Q97UY9 - SULSO - GREMLIN Contacts

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Q97UY9 - ABC transporter, permease (Glucose)

UniProt:	Q97UY9	Sequences: MDKKMRPVIKASLHYLALAIVSVIWLIPVYAMLINGFKSNFEVLSTPVLVPPTKITFEAYVSVLLSLAKPLINSLIIVIPTSFISAFLGAMGAYFFYTLSYSFSRASSAISDVLFSLISLATFIPQEATLLPLTRLIVSMGLLDSYIGIIFALLIFYIPTGALLMSMFISVIPRSLIEAAKMDGTGDLKIFMKIVFPLSMPGFISTLIFIIIQAWNNFFIPLVLVTTPGMKLTSIAVLSYSGAYGTLYNDTFAAGMVASIIPLAIFVFLGRYFIRGLMALGGGGKGV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	287 (252)
Sequences:	67746 (44565)
Seq/√Len:	2807.3

ECOLI - YCJP MALG UGPE POTH UGPA YCJO YDCU YDCV POTI THIP POTB PSTA POTC PSTC CYST YNJC CYSW MALF MODB SSUC TAUC PHNE YEHY METI YECS YEHW PROW
BACSU - MDXG GANQ ARAQ YESQ YURM AMYC YTCP LPLC GANP MDXF AMYD ARAP YTEP YESP YQGI LPLB YURN YQGH YVGM SSUC YTLD OPUAB TCYB TCYL YXEN OPUCB OPUBB METP OPUBD OPUCD
HALSA - Q9HML6 Q9HHQ6 Q9HP02 Q9HMT4 Q9HP01 Q9HHQ7 Q9HR05 Q9HS11 Q9HPK3 Q9HNI9 Q9HS12
SULSO - Q97UY9 Q97UF3 Q97YY3 Q97ZC1 Q97VC0 Q97YY2 Q97UZ0 Q97ZT7 Q97ZT6 Q97UF4 Q97ZC2 Q97Z98

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
189_K	193_K	4.292	1.00
72_I	76_I	3.226	1.00
166_S	170_S	3.069	1.00
181_K	190_I	3.004	1.00
36_G	60_Y	2.927	1.00
98_T	177_I	2.761	1.00
177_I	195_V	2.696	1.00
69_K	72_I	2.660	1.00
70_P	236_A	2.611	1.00
180_A	190_I	2.551	1.00
58_E	61_V	2.505	1.00
80_P	150_I	2.460	1.00
186_G	189_K	2.450	1.00
84_I	154_L	2.445	1.00
231_K	239_S	2.436	1.00
101_Y	110_I	2.427	1.00
168_F	202_G	2.423	1.00
61_V	65_L	2.393	1.00
68_A	72_I	2.380	1.00
58_E	62_S	2.370	1.00
82_S	207_L	2.363	1.00
165_M	203_F	2.348	1.00
188_L	192_M	2.306	1.00
187_D	190_I	2.254	1.00
90_A	191_F	2.184	1.00
189_K	192_M	2.090	1.00
185_T	189_K	2.080	1.00
247_L	250_D	2.050	1.00
169_I	199_S	2.043	1.00
161_G	206_T	2.017	1.00
97_Y	170_S	2.014	1.00
176_L	198_L	1.952	1.00
180_A	185_T	1.871	1.00
86_A	207_L	1.863	1.00
90_A	199_S	1.834	1.00
236_A	240_Y	1.797	1.00
101_Y	111_S	1.794	1.00
78_V	211_I	1.786	1.00
30_Y	34_I	1.781	1.00
69_K	73_N	1.768	1.00
89_G	161_G	1.768	1.00
115_F	166_S	1.753	1.00
181_K	187_D	1.719	1.00
34_I	38_K	1.715	1.00
177_I	190_I	1.696	1.00
90_A	165_M	1.667	1.00
76_I	80_P	1.655	1.00
92_G	162_A	1.651	1.00
96_F	162_A	1.649	1.00
81_T	214_A	1.588	1.00
218_F	222_L	1.546	1.00
62_S	250_D	1.525	1.00
177_I	181_K	1.521	1.00
33_L	256_M	1.513	1.00
93_A	165_M	1.466	1.00
15_Y	19_A	1.465	1.00
27_I	31_A	1.453	1.00
110_I	113_V	1.452	1.00
62_S	65_L	1.451	1.00
205_S	209_F	1.445	1.00
97_Y	166_S	1.438	1.00
196_F	203_F	1.438	1.00
161_G	210_I	1.430	1.00
