Q97UZ8 - SULSO - GREMLIN Contacts

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Q97UZ8 - ABC transporter, permease (Branched chain amino acid)

UniProt:	Q97UZ8	Sequences: MVVDISSLILAILLDFSVYLMVVISLNVEIGLTGVPNFGRVLAYAGGAFIAGAVPGRILQIIYGLHGDYILNNPSIIAEINDKLLEQPLMALAILILTLALAGIVGATLGYISSYPALRLREDYLGILLLVAGTSLVVVGITYPPIVGGTVGVQVPAVFNALLGQGASLYYKISILLLVFSLIMLLLFNLISNSPMGRAFRAVRENEDLVEVLGRDIGVIRGKAMALGGFLAGVAGSLYAFYIGSVFAGAFDNLTWSFNPYLMLILGGAGTSIGALLGALIYSTLYHVIDLYKQTIGYYLHFDAVWLQYMLFGLVLTIILILRPQGIVVEKAKPLVKPKAKDQKT	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	345 (266)
Sequences:	30682 (19837)
Seq/√Len:	1216.2

ECOLI - LIVM LSRC LIVH YTFT YJFF LSRD YPHD MGLC ARAH XYLH RBSC ALSC
BACSU - YUFQ YUFP RBSC
HALSA - Q9HR22 Q9HR23
SULSO - Q97UZ8 Q97UZ9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
103_G	230_F	4.409	1.00
107_A	226_A	4.016	1.00
107_A	230_F	3.432	1.00
207_E	221_R	3.182	1.00
111_Y	226_A	3.162	1.00
119_R	218_G	2.911	1.00
200_F	224_A	2.778	1.00
216_D	219_V	2.688	1.00
50_I	105_V	2.668	1.00
113_S	132_A	2.645	1.00
219_V	223_K	2.537	1.00
110_G	229_G	2.518	1.00
190_L	196_M	2.506	1.00
188_F	192_S	2.496	1.00
189_N	193_N	2.470	1.00
106_G	233_G	2.450	1.00
111_Y	222_G	2.398	1.00
259_N	286_Y	2.385	1.00
196_M	223_K	2.348	1.00
199_A	220_I	2.342	1.00
115_Y	119_R	2.254	1.00
186_L	190_L	2.224	1.00
103_G	234_V	2.081	1.00
106_G	229_G	2.064	1.00
96_I	100_A	2.051	1.00
203_V	220_I	2.000	1.00
42_L	180_F	1.931	1.00
45_A	140_G	1.922	1.00
185_L	189_N	1.901	1.00
99_L	237_S	1.898	1.00
114_S	222_G	1.877	1.00
134_T	137_V	1.858	1.00
259_N	312_F	1.819	1.00
132_A	136_L	1.809	1.00
94_I	97_L	1.774	1.00
202_A	210_V	1.758	1.00
54_V	101_L	1.726	1.00
109_L	136_L	1.723	1.00
196_M	200_F	1.716	1.00
195_P	199_A	1.691	1.00
207_E	211_E	1.636	1.00
253_N	257_S	1.633	1.00
184_M	276_L	1.627	1.00
223_K	226_A	1.592	1.00
103_G	237_S	1.587	1.00
271_T	274_G	1.577	1.00
51_A	237_S	1.558	1.00
22_V	260_P	1.544	1.00
199_A	215_R	1.543	1.00
119_R	222_G	1.541	1.00
208_D	211_E	1.532	1.00
199_A	210_V	1.507	1.00
115_Y	222_G	1.454	1.00
97_L	100_A	1.453	1.00
118_L	218_G	1.422	1.00
215_R	220_I	1.411	1.00
148_G	153_V	1.402	1.00
98_T	102_A	1.398	1.00
222_G	226_A	1.387	1.00
54_V	201_R	1.380	1.00
210_V	215_R	1.345	1.00
94_I	101_L	1.334	1.00
267_G	278_G	1.333	1.00
20_L	279_A	1.328	1.00
203_V	217_I	1.326	1.00
104_I	107_A	1.320	1.00
102_A	106_G	1.318	1.00
183_I	231_L	1.308	1.00
46_G	109_L	1.304	1.00
188_F	193_N	1.290	1.00
100_A	104_I	1.288	1.00
58_I	94_I	1.283	1.00
287_H	290_D	1.280	1.00
54_V	58_I	1.272	1.00
226_A	230_F	1.271	1.00
267_G	274_G	1.267	1.00
26_L	30_I	1.247	1.00
