GREMLIN Database
Q97UZ0 - ABC transporter, permease (Glucose)
UniProt: Q97UZ0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 286 (249)
Sequences: 70684 (45480)
Seq/√Len: 2882.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
194_K198_K3.9491.00
64_L68_E3.2821.00
186_R195_I3.1581.00
171_L175_M3.0341.00
61_N64_L2.6291.00
173_G207_S2.5711.00
72_I155_V2.5211.00
191_S194_K2.5121.00
185_A195_I2.5111.00
239_Q247_Y2.5081.00
182_V200_L2.5041.00
76_I159_V2.4621.00
31_S50_Y2.4351.00
51_S55_R2.4261.00
192_A195_I2.3731.00
60_T64_L2.3591.00
48_E51_S2.3221.00
74_V212_T2.3061.00
170_Y208_F2.2151.00
193_F197_Y2.2101.00
48_E52_I2.1691.00
62_S244_Y2.1501.00
253_Y256_Q2.1371.00
94_N97_R2.1261.00
190_T194_K2.0801.00
68_E151_F1.9921.00
194_K197_Y1.9921.00
166_A211_A1.9671.00
82_I196_L1.9501.00
89_Y175_M1.9331.00
181_I203_N1.9131.00
174_F204_S1.8981.00
185_A190_T1.8891.00
101_L171_L1.8761.00
29_V33_M1.8711.00
25_I29_V1.8091.00
78_N212_T1.7901.00
82_I204_S1.7891.00
61_N65_H1.7701.00
182_V195_I1.7511.00
91_L182_V1.7501.00
186_R192_A1.7351.00
273_I277_L1.7191.00
239_Q244_Y1.6871.00
73_L219_S1.6821.00
52_I256_Q1.6821.00
70_S216_F1.6621.00
182_V186_R1.6581.00
68_E72_I1.6531.00
82_I170_Y1.6181.00
84_I167_A1.6151.00
81_G166_A1.5921.00
88_L167_A1.5781.00
52_I55_R1.5011.00
166_A215_L1.4821.00
179_K182_V1.4821.00
91_L179_K1.4811.00
22_Y26_W1.4701.00
28_A262_T1.4641.00
96_A99_T1.4531.00
93_S97_R1.4471.00
79_I83_F1.4251.00
89_Y171_L1.4001.00
58_Q61_N1.3931.00
47_L51_S1.3881.00
201_I208_F1.3821.00
10_V14_A1.3641.00
85_A170_Y1.3521.00
77_G215_L1.3441.00
46_G49_T1.3431.00
174_F200_L1.3361.00
26_W30_M1.3351.00
210_I214_L1.3211.00
170_Y211_A1.3031.00
82_I208_F1.2891.00
179_K183_E1.2881.00
223_F227_Y1.2871.00
86_A174_F1.2781.00
7_I10_V1.2581.00
180_T183_E1.2501.00
123_F153_S1.2431.00
225_L229_L1.2241.00
99_T102_S1.2151.00
240_T243_L1.1961.00
185_A199_I1.1951.00
177_I203_N1.1941.00
75_V79_I1.1831.00
151_F238_L1.1741.00
72_I75_V1.1711.00
65_H68_E1.1661.00
157_V229_L1.1531.00
230_S238_L1.1451.00
66_S241_S1.1441.00
205_L209_I1.1401.00
78_N208_F1.1401.00
191_S195_I1.1361.00
37_L44_F1.1341.00
244_Y247_Y1.1181.00
154_L226_P1.1031.00
150_M238_L1.1031.00
34_N37_L1.1001.00
76_I155_V1.0791.00
170_Y207_S1.0771.00
99_T103_I1.0751.00
27_N262_T1.0701.00
247_Y250_T1.0701.00
163_T167_A1.0571.00
89_Y174_F1.0561.00
277_L280_I1.0471.00
26_W29_V1.0401.00
125_I128_G1.0341.00
72_I76_I1.0271.00
155_V159_V1.0241.00
239_Q243_L1.0181.00
86_A196_L1.0151.00
121_W125_I1.0111.00
52_I56_T1.0101.00
223_F246_Y1.0091.00
151_F155_V1.0091.00
244_Y260_V1.0051.00
190_T195_I1.0021.00
274_P278_T1.0001.00
54_I60_T0.9991.00
83_F87_L0.9981.00
169_F211_A0.9981.00
