GREMLIN Database
Q97UY8 - ABC transporter, ATP binding protein (Glucose)
UniProt: Q97UY8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 353 (289)
Sequences: 25565 (17664)
Seq/√Len: 1039.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
35_G208_A3.7861.00
32_E210_R3.7701.00
61_E68_L3.6881.00
8_N23_N3.6401.00
223_G227_D3.6171.00
5_I27_N3.3981.00
19_V22_D3.3901.00
7_K61_E3.3481.00
126_K131_H2.9351.00
118_R122_E2.6551.00
133_V136_H2.6481.00
224_K227_D2.6111.00
10_S59_T2.5931.00
34_F212_G2.5611.00
7_K63_Y2.5251.00
11_K50_I2.4531.00
10_S19_V2.4451.00
6_V9_V2.4221.00
5_I63_Y2.3921.00
100_F104_A2.3741.00
29_E32_E2.3641.00
113_S116_E2.3621.00
12_V19_V2.3461.00
120_R158_D2.3431.00
22_D218_K2.3431.00
220_V234_S2.2951.00
83_K160_S2.2161.00
9_V57_P2.2111.00
10_S23_N2.1281.00
100_F135_N2.0891.00
205_F226_E2.0101.00
8_N25_N1.9981.00
129_D178_S1.9961.00
63_Y68_L1.9301.00
100_F118_R1.9181.00
100_F122_E1.9051.00
212_G219_L1.9001.00
4_I161_L1.8461.00
11_K58_S1.8221.00
125_A134_L1.8081.00
11_K55_D1.8051.00
50_I57_P1.8021.00
215_V220_V1.7971.00
212_G222_V1.7871.00
48_M197_V1.7661.00
65_D160_S1.7641.00
235_I273_I1.7541.00
120_R123_E1.7491.00
225_P229_Y1.7221.00
116_E119_K1.7141.00
119_K123_E1.6881.00
51_I195_L1.5861.00
48_M163_L1.5811.00
128_L152_A1.5681.00
68_L71_S1.5601.00
21_L50_I1.5571.00
115_E119_K1.5371.00
186_V192_V1.5301.00
104_A121_V1.5151.00
49_R55_D1.4921.00
67_R77_V1.4831.00
256_V260_S1.4731.00
6_V26_I1.4661.00
26_I212_G1.4421.00
28_I34_F1.4381.00
260_S263_F1.4301.00
263_F266_S1.4261.00
235_I239_S1.4121.00
12_V58_S1.4001.00
124_V156_V1.3911.00
100_F121_V1.3861.00
226_E230_D1.3861.00
122_E134_L1.3861.00
10_S22_D1.3771.00
98_T101_E1.3731.00
34_F222_V1.3441.00
164_L194_L1.3271.00
244_I247_L1.3211.00
67_R160_S1.3091.00
123_E126_K1.2951.00
112_M116_E1.2911.00
49_R54_L1.2731.00
50_I62_L1.2721.00
101_E104_A1.2701.00
104_A117_I1.2611.00
6_V51_I1.2591.00
267_V270_D1.2531.00
235_I246_E1.2491.00
136_H140_E1.2371.00
116_E120_R1.2351.00
112_M117_I1.2321.00
34_F210_R1.2291.00
24_V47_F1.2281.00
122_E126_K1.2191.00
105_F109_N1.2161.00
261_L264_P1.2151.00
69_V77_V1.2131.00
97_L105_F1.2111.00
35_G204_I1.2021.00
6_V47_F1.2011.00
184_K207_I1.1911.00
57_P62_L1.1901.00
210_R222_V1.1891.00
210_R221_Q1.1861.00
223_G228_L1.1721.00
256_V259_G1.1641.00
85_G154_A1.1571.00
7_K25_N1.1561.00
226_E229_Y1.1511.00
225_P228_L1.1491.00
250_K271_R1.1481.00
187_Q194_L1.1471.00
137_F140_E1.1441.00
98_T137_F1.1391.00
227_D231_N1.1291.00
187_Q192_V1.1271.00
64_F69_V1.1261.00
262_R265_V1.1221.00
258_I261_L1.1151.00
259_G263_F1.1131.00
239_S246_E1.1081.00
246_E273_I1.1021.00
198_S204_I1.1021.00
12_V17_K1.0931.00
123_E127_I1.0891.00
261_L265_V1.0891.00
21_L47_F1.0871.00
96_N139_R1.0811.00
77_V81_D1.0721.00
21_L24_V1.0691.00
276_I281_V1.0631.00
99_A141_L1.0621.00
219_L222_V1.0451.00
12_V59_T1.0401.00
42_A214_L1.0351.00
29_E210_R1.0351.00
245_N248_E1.0331.00
106_P109_N1.0211.00
100_F134_L1.0131.00
238_A242_G1.0071.00
284_S288_I0.9961.00
117_I121_V0.9951.00
13_F20_A0.9931.00
12_V20_A0.9861.00
33_R194_L0.9801.00
184_K206_A0.9781.00
52_A163_L0.9781.00
