GREMLIN Database
Q97UY9 - ABC transporter, permease (Glucose)
UniProt: Q97UY9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 287 (252)
Sequences: 67746 (44565)
Seq/√Len: 2807.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
189_K193_K4.2921.00
72_I76_I3.2261.00
166_S170_S3.0691.00
181_K190_I3.0041.00
36_G60_Y2.9271.00
98_T177_I2.7611.00
177_I195_V2.6961.00
69_K72_I2.6601.00
70_P236_A2.6111.00
180_A190_I2.5511.00
58_E61_V2.5051.00
80_P150_I2.4601.00
186_G189_K2.4501.00
84_I154_L2.4451.00
231_K239_S2.4361.00
101_Y110_I2.4271.00
168_F202_G2.4231.00
61_V65_L2.3931.00
68_A72_I2.3801.00
58_E62_S2.3701.00
82_S207_L2.3631.00
165_M203_F2.3481.00
188_L192_M2.3061.00
187_D190_I2.2541.00
90_A191_F2.1841.00
189_K192_M2.0901.00
185_T189_K2.0801.00
247_L250_D2.0501.00
169_I199_S2.0431.00
161_G206_T2.0171.00
97_Y170_S2.0141.00
176_L198_L1.9521.00
180_A185_T1.8711.00
86_A207_L1.8631.00
90_A199_S1.8341.00
236_A240_Y1.7971.00
101_Y111_S1.7941.00
78_V211_I1.7861.00
30_Y34_I1.7811.00
69_K73_N1.7681.00
89_G161_G1.7681.00
115_F166_S1.7531.00
181_K187_D1.7191.00
34_I38_K1.7151.00
177_I190_I1.6961.00
90_A165_M1.6671.00
76_I80_P1.6551.00
92_G162_A1.6511.00
96_F162_A1.6491.00
81_T214_A1.5881.00
218_F222_L1.5461.00
62_S250_D1.5251.00
177_I181_K1.5211.00
33_L256_M1.5131.00
93_A165_M1.4661.00
15_Y19_A1.4651.00
27_I31_A1.4531.00
110_I113_V1.4521.00
62_S65_L1.4511.00
205_S209_F1.4451.00
97_Y166_S1.4381.00
196_F203_F1.4381.00
161_G210_I1.4301.00
174_R177_I1.4241.00
56_T59_A1.4221.00
57_F61_V1.4091.00
165_M206_T1.3651.00
31_A35_N1.3611.00
169_I195_V1.3521.00
100_S111_S1.3491.00
180_A194_I1.3251.00
85_S210_I1.3091.00
87_F91_M1.2931.00
98_T174_R1.2911.00
220_I224_L1.2711.00
77_I232_L1.2601.00
152_A224_L1.2451.00
174_R178_E1.2341.00
90_A203_F1.2291.00
146_Y230_M1.2231.00
172_I198_L1.2211.00
137_I148_G1.2071.00
231_K236_A1.2061.00
60_Y256_M1.2051.00
94_Y169_I1.2051.00
80_P83_F1.1871.00
186_G190_I1.1821.00
62_S66_S1.1751.00
175_S178_E1.1641.00
267_V271_R1.1611.00
83_F87_F1.1561.00
19_A23_V1.1541.00
218_F238_L1.1351.00
113_V116_S1.1191.00
32_M256_M1.1171.00
164_L206_T1.1141.00
10_K14_H1.1071.00
149_I221_P1.1031.00
225_V230_M1.1021.00
165_M202_G1.1001.00
236_A239_S1.0981.00
73_N76_I1.0941.00
200_M204_I1.0911.00
64_L68_A1.0871.00
271_R274_I1.0831.00
86_A203_F1.0811.00
81_T153_L1.0771.00
158_I162_A1.0761.00
9_I13_L1.0741.00
232_L235_I1.0701.00
42_E54_K1.0561.00
217_N220_I1.0521.00
198_L201_P1.0441.00
80_P84_I1.0431.00
227_T230_M1.0381.00
12_S16_L1.0381.00
94_Y191_F1.0321.00
39_S42_E1.0311.00
177_I187_D1.0301.00
142_L147_I1.0261.00
113_V117_L1.0251.00
84_I150_I1.0231.00
111_S170_S1.0171.00
231_K235_I1.0161.00
94_Y187_D1.0151.00
91_M95_F1.0091.00
81_T85_S1.0051.00
