GREMLIN Database
Q97UY0 - Selenium-binding protein
UniProt: Q97UY0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 466 (438)
Sequences: 417 (199)
Seq/√Len: 9.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
332_L354_V5.6391.00
30_D55_K5.4121.00
207_V236_F5.2041.00
115_V126_I4.7791.00
424_K436_D4.6871.00
356_N359_K4.4160.99
111_R131_E4.2230.99
402_T422_M4.1550.99
272_F357_P4.0340.99
103_V114_I3.7070.98
111_R132_P3.6150.97
204_E238_D3.5990.97
270_M288_L3.1050.93
72_Y113_Y2.9490.91
270_M357_P2.9190.91
248_V298_G2.9170.91
299_E358_F2.9120.90
285_S303_E2.8290.89
135_V144_L2.7330.87
141_Y169_G2.7200.87
235_H244_K2.7100.87
271_G289_W2.6980.87
32_A422_M2.6820.86
451_V459_S2.6320.85
323_V371_I2.6260.85
161_N165_E2.5770.84
70_L115_V2.5190.82
340_Y351_Q2.5140.82
72_Y132_P2.5120.82
348_E365_K2.4900.82
350_R362_L2.4830.81
60_T63_K2.3910.79
352_Y362_L2.3550.78
49_I115_V2.3490.78
251_G271_G2.3290.77
397_K429_P2.3180.77
68_V115_V2.3170.77
351_Q432_G2.2140.73
143_R218_E2.2010.73
290_Y299_E2.1440.71
236_F248_V2.1140.69
49_I104_V2.0530.67
346_I459_S2.0520.67
238_D338_F2.0400.67
383_L421_W2.0260.66
290_Y297_N2.0120.65
202_P267_T2.0000.65
108_R218_E1.9410.63
46_P75_D1.8820.60
205_V363_T1.8720.60
304_I341_V1.8670.59
307_E367_K1.8610.59
460_S463_Y1.8590.59
114_I130_I1.8510.59
113_Y448_S1.8340.58
38_Y43_I1.7980.56
110_S136_K1.7930.56
274_N286_I1.7860.56
138_V185_E1.7770.55
253_E287_W1.7650.55
22_M25_K1.7430.54
157_S197_F1.7420.54
119_L125_N1.7240.53
389_M405_L1.7240.53
126_I253_E1.7130.53
53_D58_S1.7080.52
104_V115_V1.6940.52
145_H389_M1.6750.51
112_I233_R1.6650.50
238_D241_R1.6650.50
366_V435_V1.6600.50
63_K117_T1.6440.50
206_M407_S1.6320.49
88_A97_F1.6310.49
392_I399_V1.6270.49
210_E235_H1.6250.49
151_P206_M1.6150.48
290_Y355_S1.5940.47
77_L122_R1.5930.47
383_L403_N1.5890.47
338_F351_Q1.5890.47
422_M448_S1.5800.47
206_M253_E1.5700.46
103_V234_I1.5350.45
139_T169_G1.5330.45
113_Y129_T1.5200.44
288_L299_E1.5190.44
204_E237_W1.5190.44
19_S22_M1.5150.44
49_I68_V1.5120.44
54_V451_V1.5030.43
349_I423_V1.4900.43
74_N133_E1.4820.42
40_G171_L1.4740.42
101_F114_I1.4520.41
348_E367_K1.4480.41
33_Y68_V1.4410.41
30_D57_E1.4320.40
80_F104_V1.4170.40
427_A433_L1.4150.39
207_V422_M1.4030.39
103_V163_N1.3990.39
300_K303_E1.3970.39
169_G185_E1.3940.39
33_Y124_P1.3850.38
390_I459_S1.3840.38
144_L158_A1.3800.38
350_R365_K1.3720.38
259_E405_L1.3680.37
421_W440_F1.3590.37
426_N434_D1.3540.37
155_Y206_M1.3440.36
46_P71_S1.3400.36
204_E240_R1.3290.36
156_I246_S1.3220.36
453_L462_S1.3180.35
363_T433_L1.3030.35
142_S173_L1.2960.34
159_F357_P1.2920.34
35_A97_F1.2890.34
48_F446_A1.2840.34
64_V126_I1.2780.34
110_S159_F1.2760.34
403_N421_W1.2710.33
145_H195_Y1.2680.33
142_S162_E1.2650.33
235_H238_D1.2580.33
268_K288_L1.2530.33
