GREMLIN Database
Q97UZ8 - ABC transporter, permease (Branched chain amino acid)
UniProt: Q97UZ8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 345 (266)
Sequences: 30682 (19837)
Seq/√Len: 1216.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
103_G230_F4.4091.00
107_A226_A4.0161.00
107_A230_F3.4321.00
207_E221_R3.1821.00
111_Y226_A3.1621.00
119_R218_G2.9111.00
200_F224_A2.7781.00
216_D219_V2.6881.00
50_I105_V2.6681.00
113_S132_A2.6451.00
219_V223_K2.5371.00
110_G229_G2.5181.00
190_L196_M2.5061.00
188_F192_S2.4961.00
189_N193_N2.4701.00
106_G233_G2.4501.00
111_Y222_G2.3981.00
259_N286_Y2.3851.00
196_M223_K2.3481.00
199_A220_I2.3421.00
115_Y119_R2.2541.00
186_L190_L2.2241.00
103_G234_V2.0811.00
106_G229_G2.0641.00
96_I100_A2.0511.00
203_V220_I2.0001.00
42_L180_F1.9311.00
45_A140_G1.9221.00
185_L189_N1.9011.00
99_L237_S1.8981.00
114_S222_G1.8771.00
134_T137_V1.8581.00
259_N312_F1.8191.00
132_A136_L1.8091.00
94_I97_L1.7741.00
202_A210_V1.7581.00
54_V101_L1.7261.00
109_L136_L1.7231.00
196_M200_F1.7161.00
195_P199_A1.6911.00
207_E211_E1.6361.00
253_N257_S1.6331.00
184_M276_L1.6271.00
223_K226_A1.5921.00
103_G237_S1.5871.00
271_T274_G1.5771.00
51_A237_S1.5581.00
22_V260_P1.5441.00
199_A215_R1.5431.00
119_R222_G1.5411.00
208_D211_E1.5321.00
199_A210_V1.5071.00
115_Y222_G1.4541.00
97_L100_A1.4531.00
118_L218_G1.4221.00
215_R220_I1.4111.00
148_G153_V1.4021.00
98_T102_A1.3981.00
222_G226_A1.3871.00
54_V201_R1.3801.00
210_V215_R1.3451.00
94_I101_L1.3341.00
267_G278_G1.3331.00
20_L279_A1.3281.00
203_V217_I1.3261.00
104_I107_A1.3201.00
102_A106_G1.3181.00
183_I231_L1.3081.00
46_G109_L1.3041.00
188_F193_N1.2901.00
100_A104_I1.2881.00
58_I94_I1.2831.00
287_H290_D1.2801.00
54_V58_I1.2721.00
226_A230_F1.2711.00
267_G274_G1.2671.00
26_L30_I1.2471.00
229_G233_G1.2401.00
148_G151_V1.2371.00
203_V210_V1.2361.00
185_L188_F1.2301.00
49_F260_P1.2291.00
155_V158_V1.2271.00
286_Y312_F1.2191.00
211_E218_G1.2011.00
149_G153_V1.1981.00
102_A237_S1.1981.00
192_S201_R1.1891.00
228_G232_A1.1891.00
116_P128_L1.1861.00
53_A57_R1.1851.00
26_L29_E1.1801.00
263_M278_G1.1791.00
223_K227_L1.1711.00
27_N31_G1.1641.00
118_L129_L1.1521.00
16_F280_L1.1481.00
307_L310_M1.1481.00
187_L227_L1.1471.00
178_L182_L1.1441.00
200_F220_I1.1341.00
113_S128_L1.1321.00
51_A241_F1.1201.00
137_V257_S1.1171.00
168_S171_Y1.1121.00
9_I288_V1.1121.00
108_T111_Y1.1051.00
28_V31_G1.1031.00
148_G152_G1.1001.00
232_A236_G1.0941.00
273_I277_L1.0921.00
236_G240_A1.0881.00
53_A148_G1.0871.00
49_F248_A1.0871.00
182_L186_L1.0871.00
50_I275_A1.0811.00
227_L231_L1.0791.00
29_E228_G1.0761.00
263_M279_A1.0761.00
115_Y120_L1.0691.00
196_M220_I1.0661.00
107_A233_G1.0601.00
51_A187_L1.0581.00
220_I223_K1.0571.00
282_Y312_F1.0571.00
176_L238_L1.0511.00
44_Y239_Y1.0481.00
288_V292_Y1.0461.00
12_I284_T1.0401.00
175_I178_L1.0361.00
211_E217_I1.0341.00
271_T275_A1.0261.00