203_N206_N0.9971.00
226_P240_T0.9971.00
7_I11_A0.9971.00
222_I225_L0.9811.00
73_L158_S0.9791.00
97_R175_M0.9791.00
182_V192_A0.9741.00
73_L77_G0.9741.00
195_I198_K0.9701.00
152_P156_L0.9681.00
86_A192_A0.9631.00
67_I71_V0.9531.00
65_H151_F0.9521.00
75_V212_T0.9391.00
50_Y262_T0.9371.00
238_L242_E0.9361.00
69_L240_T0.9231.00
68_E152_P0.9181.00
222_I226_P0.9181.00
119_W229_L0.9151.00
85_A89_Y0.9151.00
59_F260_V0.9151.00
68_E71_V0.9051.00
23_L27_N0.9031.00
31_S35_W0.8911.00
17_S21_L0.8901.00
274_P277_L0.8891.00
71_V75_V0.8881.00
41_K44_F0.8821.00
242_E246_Y0.8801.00
81_G167_A0.8781.00
77_G81_G0.8721.00
119_W157_V0.8681.00
69_L151_F0.8681.00
73_L155_V0.8641.00
98_S101_L0.8631.00
157_V225_L0.8591.00
33_M37_L0.8591.00
49_T255_S0.8521.00
190_T198_K0.8511.00
195_I200_L0.8511.00
239_Q242_E0.8481.00
227_Y243_L0.8471.00
105_I168_L0.8441.00
36_S39_N0.8431.00
88_L101_L0.8411.00
30_M33_M0.8401.00
197_Y201_I0.8381.00
243_L247_Y0.8371.00
158_S219_S0.8341.00
116_G224_D0.8331.00
173_G204_S0.8321.00
63_L67_I0.8311.00
30_M258_T0.8311.00
53_V263_M0.8301.00
170_Y204_S0.8291.00
204_S207_S0.8271.00
63_L241_S0.8261.00
69_L158_S0.8241.00
95_K98_S0.8231.00
10_V13_T0.8191.00
242_E245_M0.8171.00
205_L208_F0.8141.00
35_W39_N0.8121.00
248_L251_V0.8111.00
8_I12_P0.8111.00
64_L67_I0.8091.00
112_M161_A0.8091.00
87_L94_N0.8071.00
268_A272_I0.8051.00
85_A167_A0.8051.00
166_A170_Y0.8041.00
239_Q246_Y0.8041.00
9_L13_T0.8031.00
120_L124_N0.8001.00
215_L219_S0.7991.00
32_F45_V0.7961.00
76_I79_I0.7961.00
152_P155_V0.7931.00
192_A196_L0.7911.00
11_A15_I0.7901.00
196_L201_I0.7871.00
85_A174_F0.7741.00
248_L257_A0.7681.00
150_M153_S0.7671.00
205_L278_T0.7671.00
49_T52_I0.7671.00
270_I274_P0.7661.00
30_M34_N0.7641.00
254_F257_A0.7621.00
27_N261_A0.7571.00
275_Y278_T0.7551.00
72_I159_V0.7491.00
84_I163_T0.7481.00
11_A14_A0.7481.00
256_Q260_V0.7481.00
254_F258_T0.7441.00
34_N44_F0.7431.00
232_G238_L0.7401.00
77_G162_Y0.7361.00
128_G144_L0.7331.00
88_L171_L0.7331.00
81_G170_Y0.7301.00
196_L200_L0.7261.00
115_N160_W0.7251.00
37_L43_T0.7211.00
51_S54_I0.7211.00
181_I199_I0.7161.00
78_N170_Y0.7111.00
74_V216_F0.7111.00
112_M224_D0.7111.00
45_V48_E0.7081.00
80_L163_T0.7051.00
162_Y215_L0.7031.00
62_S65_H0.7021.00
184_A188_D0.7021.00
70_S74_V0.6971.00
77_G219_S0.6971.00
92_N95_K0.6961.00
77_G166_A0.6961.00
22_Y25_I0.6921.00
233_T239_Q0.6911.00
208_F211_A0.6901.00
54_I57_F0.6881.00
177_I204_S0.6831.00
116_G228_V0.6791.00
47_L50_Y0.6741.00
88_L100_F0.6741.00
269_T273_I0.6721.00
105_I108_L0.6691.00
200_L203_N0.6661.00
80_L159_V0.6661.00
60_T63_L0.6661.00
33_M42_P0.6661.00
56_T60_T0.6611.00
222_I240_T0.6611.00
184_A187_L0.6571.00
57_F61_N0.6561.00
