GREMLIN Database
Q97UX4 - Uncharacterized protein
UniProt: Q97UX4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 117 (108)
Sequences: 120 (109)
Seq/√Len: 10.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
82_Q87_K3.0260.94
19_D48_P2.9060.93
78_I99_P2.8420.92
37_R99_P2.6400.88
43_V108_V2.6070.88
37_R97_L2.4540.84
15_I46_F2.3340.81
44_I100_A2.3180.80
13_F29_A2.1380.75
31_N37_R1.9410.67
40_D112_Y1.9250.66
20_E49_S1.8950.65
18_G49_S1.8910.65
20_E48_P1.8560.63
102_E106_Y1.7370.58
57_D66_E1.6370.53
78_I82_Q1.6070.52
23_D83_A1.5840.51
31_N99_P1.5710.50
10_K40_D1.5700.50
97_L115_I1.5600.50
100_A104_V1.5580.50
38_Y105_S1.5280.48
100_A103_R1.5240.48
45_Y54_T1.5080.47
24_L104_V1.4840.46
10_K42_K1.4760.46
106_Y110_Q1.4110.43
37_R78_I1.3970.42
54_T60_M1.3620.40
48_P112_Y1.3150.38
60_M114_V1.3130.38
31_N97_L1.2920.37
44_I51_K1.2860.37
69_Q96_S1.2650.36
9_A92_N1.2360.35
44_I104_V1.2120.34
14_L84_M1.1650.32
12_L100_A1.1410.31
31_N101_G1.1340.31
58_G62_N1.1180.30
42_K107_Y1.1110.30
9_A39_E1.1080.30
15_I27_R1.1020.29
44_I92_N1.0940.29
26_M78_I1.0920.29
33_V72_I1.0790.28
15_I38_Y1.0760.28
48_P84_M1.0580.28
16_M24_L1.0570.28
46_F104_V1.0510.27
18_G43_V1.0440.27
46_F80_V1.0400.27
51_K64_F1.0100.26
37_R108_V0.9860.25
10_K115_I0.9790.25
28_M109_N0.9720.25
100_A107_Y0.9670.24
82_Q99_P0.9640.24
34_K40_D0.9570.24
10_K67_L0.9560.24
82_Q90_L0.9540.24
13_F28_M0.9450.24
40_D110_Q0.9450.24
24_L48_P0.9430.24
28_M105_S0.9330.23
19_D54_T0.9320.23
15_I28_M0.9150.23
43_V105_S0.9150.23
26_M99_P0.9090.22
28_M37_R0.8990.22
36_K57_D0.8970.22
73_V78_I0.8920.22
22_F25_A0.8870.22
22_F96_S0.8840.22
21_K48_P0.8840.22
8_M12_L0.8740.21
29_A62_N0.8690.21
9_A54_T0.8510.21
35_N58_G0.8490.21
80_V93_L0.8440.20
58_G89_H0.8420.20
13_F38_Y0.8360.20
32_S101_G0.8250.20
15_I104_V0.8250.20
89_H110_Q0.8210.20
30_Y70_N0.8170.20
15_I25_A0.8140.19
12_L114_V0.8110.19
48_P54_T0.8060.19
14_L116_T0.8010.19
50_Q86_I0.7980.19
43_V83_A0.7830.19
100_A114_V0.7670.18
20_E59_D0.7590.18
12_L112_Y0.7580.18
65_Q92_N0.7560.18
15_I80_V0.7390.17
40_D57_D0.7390.17
15_I29_A0.7330.17
35_N44_I0.7320.17
59_D111_G0.7310.17
36_K111_G0.7300.17
14_L104_V0.7070.17
17_S63_M0.7060.16
60_M69_Q0.7050.16
90_L97_L0.7050.16
17_S107_Y0.7010.16
19_D108_V0.6990.16
53_L106_Y0.6960.16
43_V60_M0.6910.16
55_Q89_H0.6890.16
14_L81_A0.6870.16
11_V33_V0.6830.16
16_M104_V0.6690.16
20_E98_M0.6680.16
14_L113_E0.6530.15
39_E78_I0.6500.15
95_V115_I0.6490.15
29_A66_E0.6440.15
30_Y67_L0.6340.15
22_F45_Y0.6210.14
38_Y109_N0.6200.14
32_S109_N0.6170.14
28_M80_V0.6130.14
33_V85_N0.6060.14
31_N105_S0.6060.14
107_Y114_V0.6050.14
82_Q111_G0.5960.14
70_N102_E0.5960.14
89_H92_N0.5860.14
29_A51_K0.5820.14
25_A46_F0.5790.13
14_L69_Q0.5780.13
14_L24_L0.5770.13
87_K115_I0.5770.13
14_L34_K0.5760.13
16_M61_K0.5730.13
61_K65_Q0.5730.13
34_K78_I0.5680.13
107_Y112_Y0.5640.13
11_V38_Y0.5580.13
30_Y33_V0.5580.13
22_F59_D0.5570.13
26_M69_Q0.5500.13
18_G92_N0.5500.13
31_N79_G0.5460.13
99_P107_Y0.5440.13
67_L111_G0.5410.13
26_M37_R0.5410.13
36_K58_G0.5390.13
47_G77_C0.5390.13
41_V57_D0.5360.13
45_Y50_Q0.5320.12
75_S78_I0.5290.12
17_S74_D0.5280.12
71_K104_V0.5270.12
27_R79_G0.5240.12
87_K96_S0.5160.12
13_F37_R0.5160.12
81_A100_A0.5100.12
23_D63_M0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2fb6A 3 0.9744 99.9 0.504 Contact Map
1jx7A 5 0.9316 99.4 0.682 Contact Map
1l1sA 3 0.9316 99.4 0.683 Contact Map
2pd2A 3 0.9145 99.4 0.691 Contact Map
3mc3A 3 0.8291 99.2 0.706 Contact Map
2qs7A 3 0.8974 98.6 0.771 Contact Map
2hy5B 1 0.9145 98.6 0.773 Contact Map
2hy5A 2 0.8889 98.6 0.774 Contact Map
2d1pB 1 0.906 98.5 0.777 Contact Map
2d1pA 2 0.9145 97.9 0.81 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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