GREMLIN Database
Q97UZ1 - Sugar-binding periplasmic protein
UniProt: Q97UZ1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 554 (429)
Sequences: 8449 (7308)
Seq/√Len: 352.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
286_N290_L4.2581.00
73_T105_Q4.2491.00
461_V464_V4.2391.00
73_T103_Q3.7211.00
203_T207_R3.6541.00
225_V291_N3.3371.00
221_V287_Y3.3251.00
287_Y291_N3.2741.00
157_V379_E3.2651.00
279_Q463_K3.2261.00
158_N185_T3.0841.00
225_V229_N3.0831.00
471_S475_S2.9651.00
75_V105_Q2.9551.00
160_T185_T2.9271.00
204_Q351_S2.8711.00
283_N287_Y2.8251.00
29_I32_G2.7701.00
474_V478_Q2.7551.00
203_T353_V2.6321.00
467_S471_S2.6321.00
216_N219_T2.5951.00
222_Y226_Q2.5651.00
90_S94_P2.5451.00
276_P280_K2.4801.00
463_K467_S2.4681.00
91_Q94_P2.3751.00
71_S103_Q2.3321.00
174_Y178_Q2.3321.00
219_T222_Y2.3281.00
95_A98_Q2.3191.00
222_Y225_V2.2731.00
97_K103_Q2.2581.00
212_P215_Y2.2571.00
206_L319_F2.2491.00
468_A472_T2.2121.00
102_L381_Q2.1671.00
280_K283_N2.1621.00
291_N295_Y2.1441.00
378_Q381_Q2.1411.00
424_Q428_N2.1391.00
384_Q387_H2.1171.00
99_Y384_Q2.1071.00
96_V384_Q2.0871.00
226_Q230_H2.0651.00
204_Q208_E2.0341.00
30_I33_V2.0251.00
283_N463_K1.9961.00
201_V353_V1.9951.00
116_N119_Y1.9931.00
477_M480_E1.9901.00
265_E268_Y1.9771.00
221_V288_W1.9731.00
304_S307_Q1.9671.00
283_N462_G1.9581.00
158_N161_P1.8851.00
274_S467_S1.8801.00
75_V107_Y1.8781.00
471_S474_V1.8531.00
470_N474_V1.8531.00
211_L223_D1.8421.00
156_F372_G1.8341.00
464_V468_A1.8031.00
468_A471_S1.8001.00
77_Y124_L1.7481.00
279_Q283_N1.7451.00
221_V225_V1.7211.00
472_T475_S1.7121.00
391_S394_G1.7091.00
284_E288_W1.7041.00
181_A186_L1.6961.00
71_S101_G1.6871.00
464_V467_S1.6421.00
454_G460_Q1.6411.00
221_V291_N1.6311.00
162_Y383_L1.6131.00
284_E287_Y1.5991.00
188_S370_T1.5961.00
218_S222_Y1.5701.00
218_S221_V1.5691.00
72_N381_Q1.5671.00
203_T351_S1.5481.00
467_S470_N1.5401.00
132_A378_Q1.5391.00
454_G459_Q1.5381.00
460_Q468_A1.5381.00
225_V295_Y1.5241.00
87_E91_Q1.5231.00
178_Q181_A1.5171.00
447_V472_T1.5141.00
396_E400_K1.5091.00
120_A124_L1.5081.00
211_L226_Q1.4991.00
455_L465_G1.4971.00
224_T319_F1.4961.00
157_V375_V1.4781.00
205_L227_L1.4771.00
380_Q384_Q1.4731.00
359_G362_H1.4411.00
425_Q428_N1.4401.00
264_N268_Y1.4351.00
279_Q462_G1.4321.00
20_V26_V1.4311.00
134_F374_P1.4291.00
227_L318_A1.4221.00
381_Q384_Q1.4141.00
205_L318_A1.4011.00
86_G90_S1.3971.00
74_V382_A1.3921.00
161_P164_I1.3921.00
171_N410_G1.3911.00
209_Y227_L1.3901.00
205_L209_Y1.3861.00
421_Y424_Q1.3861.00
392_Y396_E1.3861.00
214_P219_T1.3821.00
72_N378_Q1.3811.00
215_Y219_T1.3781.00
418_A421_Y1.3721.00
228_A295_Y1.3581.00
94_P97_K1.3521.00
446_D450_Q1.3521.00
274_S470_N1.3431.00
