GREMLIN Database
Q97UX3 - Uncharacterized protein
UniProt: Q97UX3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 274 (261)
Sequences: 35235 (26185)
Seq/√Len: 1620.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
76_G142_T3.3851.00
84_E139_S2.9181.00
6_Y216_M2.8971.00
216_M220_A2.7391.00
241_E247_V2.6431.00
75_Y141_I2.4741.00
42_S173_S2.4181.00
35_L180_A2.3601.00
20_F201_Y2.3381.00
216_M219_K2.3331.00
115_G263_G2.3171.00
72_L144_V2.2991.00
15_S236_L2.2231.00
86_A237_T2.2061.00
106_E157_R2.1471.00
40_I203_S2.1271.00
22_K247_V2.1141.00
21_A74_A2.0721.00
99_I154_V2.0671.00
95_F146_A2.0601.00
72_L141_I2.0171.00
7_L217_M1.9831.00
101_F108_P1.9271.00
68_V148_F1.8831.00
193_P197_I1.8461.00
15_S240_V1.8051.00
39_V176_S1.7891.00
96_S227_T1.7841.00
100_S106_E1.7741.00
80_V139_S1.7651.00
97_I116_V1.7321.00
203_S208_A1.7211.00
12_T236_L1.7161.00
79_Y137_F1.7151.00
42_S176_S1.7061.00
46_L169_A1.6871.00
109_A112_E1.6871.00
140_I144_V1.6741.00
91_T95_F1.6721.00
119_G231_F1.6641.00
80_V138_G1.6561.00
16_F201_Y1.6501.00
13_I205_L1.6381.00
27_F195_F1.6331.00
95_F150_G1.6141.00
28_S195_F1.6091.00
72_L148_F1.5881.00
222_K225_K1.5821.00
85_S142_T1.5631.00
46_L50_R1.5631.00
192_N195_F1.5531.00
163_D166_T1.5471.00
177_I181_L1.5431.00
250_F253_Q1.5371.00
47_S50_R1.5091.00
75_Y79_Y1.5031.00
136_L139_S1.4911.00
53_I56_N1.4811.00
156_Y215_N1.4741.00
10_Y217_M1.4721.00
95_F147_L1.4181.00
24_A33_F1.4121.00
6_Y213_L1.4091.00
185_I188_N1.4071.00
251_P255_F1.3991.00
35_L176_S1.3881.00
115_G267_S1.3731.00
100_S104_L1.3671.00
41_S172_F1.3661.00
33_F202_T1.3641.00
43_I47_S1.3541.00
80_V84_E1.3231.00
194_E197_I1.3231.00
125_L259_L1.3201.00
44_I208_A1.3151.00
240_V244_L1.2861.00
75_Y78_L1.2831.00
19_Y240_V1.2811.00
194_E198_G1.2731.00
150_G154_V1.2721.00
115_G266_I1.2701.00
83_A238_T1.2691.00
82_P241_E1.2651.00
99_I103_I1.2611.00
23_D198_G1.2601.00
87_V257_I1.2551.00
16_F240_V1.2531.00
29_S32_F1.2521.00
61_Q155_F1.2461.00
254_L258_F1.2401.00
236_L240_V1.2361.00
110_V114_V1.2331.00
232_S236_L1.2141.00
258_F262_L1.2131.00
113_I117_V1.2031.00
178_I181_L1.2021.00
22_K26_T1.2001.00
14_T210_S1.1901.00
65_Y151_L1.1831.00
125_L252_I1.1781.00
119_G263_G1.1771.00
117_V121_S1.1711.00
60_I174_I1.1691.00
79_Y141_I1.1621.00
111_L266_I1.1611.00
249_P254_L1.1471.00
20_F198_G1.1461.00
67_T178_I1.1461.00
122_G256_G1.1451.00
157_R222_K1.1431.00
108_P113_I1.1401.00
136_L140_I1.1391.00
66_T152_F1.1321.00
193_P196_Y1.1321.00
102_I105_L1.1171.00
