GREMLIN Database
Q97UY3 - Uncharacterized protein
UniProt: Q97UY3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 136 (123)
Sequences: 95215 (69338)
Seq/√Len: 6252.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
69_T77_Q3.3891.00
38_S42_V3.1601.00
33_G46_D2.9091.00
26_I53_A2.6821.00
35_A112_G2.3351.00
70_N73_S2.1561.00
6_Q56_I2.1531.00
39_N42_V2.1341.00
73_S76_R2.1271.00
15_K67_S2.0341.00
21_V126_L1.8521.00
30_G49_I1.8421.00
123_A127_Y1.8401.00
17_M21_V1.8331.00
41_L44_S1.7741.00
14_S18_W1.7011.00
8_L12_L1.6941.00
23_G56_I1.6941.00
41_L45_I1.6731.00
66_N74_R1.6621.00
30_G46_D1.6551.00
30_G53_A1.6211.00
18_W21_V1.6141.00
40_F44_S1.5691.00
18_W22_I1.5451.00
42_V46_D1.5381.00
103_Y109_I1.5251.00
98_E102_Y1.4861.00
71_Q74_R1.4511.00
66_N78_I1.4361.00
37_I42_V1.4301.00
21_V122_A1.4171.00
10_G60_L1.3811.00
9_V13_I1.3431.00
65_A81_Y1.3241.00
5_F8_L1.3121.00
32_F36_F1.3111.00
108_V112_G1.2861.00
104_L108_V1.2801.00
109_I112_G1.2401.00
7_D11_R1.2221.00
25_L122_A1.2171.00
28_T118_G1.2121.00
13_I18_W1.2051.00
10_G15_K1.1801.00
124_I128_Q1.1641.00
85_T89_R1.1241.00
62_Q81_Y1.1201.00
112_G116_S1.1131.00
61_S81_Y1.1031.00
57_V61_S1.0811.00
35_A115_S1.0721.00
4_A8_L1.0721.00
31_Y50_I1.0711.00
75_G79_G1.0701.00
122_A126_L1.0581.00
56_I60_L1.0481.00
30_G50_I1.0451.00
125_Y129_I1.0421.00
42_V45_I1.0371.00
11_R15_K1.0321.00
45_I48_A1.0271.00
123_A126_L1.0241.00
19_L22_I1.0211.00
13_I19_L1.0161.00
33_G36_F1.0151.00
33_G42_V1.0091.00
27_Y118_G0.9781.00
98_E101_N0.9771.00
22_I25_L0.9741.00
116_S120_V0.9701.00
86_G89_R0.9551.00
109_I113_I0.9491.00
24_T121_S0.9381.00
15_K63_A0.9361.00
28_T122_A0.9291.00
22_I26_I0.9271.00
62_Q78_I0.9261.00
94_S98_E0.9131.00
32_F115_S0.9051.00
44_S48_A0.9041.00
47_I50_I0.9011.00
28_T115_S0.8891.00
34_V46_D0.8791.00
81_Y86_G0.8741.00
82_S85_T0.8681.00
8_L11_R0.8621.00
124_I127_Y0.8491.00
29_S33_G0.8491.00
25_L29_S0.8471.00
59_P62_Q0.8451.00
21_V25_L0.8431.00
26_I30_G0.8381.00
97_S101_N0.8351.00
24_T122_A0.8251.00
59_P63_A0.8201.00
104_L109_I0.8171.00
28_T119_L0.8061.00
80_L84_V0.8041.00
9_V19_L0.8031.00
74_R78_I0.7901.00
34_V43_A0.7891.00
83_M86_G0.7881.00
69_T73_S0.7871.00
23_G57_V0.7781.00
20_I125_Y0.7731.00
51_T55_M0.7731.00
119_L123_A0.7721.00
38_S41_L0.7671.00
45_I49_I0.7671.00
31_Y47_I0.7661.00
36_F112_G0.7651.00
20_I61_S0.7521.00
28_T32_F0.7501.00
113_I117_F0.7401.00
87_I91_S0.7401.00
115_S119_L0.7391.00
34_V47_I0.7311.00
58_T62_Q0.7271.00
32_F35_A0.7171.00
126_L130_K0.7161.00
62_Q66_N0.7121.00
81_Y85_T0.7061.00
27_Y54_E0.7051.00
78_I82_S0.6991.00
21_V24_T0.6911.00
63_A67_S0.6911.00
114_M118_G0.6871.00
44_S47_I0.6831.00
127_Y130_K0.6821.00
62_Q82_S0.6791.00
112_G115_S0.6741.00
91_S95_L0.6681.00
23_G53_A0.6621.00
95_L98_E0.6561.00
82_S86_G0.6551.00
21_V125_Y0.6551.00
36_F46_D0.6501.00
29_S32_F0.6491.00
34_V50_I0.6491.00
31_Y114_M0.6431.00
10_G63_A0.6411.00
86_G90_V0.6401.00
37_I46_D0.6401.00
114_M117_F0.6381.00
120_V123_A0.6361.00
30_G34_V0.6361.00
126_L129_I0.6361.00
62_Q85_T0.6331.00
47_I51_T0.6321.00
90_V93_S0.6171.00
88_G92_G0.6141.00
48_A51_T0.6001.00
14_S19_L0.5991.00
6_Q10_G0.5981.00
96_I114_M0.5851.00
76_R79_G0.5841.00
113_I116_S0.5831.00
110_L113_I0.5781.00
15_K64_I0.5751.00
58_T81_Y0.5741.00
83_M87_I0.5711.00
55_M59_P0.5701.00
27_Y53_A0.5701.00
50_I54_E0.5701.00
91_S94_S0.5641.00
39_N44_S0.5571.00
27_Y50_I0.5551.00
79_G82_S0.5551.00
20_I64_I0.5431.00
11_R63_A0.5391.00
121_S125_Y0.5371.00
94_S97_S0.5341.00
36_F42_V0.5291.00
99_L103_Y0.5241.00
12_L15_K0.5161.00
37_I40_F0.5141.00
23_G60_L0.5141.00
93_S97_S0.5121.00
95_L99_L0.5081.00
81_Y84_V0.5061.00
24_T57_V0.5051.00
79_G83_M0.5031.00
78_I81_Y0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2gfpA 2 0.9779 99.6 0.219 Contact Map
1pw4A 1 0.9853 99.6 0.224 Contact Map
4j05A 3 0.9118 99.6 0.235 Contact Map
4oh3A 2 0.9779 99.6 0.25 Contact Map
4gc0A 1 0.9926 99.6 0.253 Contact Map
4zw9A 1 0.9926 99.6 0.254 Contact Map
4pypA 1 0.9779 99.6 0.254 Contact Map
4xnjA 1 0.9779 99.6 0.26 Contact Map
3o7qA 1 0.9926 99.6 0.26 Contact Map
3wdoA 1 0.9632 99.6 0.262 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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