GREMLIN Database
Q97UZ9 - ABC transporter, permease (Branched chain amino acid)
UniProt: Q97UZ9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 305 (264)
Sequences: 30470 (19835)
Seq/√Len: 1220.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
67_F201_G3.4241.00
71_G197_F3.2821.00
71_G201_G3.0321.00
178_S192_K2.9621.00
75_L197_F2.8111.00
17_G151_A2.6771.00
171_I195_S2.6621.00
187_N190_L2.6161.00
190_L194_I2.4421.00
51_I65_I2.4361.00
161_F167_L2.4331.00
159_Y163_N2.3861.00
47_M69_L2.3501.00
160_I164_K2.3251.00
83_L189_K2.2561.00
75_L193_A2.2301.00
170_S191_V2.2291.00
58_N61_I2.2261.00
74_A200_G2.2251.00
70_G204_S2.2211.00
24_T243_G2.2171.00
227_S254_E2.1871.00
167_L194_I2.1851.00
79_Y83_L2.1461.00
157_S161_F2.0881.00
77_Q102_F2.0751.00
19_S228_I2.0301.00
60_Y64_P2.0261.00
48_T66_A1.9391.00
156_L160_I1.9161.00
42_L110_L1.8861.00
67_F205_T1.8711.00
48_T208_S1.8311.00
174_T191_V1.8281.00
13_G251_G1.8101.00
70_G200_G1.7561.00
20_S243_G1.7531.00
104_I107_Y1.7451.00
173_A181_A1.6961.00
63_L208_S1.6701.00
78_Y193_A1.6331.00
166_R170_S1.6191.00
17_G247_G1.6151.00
13_G248_F1.5991.00
227_S284_P1.5871.00
29_T172_R1.5661.00
61_I64_P1.5461.00
102_F106_L1.5291.00
167_L171_I1.5271.00
26_T199_A1.5121.00
179_S182_E1.5041.00
239_S242_G1.5001.00
39_I107_Y1.4821.00
32_V95_Q1.4741.00
83_L193_A1.4711.00
194_I197_F1.4711.00
134_D137_I1.4691.00
52_A62_S1.4621.00
178_S182_E1.4621.00
50_T113_Y1.4501.00
155_I244_F1.4461.00
51_I55_L1.4091.00
50_T54_V1.3961.00
19_S41_L1.3901.00
18_L206_A1.3891.00
170_S186_I1.3881.00
41_L210_Y1.3741.00
235_G242_G1.3661.00
25_L158_L1.3551.00
30_T195_S1.3441.00
51_I57_Q1.3331.00
22_S202_I1.3151.00
170_S181_A1.3121.00
67_F208_S1.2991.00
17_G244_F1.2951.00
57_Q65_I1.2931.00
131_G134_D1.2901.00
193_A197_F1.2871.00
181_A186_I1.2841.00
32_V192_K1.2841.00
18_L209_L1.2841.00
57_Q61_I1.2771.00
186_I191_V1.2641.00
235_G246_G1.2571.00
174_T188_T1.2551.00
21_L158_L1.2481.00
37_H203_A1.2361.00
66_A70_G1.2311.00
79_Y193_A1.2271.00
159_Y164_K1.2241.00
23_L228_I1.2131.00
64_P68_L1.2131.00
62_S66_A1.2111.00
43_F73_I1.1911.00
25_L195_S1.1911.00
174_T181_A1.1831.00
39_I106_L1.1801.00
32_V196_W1.1761.00
163_N172_R1.1761.00
136_E139_G1.1731.00
47_M51_I1.1681.00
9_T252_F1.1631.00
154_F202_I1.1621.00
23_L232_S1.1481.00
197_F201_G1.1401.00
9_T251_G1.1291.00
5_L255_K1.1251.00
20_S231_A1.1221.00
73_I106_L1.1141.00
194_I198_L1.1131.00
107_Y111_N1.1071.00
40_F73_I1.1041.00
48_T212_L1.0991.00
22_S37_H1.0971.00
182_E189_K1.0881.00
82_L189_K1.0831.00
153_A157_S1.0811.00
254_E284_P1.0771.00
255_K258_M1.0741.00
224_I227_S1.0681.00
13_G247_G1.0551.00
182_E188_T1.0541.00
200_G204_S1.0541.00
198_L202_I1.0531.00
155_I202_I1.0531.00
68_L71_G1.0461.00
156_L159_Y1.0421.00
20_S232_S1.0411.00
66_A208_S1.0391.00
191_V194_I1.0351.00
29_T238_M1.0311.00
171_I191_V1.0301.00