221_V284_E1.3311.00
164_I169_L1.3251.00
421_Y425_Q1.2971.00
418_A422_D1.2921.00
23_A26_V1.2871.00
425_Q429_T1.2871.00
95_A99_Y1.2861.00
465_G468_A1.2781.00
460_Q465_G1.2691.00
149_A375_V1.2691.00
466_L470_N1.2571.00
224_T295_Y1.2411.00
373_I383_L1.2321.00
87_E90_S1.2311.00
223_D226_Q1.2271.00
91_Q95_A1.2271.00
125_I130_P1.2181.00
451_I454_G1.2151.00
201_V355_T1.2131.00
228_A234_P1.1971.00
455_L462_G1.1971.00
28_V31_I1.1941.00
286_N455_L1.1921.00
199_L319_F1.1911.00
97_K100_A1.1911.00
264_N270_T1.1901.00
93_I97_K1.1831.00
307_Q310_A1.1831.00
199_L355_T1.1811.00
167_G387_H1.1791.00
206_L223_D1.1781.00
450_Q454_G1.1691.00
451_I468_A1.1591.00
312_I352_V1.1531.00
232_V235_W1.1431.00
136_V372_G1.1411.00
220_L319_F1.1391.00
223_D227_L1.1281.00
220_L224_T1.1271.00
211_L227_L1.1201.00
450_Q472_T1.1151.00
146_V182_Y1.1131.00
146_V187_L1.1131.00
33_V36_G1.1061.00
29_I33_V1.1061.00
228_A294_S1.1061.00
74_V385_L1.1041.00
373_I386_A1.1011.00
445_D449_A1.0951.00
422_D425_Q1.0921.00
451_I469_W1.0881.00
166_W387_H1.0871.00
133_A386_A1.0871.00
212_P219_T1.0861.00
209_Y230_H1.0851.00
133_A382_A1.0821.00
236_I317_V1.0811.00
311_L316_K1.0791.00
121_I134_F1.0771.00
92_I95_A1.0771.00
226_Q229_N1.0761.00
388_F394_G1.0701.00
180_G186_L1.0701.00
93_I385_L1.0701.00
88_A91_Q1.0661.00
466_L469_W1.0651.00
31_I34_V1.0601.00
261_Q264_N1.0591.00
231_G235_W1.0571.00
417_P421_Y1.0511.00
287_Y290_L1.0481.00
120_A123_A1.0341.00
76_F371_I1.0331.00
28_V32_G1.0321.00
180_G370_T1.0301.00
288_W295_Y1.0231.00
279_Q467_S1.0101.00
134_F372_G1.0101.00
30_I34_V1.0071.00
160_T164_I1.0051.00
95_A388_F0.9991.00
221_V295_Y0.9941.00
417_P420_W0.9941.00
198_V354_E0.9921.00
175_A178_Q0.9911.00
277_T280_K0.9901.00
17_Q20_V0.9891.00
110_P116_N0.9861.00
167_G170_N0.9841.00
286_N462_G0.9841.00
259_G262_L0.9831.00
201_V206_L0.9821.00
27_I33_V0.9801.00
443_V446_D0.9801.00
102_L384_Q0.9761.00
385_L389_W0.9721.00
125_I150_P0.9641.00
65_T68_S0.9631.00
209_Y226_Q0.9601.00
163_L186_L0.9581.00
233_S236_I0.9561.00
96_V388_F0.9551.00
375_V379_E0.9531.00
231_G237_I0.9501.00
447_V450_Q0.9471.00
40_T43_P0.9461.00
394_G397_V0.9451.00
97_K101_G0.9431.00
28_V33_V0.9421.00
157_V374_P0.9411.00
376_G379_E0.9371.00
18_I21_I0.9371.00
207_R351_S0.9351.00
205_L208_E0.9341.00
71_S100_A0.9331.00
294_S298_P0.9271.00
451_I460_Q0.9271.00
160_T186_L0.9271.00
177_L186_L0.9261.00
231_G234_P0.9231.00
20_V23_A0.9221.00
261_Q265_E0.9221.00
265_E270_T0.9221.00
447_V451_I0.9211.00
276_P279_Q0.9211.00
22_V26_V0.9191.00
408_K411_T0.9191.00
96_V385_L0.9151.00
234_P237_I0.9121.00
78_T106_T0.9111.00
264_N269_G0.9101.00
36_G39_L0.9051.00
77_Y109_I0.9001.00
472_T476_S0.8991.00
348_S352_V0.8981.00
279_Q466_L0.8971.00