174_R	177_I	1.424	1.00
56_T	59_A	1.422	1.00
57_F	61_V	1.409	1.00
165_M	206_T	1.365	1.00
31_A	35_N	1.361	1.00
169_I	195_V	1.352	1.00
100_S	111_S	1.349	1.00
180_A	194_I	1.325	1.00
85_S	210_I	1.309	1.00
87_F	91_M	1.293	1.00
98_T	174_R	1.291	1.00
220_I	224_L	1.271	1.00
77_I	232_L	1.260	1.00
152_A	224_L	1.245	1.00
174_R	178_E	1.234	1.00
90_A	203_F	1.229	1.00
146_Y	230_M	1.223	1.00
172_I	198_L	1.221	1.00
137_I	148_G	1.207	1.00
231_K	236_A	1.206	1.00
60_Y	256_M	1.205	1.00
94_Y	169_I	1.205	1.00
80_P	83_F	1.187	1.00
186_G	190_I	1.182	1.00
62_S	66_S	1.175	1.00
175_S	178_E	1.164	1.00
267_V	271_R	1.161	1.00
83_F	87_F	1.156	1.00
19_A	23_V	1.154	1.00
218_F	238_L	1.135	1.00
113_V	116_S	1.119	1.00
32_M	256_M	1.117	1.00
164_L	206_T	1.114	1.00
10_K	14_H	1.107	1.00
149_I	221_P	1.103	1.00
225_V	230_M	1.102	1.00
165_M	202_G	1.100	1.00
236_A	239_S	1.098	1.00
73_N	76_I	1.094	1.00
200_M	204_I	1.091	1.00
64_L	68_A	1.087	1.00
271_R	274_I	1.083	1.00
86_A	203_F	1.081	1.00
81_T	153_L	1.077	1.00
158_I	162_A	1.076	1.00
9_I	13_L	1.074	1.00
232_L	235_I	1.070	1.00
42_E	54_K	1.056	1.00
217_N	220_I	1.052	1.00
198_L	201_P	1.044	1.00
80_P	84_I	1.043	1.00
227_T	230_M	1.038	1.00
12_S	16_L	1.038	1.00
94_Y	191_F	1.032	1.00
39_S	42_E	1.031	1.00
177_I	187_D	1.030	1.00
142_L	147_I	1.026	1.00
113_V	117_L	1.025	1.00
84_I	150_I	1.023	1.00
111_S	170_S	1.017	1.00
231_K	235_I	1.016	1.00
94_Y	187_D	1.015	1.00
91_M	95_F	1.009	1.00
81_T	85_S	1.005	1.00
75_L	79_I	1.000	1.00
97_Y	169_I	0.994	1.00
217_N	221_P	0.993	1.00
150_I	154_L	0.985	1.00
239_S	243_A	0.981	1.00
185_T	190_I	0.978	1.00
59_A	249_N	0.962	1.00
102_S	110_I	0.955	1.00
153_L	214_A	0.953	1.00
190_I	193_K	0.952	1.00
31_A	34_I	0.951	1.00
262_P	266_F	0.947	1.00
133_L	224_L	0.923	1.00
12_S	15_Y	0.921	1.00
240_Y	247_L	0.919	1.00
81_T	150_I	0.916	1.00
238_L	242_G	0.912	1.00
119_S	163_L	0.910	1.00
71_L	75_L	0.899	1.00
22_S	26_L	0.894	1.00
168_F	199_S	0.894	1.00
268_F	272_Y	0.893	1.00
200_M	203_F	0.891	1.00
191_F	196_F	0.886	1.00
225_V	231_K	0.882	1.00
93_A	97_Y	0.880	1.00
83_F	207_L	0.880	1.00
14_H	18_L	0.878	1.00
11_A	15_Y	0.877	1.00
240_Y	245_G	0.877	1.00
85_S	89_G	0.876	1.00
199_S	202_G	0.875	1.00
67_L	254_A	0.875	1.00
165_M	199_S	0.874	1.00
161_G	165_M	0.872	1.00
95_F	101_Y	0.870	1.00
36_G	40_N	0.870	1.00
79_I	83_F	0.866	1.00
133_L	152_A	0.865	1.00
37_F	56_T	0.865	1.00
35_N	252_F	0.864	1.00
76_I	79_I	0.862	1.00
9_I	12_S	0.861	1.00
221_P	232_L	0.859	1.00
71_L	233_T	0.859	1.00
239_S	242_G	0.857	1.00
93_A	162_A	0.857	1.00
84_I	87_F	0.856	1.00
192_M	196_F	0.848	1.00