75_L79_I1.0001.00
97_Y169_I0.9941.00
217_N221_P0.9931.00
150_I154_L0.9851.00
239_S243_A0.9811.00
185_T190_I0.9781.00
59_A249_N0.9621.00
102_S110_I0.9551.00
153_L214_A0.9531.00
190_I193_K0.9521.00
31_A34_I0.9511.00
262_P266_F0.9471.00
133_L224_L0.9231.00
12_S15_Y0.9211.00
240_Y247_L0.9191.00
81_T150_I0.9161.00
238_L242_G0.9121.00
119_S163_L0.9101.00
71_L75_L0.8991.00
22_S26_L0.8941.00
168_F199_S0.8941.00
268_F272_Y0.8931.00
200_M203_F0.8911.00
191_F196_F0.8861.00
225_V231_K0.8821.00
93_A97_Y0.8801.00
83_F207_L0.8801.00
14_H18_L0.8781.00
11_A15_Y0.8771.00
240_Y245_G0.8771.00
85_S89_G0.8761.00
199_S202_G0.8751.00
67_L254_A0.8751.00
165_M199_S0.8741.00
161_G165_M0.8721.00
95_F101_Y0.8701.00
36_G40_N0.8701.00
79_I83_F0.8661.00
133_L152_A0.8651.00
37_F56_T0.8651.00
35_N252_F0.8641.00
76_I79_I0.8621.00
9_I12_S0.8611.00
221_P232_L0.8591.00
71_L233_T0.8591.00
239_S242_G0.8571.00
93_A162_A0.8571.00
84_I87_F0.8561.00
192_M196_F0.8481.00
80_P154_L0.8481.00
126_Q156_F0.8481.00
112_D115_F0.8391.00
96_F115_F0.8361.00
37_F55_I0.8361.00
38_K42_E0.8351.00
89_G162_A0.8341.00
130_L223_V0.8341.00
152_A220_I0.8191.00
74_S233_T0.8191.00
35_N38_K0.8181.00
77_I153_L0.8171.00
63_V257_V0.8161.00
248_Y251_T0.8141.00
93_A169_I0.8091.00
176_L194_I0.8071.00
102_S112_D0.8071.00
236_A241_S0.8061.00
130_L219_F0.8051.00
134_T138_V0.8021.00
148_G152_A0.8001.00
144_D227_T0.7991.00
165_M169_I0.7981.00
32_M252_F0.7951.00
210_I214_A0.7901.00
27_I30_Y0.7841.00
51_P54_K0.7821.00
236_A254_A0.7811.00
200_M272_Y0.7791.00
252_F256_M0.7771.00
190_I195_V0.7761.00
135_R139_S0.7731.00
228_P231_K0.7641.00
70_P73_N0.7601.00
191_F195_V0.7591.00
85_S157_Y0.7571.00
187_D191_F0.7551.00
62_S247_L0.7541.00
222_L235_I0.7531.00
76_I146_Y0.7501.00
72_I75_L0.7481.00
86_A165_M0.7461.00
85_S161_G0.7461.00
235_I239_S0.7401.00
264_A268_F0.7371.00
235_I238_L0.7351.00
61_V64_L0.7301.00
119_S122_T0.7301.00
234_S237_V0.7301.00
138_V143_L0.7281.00
92_G158_I0.7271.00
96_F114_L0.7121.00
16_L19_A0.7121.00
78_V82_S0.7091.00
39_S53_T0.7071.00
250_D254_A0.7071.00
82_S211_I0.7061.00
172_I199_S0.7041.00
174_R181_K0.7001.00
148_G224_L0.6971.00
258_A262_P0.6951.00
149_I153_L0.6931.00
195_V198_L0.6911.00
203_F206_T0.6901.00
68_A71_L0.6891.00
89_G165_M0.6841.00
35_N39_S0.6841.00
63_V254_A0.6831.00
185_T193_K0.6821.00
126_Q219_F0.6811.00
82_S86_A0.6801.00
96_F166_S0.6781.00
42_E53_T0.6761.00
41_F44_L0.6751.00
101_Y114_L0.6691.00
32_M255_G0.6681.00
39_S54_K0.6661.00
122_T159_P0.6661.00
22_S25_W0.6611.00
13_L17_A0.6611.00
129_T155_I0.6591.00
60_Y253_A0.6581.00
77_I149_I0.6541.00
40_N44_L0.6541.00
149_I225_V0.6541.00
59_A62_S0.6491.00
56_T60_Y0.6491.00
63_V250_D0.6491.00
55_I58_E0.6481.00
179_A183_D0.6471.00