162_Y380_Q0.8951.00
27_I31_I0.8941.00
225_V228_A0.8941.00
64_S67_T0.8921.00
207_R213_F0.8871.00
436_Y441_G0.8861.00
224_T228_A0.8861.00
20_V27_I0.8831.00
403_A407_Y0.8831.00
76_F133_A0.8801.00
202_N205_L0.8771.00
280_K284_E0.8751.00
157_V162_Y0.8741.00
96_V102_L0.8701.00
74_V378_Q0.8691.00
259_G264_N0.8681.00
204_Q207_R0.8671.00
61_T64_S0.8661.00
72_N101_G0.8661.00
310_A314_Q0.8661.00
447_V476_S0.8641.00
443_V476_S0.8611.00
297_Y311_L0.8571.00
397_V401_Y0.8551.00
160_T181_A0.8541.00
385_L388_F0.8531.00
217_F284_E0.8511.00
146_V156_F0.8501.00
25_I29_I0.8491.00
58_T61_T0.8491.00
414_Y418_A0.8491.00
25_I28_V0.8481.00
25_I31_I0.8441.00
420_W424_Q0.8411.00
232_V236_I0.8401.00
22_V25_I0.8371.00
41_K44_S0.8341.00
208_E230_H0.8301.00
95_A397_V0.8271.00
446_D449_A0.8171.00
133_A385_L0.8161.00
205_L232_V0.8141.00
162_Y166_W0.8141.00
451_I472_T0.8131.00
62_I65_T0.8101.00
118_K141_E0.8101.00
397_V400_K0.8091.00
379_E383_L0.8091.00
130_P374_P0.8091.00
444_F473_L0.8081.00
423_Y427_I0.8081.00
119_Y123_A0.8011.00
474_V479_Q0.8001.00
27_I30_I0.7981.00
69_T101_G0.7971.00
162_Y379_E0.7931.00
55_T58_T0.7901.00
104_M385_L0.7871.00
249_V252_D0.7871.00
158_N187_L0.7871.00
382_A386_A0.7861.00
202_N350_V0.7831.00
161_P185_T0.7761.00
329_Y332_Y0.7751.00
18_I26_V0.7731.00
54_S57_T0.7731.00
347_N350_V0.7721.00
393_Q396_E0.7711.00
188_S372_G0.7701.00
383_L387_H0.7671.00
26_V30_I0.7661.00
96_V99_Y0.7621.00
460_Q464_V0.7611.00
134_F156_F0.7581.00
379_E382_A0.7581.00
60_T63_P0.7571.00
303_M311_L0.7571.00
233_S298_P0.7541.00
414_Y417_P0.7541.00
415_A419_Q0.7511.00
168_L387_H0.7501.00
209_Y223_D0.7501.00
142_M156_F0.7501.00
416_Q420_W0.7481.00
419_Q422_D0.7451.00
322_N326_V0.7441.00
67_T70_P0.7441.00
289_F296_N0.7421.00
283_N286_N0.7401.00
232_V237_I0.7361.00
290_L294_S0.7361.00
181_A184_G0.7351.00
455_L460_Q0.7341.00
223_D319_F0.7321.00
420_W423_Y0.7321.00
145_Y156_F0.7311.00
206_L211_L0.7311.00
437_Q440_D0.7301.00
436_Y440_D0.7290.99
70_P101_G0.7290.99
217_F221_V0.7280.99
143_I147_E0.7270.99
200_Y322_N0.7260.99
448_F469_W0.7250.99
40_T44_S0.7250.99
409_N412_D0.7240.99
100_A385_L0.7240.99
156_F187_L0.7230.99
403_A409_N0.7230.99
32_G35_A0.7220.99
123_A126_Q0.7200.99
77_Y131_P0.7180.99
213_F353_V0.7170.99
328_N332_Y0.7160.99
71_S97_K0.7140.99
123_A127_A0.7140.99
60_T64_S0.7110.99
213_F223_D0.7100.99
57_T60_T0.7090.99
447_V469_W0.7080.99
56_F59_T0.7080.99
273_F278_V0.7060.99
465_G469_W0.7050.99
433_N437_Q0.7040.99
95_A393_Q0.7030.99
434_F437_Q0.7020.99
202_N315_G0.7020.99
207_R210_N0.7010.99
208_E234_P0.7010.99
172_A177_L0.6980.99
34_V37_F0.6970.99
17_Q21_I0.6970.99
161_P165_Q0.6960.99
34_V39_L0.6940.99
66_T69_T0.6910.99
278_V282_I0.6900.99
286_N461_V0.6870.99