80_P	154_L	0.848	1.00
126_Q	156_F	0.848	1.00
112_D	115_F	0.839	1.00
96_F	115_F	0.836	1.00
37_F	55_I	0.836	1.00
38_K	42_E	0.835	1.00
89_G	162_A	0.834	1.00
130_L	223_V	0.834	1.00
152_A	220_I	0.819	1.00
74_S	233_T	0.819	1.00
35_N	38_K	0.818	1.00
77_I	153_L	0.817	1.00
63_V	257_V	0.816	1.00
248_Y	251_T	0.814	1.00
93_A	169_I	0.809	1.00
176_L	194_I	0.807	1.00
102_S	112_D	0.807	1.00
236_A	241_S	0.806	1.00
130_L	219_F	0.805	1.00
134_T	138_V	0.802	1.00
148_G	152_A	0.800	1.00
144_D	227_T	0.799	1.00
165_M	169_I	0.798	1.00
32_M	252_F	0.795	1.00
210_I	214_A	0.790	1.00
27_I	30_Y	0.784	1.00
51_P	54_K	0.782	1.00
236_A	254_A	0.781	1.00
200_M	272_Y	0.779	1.00
252_F	256_M	0.777	1.00
190_I	195_V	0.776	1.00
135_R	139_S	0.773	1.00
228_P	231_K	0.764	1.00
70_P	73_N	0.760	1.00
191_F	195_V	0.759	1.00
85_S	157_Y	0.757	1.00
187_D	191_F	0.755	1.00
62_S	247_L	0.754	1.00
222_L	235_I	0.753	1.00
76_I	146_Y	0.750	1.00
72_I	75_L	0.748	1.00
86_A	165_M	0.746	1.00
85_S	161_G	0.746	1.00
235_I	239_S	0.740	1.00
264_A	268_F	0.737	1.00
235_I	238_L	0.735	1.00
61_V	64_L	0.730	1.00
119_S	122_T	0.730	1.00
234_S	237_V	0.730	1.00
138_V	143_L	0.728	1.00
92_G	158_I	0.727	1.00
96_F	114_L	0.712	1.00
16_L	19_A	0.712	1.00
78_V	82_S	0.709	1.00
39_S	53_T	0.707	1.00
250_D	254_A	0.707	1.00
82_S	211_I	0.706	1.00
172_I	199_S	0.704	1.00
174_R	181_K	0.700	1.00
148_G	224_L	0.697	1.00
258_A	262_P	0.695	1.00
149_I	153_L	0.693	1.00
195_V	198_L	0.691	1.00
203_F	206_T	0.690	1.00
68_A	71_L	0.689	1.00
89_G	165_M	0.684	1.00
35_N	39_S	0.684	1.00
63_V	254_A	0.683	1.00
185_T	193_K	0.682	1.00
126_Q	219_F	0.681	1.00
82_S	86_A	0.680	1.00
96_F	166_S	0.678	1.00
42_E	53_T	0.676	1.00
41_F	44_L	0.675	1.00
101_Y	114_L	0.669	1.00
32_M	255_G	0.668	1.00
39_S	54_K	0.666	1.00
122_T	159_P	0.666	1.00
22_S	25_W	0.661	1.00
13_L	17_A	0.661	1.00
129_T	155_I	0.659	1.00
60_Y	253_A	0.658	1.00
77_I	149_I	0.654	1.00
40_N	44_L	0.654	1.00
149_I	225_V	0.654	1.00
59_A	62_S	0.649	1.00
56_T	60_Y	0.649	1.00
63_V	250_D	0.649	1.00
55_I	58_E	0.648	1.00
179_A	183_D	0.647	1.00
249_N	252_F	0.646	1.00
241_S	251_T	0.645	1.00
85_S	214_A	0.636	1.00
267_V	270_G	0.635	1.00
157_Y	210_I	0.634	1.00
57_F	60_Y	0.629	1.00
88_L	158_I	0.625	1.00
77_I	150_I	0.625	1.00
137_I	143_L	0.624	1.00
28_P	40_N	0.623	1.00
202_G	206_T	0.623	1.00
203_F	207_L	0.622	1.00
240_Y	254_A	0.619	1.00
263_L	267_V	0.619	1.00
54_K	57_F	0.618	1.00
269_L	272_Y	0.614	1.00
21_V	25_W	0.614	1.00
157_Y	213_Q	0.613	1.00
74_S	234_S	0.612	1.00
268_F	271_R	0.611	1.00
60_Y	64_L	0.610	1.00
110_I	114_L	0.608	1.00
164_L	202_G	0.607	1.00
