GREMLIN Database
Q97UY6 - Permease, putative
UniProt: Q97UY6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 257 (206)
Sequences: 63235 (45497)
Seq/√Len: 3169.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
89_N93_P4.1011.00
84_T97_L3.7021.00
77_V104_F3.6741.00
67_R118_D3.5271.00
86_Y161_L3.4021.00
79_S167_A3.1401.00
58_G107_I2.8531.00
50_I99_L2.8531.00
120_Y128_A2.7481.00
90_L93_P2.5911.00
81_A97_L2.5831.00
124_D127_K2.4281.00
184_G190_N2.3911.00
92_I96_G2.3761.00
74_S107_I2.2051.00
91_P95_A2.1981.00
154_Y158_T2.1731.00
121_K124_D2.1551.00
81_A104_F2.1421.00
62_V111_S2.1181.00
81_A100_L2.0571.00
35_F91_P2.0161.00
36_S39_T1.9841.00
54_A103_F1.9621.00
68_R72_M1.9481.00
199_L202_T1.9121.00
46_I99_L1.8891.00
193_K196_I1.8741.00
39_T91_P1.8691.00
88_V93_P1.8331.00
8_A135_G1.8061.00
88_V97_L1.7801.00
60_I64_Y1.7471.00
83_F164_S1.7021.00
191_V194_Q1.6971.00
85_A97_L1.6681.00
35_F39_T1.6071.00
172_F175_R1.6051.00
43_F94_I1.5641.00
50_I54_A1.5621.00
93_P97_L1.5601.00
149_Y153_F1.5491.00
194_Q197_L1.5301.00
15_S136_I1.5221.00
79_S171_I1.5021.00
76_I171_I1.4841.00
81_A101_Q1.4821.00
117_G125_L1.4741.00
198_F201_S1.4541.00
59_G63_D1.4401.00
85_A94_I1.4381.00
46_I95_A1.4331.00
66_G69_N1.4171.00
86_Y164_S1.3711.00
74_S104_F1.3621.00
175_R178_P1.3511.00
29_L32_V1.3501.00
72_M171_I1.3191.00
79_S164_S1.2881.00
83_F87_L1.2831.00
73_L77_V1.2761.00
10_I108_Y1.2651.00
92_I95_A1.2561.00
54_A106_N1.2501.00
122_R125_L1.2411.00
54_A57_S1.2401.00
155_G158_T1.2361.00
161_L165_L1.2121.00
116_V132_Q1.2041.00
79_S168_I1.1951.00
69_N73_L1.1831.00
27_F31_K1.1811.00
77_V81_A1.1761.00
61_V65_L1.1741.00
173_L176_L1.1661.00
158_T161_L1.1601.00
84_T93_P1.1541.00
200_I203_F1.1481.00
61_V70_A1.1441.00
192_N196_I1.1441.00
50_I102_T1.1391.00
69_N179_E1.1241.00
150_I158_T1.1241.00
47_Q105_N1.1241.00
62_V67_R1.1241.00
69_N72_M1.1141.00
87_L161_L1.1041.00
65_L69_N1.0881.00
195_F199_L1.0531.00
127_K131_R1.0491.00
202_T206_F1.0451.00
89_N92_I1.0271.00
65_L70_A1.0241.00
24_F151_F1.0221.00
17_S20_V1.0221.00
80_F84_T1.0091.00
12_G139_G1.0021.00
196_I200_I0.9931.00
120_Y124_D0.9881.00
180_F183_G0.9871.00
86_Y157_R0.9761.00
174_V177_L0.9721.00
71_M174_V0.9671.00
82_L163_S0.9561.00
193_K197_L0.9471.00
47_Q102_T0.9461.00
57_S60_I0.9441.00
199_L203_F0.9401.00
63_D67_R0.9391.00
20_V23_P0.9191.00
96_G100_L0.9141.00
42_I46_I0.9111.00
72_M76_I0.9111.00
82_L101_Q0.9101.00
49_L52_V0.9081.00
73_L76_I0.9071.00
98_I101_Q0.9051.00
6_R173_L0.9041.00
84_T87_L0.8991.00
67_R114_A0.8971.00
115_I177_L0.8971.00
10_I71_M0.8881.00
98_I102_T0.8841.00
196_I199_L0.8781.00
41_S45_L0.8761.00
75_M171_I0.8651.00
145_L149_Y0.8641.00
209_V213_G0.8561.00
197_L201_S0.8541.00
165_L169_I0.8521.00
9_I170_P0.8481.00
72_M174_V0.8471.00
164_S168_I0.8451.00
68_R179_E0.8411.00
67_R179_E0.8361.00
85_A160_L0.8291.00
6_R170_P0.8281.00
19_S22_W0.8241.00
195_F198_F0.8231.00
66_G70_A0.8221.00
110_V113_T0.8151.00
178_P181_K0.8151.00
123_A127_K0.8111.00
71_M115_I0.8101.00
24_F159_L0.8101.00
20_V159_L0.8091.00
198_F202_T0.8091.00
117_G129_F0.8081.00
96_G99_L0.8061.00
83_F161_L0.8041.00
199_L213_G0.8031.00
172_F176_L0.8031.00
47_Q51_N0.8021.00
210_G213_G0.7951.00
16_F20_V0.7951.00
56_V60_I0.7901.00
168_I172_F0.7881.00
35_F40_V0.7861.00
38_D42_I0.7851.00
54_A58_G0.7841.00
165_L168_I0.7801.00
150_I154_Y0.7781.00
78_S167_A0.7751.00
