Q97UY8 - SULSO - GREMLIN Contacts

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Q97UY8 - ABC transporter, ATP binding protein (Glucose)

UniProt:	Q97UY8	Sequences: MVRIIVKNVSKVFKKGKVVALDNVNINIENGERFGILGPSGAGKTTFMRIIAGLDVPSTGELYFDDRLVASNGKLIVPPEDRKIGMVFQTWALYPNLTAFENIAFPLTNMKMSKEEIRKRVEEVAKILDIHHVLNHFPRELSGGQQQRVALARALVKDPSLLLLDEPFSNLDARMRDSARALVKEVQSRLGVTLLVVSHDPADIFAIADRVGVLVKGKLVQVGKPEDLYDNPVSIQVASLIGEINELEGKVTNEGVVIGSLRFPVSVSSDRAIIGIRPEDVKLSKDVIKDDSWILVGKGKVKVIGYQGGLFRITITPLDSEEEIFTYSDHPIHSGEEVLVYVRKDKIKVFEKN	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	353 (289)
Sequences:	25565 (17664)
Seq/√Len:	1039.1

ECOLI - MALK YCJV FBPC UGPC CYSA POTA POTG PROV METN YDCT MODC DPPF DPPD SAPD OPPD YEHX YADG OPPF DDPD RBSA GSIA DDPF ARAG YHES MACB UUP MLAF YECC FEPC CYDC NIKE TAUB SAPF MDLA HISP MDLB LPTB MSBA FECE YTFR LSRA FHUC ETTA SSUB YOJI GLNQ CYDD PHNC YHDZ GLTL MODF YPHE ZNUC THIQ SUFC XYLG FTSE PHNK LIVG ARTP PSTB ALSA LOLD LIVF MGLA NIKD BTUD FETA YBBA CCMA PHNL YEJF YDDA YBHF YNJD YBIT YHIH
BACSU - MSMX YURJ OPUCA OPUBA YVRA OPUAA METN OPPD YKFD YFMM TAGH APPF DPPD APPD YXLF YKPA YHCH YFIL YHAQ YDBJ YVFR YCBN OPPF YDIF RBSA FHUC YFMF ECFA1 YTRB YFMR YUSV BCEA YTLC ECSA SUNT YFIB YVCR YHEH YFIC TCYN YGAD SKFE YCLP YKNU YHEI YKNV YLMA YXDL ECFA2 YWJA CYDD BMRA SUFC NATA YXEO ALBC MNTB YKOD TCYC CYDC GLNQ SSUB YCLH FTSE ARTM PSTB1 YVRO YKNY YJKB PSTB2 ZNUC YTHP EXPZ YHCG YUFO YYBJ YTRE YYDI
HALSA - Q9HHQ5 Q9HR06 Q9HNZ9 Q9HMX3 Q9HMW0 Q9HMT3 BTUDA Q9HMX2 Q9HMU8 Q9HRJ6 Q9HMG1 PHNC PSTB2 Q9HRH8 Q9HSQ7 Q9HMG6 Q9HHM2 Q9HRV7 Q9HNY3 Y2317 Q9HRZ9 Y1631 PSTB1 Q9HR96 Q9HHR7 Q9HT03 Q9HS04 Q9HR21 Q9HQA8 Q9HMC1 Q9HMW1
SULSO - Q97UY8 Q97UF2 Q97YY4 Q97ZC0 Q7LX64 Q97VC1 Q97UH3 Q97YP3 Q97VF5 Q97VH6 Q97VK8 Q97VK9 Q97VF4 Q97UD4 Q97YP7 Q97X18 Q97YK2 Q97UJ9 Q97YP8 Q97YQ7 Q97Z03 Y1893 Y2030 Q97U54 Q980W0 Q97UH4 Q97V01 PSTB Q97W42 Q7LXM4 Q97V00 Q7LY07 Q97Z56 Q97VY4 Q97VM2 Q7LX80 Q97UG5 Q97YP4 Q97Z96 Q97UC2 Q980K5 Q97ZU0 Q980E6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
35_G	208_A	3.786	1.00
32_E	210_R	3.770	1.00
61_E	68_L	3.688	1.00
8_N	23_N	3.640	1.00
223_G	227_D	3.617	1.00
5_I	27_N	3.398	1.00
19_V	22_D	3.390	1.00
7_K	61_E	3.348	1.00
126_K	131_H	2.935	1.00
118_R	122_E	2.655	1.00
133_V	136_H	2.648	1.00
224_K	227_D	2.611	1.00
10_S	59_T	2.593	1.00
34_F	212_G	2.561	1.00
7_K	63_Y	2.525	1.00
11_K	50_I	2.453	1.00
10_S	19_V	2.445	1.00
6_V	9_V	2.422	1.00
5_I	63_Y	2.392	1.00
100_F	104_A	2.374	1.00
29_E	32_E	2.364	1.00