79_Y135_T1.1141.00
81_S84_E1.1101.00
99_I150_G1.1071.00
197_I201_Y1.1061.00
80_V142_T1.1051.00
37_R207_G1.1021.00
53_I57_R1.1001.00
64_V178_I1.0981.00
10_Y14_T1.0961.00
73_W77_L1.0941.00
77_L85_S1.0931.00
99_I151_L1.0921.00
35_L39_V1.0901.00
10_Y213_L1.0891.00
96_S223_I1.0891.00
106_E112_E1.0881.00
104_L154_V1.0861.00
5_K9_P1.0811.00
24_A195_F1.0741.00
110_V113_I1.0711.00
42_S169_A1.0691.00
88_L146_A1.0551.00
27_F192_N1.0541.00
137_F141_I1.0511.00
126_Y256_G1.0481.00
101_F107_R1.0481.00
31_I71_L1.0221.00
128_L250_F1.0121.00
67_T179_L1.0091.00
31_I182_L1.0091.00
88_L139_S1.0041.00
79_Y138_G1.0011.00
34_N74_A1.0001.00
218_V226_V1.0001.00
21_A77_L0.9991.00
55_F58_D0.9961.00
82_P245_Y0.9951.00
14_T214_W0.9931.00
157_R223_I0.9931.00
44_I204_T0.9901.00
122_G260_M0.9881.00
13_I213_L0.9861.00
30_P34_N0.9841.00
137_F140_I0.9821.00
96_S153_T0.9781.00
9_P213_L0.9771.00
197_I200_A0.9751.00
91_T123_V0.9661.00
190_D193_P0.9651.00
201_Y205_L0.9651.00
96_S150_G0.9561.00
251_P254_L0.9531.00
54_L57_R0.9501.00
59_V162_Y0.9481.00
65_Y148_F0.9441.00
19_Y244_L0.9421.00
99_I147_L0.9411.00
221_E226_V0.9411.00
200_A203_S0.9401.00
97_I108_P0.9341.00
218_V222_K0.9311.00
118_I263_G0.9311.00
235_I257_I0.9291.00
24_A198_G0.9281.00
222_K226_V0.9281.00
63_A174_I0.9241.00
138_G142_T0.9231.00
39_V180_A0.9221.00
221_E225_K0.9211.00
88_L142_T0.9201.00
87_V124_I0.9141.00
238_T249_P0.9121.00
11_V15_S0.9111.00
124_I128_L0.9001.00
82_P247_V0.8981.00
196_Y200_A0.8921.00
8_L236_L0.8901.00
99_I102_I0.8851.00
109_A113_I0.8801.00
11_V232_S0.8791.00
183_L186_H0.8781.00
38_Y175_G0.8771.00
205_L209_I0.8761.00
146_A150_G0.8741.00
199_I203_S0.8571.00
34_N179_L0.8541.00
173_S177_I0.8501.00
11_V236_L0.8441.00
46_L173_S0.8421.00
107_R111_L0.8341.00
67_T71_L0.8331.00
135_T139_S0.8331.00
174_I177_I0.8331.00
123_V127_G0.8301.00
238_T257_I0.8261.00
97_I112_E0.8261.00
242_F249_P0.8251.00
125_L255_F0.8221.00
158_K161_G0.8191.00
164_P168_N0.8181.00
62_L66_T0.8161.00
96_S154_V0.8131.00
175_G179_L0.8121.00
200_A204_T0.8051.00
65_Y155_F0.8041.00
168_N171_Q0.8031.00
252_I255_F0.8021.00
45_F208_A0.8021.00
19_Y241_E0.7981.00
107_R110_V0.7941.00
174_I178_I0.7941.00
71_L75_Y0.7931.00
121_S125_L0.7921.00
94_L119_G0.7911.00
186_H189_I0.7911.00
191_P196_Y0.7901.00
217_M226_V0.7821.00
170_S174_I0.7771.00
209_I213_L0.7741.00
242_F248_L0.7731.00
255_F259_L0.7691.00
63_A67_T0.7651.00
169_A173_S0.7651.00
192_N196_Y0.7591.00
257_I261_F0.7581.00
101_F105_L0.7551.00