344_W352_Y1.2530.33
401_V451_V1.2530.33
217_I293_D1.2510.33
204_E299_E1.2460.32
257_A273_I1.2430.32
288_L357_P1.2380.32
195_Y389_M1.2360.32
306_A403_N1.2330.32
401_V425_L1.2270.32
262_P271_G1.2250.32
132_P139_T1.2230.32
134_E138_V1.2160.31
258_L409_W1.2130.31
36_C50_A1.2010.31
388_Q405_L1.1830.30
135_V139_T1.1820.30
144_L212_A1.1790.30
206_M228_D1.1770.30
155_Y172_M1.1770.30
172_M337_K1.1740.30
246_S297_N1.1690.30
158_A242_R1.1670.29
349_I425_L1.1580.29
132_P136_K1.1540.29
220_G412_Q1.1540.29
138_V169_G1.1510.29
103_V161_N1.1430.29
204_E268_K1.1320.28
85_C211_W1.1310.28
174_D212_A1.1220.28
259_E389_M1.1100.27
364_G432_G1.1090.27
307_E372_F1.1060.27
171_L209_S1.1050.27
51_V66_H1.1050.27
34_V107_L1.1020.27
79_H259_E1.1020.27
402_T448_S1.1010.27
20_P208_T1.0870.27
62_S459_S1.0800.26
389_M449_H1.0780.26
304_I325_P1.0740.26
208_T260_L1.0720.26
19_S372_F1.0710.26
151_P155_Y1.0700.26
67_K444_G1.0690.26
287_W298_G1.0620.26
85_C146_T1.0610.26
199_W450_Q1.0610.26
61_Y207_V1.0560.26
260_L284_S1.0550.25
145_H449_H1.0530.25
116_D124_P1.0510.25
206_M247_S1.0490.25
226_L282_L1.0450.25
54_V438_E1.0400.25
33_Y251_G1.0370.25
170_I206_M1.0350.25
209_S301_V1.0330.25
75_D113_Y1.0300.25
144_L459_S1.0300.25
181_L437_K1.0280.25
232_N249_T1.0260.25
362_L365_K1.0260.25
17_Y23_A1.0120.24
126_I252_E1.0090.24
384_T416_E1.0060.24
57_E359_K1.0040.24
140_G372_F0.9980.24
255_R283_S0.9970.24
198_W264_H0.9950.23
242_R270_M0.9940.23
313_L353_D0.9920.23
145_H405_L0.9900.23
117_T194_A0.9870.23
57_E228_D0.9840.23
86_S211_W0.9840.23
106_G134_E0.9810.23
256_M326_L0.9730.23
378_P382_K0.9710.23
379_S382_K0.9710.23
154_I269_L0.9710.23
115_V294_G0.9700.23
273_I288_L0.9620.22
72_Y96_N0.9600.22
137_K179_E0.9590.22
340_Y432_G0.9580.22
194_A257_A0.9560.22
157_S362_L0.9560.22
26_S334_L0.9540.22
167_P447_R0.9470.22
179_E421_W0.9420.22
185_E271_G0.9380.22
60_T438_E0.9370.22
195_Y449_H0.9350.22
211_W406_Y0.9340.22
22_M186_I0.9330.22
274_N327_V0.9310.22
232_N252_E0.9270.21
304_I350_R0.9210.21
19_S152_D0.9200.21
120_N430_D0.9170.21
97_F375_A0.9160.21
169_G238_D0.9140.21
131_E328_T0.9140.21
14_P17_Y0.9130.21
30_D390_I0.9100.21
288_L301_V0.9100.21
85_C145_H0.9070.21
272_F336_D0.9050.21
167_P183_K0.9040.21
117_T341_V0.9030.21
71_S402_T0.8980.21
263_L270_M0.8960.20
52_V441_V0.8940.20
55_K117_T0.8920.20
346_I365_K0.8920.20
206_M418_L0.8900.20
183_K330_I0.8900.20
259_E388_Q0.8900.20
299_E359_K0.8890.20
348_E370_G0.8880.20
28_P380_D0.8860.20
146_T329_D0.8850.20
204_E242_R0.8850.20
205_V403_N0.8830.20
333_S336_D0.8810.20
57_E125_N0.8800.20
272_F354_V0.8800.20
144_L303_E0.8790.20
177_S181_L0.8770.20
360_P427_A0.8760.20
89_L209_S0.8750.20
199_W452_R0.8730.20
169_G237_W0.8720.20
334_L458_A0.8710.20
325_P459_S0.8690.20
52_V422_M0.8690.20