113_S	116_E	2.362	1.00
12_V	19_V	2.346	1.00
120_R	158_D	2.343	1.00
22_D	218_K	2.343	1.00
220_V	234_S	2.295	1.00
83_K	160_S	2.216	1.00
9_V	57_P	2.211	1.00
10_S	23_N	2.128	1.00
100_F	135_N	2.089	1.00
205_F	226_E	2.010	1.00
8_N	25_N	1.998	1.00
129_D	178_S	1.996	1.00
63_Y	68_L	1.930	1.00
100_F	118_R	1.918	1.00
100_F	122_E	1.905	1.00
212_G	219_L	1.900	1.00
4_I	161_L	1.846	1.00
11_K	58_S	1.822	1.00
125_A	134_L	1.808	1.00
11_K	55_D	1.805	1.00
50_I	57_P	1.802	1.00
215_V	220_V	1.797	1.00
212_G	222_V	1.787	1.00
48_M	197_V	1.766	1.00
65_D	160_S	1.764	1.00
235_I	273_I	1.754	1.00
120_R	123_E	1.749	1.00
225_P	229_Y	1.722	1.00
116_E	119_K	1.714	1.00
119_K	123_E	1.688	1.00
51_I	195_L	1.586	1.00
48_M	163_L	1.581	1.00
128_L	152_A	1.568	1.00
68_L	71_S	1.560	1.00
21_L	50_I	1.557	1.00
115_E	119_K	1.537	1.00
186_V	192_V	1.530	1.00
104_A	121_V	1.515	1.00
49_R	55_D	1.492	1.00
67_R	77_V	1.483	1.00
256_V	260_S	1.473	1.00
6_V	26_I	1.466	1.00
26_I	212_G	1.442	1.00
28_I	34_F	1.438	1.00
260_S	263_F	1.430	1.00
263_F	266_S	1.426	1.00
235_I	239_S	1.412	1.00
12_V	58_S	1.400	1.00
124_V	156_V	1.391	1.00
100_F	121_V	1.386	1.00
226_E	230_D	1.386	1.00
122_E	134_L	1.386	1.00
10_S	22_D	1.377	1.00
98_T	101_E	1.373	1.00
34_F	222_V	1.344	1.00
164_L	194_L	1.327	1.00
244_I	247_L	1.321	1.00
67_R	160_S	1.309	1.00
123_E	126_K	1.295	1.00
112_M	116_E	1.291	1.00
49_R	54_L	1.273	1.00
50_I	62_L	1.272	1.00
101_E	104_A	1.270	1.00
104_A	117_I	1.261	1.00
6_V	51_I	1.259	1.00
267_V	270_D	1.253	1.00
235_I	246_E	1.249	1.00
136_H	140_E	1.237	1.00
116_E	120_R	1.235	1.00
112_M	117_I	1.232	1.00
34_F	210_R	1.229	1.00
24_V	47_F	1.228	1.00
122_E	126_K	1.219	1.00
105_F	109_N	1.216	1.00
261_L	264_P	1.215	1.00
69_V	77_V	1.213	1.00
97_L	105_F	1.211	1.00
35_G	204_I	1.202	1.00
6_V	47_F	1.201	1.00
184_K	207_I	1.191	1.00
57_P	62_L	1.190	1.00
210_R	222_V	1.189	1.00
210_R	221_Q	1.186	1.00
223_G	228_L	1.172	1.00
256_V	259_G	1.164	1.00
85_G	154_A	1.157	1.00
7_K	25_N	1.156	1.00
226_E	229_Y	1.151	1.00
225_P	228_L	1.149	1.00
250_K	271_R	1.148	1.00
187_Q	194_L	1.147	1.00
137_F	140_E	1.144	1.00
98_T	137_F	1.139	1.00
227_D	231_N	1.129	1.00
187_Q	192_V	1.127	1.00
64_F	69_V	1.126	1.00
262_R	265_V	1.122	1.00
258_I	261_L	1.115	1.00
259_G	263_F	1.113	1.00
239_S	246_E	1.108	1.00
246_E	273_I	1.102	1.00
198_S	204_I	1.102	1.00
12_V	17_K	1.093	1.00
123_E	127_I	1.089	1.00
261_L	265_V	1.089	1.00
21_L	47_F	1.087	1.00
96_N	139_R	1.081	1.00
77_V	81_D	1.072	1.00
21_L	24_V	1.069	1.00
276_I	281_V	1.063	1.00
