
131_G	142_A	0.540	1.00
172_R	238_M	0.538	1.00
50_T	53_E	0.532	1.00
12_Y	255_K	0.530	1.00
153_A	156_L	0.530	1.00
76_L	79_Y	0.529	1.00
26_T	196_W	0.527	1.00
163_N	166_R	0.526	1.00
21_L	159_Y	0.524	1.00
179_S	183_S	0.524	1.00
118_G	123_V	0.522	1.00
92_L	95_Q	0.521	1.00
235_G	243_G	0.521	1.00
121_Y	124_Q	0.521	1.00
144_F	147_S	0.519	1.00
231_A	250_E	0.516	1.00
11_V	148_I	0.513	1.00
14_S	18_L	0.512	1.00
67_F	70_G	0.511	1.00
43_F	106_L	0.507	1.00
40_F	74_A	0.507	1.00
6_I	10_I	0.506	1.00
48_T	51_I	0.506	1.00
197_F	200_G	0.506	1.00
74_A	197_F	0.505	1.00
284_P	288_V	0.504	1.00
51_I	66_A	0.504	1.00
96_M	100_L	0.503	1.00
150_L	205_T	0.502	1.00
16_L	20_S	0.502	1.00
173_A	180_L	0.501	1.00
26_T	195_S	0.501	1.00
25_L	161_F	0.500	1.00
114_A	118_G	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4g1uA	2	0.8459	96.5	0.876	Contact Map
2nq2A	2	0.823	96.2	0.88	Contact Map
2qi9A	2	0.8623	95.6	0.886	Contact Map
1iijA	1	0.1148	4.4	0.96	Contact Map
4p02B	1	0.2393	3.5	0.962	Contact Map
2l2tA	2	0.141	3.4	0.963	Contact Map
4pypA	1	0.6262	2.8	0.964	Contact Map
2zy9A	2	0.282	2.7	0.964	Contact Map
2gfpA	2	0.5934	2.3	0.966	Contact Map
2jwaA	2	0.1443	2.1	0.966	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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