35_A403_N0.8680.20
125_N166_G0.8650.20
115_V120_N0.8650.20
86_S145_H0.8640.20
120_N154_I0.8610.19
288_L358_F0.8610.19
69_E386_A0.8580.19
116_D360_P0.8560.19
83_N149_C0.8560.19
108_R142_S0.8540.19
95_P290_Y0.8540.19
120_N159_F0.8530.19
145_H259_E0.8530.19
79_H449_H0.8520.19
50_A208_T0.8510.19
243_K337_K0.8480.19
136_K407_S0.8420.19
59_E359_K0.8410.19
18_P22_M0.8410.19
104_V376_D0.8410.19
60_T155_Y0.8390.19
434_D438_E0.8390.19
347_G369_G0.8370.19
50_A64_V0.8340.19
254_N276_V0.8290.19
123_Q424_K0.8280.19
375_A382_K0.8270.19
290_Y358_F0.8250.18
396_G410_D0.8240.18
425_L435_V0.8240.18
331_D392_I0.8230.18
360_P432_G0.8210.18
426_N460_S0.8190.18
103_V331_D0.8190.18
209_S303_E0.8180.18
130_I451_V0.8170.18
304_I337_K0.8140.18
155_Y284_S0.8110.18
195_Y259_E0.8100.18
55_K59_E0.8090.18
106_G167_P0.8080.18
271_G302_I0.8050.18
245_V294_G0.8050.18
195_Y258_L0.8030.18
155_Y239_L0.7990.18
286_I302_I0.7980.18
286_I368_L0.7960.18
72_Y111_R0.7960.18
268_K357_P0.7930.18
46_P203_N0.7930.18
151_P306_A0.7920.18
233_R247_S0.7900.18
203_N269_L0.7880.18
165_E215_N0.7860.17
308_P322_A0.7860.17
454_R462_S0.7850.17
331_D399_V0.7850.17
48_F64_V0.7810.17
247_S303_E0.7800.17
140_G303_E0.7790.17
271_G286_I0.7740.17
123_Q343_L0.7740.17
95_P120_N0.7710.17
63_K72_Y0.7700.17
19_S241_R0.7690.17
237_W282_L0.7680.17
84_A282_L0.7680.17
326_L368_L0.7680.17
65_I249_T0.7680.17
256_M282_L0.7660.17
152_D429_P0.7620.17
396_G404_S0.7590.17
34_V451_V0.7590.17
85_C195_Y0.7580.17
422_M439_F0.7580.17
170_I239_L0.7560.17
34_V77_L0.7550.17
430_D445_E0.7540.17
123_Q361_V0.7540.17
438_E441_V0.7530.17
210_E300_K0.7500.17
146_T195_Y0.7490.17
368_L401_V0.7490.17
66_H441_V0.7450.16
142_S163_N0.7450.16
221_L448_S0.7440.16
376_D380_D0.7420.16
162_E236_F0.7410.16
61_Y286_I0.7400.16
63_K438_E0.7370.16
85_C389_M0.7360.16
85_C148_H0.7360.16
256_M267_T0.7330.16
135_V286_I0.7320.16
99_R196_D0.7260.16
387_P401_V0.7260.16
159_F209_S0.7250.16
33_Y51_V0.7250.16
52_V297_N0.7240.16
286_I362_L0.7240.16
120_N349_I0.7220.16
398_R410_D0.7220.16
160_G214_P0.7220.16
325_P346_I0.7220.16
313_L355_S0.7220.16
172_M186_I0.7210.16
441_V444_G0.7190.16
207_V234_I0.7170.16
12_R65_I0.7160.16
174_D366_V0.7150.16
453_L458_A0.7140.16
265_D291_Y0.7130.16
357_P363_T0.7100.16
103_V310_E0.7100.16
66_H123_Q0.7090.16
333_S351_Q0.7080.16
222_R419_K0.7060.15
197_F206_M0.7040.15
79_H145_H0.7040.15
367_K371_I0.7030.15
158_A284_S0.7020.15
199_W262_P0.7010.15
71_S237_W0.6960.15
55_K60_T0.6940.15
174_D403_N0.6940.15
86_S195_Y0.6930.15
216_T226_L0.6920.15
85_C149_C0.6910.15
429_P442_D0.6860.15
113_Y197_F0.6850.15
51_V68_V0.6840.15
130_I409_W0.6830.15
22_M215_N0.6790.15
14_P18_P0.6780.15
94_R453_L0.6760.15
140_G397_K0.6730.15
333_S340_Y0.6730.15
145_H388_Q0.6720.15
309_T312_G0.6710.15