28_I193_T0.9701.00
244_I248_E0.9701.00
61_E70_A0.9641.00
97_L102_N0.9641.00
125_A130_I0.9641.00
274_I277_R0.9611.00
274_I278_P0.9601.00
63_Y66_D0.9601.00
85_G159_P0.9531.00
301_V304_I0.9511.00
196_V208_A0.9501.00
30_N160_S0.9491.00
213_V228_L0.9471.00
304_I307_Q0.9461.00
32_E209_D0.9411.00
158_D192_V0.9401.00
114_K118_R0.9391.00
168_F183_V0.9351.00
101_E108_T0.9281.00
9_V50_I0.9221.00
284_S287_V0.9151.00
229_Y232_P0.9091.00
276_I280_D0.9071.00
257_V260_S0.9041.00
184_K188_S0.9031.00
275_G278_P0.9021.00
272_A275_G0.8951.00
123_E158_D0.8921.00
138_P149_V0.8881.00
47_F214_L0.8871.00
94_Y97_L0.8851.00
57_P70_A0.8831.00
257_V262_R0.8831.00
260_S264_P0.8781.00
180_R206_A0.8771.00
299_G302_K0.8761.00
30_N65_D0.8721.00
228_L232_P0.8631.00
6_V62_L0.8631.00
104_A108_T0.8591.00
303_V306_Y0.8571.00
256_V261_L0.8551.00
287_V290_D0.8551.00
229_Y233_V0.8551.00
208_A211_V0.8551.00
102_N153_R0.8441.00
257_V261_L0.8421.00
275_G279_E0.8371.00
244_I275_G0.8291.00
176_R200_D0.8271.00
106_P157_K0.8261.00
106_P110_M0.8221.00
262_R266_S0.8221.00
124_V155_L0.8211.00
277_R281_V0.8201.00
260_S265_V0.8151.00
278_P284_S0.8141.00
278_P281_V0.8081.00
227_D230_D0.8041.00
258_I263_F0.8021.00
259_G262_R0.8021.00
33_R187_Q0.8011.00
94_Y106_P0.8001.00
177_D181_A0.8001.00
8_N59_T0.8001.00
108_T114_K0.7971.00
274_I279_E0.7961.00
103_I152_A0.7951.00
237_V241_I0.7951.00
226_E306_Y0.7931.00
31_G193_T0.7921.00
271_R275_G0.7891.00
259_G264_P0.7871.00
11_K46_T0.7871.00
50_I58_S0.7861.00
258_I265_V0.7851.00
168_F196_V0.7841.00
269_S272_A0.7811.00
285_K289_K0.7791.00
103_I156_V0.7771.00
248_E273_I0.7751.00
31_G191_G0.7731.00
122_E131_H0.7721.00
257_V265_V0.7701.00
182_L185_E0.7671.00
261_L266_S0.7621.00
78_P81_D0.7581.00
253_N256_V0.7541.00
110_M157_K0.7501.00
256_V263_F0.7461.00
230_D306_Y0.7441.00
36_I47_F0.7431.00
278_P285_K0.7431.00
248_E271_R0.7391.00
124_V127_I0.7381.00
276_I283_L0.7351.00
45_T49_R0.7341.00
103_I125_A0.7341.00
39_P42_A0.7331.00
283_L288_I0.7311.00
257_V264_P0.7291.00
256_V264_P0.7291.00
62_L69_V0.7261.00
282_K285_K0.7261.00
249_G272_A0.7201.00
300_K303_V0.7161.00
122_E130_I0.7121.00
124_V152_A0.7121.00
260_S266_S0.7081.00
278_P282_K0.7061.00
213_V237_V0.7041.00
84_I161_L0.6971.00
277_R280_D0.6971.00
5_I66_D0.6941.00
245_N249_G0.6931.00
278_P283_L0.6911.00
114_K117_I0.6901.00
141_L149_V0.6891.00
202_A206_A0.6881.00
54_L88_F0.6881.00
70_A77_V0.6861.00
271_R274_I0.6841.00
271_R278_P0.6841.00
107_L110_M0.6841.00
223_G226_E0.6841.00
151_L164_L0.6831.00
162_L192_V0.6781.00
102_N138_P0.6771.00
224_K228_L0.6751.00
276_I279_E0.6751.00
270_D278_P0.6731.00
23_N59_T0.6721.00
7_K27_N0.6711.00
215_V236_Q0.6701.00
236_Q239_S0.6691.00
36_I212_G0.6671.00
91_W170_N0.6581.00
283_L287_V0.6531.00
52_A86_M0.6521.00
33_R207_I0.6521.00
103_I106_P0.6511.00
255_G259_G0.6501.00
26_I222_V0.6481.00
273_I277_R0.6471.00
239_S243_E0.6471.00
166_E199_H0.6471.00
12_V22_D0.6461.00
163_L195_L0.6431.00
285_K288_I0.6421.00
272_A276_I0.6421.00
50_I55_D0.6411.00
215_V218_K0.6411.00
36_I214_L0.6411.00
131_H134_L0.6381.00
16_G19_V0.6371.00
118_R121_V0.6311.00
9_V62_L0.6311.00