212_I	216_N	0.605	1.00
36_G	253_A	0.604	1.00
140_M	143_L	0.602	1.00
38_K	54_K	0.602	1.00
13_L	16_L	0.600	1.00
230_M	234_S	0.598	1.00
240_Y	243_A	0.592	1.00
38_K	52_P	0.591	1.00
179_A	182_M	0.590	1.00
28_P	32_M	0.589	1.00
17_A	21_V	0.588	1.00
92_G	118_I	0.588	1.00
233_T	237_V	0.587	1.00
248_Y	252_F	0.586	1.00
88_L	154_L	0.585	1.00
115_F	163_L	0.585	1.00
136_L	143_L	0.580	1.00
135_R	138_V	0.576	1.00
255_G	258_A	0.575	1.00
142_L	145_S	0.574	1.00
238_L	241_S	0.574	1.00
118_I	159_P	0.574	1.00
249_N	253_A	0.573	1.00
156_F	159_P	0.572	1.00
122_T	160_T	0.569	1.00
93_A	166_S	0.564	1.00
78_V	214_A	0.562	1.00
114_L	118_I	0.560	1.00
85_S	154_L	0.558	1.00
100_S	174_R	0.557	1.00
28_P	36_G	0.557	1.00
186_G	192_M	0.556	1.00
219_F	223_V	0.555	1.00
126_Q	130_L	0.555	1.00
233_T	242_G	0.554	1.00
127_E	223_V	0.554	1.00
233_T	258_A	0.554	1.00
100_S	112_D	0.552	1.00
74_S	215_W	0.552	1.00
250_D	253_A	0.552	1.00
219_F	222_L	0.551	1.00
124_I	128_A	0.551	1.00
213_Q	216_N	0.550	1.00
153_L	221_P	0.549	1.00
15_Y	18_L	0.548	1.00
18_L	22_S	0.546	1.00
40_N	52_P	0.546	1.00
172_I	177_I	0.544	1.00
81_T	154_L	0.543	1.00
246_T	250_D	0.542	1.00
36_G	256_M	0.542	1.00
28_P	35_N	0.542	1.00
77_I	146_Y	0.541	1.00
95_F	99_L	0.541	1.00
116_S	120_L	0.541	1.00
82_S	214_A	0.540	1.00
38_K	53_T	0.540	1.00
133_L	136_L	0.538	1.00
252_F	255_G	0.538	1.00
54_K	58_E	0.537	1.00
266_F	270_G	0.536	1.00
190_I	194_I	0.533	1.00
230_M	241_S	0.531	1.00
112_D	116_S	0.530	1.00
77_I	81_T	0.528	1.00
218_F	221_P	0.526	1.00
92_G	95_F	0.525	1.00
204_I	207_L	0.524	1.00
129_T	156_F	0.523	1.00
24_I	28_P	0.523	1.00
61_V	66_S	0.523	1.00
86_A	90_A	0.522	1.00
78_V	215_W	0.521	1.00
192_M	195_V	0.521	1.00
264_A	267_V	0.520	1.00
207_L	210_I	0.518	1.00
11_A	14_H	0.517	1.00
76_I	150_I	0.517	1.00
240_Y	250_D	0.517	1.00
153_L	156_F	0.516	1.00
94_Y	195_V	0.512	1.00
221_P	225_V	0.511	1.00
52_P	55_I	0.508	1.00
214_A	217_N	0.507	1.00
121_A	159_P	0.506	1.00
26_L	30_Y	0.503	1.00
178_E	181_K	0.502	1.00
199_S	203_F	0.502	1.00
210_I	213_Q	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3rlfG	1	0.9233	100	0.287	Contact Map
4tquN	1	0.9199	100	0.299	Contact Map
2onkC	2	0.8362	100	0.355	Contact Map
4tquM	1	0.885	100	0.367	Contact Map
3d31C	2	0.8188	100	0.375	Contact Map
3rlfF	1	0.892	100	0.412	Contact Map
4ymuD	2	0.7456	99.9	0.508	Contact Map
3tuiA	2	0.7491	99.9	0.547	Contact Map
2nwlA	3	0.5331	3.6	0.96	Contact Map
4mrsA	2	0.3415	3.4	0.96	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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