135_V219_N0.6690.15
39_T110_S0.6690.15
366_V401_V0.6680.15
54_V87_S0.6670.15
185_E237_W0.6630.15
96_N209_S0.6610.14
361_V434_D0.6600.14
103_V451_V0.6600.14
160_G164_G0.6600.14
146_T405_L0.6600.14
225_H228_D0.6580.14
93_G381_H0.6580.14
119_L209_S0.6560.14
15_T453_L0.6560.14
123_Q433_L0.6560.14
108_R143_R0.6550.14
344_W348_E0.6530.14
113_Y172_M0.6530.14
14_P453_L0.6530.14
353_D356_N0.6510.14
306_A332_L0.6490.14
170_I197_F0.6490.14
200_N262_P0.6490.14
352_Y360_P0.6460.14
52_V361_V0.6430.14
106_G336_D0.6400.14
380_D392_I0.6390.14
27_P31_L0.6390.14
155_Y257_A0.6380.14
93_G380_D0.6380.14
110_S143_R0.6380.14
11_K30_D0.6370.14
344_W360_P0.6360.14
101_F289_W0.6360.14
28_P438_E0.6340.14
128_K179_E0.6330.14
72_Y129_T0.6330.14
105_P220_G0.6330.14
189_S355_S0.6320.14
70_L75_D0.6300.14
285_S331_D0.6300.14
226_L276_V0.6300.14
176_Y334_L0.6300.14
53_D56_P0.6290.14
400_Y404_S0.6290.14
235_H256_M0.6270.14
250_L260_L0.6260.14
86_S389_M0.6240.14
48_F417_G0.6230.14
338_F363_T0.6220.14
117_T445_E0.6220.14
256_M345_G0.6210.14
70_L77_L0.6210.14
110_S169_G0.6210.14
382_K419_K0.6210.14
286_I341_V0.6180.14
357_P406_Y0.6170.14
330_I353_D0.6160.13
70_L402_T0.6150.13
107_L217_I0.6140.13
72_Y243_K0.6140.13
272_F358_F0.6140.13
38_Y407_S0.6140.13
393_S409_W0.6130.13
70_L205_V0.6130.13
117_T363_T0.6130.13
404_S410_D0.6120.13
52_V135_V0.6110.13
55_K291_Y0.6110.13
426_N438_E0.6110.13
125_N209_S0.6100.13
396_G400_Y0.6100.13
384_T418_L0.6100.13
425_L433_L0.6090.13
261_R405_L0.6090.13
71_S74_N0.6080.13
77_L124_P0.6070.13
234_I265_D0.6070.13
238_D244_K0.6060.13
342_S390_I0.6050.13
213_V407_S0.6050.13
349_I397_K0.6040.13
262_P450_Q0.6040.13
132_P368_L0.6020.13
126_I228_D0.6010.13
64_V269_L0.6000.13
139_T197_F0.6000.13
369_G443_F0.5990.13
428_N435_V0.5990.13
57_E338_F0.5980.13
53_D61_Y0.5980.13
393_S396_G0.5970.13
142_S366_V0.5960.13
335_D362_L0.5940.13
157_S206_M0.5940.13
158_A204_E0.5940.13
338_F429_P0.5930.13
36_C296_W0.5920.13
74_N118_K0.5920.13
135_V209_S0.5920.13
18_P268_K0.5910.13
353_D361_V0.5900.13
114_I381_H0.5890.13
232_N235_H0.5880.13
62_S187_D0.5850.13
16_F20_P0.5850.13
22_M64_V0.5850.13
254_N257_A0.5840.13
157_S258_L0.5840.13
218_E226_L0.5830.13
355_S418_L0.5830.13
234_I273_I0.5820.13
97_F460_S0.5810.13
81_G184_W0.5800.13
228_D451_V0.5790.13
172_M397_K0.5760.13
67_K206_M0.5750.13
228_D247_S0.5750.13
204_E288_L0.5750.13
33_Y184_W0.5720.13
396_G409_W0.5720.13
195_Y388_Q0.5720.13
56_P223_L0.5700.13
263_L288_L0.5700.13
227_K361_V0.5690.13
286_I401_V0.5680.13
393_S410_D0.5670.13
238_D245_V0.5670.13
453_L464_C0.5670.13
294_G311_G0.5660.12
146_T149_C0.5660.12
171_L341_V0.5660.12
232_N256_M0.5660.12
123_Q204_E0.5650.12
376_D437_K0.5650.12
107_L304_I0.5650.12
295_K303_E0.5640.12
26_S106_G0.5640.12
174_D306_A0.5630.12