258_I266_S0.6301.00
124_V128_L0.6301.00
276_I284_S0.6271.00
34_F195_L0.6261.00
164_L196_V0.6261.00
286_D289_K0.6231.00
254_E259_G0.6231.00
160_S192_V0.6231.00
51_I163_L0.6221.00
159_P162_L0.6221.00
181_A185_E0.6211.00
280_D283_L0.6191.00
104_A118_R0.6171.00
108_T117_I0.6151.00
95_P139_R0.6151.00
224_K229_Y0.6141.00
259_G265_V0.6111.00
13_F55_D0.6111.00
279_E283_L0.6101.00
179_A182_L0.6101.00
246_E249_G0.6091.00
93_L138_P0.6081.00
277_R284_S0.6081.00
105_F108_T0.6071.00
177_D202_A0.6041.00
267_V271_R0.6031.00
268_S272_A0.6031.00
106_P153_R0.6011.00
185_E303_V0.6001.00
300_K304_I0.5991.00
284_S289_K0.5981.00
64_F84_I0.5971.00
256_V265_V0.5961.00
280_D287_V0.5951.00
225_P233_V0.5931.00
280_D284_S0.5931.00
271_R277_R0.5911.00
30_N191_G0.5901.00
183_V194_L0.5891.00
281_V287_V0.5861.00
257_V263_F0.5851.00
33_R196_V0.5851.00
132_H136_H0.5851.00
281_V284_S0.5841.00
162_L194_L0.5831.00
161_L193_T0.5831.00
205_F227_D0.5831.00
284_S290_D0.5811.00
246_E250_K0.5811.00
97_L101_E0.5741.00
85_G157_K0.5721.00
277_R283_L0.5721.00
93_L102_N0.5721.00
42_A47_F0.5701.00
231_N234_S0.5691.00
272_A280_D0.5691.00
16_G20_A0.5681.00
258_I262_R0.5661.00
170_N175_M0.5651.00
297_G301_V0.5651.00
37_L213_V0.5641.00
272_A277_R0.5641.00
202_A307_Q0.5631.00
254_E257_V0.5631.00
174_R239_S0.5631.00
223_G229_Y0.5621.00
83_K157_K0.5611.00
115_E118_R0.5611.00
204_I208_A0.5611.00
231_N235_I0.5611.00
173_A177_D0.5601.00
252_T257_V0.5591.00
99_A149_V0.5591.00
235_I238_A0.5581.00
178_S182_L0.5571.00
269_S273_I0.5561.00
278_P290_D0.5551.00
256_V266_S0.5541.00
132_H135_N0.5531.00
259_G266_S0.5521.00
214_L219_L0.5511.00
283_L286_D0.5511.00
268_S271_R0.5501.00
282_K286_D0.5501.00
112_M120_R0.5481.00
301_V307_Q0.5471.00
301_V306_Y0.5471.00
184_K187_Q0.5451.00
267_V272_A0.5431.00
286_D290_D0.5391.00
125_A131_H0.5391.00
100_F103_I0.5361.00
128_L179_A0.5361.00
96_N137_F0.5341.00
173_A180_R0.5321.00
250_K254_E0.5311.00
251_V254_E0.5281.00
232_P235_I0.5271.00
240_L243_E0.5271.00
186_V194_L0.5261.00
98_T135_N0.5261.00
270_D274_I0.5261.00
277_R285_K0.5251.00
281_V288_I0.5201.00
298_K301_V0.5171.00
234_S238_A0.5171.00
237_V240_L0.5151.00
282_K288_I0.5141.00
236_Q240_L0.5141.00
100_F117_I0.5131.00
98_T102_N0.5121.00
213_V232_P0.5121.00
181_A303_V0.5121.00
87_V154_A0.5121.00
22_D216_K0.5111.00
273_I278_P0.5111.00
254_E261_L0.5091.00
251_V255_G0.5091.00
4_I64_F0.5081.00
130_I133_V0.5071.00
273_I276_I0.5071.00
71_S77_V0.5061.00
278_P287_V0.5051.00
113_S117_I0.5031.00
253_N260_S0.5021.00
184_K306_Y0.5011.00
13_F46_T0.5011.00
278_P288_I0.5001.00
270_D273_I0.5001.00
230_D233_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1oxxK 1 0.9972 100 0.168 Contact Map
1v43A 2 0.9433 100 0.179 Contact Map
2it1A 1 0.9632 100 0.184 Contact Map
2yyzA 1 0.9632 100 0.189 Contact Map
1g291 4 0.9858 100 0.19 Contact Map
3rlfA 2 0.9603 100 0.197 Contact Map
3fvqA 2 0.9773 100 0.206 Contact Map
1z47A 2 0.9575 100 0.218 Contact Map
3d31A 2 0.9518 100 0.222 Contact Map
4tquS 2 0.9717 100 0.227 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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