461_V465_G0.6860.99
26_V33_V0.6850.99
221_V224_T0.6840.99
282_I455_L0.6840.99
18_I22_V0.6840.99
107_Y124_L0.6830.99
58_T64_S0.6820.99
63_P66_T0.6810.99
211_L214_P0.6810.99
23_A27_I0.6810.99
98_Q101_G0.6810.99
35_A39_L0.6800.99
166_W383_L0.6790.99
165_Q380_Q0.6780.99
26_V29_I0.6760.99
366_L369_D0.6760.99
18_I25_I0.6750.99
55_T61_T0.6730.99
18_I23_A0.6710.99
272_N275_N0.6690.99
281_L285_T0.6680.99
97_K104_M0.6680.99
93_I106_T0.6680.99
259_G263_Y0.6670.99
424_Q427_I0.6670.99
407_Y411_T0.6620.99
157_V161_P0.6610.99
432_Q437_Q0.6600.99
133_A371_I0.6580.99
213_F219_T0.6570.99
418_A424_Q0.6540.99
299_G311_L0.6510.99
84_D87_E0.6510.99
462_G466_L0.6500.99
278_V452_D0.6500.99
124_L131_P0.6480.99
64_S68_S0.6460.99
348_S351_S0.6460.99
388_F391_S0.6450.99
433_N436_Y0.6430.99
473_L477_M0.6430.99
157_V373_I0.6420.99
224_T234_P0.6410.99
72_N102_L0.6410.99
211_L318_A0.6410.99
204_Q350_V0.6400.99
125_I374_P0.6390.99
469_W473_L0.6380.99
87_E94_P0.6360.99
109_I120_A0.6360.99
30_I36_G0.6360.99
451_I465_G0.6350.99
20_V31_I0.6350.99
92_I388_F0.6350.99
56_F60_T0.6340.99
297_Y303_M0.6330.99
117_A121_I0.6330.99
201_V223_D0.6310.99
435_V438_L0.6310.99
233_S316_K0.6300.99
32_G36_G0.6280.99
228_A233_S0.6270.98
451_I455_L0.6270.98
208_E232_V0.6270.98
401_Y407_Y0.6260.98
206_L227_L0.6260.98
212_P223_D0.6260.98
54_S60_T0.6250.98
69_T381_Q0.6240.98
94_P98_Q0.6240.98
403_A406_Y0.6240.98
435_V439_S0.6240.98
252_D256_Y0.6230.98
435_V440_D0.6220.98
282_I466_L0.6210.98
219_T223_D0.6200.98
404_V408_K0.6200.98
72_N76_F0.6180.98
147_E183_N0.6130.98
26_V32_G0.6110.98
189_V386_A0.6080.98
224_T288_W0.6080.98
58_T62_I0.6070.98
413_W417_P0.6070.98
62_I66_T0.6060.98
434_F439_S0.6060.98
89_L92_I0.6040.98
286_N289_F0.6040.98
99_Y388_F0.6020.98
142_M188_S0.6010.98
297_Y300_W0.6010.98
383_L386_A0.5990.98
24_V28_V0.5990.98
308_A317_V0.5970.98
95_A394_G0.5960.98
419_Q426_L0.5950.98
209_Y318_A0.5910.98
416_Q419_Q0.5910.98
142_M146_V0.5900.98
25_I32_G0.5900.98
163_L166_W0.5900.98
299_G302_S0.5900.98
427_I430_S0.5850.98
39_L42_G0.5850.98
372_G375_V0.5850.98
33_V37_F0.5840.98
373_I382_A0.5820.98
24_V27_I0.5820.98
159_M186_L0.5820.98
432_Q439_S0.5810.98
250_W253_I0.5810.98
447_V455_L0.5810.98
77_Y107_Y0.5800.97
22_V32_G0.5800.97
141_E145_Y0.5800.97
18_I33_V0.5790.97
291_N294_S0.5780.97
225_V287_Y0.5780.97
415_A418_A0.5780.97
271_L474_V0.5780.97
122_L144_S0.5760.97
438_L441_G0.5740.97
290_L458_L0.5740.97
173_V177_L0.5740.97
220_L235_W0.5720.97
57_T63_P0.5720.97
164_I167_G0.5710.97
74_V381_Q0.5710.97
475_S478_Q0.5710.97
144_S148_A0.5710.97
69_T72_N0.5700.97
231_G236_I0.5690.97
432_Q436_Y0.5690.97
232_V316_K0.5690.97
203_T213_F0.5670.97
393_Q397_V0.5670.97
150_P158_N0.5670.97