231_A246_G1.0281.00
279_Y282_L1.0271.00
50_T114_A1.0251.00
158_L198_L1.0231.00
231_A247_G1.0161.00
79_Y84_P1.0061.00
207_G211_P1.0031.00
149_I153_A1.0011.00
80_G98_A1.0001.00
82_L99_T0.9961.00
103_S107_Y0.9921.00
71_G204_S0.9851.00
237_L243_G0.9821.00
19_S206_A0.9761.00
46_Y110_L0.9731.00
46_Y218_P0.9721.00
250_E284_P0.9701.00
167_L191_V0.9691.00
64_P67_F0.9691.00
38_G225_L0.9661.00
14_S148_I0.9611.00
241_F245_I0.9611.00
130_L134_D0.9531.00
133_L136_E0.9521.00
84_P92_L0.9481.00
199_A203_A0.9431.00
115_S118_G0.9421.00
135_Y138_G0.9331.00
15_I206_A0.9311.00
12_Y16_L0.9301.00
43_F47_M0.9281.00
146_I149_I0.9271.00
7_I11_V0.9261.00
6_I256_Y0.9231.00
257_I283_V0.9231.00
132_F136_E0.9221.00
72_A75_L0.9191.00
114_A117_L0.9191.00
39_I103_S0.9161.00
142_A149_I0.9151.00
109_G113_Y0.9141.00
81_V98_A0.9101.00
45_S220_L0.9031.00
34_N37_H0.9021.00
190_L193_A0.8961.00
151_A155_I0.8951.00
152_I156_L0.8951.00
147_S209_L0.8921.00
68_L72_A0.8901.00
27_Y232_S0.8901.00
290_A294_I0.8901.00
44_G70_G0.8901.00
159_Y241_F0.8851.00
61_I65_I0.8841.00
41_L224_I0.8801.00
17_G155_I0.8721.00
169_I172_R0.8711.00
80_G84_P0.8691.00
30_T171_I0.8651.00
112_A279_Y0.8651.00
20_S247_G0.8461.00
18_L151_A0.8461.00
189_K192_K0.8451.00
40_F203_A0.8431.00
180_L184_M0.8381.00
44_G66_A0.8371.00
51_I62_S0.8361.00
145_L149_I0.8291.00
45_S211_P0.8271.00
19_S37_H0.8261.00
67_F204_S0.8231.00
162_L171_I0.8221.00
174_T195_S0.8211.00
29_T163_N0.8191.00
49_F53_E0.8161.00
148_I152_I0.8161.00
48_T52_A0.8161.00
45_S216_F0.8161.00
18_L154_F0.8131.00
24_T238_M0.8111.00
223_S227_S0.8101.00
108_G111_N0.8061.00
21_L154_F0.8051.00
117_L120_V0.8001.00
203_A207_G0.8001.00
25_L162_L0.7981.00
24_T232_S0.7921.00
178_S188_T0.7911.00
177_N180_L0.7881.00
21_L243_G0.7871.00
119_Y123_V0.7861.00
47_M50_T0.7861.00
24_T27_Y0.7831.00
44_G207_G0.7821.00
188_T192_K0.7801.00
157_S160_I0.7791.00
161_F164_K0.7781.00
49_F216_F0.7771.00
286_I290_A0.7761.00
40_F70_G0.7741.00
174_T192_K0.7731.00
239_S243_G0.7711.00
41_L221_A0.7701.00
141_R149_I0.7661.00
130_L133_L0.7631.00
230_A288_V0.7581.00
95_Q196_W0.7561.00
139_G142_A0.7551.00
46_Y114_A0.7551.00
23_L37_H0.7531.00
201_G204_S0.7521.00
189_K193_A0.7511.00
281_T284_P0.7431.00
201_G205_T0.7421.00
118_G121_Y0.7421.00
24_T237_L0.7391.00
146_I150_L0.7311.00
76_L80_G0.7311.00
16_L227_S0.7281.00
134_D139_G0.7271.00
134_D138_G0.7251.00
232_S237_L0.7201.00
22_S203_A0.7201.00
243_G247_G0.7191.00
41_L206_A0.7181.00
26_T34_N0.7161.00
75_L79_Y0.7131.00
78_Y83_L0.7101.00
170_S187_N0.7071.00
19_S22_S0.7021.00
48_T62_S0.7011.00
133_L138_G0.6941.00
278_Q281_T0.6891.00
47_M73_I0.6871.00
158_L202_I0.6851.00
248_F252_F0.6821.00
13_G17_G0.6781.00
72_A76_L0.6761.00
51_I69_L0.6731.00
8_N12_Y0.6731.00
35_F229_F0.6731.00
160_I163_N0.6731.00
40_F77_Q0.6721.00
227_S281_T0.6661.00
116_Y119_Y0.6641.00