93_A96_I1.0261.00
133_G137_V1.0221.00
50_I54_V1.0181.00
256_W259_N1.0141.00
171_Y178_L1.0111.00
24_I27_N1.0091.00
42_L137_V1.0001.00
27_N30_I0.9931.00
137_V141_I0.9871.00
181_S185_L0.9861.00
289_I311_L0.9851.00
100_A103_G0.9841.00
103_G233_G0.9831.00
164_G167_A0.9831.00
188_F273_I0.9811.00
318_I322_L0.9791.00
117_A128_L0.9791.00
184_M231_L0.9691.00
209_L213_L0.9681.00
287_H291_L0.9621.00
180_F184_M0.9521.00
219_V222_G0.9501.00
198_R201_R0.9471.00
17_S177_L0.9461.00
206_N209_L0.9411.00
21_M235_A0.9391.00
161_A164_G0.9371.00
169_L172_K0.9351.00
46_G50_I0.9271.00
217_I221_R0.9261.00
247_F250_A0.9211.00
104_I108_T0.9191.00
246_V251_F0.9181.00
262_L316_L0.9141.00
246_V250_A0.9121.00
155_V159_F0.9091.00
249_G252_D0.9051.00
121_R207_E0.9041.00
26_L31_G0.9011.00
167_A170_Y0.9001.00
157_A160_N0.8931.00
207_E217_I0.8901.00
203_V224_A0.8881.00
15_D19_Y0.8821.00
57_R221_R0.8811.00
42_L136_L0.8811.00
44_Y260_P0.8771.00
25_S28_V0.8771.00
218_G221_R0.8741.00
12_I283_S0.8671.00
52_G56_G0.8651.00
121_R124_Y0.8601.00
175_I179_V0.8561.00
199_A216_D0.8561.00
177_L181_S0.8541.00
174_S178_L0.8531.00
57_R225_M0.8531.00
190_L193_N0.8481.00
40_R232_A0.8481.00
112_I116_P0.8481.00
218_G222_G0.8441.00
124_Y225_M0.8421.00
46_G187_L0.8331.00
111_Y115_Y0.8331.00
44_Y256_W0.8311.00
54_V57_R0.8301.00
170_Y178_L0.8301.00
306_W309_Y0.8291.00
32_L192_S0.8261.00
164_G168_S0.8261.00
114_S119_R0.8251.00
103_G107_A0.8241.00
191_I200_F0.8231.00
230_F233_G0.8221.00
230_F234_V0.8201.00
138_V141_I0.8201.00
269_A273_I0.8201.00
20_L24_I0.8181.00
314_L318_I0.8171.00
203_V221_R0.8171.00
35_V38_F0.8161.00
108_T112_I0.8161.00
97_L101_L0.8141.00
23_V263_M0.8111.00
55_P98_T0.8061.00
45_A48_A0.8051.00
22_V26_L0.7951.00
17_S20_L0.7871.00
186_L189_N0.7831.00
114_S118_L0.7811.00
141_I150_T0.7781.00
22_V25_S0.7701.00
239_Y243_I0.7701.00
117_A124_Y0.7681.00
120_L124_Y0.7671.00
22_V44_Y0.7671.00
135_S139_V0.7521.00
19_Y22_V0.7511.00
37_N40_R0.7511.00
187_L231_L0.7501.00
42_L45_A0.7501.00
16_F20_L0.7471.00
99_L103_G0.7461.00
107_A110_G0.7461.00
280_L284_T0.7391.00
147_V152_G0.7371.00
122_E125_L0.7361.00
319_I323_R0.7351.00
27_N270_G0.7351.00
286_Y308_Q0.7331.00
34_G38_F0.7321.00
183_I234_V0.7311.00
16_F27_N0.7291.00
233_G237_S0.7261.00
293_K304_A0.7231.00
133_G257_S0.7231.00
162_L165_Q0.7201.00
262_L312_F0.7191.00
43_A113_S0.7181.00
201_R270_G0.7181.00
166_G169_L0.7121.00
196_M227_L0.7051.00
263_M275_A0.7051.00
187_L191_I0.7051.00
118_L222_G0.7041.00
20_L27_N0.7021.00
309_Y312_F0.7011.00
150_T153_V0.6981.00
264_L275_A0.6981.00
275_A279_A0.6971.00
52_G153_V0.6951.00
21_M25_S0.6911.00
279_A283_S0.6891.00
55_P224_A0.6881.00
149_G152_G0.6871.00
147_V150_T0.6821.00
24_I28_V0.6821.00
42_L47_G0.6811.00
239_Y256_W0.6771.00
33_T224_A0.6761.00
259_N309_Y0.6731.00
190_L194_S0.6721.00
57_R124_Y0.6721.00
43_A238_L0.6711.00
227_L230_F0.6711.00
121_R218_G0.6681.00
27_N32_L0.6671.00
