GREMLIN Database
Q97UX9 - Uncharacterized protein
UniProt: Q97UX9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 147 (122)
Sequences: 6130 (4175)
Seq/√Len: 378.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
39_Q96_P3.4031.00
29_L39_Q3.0981.00
82_Q110_A2.6571.00
37_K100_E2.5951.00
100_E118_K2.3221.00
30_E37_K2.3111.00
27_K39_Q2.2471.00
38_T65_T2.2371.00
30_E35_Y2.2051.00
59_V84_L2.0651.00
32_K35_Y2.0431.00
116_T124_L1.9281.00
66_G115_I1.8951.00
65_T99_V1.8851.00
35_Y102_N1.8191.00
35_Y100_E1.8111.00
40_I57_M1.7991.00
90_E123_S1.7711.00
39_Q98_T1.7611.00
37_K98_T1.7611.00
70_V111_V1.7551.00
119_D123_S1.7081.00
62_I128_G1.6691.00
114_E127_I1.6661.00
104_I114_E1.6101.00
102_N114_E1.5511.00
102_N116_T1.5371.00
41_P96_P1.5151.00
103_V106_K1.5041.00
66_G130_G1.4771.00
62_I115_I1.4571.00
59_V86_V1.4551.00
83_E87_N1.4481.00
29_L37_K1.4351.00
20_V57_M1.4071.00
77_M136_R1.4031.00
92_M125_G1.3531.00
23_Y45_E1.3221.00
104_I127_I1.3191.00
70_V132_W1.2871.00
34_G72_S1.2621.00
73_I106_K1.2531.00
42_F53_L1.2391.00
43_K46_L1.2281.00
116_T127_I1.2051.00
58_I126_A1.1941.00
59_V88_F1.1911.00
20_V60_A1.1711.00
95_G120_V1.1591.00
62_I117_F1.1511.00
105_R110_A1.1421.00
118_K122_G1.1321.00
86_V126_A1.1191.00
44_K47_T1.1191.00
111_V134_I1.1061.00
92_M97_F1.1051.00
53_L97_F1.0961.00
118_K124_L1.0831.00
99_V115_I1.0731.00
114_E129_L1.0601.00
61_S99_V1.0271.00
89_L127_I1.0191.00
27_K96_P0.9891.00
96_P120_V0.9881.00
110_A133_Y0.9831.00
58_I117_F0.9801.00
52_I80_V0.9641.00
40_I61_S0.9631.00
85_K129_L0.9571.00
73_I103_V0.9481.00
63_D81_T0.9451.00
26_V38_T0.9431.00
70_V113_V0.9421.00
56_G60_A0.9351.00
87_N131_T0.9161.00
69_A103_V0.9111.00
58_I125_G0.8901.00
109_T133_Y0.8891.00
74_N77_M0.8831.00
105_R112_T0.8801.00
95_G119_D0.8691.00
27_K41_P0.8571.00
69_A101_A0.8551.00
98_T120_V0.8551.00
80_V135_I0.8471.00
98_T118_K0.8261.00
69_A113_V0.8231.00
66_G132_W0.8211.00
100_E116_T0.8181.00
53_L92_M0.8071.00
103_V113_V0.8061.00
83_E129_L0.8041.00
89_L124_L0.7981.00
31_I72_S0.7971.00
21_F64_Y0.7911.00
84_L88_F0.7791.00
112_T131_T0.7661.00
83_E131_T0.7611.00
99_V117_F0.7611.00
97_F117_F0.7581.00
58_I88_F0.7511.00
87_N112_T0.7481.00
19_Y22_H0.7461.00
33_E73_I0.7431.00
89_L105_R0.7411.00
46_L57_M0.7341.00
97_F125_G0.7311.00
55_G88_F0.7281.00
41_P46_L0.7161.00
29_L96_P0.7141.00
24_L60_A0.7141.00
28_I38_T0.7111.00
52_I91_P0.7061.00
49_R67_G0.7051.00
71_L78_D0.6980.99
98_T122_G0.6880.99
47_T94_R0.6860.99
54_N64_Y0.6840.99
84_L128_G0.6820.99
71_L79_Q0.6790.99
34_G73_I0.6720.99
100_E122_G0.6680.99
62_I86_V0.6660.99
66_G113_V0.6620.99
115_I130_G0.6600.99
90_E105_R0.6570.99
42_F46_L0.6570.99
81_T84_L0.6550.99
34_G69_A0.6540.99
42_F47_T0.6540.99
63_D67_G0.6490.99
79_Q134_I0.6490.99
66_G128_G0.6480.99
89_L112_T0.6450.99
36_A69_A0.6440.99
58_I92_M0.6400.99
64_Y68_L0.6340.99
34_G103_V0.6310.99
26_V40_I0.6270.99
16_D22_H0.6270.99
17_S22_H0.6260.99
21_F68_L0.6220.99
25_G45_E0.6180.99
65_T101_A0.6150.99
81_T132_W0.6130.99
67_G132_W0.6080.99
106_K111_V0.6030.98
81_T130_G0.6010.98
25_G43_K0.6010.98
101_A115_I0.6000.98
59_V128_G0.5880.98
124_L127_I0.5830.98
92_M119_D0.5820.98
77_M134_I0.5770.98
101_A113_V0.5760.98
106_K134_I0.5700.98
46_L53_L0.5650.98
22_H45_E0.5640.98
115_I128_G0.5590.97
28_I68_L0.5590.97
39_Q120_V0.5590.97
98_T119_D0.5570.97
108_R136_R0.5560.97
53_L58_I0.5550.97
79_Q132_W0.5530.97
58_I63_D0.5470.97
112_T127_I0.5440.97
90_E133_Y0.5420.97
29_L38_T0.5420.97
36_A72_S0.5340.97
111_V132_W0.5290.96
82_Q133_Y0.5230.96
50_G80_V0.5200.96
86_V128_G0.5200.96
78_D135_I0.5160.96
85_K131_T0.5150.96
80_V133_Y0.5120.96
87_N129_L0.5070.96
20_V24_L0.5040.95
21_F26_V0.5040.95
23_Y57_M0.5010.95
26_V60_A0.5000.95
20_V23_Y0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3e8pA 3 0.9184 99.9 0.33 Contact Map
3f1tA 2 0.898 99.9 0.334 Contact Map
4rmmA 2 0.8912 99.9 0.335 Contact Map
3hduA 4 0.9184 99.9 0.338 Contact Map
1t82A 2 0.898 99.9 0.338 Contact Map
1sh8A 2 0.932 99.9 0.34 Contact Map
3gekA 3 0.8231 99.9 0.342 Contact Map
3e29A 3 0.9048 99.9 0.354 Contact Map
3e1eA 3 0.932 99.9 0.357 Contact Map
4qd8A 3 0.9184 99.9 0.359 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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