99_A	141_L	1.062	1.00
219_L	222_V	1.045	1.00
12_V	59_T	1.040	1.00
42_A	214_L	1.035	1.00
29_E	210_R	1.035	1.00
245_N	248_E	1.033	1.00
106_P	109_N	1.021	1.00
100_F	134_L	1.013	1.00
238_A	242_G	1.007	1.00
284_S	288_I	0.996	1.00
117_I	121_V	0.995	1.00
13_F	20_A	0.993	1.00
12_V	20_A	0.986	1.00
33_R	194_L	0.980	1.00
184_K	206_A	0.978	1.00
52_A	163_L	0.978	1.00
28_I	193_T	0.970	1.00
244_I	248_E	0.970	1.00
61_E	70_A	0.964	1.00
97_L	102_N	0.964	1.00
125_A	130_I	0.964	1.00
274_I	277_R	0.961	1.00
274_I	278_P	0.960	1.00
63_Y	66_D	0.960	1.00
85_G	159_P	0.953	1.00
301_V	304_I	0.951	1.00
196_V	208_A	0.950	1.00
30_N	160_S	0.949	1.00
213_V	228_L	0.947	1.00
304_I	307_Q	0.946	1.00
32_E	209_D	0.941	1.00
158_D	192_V	0.940	1.00
114_K	118_R	0.939	1.00
168_F	183_V	0.935	1.00
101_E	108_T	0.928	1.00
9_V	50_I	0.922	1.00
284_S	287_V	0.915	1.00
229_Y	232_P	0.909	1.00
276_I	280_D	0.907	1.00
257_V	260_S	0.904	1.00
184_K	188_S	0.903	1.00
275_G	278_P	0.902	1.00
272_A	275_G	0.895	1.00
123_E	158_D	0.892	1.00
138_P	149_V	0.888	1.00
47_F	214_L	0.887	1.00
94_Y	97_L	0.885	1.00
57_P	70_A	0.883	1.00
257_V	262_R	0.883	1.00
260_S	264_P	0.878	1.00
180_R	206_A	0.877	1.00
299_G	302_K	0.876	1.00
30_N	65_D	0.872	1.00
228_L	232_P	0.863	1.00
6_V	62_L	0.863	1.00
104_A	108_T	0.859	1.00
303_V	306_Y	0.857	1.00
256_V	261_L	0.855	1.00
287_V	290_D	0.855	1.00
229_Y	233_V	0.855	1.00
208_A	211_V	0.855	1.00
102_N	153_R	0.844	1.00
257_V	261_L	0.842	1.00
275_G	279_E	0.837	1.00
244_I	275_G	0.829	1.00
176_R	200_D	0.827	1.00
106_P	157_K	0.826	1.00
106_P	110_M	0.822	1.00
262_R	266_S	0.822	1.00
124_V	155_L	0.821	1.00
277_R	281_V	0.820	1.00
260_S	265_V	0.815	1.00
278_P	284_S	0.814	1.00
278_P	281_V	0.808	1.00
227_D	230_D	0.804	1.00
258_I	263_F	0.802	1.00
259_G	262_R	0.802	1.00
33_R	187_Q	0.801	1.00
94_Y	106_P	0.800	1.00
177_D	181_A	0.800	1.00
8_N	59_T	0.800	1.00
108_T	114_K	0.797	1.00
274_I	279_E	0.796	1.00
103_I	152_A	0.795	1.00
237_V	241_I	0.795	1.00
226_E	306_Y	0.793	1.00
31_G	193_T	0.792	1.00
271_R	275_G	0.789	1.00
259_G	264_P	0.787	1.00
11_K	46_T	0.787	1.00
50_I	58_S	0.786	1.00
258_I	265_V	0.785	1.00
168_F	196_V	0.784	1.00
269_S	272_A	0.781	1.00
285_K	289_K	0.779	1.00
103_I	156_V	0.777	1.00
248_E	273_I	0.775	1.00
31_G	191_G	0.773	1.00
122_E	131_H	0.772	1.00
257_V	265_V	0.770	1.00
182_L	185_E	0.767	1.00
261_L	266_S	0.762	1.00
78_P	81_D	0.758	1.00
253_N	256_V	0.754	1.00
110_M	157_K	0.750	1.00
256_V	263_F	0.746	1.00
230_D	306_Y	0.744	1.00
36_I	47_F	0.743	1.00
278_P	285_K	0.743	1.00