36_C349_I0.5630.12
49_I432_G0.5630.12
207_V248_V0.5620.12
122_R233_R0.5610.12
217_I380_D0.5610.12
103_V293_D0.5600.12
38_Y446_A0.5590.12
123_Q429_P0.5590.12
82_W105_P0.5580.12
115_V402_T0.5570.12
260_L330_I0.5570.12
87_S154_I0.5550.12
372_F383_L0.5550.12
199_W239_L0.5540.12
272_F332_L0.5530.12
152_D240_R0.5530.12
146_T259_E0.5520.12
450_Q462_S0.5520.12
129_T132_P0.5520.12
28_P56_P0.5520.12
121_P145_H0.5520.12
307_E365_K0.5520.12
179_E252_E0.5510.12
84_A459_S0.5510.12
452_R461_D0.5500.12
223_L227_K0.5500.12
204_E301_V0.5500.12
237_W324_P0.5500.12
344_W370_G0.5490.12
395_D410_D0.5490.12
328_T342_S0.5490.12
338_F432_G0.5490.12
223_L372_F0.5480.12
64_V130_I0.5480.12
43_I65_I0.5470.12
332_L340_Y0.5460.12
165_E435_V0.5460.12
84_A224_E0.5460.12
418_L434_D0.5450.12
243_K355_S0.5430.12
388_Q450_Q0.5430.12
177_S207_V0.5420.12
159_F286_I0.5420.12
348_E364_G0.5410.12
46_P49_I0.5410.12
45_R446_A0.5410.12
93_G152_D0.5400.12
207_V416_E0.5390.12
283_S315_E0.5390.12
426_N431_G0.5380.12
232_N343_L0.5380.12
195_Y405_L0.5380.12
177_S291_Y0.5380.12
100_R119_L0.5380.12
378_P425_L0.5380.12
87_S149_C0.5360.12
67_K392_I0.5350.12
17_Y20_P0.5350.12
225_H245_V0.5340.12
117_T139_T0.5340.12
103_V375_A0.5340.12
200_N264_H0.5330.12
337_K361_V0.5330.12
85_C210_E0.5320.12
193_L260_L0.5320.12
392_I395_D0.5310.12
65_I437_K0.5310.12
194_A276_V0.5300.12
50_A221_L0.5300.12
140_G165_E0.5290.12
170_I276_V0.5280.12
28_P66_H0.5270.12
22_M74_N0.5270.12
34_V424_K0.5270.12
187_D282_L0.5260.12
326_L341_V0.5260.12
128_K154_I0.5260.12
40_G446_A0.5250.12
102_L332_L0.5240.12
234_I426_N0.5240.12
325_P464_C0.5240.12
66_H217_I0.5240.12
113_Y243_K0.5240.12
239_L450_Q0.5220.12
148_H388_Q0.5210.12
260_L460_S0.5200.12
68_V162_E0.5200.12
40_G290_Y0.5200.12
93_G166_G0.5200.12
27_P107_L0.5190.12
140_G169_G0.5190.12
374_R429_P0.5170.12
204_E270_M0.5160.12
21_K374_R0.5160.12
200_N391_E0.5160.12
93_G303_E0.5160.12
184_W198_W0.5140.12
93_G186_I0.5100.11
37_L100_R0.5100.11
11_K406_Y0.5080.11
368_L423_V0.5080.11
185_E191_Q0.5070.11
328_T388_Q0.5070.11
348_E352_Y0.5060.11
427_A448_S0.5050.11
71_S142_S0.5050.11
239_L331_D0.5050.11
124_P360_P0.5040.11
166_G301_V0.5030.11
12_R270_M0.5020.11
223_L285_S0.5010.11
95_P376_D0.5000.11
80_F184_W0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2eceA 1 0.9764 100 0.601 Contact Map
3vgzA 1 0.6738 99.7 0.921 Contact Map
3scyA 1 0.7017 99.5 0.931 Contact Map
3bwsA 2 0.6631 99.4 0.933 Contact Map
3dsmA 1 0.6695 99.3 0.936 Contact Map
3hfqA 1 0.676 99.3 0.937 Contact Map
4qrjA 1 0.6867 99.3 0.937 Contact Map
1ri6A 1 0.6845 99.3 0.939 Contact Map
1nirA 2 0.6652 99.2 0.939 Contact Map
1fwxA 2 0.8112 99.2 0.941 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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