140_I143_V0.6621.00
52_A212_L0.6601.00
57_Q60_Y0.6601.00
254_E280_S0.6591.00
116_Y120_V0.6591.00
63_L67_F0.6581.00
38_G223_S0.6571.00
24_T29_T0.6521.00
23_L27_Y0.6511.00
16_L231_A0.6501.00
32_V178_S0.6481.00
51_I54_V0.6481.00
27_Y229_F0.6451.00
43_F70_G0.6441.00
40_F44_G0.6421.00
167_L198_L0.6421.00
107_Y225_L0.6411.00
113_Y116_Y0.6401.00
40_F106_L0.6401.00
158_L162_L0.6371.00
247_G251_G0.6351.00
116_Y121_Y0.6341.00
44_G69_L0.6331.00
9_T13_G0.6321.00
275_V279_Y0.6301.00
105_L109_G0.6291.00
59_P63_L0.6261.00
44_G203_A0.6251.00
10_I14_S0.6241.00
59_P212_L0.6221.00
141_R144_F0.6191.00
155_I159_Y0.6171.00
204_S208_S0.6161.00
67_F71_G0.6131.00
77_Q106_L0.6081.00
14_S151_A0.6081.00
110_L113_Y0.6071.00
122_N125_S0.6061.00
40_F200_G0.6041.00
70_G74_A0.6021.00
16_L224_I0.5971.00
77_Q81_V0.5941.00
22_S26_T0.5921.00
257_I275_V0.5921.00
49_F119_Y0.5911.00
230_A284_P0.5911.00
144_F149_I0.5881.00
25_L198_L0.5881.00
30_T192_K0.5881.00
231_A243_G0.5871.00
154_F205_T0.5871.00
48_T207_G0.5861.00
117_L121_Y0.5841.00
30_T174_T0.5831.00
36_A77_Q0.5811.00
99_T103_S0.5811.00
161_F194_I0.5801.00
81_V196_W0.5801.00
9_T255_K0.5791.00
92_L189_K0.5781.00
282_L286_I0.5741.00
198_L201_G0.5731.00
77_Q98_A0.5721.00
234_L246_G0.5721.00
21_L155_I0.5691.00
104_I108_G0.5691.00
115_S120_V0.5681.00
16_L247_G0.5681.00
50_T55_L0.5671.00
103_S225_L0.5651.00
200_G203_A0.5651.00
24_T240_L0.5641.00
159_Y239_S0.5621.00
161_F165_T0.5581.00
8_N255_K0.5571.00
15_I210_Y0.5571.00
188_T191_V0.5521.00
210_Y224_I0.5521.00
47_M70_G0.5511.00
136_E140_I0.5511.00
120_V124_Q0.5501.00
181_A188_T0.5501.00
42_L220_L0.5461.00
192_K195_S0.5441.00
115_S119_Y0.5421.00
131_G142_A0.5401.00
172_R238_M0.5381.00
50_T53_E0.5321.00
12_Y255_K0.5301.00
153_A156_L0.5301.00
76_L79_Y0.5291.00
26_T196_W0.5271.00
163_N166_R0.5261.00
21_L159_Y0.5241.00
179_S183_S0.5241.00
118_G123_V0.5221.00
92_L95_Q0.5211.00
235_G243_G0.5211.00
121_Y124_Q0.5211.00
144_F147_S0.5191.00
231_A250_E0.5161.00
11_V148_I0.5131.00
14_S18_L0.5121.00
67_F70_G0.5111.00
43_F106_L0.5071.00
40_F74_A0.5071.00
6_I10_I0.5061.00
48_T51_I0.5061.00
197_F200_G0.5061.00
74_A197_F0.5051.00
284_P288_V0.5041.00
51_I66_A0.5041.00
96_M100_L0.5031.00
150_L205_T0.5021.00
16_L20_S0.5021.00
173_A180_L0.5011.00
26_T195_S0.5011.00
25_L161_F0.5001.00
114_A118_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4g1uA 2 0.8459 96.5 0.876 Contact Map
2nq2A 2 0.823 96.2 0.88 Contact Map
2qi9A 2 0.8623 95.6 0.886 Contact Map
1iijA 1 0.1148 4.4 0.96 Contact Map
4p02B 1 0.2393 3.5 0.962 Contact Map
2l2tA 2 0.141 3.4 0.963 Contact Map
4pypA 1 0.6262 2.8 0.964 Contact Map
2zy9A 2 0.282 2.7 0.964 Contact Map
2gfpA 2 0.5934 2.3 0.966 Contact Map
2jwaA 2 0.1443 2.1 0.966 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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