53_V56_V0.7741.00
39_T92_I0.7681.00
11_G136_I0.7621.00
16_F143_G0.7621.00
112_S132_Q0.7621.00
210_G214_F0.7551.00
200_I204_L0.7491.00
46_I50_I0.7491.00
146_I149_Y0.7481.00
158_T165_L0.7441.00
206_F210_G0.7431.00
25_I40_V0.7391.00
113_T132_Q0.7381.00
191_V196_I0.7301.00
70_A73_L0.7281.00
93_P96_G0.7271.00
30_Y37_L0.7241.00
207_V210_G0.7241.00
107_I111_S0.7201.00
142_L145_L0.7191.00
47_Q98_I0.7171.00
76_I79_S0.7121.00
75_M170_P0.7071.00
205_T209_V0.7061.00
20_V147_G0.7051.00
13_V166_I0.6991.00
32_V157_R0.6971.00
79_S83_F0.6971.00
126_V130_S0.6961.00
39_T95_A0.6921.00
82_L164_S0.6921.00
53_V57_S0.6891.00
89_N97_L0.6861.00
8_A131_R0.6841.00
23_P26_G0.6821.00
151_F159_L0.6811.00
191_V195_F0.6761.00
8_A12_G0.6731.00
78_S105_N0.6711.00
17_S22_W0.6691.00
193_K199_L0.6651.00
85_A88_V0.6631.00
203_F207_V0.6621.00
62_V114_A0.6621.00
15_S18_G0.6621.00
161_L164_S0.6591.00
85_A101_Q0.6581.00
137_N140_W0.6561.00
76_I80_F0.6551.00
113_T129_F0.6541.00
19_S140_W0.6541.00
127_K130_S0.6521.00
13_V17_S0.6491.00
116_V128_A0.6421.00
115_I119_I0.6411.00
6_R176_L0.6381.00
5_N8_A0.6351.00
17_S78_S0.6351.00
191_V197_L0.6321.00
39_T43_F0.6301.00
149_Y152_T0.6291.00
43_F91_P0.6281.00
193_K198_F0.6261.00
134_V137_N0.6261.00
32_V156_F0.6261.00
194_Q210_G0.6251.00
16_F163_S0.6231.00
89_N157_R0.6211.00
12_G135_G0.6191.00
150_I159_L0.6181.00
24_F147_G0.6141.00
43_F95_A0.6141.00
158_T162_V0.6081.00
87_L97_L0.6071.00
147_G151_F0.6041.00
42_I95_A0.6031.00
162_V165_L0.6031.00
78_S104_F0.6031.00
134_V138_A0.6011.00
124_D128_A0.5981.00
11_G14_R0.5961.00
149_Y154_Y0.5951.00
18_G51_N0.5941.00
133_R137_N0.5931.00
27_F32_V0.5931.00
58_G106_N0.5911.00
157_R161_L0.5891.00
87_L93_P0.5851.00
42_I45_L0.5811.00
30_Y40_V0.5801.00
75_M79_S0.5761.00
66_G179_E0.5761.00
7_I112_S0.5741.00
108_Y174_V0.5741.00
199_L209_V0.5721.00
138_A142_L0.5711.00
97_L100_L0.5701.00
206_F209_V0.5641.00
82_L167_A0.5641.00
17_S21_I0.5621.00
118_D183_G0.5611.00
68_R178_P0.5571.00
202_T210_G0.5571.00
11_G15_S0.5531.00
58_G74_S0.5521.00
191_V210_G0.5511.00
12_G142_L0.5481.00
136_I140_W0.5441.00
110_V114_A0.5401.00
10_I174_V0.5391.00
118_D180_F0.5381.00
10_I75_M0.5371.00
159_L163_S0.5361.00
11_G132_Q0.5361.00
119_I181_K0.5361.00
17_S98_I0.5361.00
150_I162_V0.5351.00
191_V199_L0.5331.00
166_I169_I0.5321.00
40_V43_F0.5311.00
44_Y48_A0.5311.00
198_F206_F0.5281.00
199_L216_L0.5251.00
81_A85_A0.5241.00
14_R108_Y0.5231.00
209_V215_G0.5221.00
191_V207_V0.5201.00
208_L212_L0.5191.00
58_G61_V0.5161.00
193_K201_S0.5161.00
48_A52_V0.5151.00
201_S205_T0.5151.00
196_I203_F0.5131.00
192_N195_F0.5101.00
145_L148_G0.5101.00
80_F83_F0.5081.00
192_N197_L0.5081.00
132_Q135_G0.5081.00
195_F201_S0.5071.00
17_S163_S0.5061.00
203_F206_F0.5051.00
194_Q204_L0.5051.00
169_I172_F0.5031.00
175_R179_E0.5021.00
193_K207_V0.5021.00
207_V211_Q0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2gfpA 2 0.9883 100 0.21 Contact Map
1pw4A 1 0.9767 100 0.234 Contact Map
3wdoA 1 0.9883 100 0.256 Contact Map
3o7qA 1 0.9961 100 0.263 Contact Map
4j05A 3 0.9377 100 0.282 Contact Map
4pypA 1 0.9844 100 0.295 Contact Map
4xnjA 1 1 100 0.311 Contact Map
2cfqA 1 0.9883 99.9 0.312 Contact Map
4gc0A 1 0.9883 99.9 0.312 Contact Map
4w6vA 1 0.9805 99.9 0.322 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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