229_G	233_G	1.240	1.00
148_G	151_V	1.237	1.00
203_V	210_V	1.236	1.00
185_L	188_F	1.230	1.00
49_F	260_P	1.229	1.00
155_V	158_V	1.227	1.00
286_Y	312_F	1.219	1.00
211_E	218_G	1.201	1.00
149_G	153_V	1.198	1.00
102_A	237_S	1.198	1.00
192_S	201_R	1.189	1.00
228_G	232_A	1.189	1.00
116_P	128_L	1.186	1.00
53_A	57_R	1.185	1.00
26_L	29_E	1.180	1.00
263_M	278_G	1.179	1.00
223_K	227_L	1.171	1.00
27_N	31_G	1.164	1.00
118_L	129_L	1.152	1.00
16_F	280_L	1.148	1.00
307_L	310_M	1.148	1.00
187_L	227_L	1.147	1.00
178_L	182_L	1.144	1.00
200_F	220_I	1.134	1.00
113_S	128_L	1.132	1.00
51_A	241_F	1.120	1.00
137_V	257_S	1.117	1.00
168_S	171_Y	1.112	1.00
9_I	288_V	1.112	1.00
108_T	111_Y	1.105	1.00
28_V	31_G	1.103	1.00
148_G	152_G	1.100	1.00
232_A	236_G	1.094	1.00
273_I	277_L	1.092	1.00
236_G	240_A	1.088	1.00
53_A	148_G	1.087	1.00
49_F	248_A	1.087	1.00
182_L	186_L	1.087	1.00
50_I	275_A	1.081	1.00
227_L	231_L	1.079	1.00
29_E	228_G	1.076	1.00
263_M	279_A	1.076	1.00
115_Y	120_L	1.069	1.00
196_M	220_I	1.066	1.00
107_A	233_G	1.060	1.00
51_A	187_L	1.058	1.00
220_I	223_K	1.057	1.00
282_Y	312_F	1.057	1.00
176_L	238_L	1.051	1.00
44_Y	239_Y	1.048	1.00
288_V	292_Y	1.046	1.00
12_I	284_T	1.040	1.00
175_I	178_L	1.036	1.00
211_E	217_I	1.034	1.00
271_T	275_A	1.026	1.00
93_A	96_I	1.026	1.00
133_G	137_V	1.022	1.00
50_I	54_V	1.018	1.00
256_W	259_N	1.014	1.00
171_Y	178_L	1.011	1.00
24_I	27_N	1.009	1.00
42_L	137_V	1.000	1.00
27_N	30_I	0.993	1.00
137_V	141_I	0.987	1.00
181_S	185_L	0.986	1.00
289_I	311_L	0.985	1.00
100_A	103_G	0.984	1.00
103_G	233_G	0.983	1.00
164_G	167_A	0.983	1.00
188_F	273_I	0.981	1.00
318_I	322_L	0.979	1.00
117_A	128_L	0.979	1.00
184_M	231_L	0.969	1.00
209_L	213_L	0.968	1.00
287_H	291_L	0.962	1.00
180_F	184_M	0.952	1.00
219_V	222_G	0.950	1.00
198_R	201_R	0.947	1.00
17_S	177_L	0.946	1.00
206_N	209_L	0.941	1.00
21_M	235_A	0.939	1.00
161_A	164_G	0.937	1.00
169_L	172_K	0.935	1.00
46_G	50_I	0.927	1.00
217_I	221_R	0.926	1.00
247_F	250_A	0.921	1.00
104_I	108_T	0.919	1.00
246_V	251_F	0.918	1.00
262_L	316_L	0.914	1.00
246_V	250_A	0.912	1.00
155_V	159_F	0.909	1.00
249_G	252_D	0.905	1.00
121_R	207_E	0.904	1.00
26_L	31_G	0.901	1.00
167_A	170_Y	0.900	1.00
157_A	160_N	0.893	1.00
207_E	217_I	0.890	1.00
203_V	224_A	0.888	1.00
15_D	19_Y	0.882	1.00
57_R	221_R	0.881	1.00
42_L	136_L	0.881	1.00
44_Y	260_P	0.877	1.00
25_S	28_V	0.877	1.00
218_G	221_R	0.874	1.00
12_I	283_S	0.867	1.00
52_G	56_G	0.865	1.00
121_R	124_Y	0.860	1.00
175_I	179_V	0.856	1.00
199_A	216_D	0.856	1.00
177_L	181_S	0.854	1.00
174_S	178_L	0.853	1.00
57_R	225_M	0.853	1.00
190_L	193_N	0.848	1.00
40_R	232_A	0.848	1.00
112_I	116_P	0.848	1.00