455_L469_W0.5670.97
475_S479_Q0.5670.97
277_T281_L0.5670.97
248_N252_D0.5660.97
282_I465_G0.5650.97
303_M307_Q0.5650.97
402_K405_T0.5640.97
213_F355_T0.5640.97
59_T63_P0.5630.97
228_A231_G0.5630.97
435_V441_G0.5630.97
22_V33_V0.5630.97
22_V29_I0.5620.97
21_I24_V0.5610.97
29_I36_G0.5610.97
56_F61_T0.5600.97
233_S237_I0.5600.97
312_I317_V0.5600.97
174_Y177_L0.5600.97
274_S463_K0.5590.97
249_V253_I0.5590.97
206_L213_F0.5590.97
76_F135_Q0.5580.97
61_T65_T0.5580.97
403_A408_K0.5570.97
274_S466_L0.5560.97
454_G458_L0.5550.97
157_V376_G0.5550.97
27_I36_G0.5540.97
96_V100_A0.5540.97
211_L222_Y0.5530.97
436_Y439_S0.5530.97
177_L181_A0.5530.97
146_V149_A0.5520.97
423_Y426_L0.5510.97
136_V156_F0.5500.97
254_F258_A0.5500.97
310_A313_A0.5490.97
218_S284_E0.5480.96
353_V356_P0.5480.96
171_N408_K0.5480.96
433_N440_D0.5470.96
111_G116_N0.5470.96
309_F326_V0.5460.96
271_L470_N0.5450.96
206_L318_A0.5450.96
110_P115_T0.5440.96
462_G465_G0.5440.96
77_Y117_A0.5440.96
23_A30_I0.5440.96
86_G89_L0.5420.96
89_L94_P0.5410.96
93_I104_M0.5410.96
311_L317_V0.5390.96
402_K406_Y0.5370.96
201_V213_F0.5360.96
274_S474_V0.5360.96
220_L288_W0.5350.96
275_N278_V0.5350.96
97_K105_Q0.5350.96
216_N220_L0.5340.96
442_G446_D0.5320.96
92_I96_V0.5310.96
173_V409_N0.5300.96
235_W240_G0.5300.96
60_T66_T0.5290.96
419_Q424_Q0.5280.96
420_W426_L0.5280.96
75_V131_P0.5280.96
70_P377_P0.5280.96
19_A29_I0.5270.96
159_M162_Y0.5270.96
119_Y122_L0.5270.96
396_E411_T0.5250.96
157_V160_T0.5240.95
103_Q106_T0.5220.95
101_G384_Q0.5220.95
380_Q383_L0.5210.95
70_P73_T0.5200.95
21_I25_I0.5200.95
75_V129_K0.5200.95
68_S71_S0.5190.95
53_T56_F0.5180.95
406_Y409_N0.5180.95
89_L93_I0.5180.95
214_P319_F0.5160.95
59_T62_I0.5160.95
437_Q441_G0.5160.95
85_G89_L0.5150.95
306_E309_F0.5140.95
56_F62_I0.5130.95
227_L319_F0.5130.95
116_N120_A0.5130.95
306_E310_A0.5130.95
454_G468_A0.5130.95
71_S99_Y0.5120.95
18_I31_I0.5100.95
77_Y121_I0.5100.95
132_A377_P0.5080.95
424_Q429_T0.5080.95
202_N351_S0.5080.95
421_Y430_S0.5080.95
420_W427_I0.5070.95
407_Y410_G0.5060.95
96_V381_Q0.5050.95
397_V402_K0.5040.94
371_I386_A0.5040.94
92_I397_V0.5020.94
92_I394_G0.5020.94
201_V319_F0.5010.94
248_N251_E0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4r2fA 1 0.6787 100 0.409 Contact Map
4r9fA 1 0.6715 100 0.443 Contact Map
4mfiA 1 0.6913 100 0.447 Contact Map
3vxbA 1 0.6769 100 0.448 Contact Map
3uorA 1 0.6968 100 0.455 Contact Map
4g68A 1 0.6841 100 0.463 Contact Map
4c1uA 1 0.6895 100 0.467 Contact Map
4r6kA 1 0.6805 100 0.469 Contact Map
2w7yA 1 0.6625 100 0.477 Contact Map
4r6hA 1 0.6787 100 0.482 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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