248_E	271_R	0.739	1.00
124_V	127_I	0.738	1.00
276_I	283_L	0.735	1.00
45_T	49_R	0.734	1.00
103_I	125_A	0.734	1.00
39_P	42_A	0.733	1.00
283_L	288_I	0.731	1.00
257_V	264_P	0.729	1.00
256_V	264_P	0.729	1.00
62_L	69_V	0.726	1.00
282_K	285_K	0.726	1.00
249_G	272_A	0.720	1.00
300_K	303_V	0.716	1.00
122_E	130_I	0.712	1.00
124_V	152_A	0.712	1.00
260_S	266_S	0.708	1.00
278_P	282_K	0.706	1.00
213_V	237_V	0.704	1.00
84_I	161_L	0.697	1.00
277_R	280_D	0.697	1.00
5_I	66_D	0.694	1.00
245_N	249_G	0.693	1.00
278_P	283_L	0.691	1.00
114_K	117_I	0.690	1.00
141_L	149_V	0.689	1.00
202_A	206_A	0.688	1.00
54_L	88_F	0.688	1.00
70_A	77_V	0.686	1.00
271_R	274_I	0.684	1.00
271_R	278_P	0.684	1.00
107_L	110_M	0.684	1.00
223_G	226_E	0.684	1.00
151_L	164_L	0.683	1.00
162_L	192_V	0.678	1.00
102_N	138_P	0.677	1.00
224_K	228_L	0.675	1.00
276_I	279_E	0.675	1.00
270_D	278_P	0.673	1.00
23_N	59_T	0.672	1.00
7_K	27_N	0.671	1.00
215_V	236_Q	0.670	1.00
236_Q	239_S	0.669	1.00
36_I	212_G	0.667	1.00
91_W	170_N	0.658	1.00
283_L	287_V	0.653	1.00
52_A	86_M	0.652	1.00
33_R	207_I	0.652	1.00
103_I	106_P	0.651	1.00
255_G	259_G	0.650	1.00
26_I	222_V	0.648	1.00
273_I	277_R	0.647	1.00
239_S	243_E	0.647	1.00
166_E	199_H	0.647	1.00
12_V	22_D	0.646	1.00
163_L	195_L	0.643	1.00
285_K	288_I	0.642	1.00
272_A	276_I	0.642	1.00
50_I	55_D	0.641	1.00
215_V	218_K	0.641	1.00
36_I	214_L	0.641	1.00
131_H	134_L	0.638	1.00
16_G	19_V	0.637	1.00
118_R	121_V	0.631	1.00
9_V	62_L	0.631	1.00
258_I	266_S	0.630	1.00
124_V	128_L	0.630	1.00
276_I	284_S	0.627	1.00
34_F	195_L	0.626	1.00
164_L	196_V	0.626	1.00
286_D	289_K	0.623	1.00
254_E	259_G	0.623	1.00
160_S	192_V	0.623	1.00
51_I	163_L	0.622	1.00
159_P	162_L	0.622	1.00
181_A	185_E	0.621	1.00
280_D	283_L	0.619	1.00
104_A	118_R	0.617	1.00
108_T	117_I	0.615	1.00
95_P	139_R	0.615	1.00
224_K	229_Y	0.614	1.00
259_G	265_V	0.611	1.00
13_F	55_D	0.611	1.00
279_E	283_L	0.610	1.00
179_A	182_L	0.610	1.00
246_E	249_G	0.609	1.00
93_L	138_P	0.608	1.00
277_R	284_S	0.608	1.00
105_F	108_T	0.607	1.00
177_D	202_A	0.604	1.00
267_V	271_R	0.603	1.00
268_S	272_A	0.603	1.00
106_P	153_R	0.601	1.00
185_E	303_V	0.600	1.00
300_K	304_I	0.599	1.00
284_S	289_K	0.598	1.00
64_F	84_I	0.597	1.00
256_V	265_V	0.596	1.00
280_D	287_V	0.595	1.00
225_P	233_V	0.593	1.00
280_D	284_S	0.593	1.00
271_R	277_R	0.591	1.00
30_N	191_G	0.590	1.00
183_V	194_L	0.589	1.00
281_V	287_V	0.586	1.00
257_V	263_F	0.585	1.00
33_R	196_V	0.585	1.00
132_H	136_H	0.585	1.00
281_V	284_S	0.584	1.00