218_G	222_G	0.844	1.00
124_Y	225_M	0.842	1.00
46_G	187_L	0.833	1.00
111_Y	115_Y	0.833	1.00
44_Y	256_W	0.831	1.00
54_V	57_R	0.830	1.00
170_Y	178_L	0.830	1.00
306_W	309_Y	0.829	1.00
32_L	192_S	0.826	1.00
164_G	168_S	0.826	1.00
114_S	119_R	0.825	1.00
103_G	107_A	0.824	1.00
191_I	200_F	0.823	1.00
230_F	233_G	0.822	1.00
230_F	234_V	0.820	1.00
138_V	141_I	0.820	1.00
269_A	273_I	0.820	1.00
20_L	24_I	0.818	1.00
314_L	318_I	0.817	1.00
203_V	221_R	0.817	1.00
35_V	38_F	0.816	1.00
108_T	112_I	0.816	1.00
97_L	101_L	0.814	1.00
23_V	263_M	0.811	1.00
55_P	98_T	0.806	1.00
45_A	48_A	0.805	1.00
22_V	26_L	0.795	1.00
17_S	20_L	0.787	1.00
186_L	189_N	0.783	1.00
114_S	118_L	0.781	1.00
141_I	150_T	0.778	1.00
22_V	25_S	0.770	1.00
239_Y	243_I	0.770	1.00
117_A	124_Y	0.768	1.00
120_L	124_Y	0.767	1.00
22_V	44_Y	0.767	1.00
135_S	139_V	0.752	1.00
19_Y	22_V	0.751	1.00
37_N	40_R	0.751	1.00
187_L	231_L	0.750	1.00
42_L	45_A	0.750	1.00
16_F	20_L	0.747	1.00
99_L	103_G	0.746	1.00
107_A	110_G	0.746	1.00
280_L	284_T	0.739	1.00
147_V	152_G	0.737	1.00
122_E	125_L	0.736	1.00
319_I	323_R	0.735	1.00
27_N	270_G	0.735	1.00
286_Y	308_Q	0.733	1.00
34_G	38_F	0.732	1.00
183_I	234_V	0.731	1.00
16_F	27_N	0.729	1.00
233_G	237_S	0.726	1.00
293_K	304_A	0.723	1.00
133_G	257_S	0.723	1.00
162_L	165_Q	0.720	1.00
262_L	312_F	0.719	1.00
43_A	113_S	0.718	1.00
201_R	270_G	0.718	1.00
166_G	169_L	0.712	1.00
196_M	227_L	0.705	1.00
263_M	275_A	0.705	1.00
187_L	191_I	0.705	1.00
118_L	222_G	0.704	1.00
20_L	27_N	0.702	1.00
309_Y	312_F	0.701	1.00
150_T	153_V	0.698	1.00
264_L	275_A	0.698	1.00
275_A	279_A	0.697	1.00
52_G	153_V	0.695	1.00
21_M	25_S	0.691	1.00
279_A	283_S	0.689	1.00
55_P	224_A	0.688	1.00
149_G	152_G	0.687	1.00
147_V	150_T	0.682	1.00
24_I	28_V	0.682	1.00
42_L	47_G	0.681	1.00
239_Y	256_W	0.677	1.00
33_T	224_A	0.676	1.00
259_N	309_Y	0.673	1.00
190_L	194_S	0.672	1.00
57_R	124_Y	0.672	1.00
43_A	238_L	0.671	1.00
227_L	230_F	0.671	1.00
121_R	218_G	0.668	1.00
27_N	32_L	0.667	1.00
54_V	94_I	0.666	1.00
20_L	276_L	0.666	1.00
117_A	225_M	0.664	1.00
38_F	283_S	0.662	1.00
94_I	98_T	0.661	1.00
11_A	15_D	0.656	1.00
95_L	158_V	0.656	1.00
110_G	226_A	0.654	1.00
217_I	220_I	0.654	1.00
23_V	28_V	0.653	1.00
190_L	223_K	0.653	1.00
54_V	270_G	0.652	1.00
184_M	188_F	0.651	1.00
11_A	14_L	0.650	1.00
151_V	154_Q	0.648	1.00
160_N	164_G	0.645	1.00
41_V	45_A	0.644	1.00
189_N	192_S	0.643	1.00
226_A	229_G	0.637	1.00
147_V	151_V	0.628	1.00
27_N	275_A	0.628	1.00
25_S	40_R	0.626	1.00
30_I	33_T	0.624	1.00
95_L	241_F	0.623	1.00
43_A	110_G	0.621	1.00
229_G	232_A	0.620	1.00
26_L	264_L	0.619	1.00
23_V	26_L	0.617	1.00