249_N252_F0.6461.00
241_S251_T0.6451.00
85_S214_A0.6361.00
267_V270_G0.6351.00
157_Y210_I0.6341.00
57_F60_Y0.6291.00
88_L158_I0.6251.00
77_I150_I0.6251.00
137_I143_L0.6241.00
28_P40_N0.6231.00
202_G206_T0.6231.00
203_F207_L0.6221.00
240_Y254_A0.6191.00
263_L267_V0.6191.00
54_K57_F0.6181.00
269_L272_Y0.6141.00
21_V25_W0.6141.00
157_Y213_Q0.6131.00
74_S234_S0.6121.00
268_F271_R0.6111.00
60_Y64_L0.6101.00
110_I114_L0.6081.00
164_L202_G0.6071.00
212_I216_N0.6051.00
36_G253_A0.6041.00
140_M143_L0.6021.00
38_K54_K0.6021.00
13_L16_L0.6001.00
230_M234_S0.5981.00
240_Y243_A0.5921.00
38_K52_P0.5911.00
179_A182_M0.5901.00
28_P32_M0.5891.00
17_A21_V0.5881.00
92_G118_I0.5881.00
233_T237_V0.5871.00
248_Y252_F0.5861.00
88_L154_L0.5851.00
115_F163_L0.5851.00
136_L143_L0.5801.00
135_R138_V0.5761.00
255_G258_A0.5751.00
142_L145_S0.5741.00
238_L241_S0.5741.00
118_I159_P0.5741.00
249_N253_A0.5731.00
156_F159_P0.5721.00
122_T160_T0.5691.00
93_A166_S0.5641.00
78_V214_A0.5621.00
114_L118_I0.5601.00
85_S154_L0.5581.00
100_S174_R0.5571.00
28_P36_G0.5571.00
186_G192_M0.5561.00
219_F223_V0.5551.00
126_Q130_L0.5551.00
233_T242_G0.5541.00
127_E223_V0.5541.00
233_T258_A0.5541.00
100_S112_D0.5521.00
74_S215_W0.5521.00
250_D253_A0.5521.00
219_F222_L0.5511.00
124_I128_A0.5511.00
213_Q216_N0.5501.00
153_L221_P0.5491.00
15_Y18_L0.5481.00
18_L22_S0.5461.00
40_N52_P0.5461.00
172_I177_I0.5441.00
81_T154_L0.5431.00
246_T250_D0.5421.00
36_G256_M0.5421.00
28_P35_N0.5421.00
77_I146_Y0.5411.00
95_F99_L0.5411.00
116_S120_L0.5411.00
82_S214_A0.5401.00
38_K53_T0.5401.00
133_L136_L0.5381.00
252_F255_G0.5381.00
54_K58_E0.5371.00
266_F270_G0.5361.00
190_I194_I0.5331.00
230_M241_S0.5311.00
112_D116_S0.5301.00
77_I81_T0.5281.00
218_F221_P0.5261.00
92_G95_F0.5251.00
204_I207_L0.5241.00
129_T156_F0.5231.00
24_I28_P0.5231.00
61_V66_S0.5231.00
86_A90_A0.5221.00
78_V215_W0.5211.00
192_M195_V0.5211.00
264_A267_V0.5201.00
207_L210_I0.5181.00
11_A14_H0.5171.00
76_I150_I0.5171.00
240_Y250_D0.5171.00
153_L156_F0.5161.00
94_Y195_V0.5121.00
221_P225_V0.5111.00
52_P55_I0.5081.00
214_A217_N0.5071.00
121_A159_P0.5061.00
26_L30_Y0.5031.00
178_E181_K0.5021.00
199_S203_F0.5021.00
210_I213_Q0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rlfG 1 0.9233 100 0.287 Contact Map
4tquN 1 0.9199 100 0.299 Contact Map
2onkC 2 0.8362 100 0.355 Contact Map
4tquM 1 0.885 100 0.367 Contact Map
3d31C 2 0.8188 100 0.375 Contact Map
3rlfF 1 0.892 100 0.412 Contact Map
4ymuD 2 0.7456 99.9 0.508 Contact Map
3tuiA 2 0.7491 99.9 0.547 Contact Map
2nwlA 3 0.5331 3.6 0.96 Contact Map
4mrsA 2 0.3415 3.4 0.96 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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