162_L	194_L	0.583	1.00
161_L	193_T	0.583	1.00
205_F	227_D	0.583	1.00
284_S	290_D	0.581	1.00
246_E	250_K	0.581	1.00
97_L	101_E	0.574	1.00
85_G	157_K	0.572	1.00
277_R	283_L	0.572	1.00
93_L	102_N	0.572	1.00
42_A	47_F	0.570	1.00
231_N	234_S	0.569	1.00
272_A	280_D	0.569	1.00
16_G	20_A	0.568	1.00
258_I	262_R	0.566	1.00
170_N	175_M	0.565	1.00
297_G	301_V	0.565	1.00
37_L	213_V	0.564	1.00
272_A	277_R	0.564	1.00
202_A	307_Q	0.563	1.00
254_E	257_V	0.563	1.00
174_R	239_S	0.563	1.00
223_G	229_Y	0.562	1.00
83_K	157_K	0.561	1.00
115_E	118_R	0.561	1.00
204_I	208_A	0.561	1.00
231_N	235_I	0.561	1.00
173_A	177_D	0.560	1.00
252_T	257_V	0.559	1.00
99_A	149_V	0.559	1.00
235_I	238_A	0.558	1.00
178_S	182_L	0.557	1.00
269_S	273_I	0.556	1.00
278_P	290_D	0.555	1.00
256_V	266_S	0.554	1.00
132_H	135_N	0.553	1.00
259_G	266_S	0.552	1.00
214_L	219_L	0.551	1.00
283_L	286_D	0.551	1.00
268_S	271_R	0.550	1.00
282_K	286_D	0.550	1.00
112_M	120_R	0.548	1.00
301_V	307_Q	0.547	1.00
301_V	306_Y	0.547	1.00
184_K	187_Q	0.545	1.00
267_V	272_A	0.543	1.00
286_D	290_D	0.539	1.00
125_A	131_H	0.539	1.00
100_F	103_I	0.536	1.00
128_L	179_A	0.536	1.00
96_N	137_F	0.534	1.00
173_A	180_R	0.532	1.00
250_K	254_E	0.531	1.00
251_V	254_E	0.528	1.00
232_P	235_I	0.527	1.00
240_L	243_E	0.527	1.00
186_V	194_L	0.526	1.00
98_T	135_N	0.526	1.00
270_D	274_I	0.526	1.00
277_R	285_K	0.525	1.00
281_V	288_I	0.520	1.00
298_K	301_V	0.517	1.00
234_S	238_A	0.517	1.00
237_V	240_L	0.515	1.00
282_K	288_I	0.514	1.00
236_Q	240_L	0.514	1.00
100_F	117_I	0.513	1.00
98_T	102_N	0.512	1.00
213_V	232_P	0.512	1.00
181_A	303_V	0.512	1.00
87_V	154_A	0.512	1.00
22_D	216_K	0.511	1.00
273_I	278_P	0.511	1.00
254_E	261_L	0.509	1.00
251_V	255_G	0.509	1.00
4_I	64_F	0.508	1.00
130_I	133_V	0.507	1.00
273_I	276_I	0.507	1.00
71_S	77_V	0.506	1.00
278_P	287_V	0.505	1.00
113_S	117_I	0.503	1.00
253_N	260_S	0.502	1.00
184_K	306_Y	0.501	1.00
13_F	46_T	0.501	1.00
278_P	288_I	0.500	1.00
270_D	273_I	0.500	1.00
230_D	233_V	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1oxxK	1	0.9972	100	0.168	Contact Map
1v43A	2	0.9433	100	0.179	Contact Map
2it1A	1	0.9632	100	0.184	Contact Map
2yyzA	1	0.9632	100	0.189	Contact Map
1g291	4	0.9858	100	0.19	Contact Map
3rlfA	2	0.9603	100	0.197	Contact Map
3fvqA	2	0.9773	100	0.206	Contact Map
1z47A	2	0.9575	100	0.218	Contact Map
3d31A	2	0.9518	100	0.222	Contact Map
4tquS	2	0.9717	100	0.227	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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