54_V94_I0.6661.00
20_L276_L0.6661.00
117_A225_M0.6641.00
38_F283_S0.6621.00
94_I98_T0.6611.00
11_A15_D0.6561.00
95_L158_V0.6561.00
110_G226_A0.6541.00
217_I220_I0.6541.00
23_V28_V0.6531.00
190_L223_K0.6531.00
54_V270_G0.6521.00
184_M188_F0.6511.00
11_A14_L0.6501.00
151_V154_Q0.6481.00
160_N164_G0.6451.00
41_V45_A0.6441.00
189_N192_S0.6431.00
226_A229_G0.6371.00
147_V151_V0.6281.00
27_N275_A0.6281.00
25_S40_R0.6261.00
30_I33_T0.6241.00
95_L241_F0.6231.00
43_A110_G0.6211.00
229_G232_A0.6201.00
26_L264_L0.6191.00
23_V26_L0.6171.00
14_L24_I0.6171.00
103_G106_G0.6151.00
264_L269_A0.6101.00
173_I178_L0.6101.00
173_I242_Y0.6101.00
55_P241_F0.6101.00
150_T154_Q0.6091.00
179_V182_L0.6081.00
266_L319_I0.6051.00
208_D212_V0.6041.00
273_I276_L0.6021.00
25_S30_I0.6021.00
266_L278_G0.6011.00
25_S29_E0.6011.00
106_G110_G0.5991.00
210_V217_I0.5981.00
274_G278_G0.5981.00
179_V238_L0.5971.00
134_T138_V0.5951.00
252_D257_S0.5941.00
179_V234_V0.5941.00
23_V27_N0.5941.00
42_L279_A0.5921.00
51_A55_P0.5921.00
22_V235_A0.5911.00
137_V252_D0.5901.00
46_G106_G0.5901.00
192_S195_P0.5891.00
283_S287_H0.5881.00
16_F24_I0.5861.00
42_L46_G0.5821.00
165_Q168_S0.5791.00
168_S172_K0.5761.00
188_F271_T0.5761.00
120_L321_I0.5761.00
116_P122_E0.5731.00
182_L185_L0.5691.00
148_G154_Q0.5691.00
95_L99_L0.5691.00
23_V275_A0.5641.00
247_F251_F0.5621.00
248_A251_F0.5581.00
21_M180_F0.5581.00
310_M314_L0.5581.00
136_L140_G0.5561.00
39_G43_A0.5551.00
41_V257_S0.5541.00
116_P120_L0.5521.00
221_R224_A0.5501.00
16_F26_L0.5501.00
146_I149_G0.5491.00
131_V317_T0.5471.00
257_S261_Y0.5441.00
258_F262_L0.5441.00
19_Y283_S0.5441.00
107_A229_G0.5431.00
247_F252_D0.5431.00
250_A253_N0.5431.00
29_E33_T0.5401.00
13_L17_S0.5381.00
128_L132_A0.5361.00
260_P264_L0.5351.00
25_S231_L0.5341.00
51_A191_I0.5331.00
41_V256_W0.5291.00
167_A171_Y0.5291.00
33_T200_F0.5271.00
170_Y175_I0.5261.00
130_L134_T0.5231.00
101_L104_I0.5211.00
112_I132_A0.5211.00
289_I303_D0.5201.00
152_G247_F0.5201.00
12_I287_H0.5191.00
303_D307_L0.5191.00
120_L123_D0.5181.00
53_A264_L0.5181.00
170_Y174_S0.5171.00
201_R204_R0.5161.00
164_G169_L0.5151.00
210_V216_D0.5151.00
202_A209_L0.5141.00
179_V183_I0.5131.00
113_S129_L0.5101.00
16_F279_A0.5091.00
14_L177_L0.5081.00
288_V291_L0.5081.00
45_A251_F0.5051.00
170_Y173_I0.5021.00
274_G279_A0.5021.00
98_T237_S0.5011.00
289_I293_K0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qi9A 2 0.8435 95.6 0.9 Contact Map
4g1uA 2 0.7594 94.9 0.905 Contact Map
2nq2A 2 0.7913 93.1 0.912 Contact Map
2gfpA 2 0.5536 38.4 0.946 Contact Map
2cfqA 1 0.5826 37.8 0.947 Contact Map
4xnjA 1 0.6087 15.4 0.956 Contact Map
4m64A 1 0.5913 14.5 0.956 Contact Map
4ezcA 3 0.8493 13.4 0.957 Contact Map
2kncA 1 0.1507 11.6 0.958 Contact Map
4tphA 2 0.5623 11.3 0.958 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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