92_N97_R0.6551.00
207_S211_A0.6531.00
170_Y174_F0.6501.00
14_A18_A0.6491.00
30_M35_W0.6471.00
69_L155_V0.6471.00
32_F46_G0.6461.00
69_L154_L0.6451.00
34_N43_T0.6441.00
44_F48_E0.6421.00
179_K186_R0.6421.00
8_I11_A0.6411.00
154_L230_S0.6391.00
87_L92_N0.6381.00
258_T262_T0.6371.00
121_W124_N0.6371.00
21_L25_I0.6361.00
27_N258_T0.6361.00
162_Y218_F0.6351.00
208_F212_T0.6321.00
94_N100_F0.6321.00
44_F47_L0.6311.00
74_V78_N0.6301.00
104_V164_G0.6291.00
84_I104_V0.6261.00
245_M260_V0.6241.00
153_S157_V0.6241.00
93_S98_S0.6171.00
243_L246_Y0.6151.00
17_S20_L0.6151.00
86_A200_L0.6141.00
119_W122_L0.6131.00
16_F20_L0.6121.00
101_L168_L0.6121.00
255_S258_T0.6111.00
42_P45_V0.6031.00
77_G159_V0.6011.00
95_K99_T0.5961.00
50_Y259_A0.5951.00
113_A228_V0.5921.00
53_V260_V0.5891.00
52_I253_Y0.5891.00
19_I24_V0.5891.00
12_P15_I0.5881.00
96_A100_F0.5871.00
197_Y200_L0.5871.00
124_N127_I0.5841.00
18_A22_Y0.5841.00
62_S241_S0.5831.00
53_V256_Q0.5831.00
46_G50_Y0.5801.00
224_D228_V0.5791.00
70_S219_S0.5791.00
58_Q239_Q0.5781.00
209_I212_T0.5761.00
212_T215_L0.5761.00
33_M44_F0.5751.00
112_M116_G0.5751.00
69_L73_L0.5711.00
58_Q244_Y0.5691.00
153_S229_L0.5691.00
217_L221_R0.5671.00
158_S161_A0.5661.00
57_F60_T0.5631.00
195_I199_I0.5621.00
66_S220_F0.5601.00
218_F221_R0.5591.00
242_E264_I0.5551.00
31_S262_T0.5541.00
240_T244_Y0.5521.00
28_A32_F0.5521.00
108_L164_G0.5501.00
116_G120_L0.5491.00
78_N82_I0.5491.00
9_L12_P0.5481.00
85_A171_L0.5441.00
108_L165_I0.5411.00
258_T261_A0.5401.00
14_A17_S0.5401.00
98_S102_S0.5391.00
154_L158_S0.5391.00
21_L24_V0.5371.00
158_S222_I0.5371.00
102_S106_Y0.5361.00
35_W42_P0.5321.00
224_D227_Y0.5311.00
103_I107_P0.5291.00
169_F207_S0.5281.00
191_S197_Y0.5281.00
74_V219_S0.5271.00
84_I87_L0.5251.00
161_A164_G0.5251.00
92_N192_A0.5231.00
219_S222_I0.5221.00
33_M43_T0.5201.00
273_I276_A0.5201.00
31_S259_A0.5191.00
226_P243_L0.5191.00
183_E186_R0.5141.00
115_N161_A0.5091.00
97_R101_L0.5081.00
70_S220_F0.5081.00
264_I268_A0.5081.00
107_P164_G0.5081.00
101_L175_M0.5061.00
61_N68_E0.5041.00
43_T46_G0.5021.00
161_A225_L0.5021.00
80_L83_F0.5021.00
230_S239_Q0.5001.00
66_S242_E0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4tquM 1 0.9545 100 0.266 Contact Map
2onkC 2 0.8636 100 0.293 Contact Map
3d31C 2 0.8671 100 0.307 Contact Map
3rlfF 1 0.9336 100 0.33 Contact Map
3rlfG 1 0.9336 100 0.35 Contact Map
4tquN 1 0.8881 100 0.387 Contact Map
4ymuD 2 0.7483 99.9 0.489 Contact Map
3tuiA 2 0.7273 99.9 0.524 Contact Map
2l2tA 2 0.1399 17.2 0.943 Contact Map
2kluA 1 0.1259 16.1 0.944 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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