14_L	24_I	0.617	1.00
103_G	106_G	0.615	1.00
264_L	269_A	0.610	1.00
173_I	178_L	0.610	1.00
173_I	242_Y	0.610	1.00
55_P	241_F	0.610	1.00
150_T	154_Q	0.609	1.00
179_V	182_L	0.608	1.00
266_L	319_I	0.605	1.00
208_D	212_V	0.604	1.00
273_I	276_L	0.602	1.00
25_S	30_I	0.602	1.00
266_L	278_G	0.601	1.00
25_S	29_E	0.601	1.00
106_G	110_G	0.599	1.00
210_V	217_I	0.598	1.00
274_G	278_G	0.598	1.00
179_V	238_L	0.597	1.00
134_T	138_V	0.595	1.00
252_D	257_S	0.594	1.00
179_V	234_V	0.594	1.00
23_V	27_N	0.594	1.00
42_L	279_A	0.592	1.00
51_A	55_P	0.592	1.00
22_V	235_A	0.591	1.00
137_V	252_D	0.590	1.00
46_G	106_G	0.590	1.00
192_S	195_P	0.589	1.00
283_S	287_H	0.588	1.00
16_F	24_I	0.586	1.00
42_L	46_G	0.582	1.00
165_Q	168_S	0.579	1.00
168_S	172_K	0.576	1.00
188_F	271_T	0.576	1.00
120_L	321_I	0.576	1.00
116_P	122_E	0.573	1.00
182_L	185_L	0.569	1.00
148_G	154_Q	0.569	1.00
95_L	99_L	0.569	1.00
23_V	275_A	0.564	1.00
247_F	251_F	0.562	1.00
248_A	251_F	0.558	1.00
21_M	180_F	0.558	1.00
310_M	314_L	0.558	1.00
136_L	140_G	0.556	1.00
39_G	43_A	0.555	1.00
41_V	257_S	0.554	1.00
116_P	120_L	0.552	1.00
221_R	224_A	0.550	1.00
16_F	26_L	0.550	1.00
146_I	149_G	0.549	1.00
131_V	317_T	0.547	1.00
257_S	261_Y	0.544	1.00
258_F	262_L	0.544	1.00
19_Y	283_S	0.544	1.00
107_A	229_G	0.543	1.00
247_F	252_D	0.543	1.00
250_A	253_N	0.543	1.00
29_E	33_T	0.540	1.00
13_L	17_S	0.538	1.00
128_L	132_A	0.536	1.00
260_P	264_L	0.535	1.00
25_S	231_L	0.534	1.00
51_A	191_I	0.533	1.00
41_V	256_W	0.529	1.00
167_A	171_Y	0.529	1.00
33_T	200_F	0.527	1.00
170_Y	175_I	0.526	1.00
130_L	134_T	0.523	1.00
101_L	104_I	0.521	1.00
112_I	132_A	0.521	1.00
289_I	303_D	0.520	1.00
152_G	247_F	0.520	1.00
12_I	287_H	0.519	1.00
303_D	307_L	0.519	1.00
120_L	123_D	0.518	1.00
53_A	264_L	0.518	1.00
170_Y	174_S	0.517	1.00
201_R	204_R	0.516	1.00
164_G	169_L	0.515	1.00
210_V	216_D	0.515	1.00
202_A	209_L	0.514	1.00
179_V	183_I	0.513	1.00
113_S	129_L	0.510	1.00
16_F	279_A	0.509	1.00
14_L	177_L	0.508	1.00
288_V	291_L	0.508	1.00
45_A	251_F	0.505	1.00
170_Y	173_I	0.502	1.00
274_G	279_A	0.502	1.00
98_T	237_S	0.501	1.00
289_I	293_K	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2qi9A	2	0.8435	95.6	0.9	Contact Map
4g1uA	2	0.7594	94.9	0.905	Contact Map
2nq2A	2	0.7913	93.1	0.912	Contact Map
2gfpA	2	0.5536	38.4	0.946	Contact Map
2cfqA	1	0.5826	37.8	0.947	Contact Map
4xnjA	1	0.6087	15.4	0.956	Contact Map
4m64A	1	0.5913	14.5	0.956	Contact Map
4ezcA	3	0.8493	13.4	0.957	Contact Map
2kncA	1	0.1507	11.6	0.958	Contact Map
4tphA	2	0.5623	11.3	0.958	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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