162_Y167_V0.7551.00
98_P102_I0.7531.00
69_S148_F0.7481.00
36_I40_I0.7441.00
151_L155_F0.7411.00
121_S259_L0.7391.00
39_V43_I0.7331.00
114_V118_I0.7321.00
142_T146_A0.7321.00
32_F36_I0.7301.00
42_S46_L0.7251.00
168_N172_F0.7201.00
76_G85_S0.7191.00
18_Y73_W0.7181.00
21_A25_I0.7141.00
184_P187_H0.7131.00
232_S235_I0.7061.00
19_Y82_P0.7041.00
80_V85_S0.7041.00
44_I47_S0.7031.00
88_L143_I0.6991.00
69_S152_F0.6971.00
7_L229_L0.6961.00
149_W153_T0.6931.00
28_S32_F0.6921.00
241_E245_Y0.6881.00
18_Y86_A0.6851.00
166_T170_S0.6821.00
168_N215_N0.6781.00
108_P112_E0.6771.00
44_I203_S0.6761.00
13_I206_G0.6741.00
157_R160_K0.6731.00
152_F215_N0.6721.00
106_E224_P0.6711.00
93_P231_F0.6711.00
68_V72_L0.6671.00
91_T94_L0.6661.00
162_Y166_T0.6661.00
264_I267_S0.6661.00
249_P253_Q0.6641.00
76_G138_G0.6641.00
49_S169_A0.6601.00
7_L221_E0.6591.00
40_I44_I0.6581.00
28_S33_F0.6571.00
262_L266_I0.6571.00
195_F198_G0.6521.00
25_I77_L0.6501.00
212_F216_M0.6481.00
176_S180_A0.6441.00
263_G267_S0.6411.00
198_G201_Y0.6401.00
250_F254_L0.6381.00
95_F143_I0.6371.00
62_L65_Y0.6311.00
63_A66_T0.6271.00
36_I199_I0.6271.00
149_W214_W0.6271.00
238_T242_F0.6251.00
253_Q257_I0.6191.00
127_G139_S0.6161.00
97_I101_F0.6141.00
73_W85_S0.6131.00
48_I165_I0.6121.00
90_Y123_V0.6101.00
120_F231_F0.6081.00
17_N206_G0.6061.00
76_G80_V0.6041.00
184_P189_I0.6031.00
239_L243_L0.6001.00
228_V267_S0.5961.00
41_S208_A0.5941.00
112_E222_K0.5931.00
40_I199_I0.5891.00
141_I144_V0.5881.00
184_P188_N0.5881.00
15_S233_V0.5861.00
173_S176_S0.5851.00
201_Y204_T0.5831.00
248_L252_I0.5821.00
98_P116_V0.5821.00
87_V127_G0.5811.00
217_M221_E0.5811.00
248_L253_Q0.5801.00
19_Y237_T0.5781.00
239_L242_F0.5741.00
91_T119_G0.5731.00
13_I210_S0.5711.00
43_I46_L0.5711.00
67_T182_L0.5701.00
90_Y146_A0.5691.00
153_T227_T0.5681.00
104_L158_K0.5671.00
153_T214_W0.5651.00
60_I178_I0.5651.00
23_D26_T0.5641.00
100_S224_P0.5621.00
59_V167_V0.5621.00
60_I64_V0.5581.00
190_D196_Y0.5531.00
96_S100_S0.5511.00
170_S173_S0.5491.00
41_S203_S0.5471.00
23_D245_Y0.5461.00
66_T211_F0.5461.00
118_I266_I0.5451.00
86_A90_Y0.5451.00
17_N202_T0.5451.00
231_F264_I0.5441.00
103_I151_L0.5441.00
8_L11_V0.5431.00
90_Y93_P0.5431.00
37_R70_S0.5421.00
9_P13_I0.5421.00
51_G163_D0.5401.00
147_L151_L0.5381.00
74_A78_L0.5361.00
152_F156_Y0.5351.00
25_I78_L0.5351.00
40_I43_I0.5351.00
41_S207_G0.5351.00
183_L187_H0.5341.00
230_S233_V0.5311.00
69_S73_W0.5311.00
91_T146_A0.5301.00
94_L116_V0.5291.00
187_H190_D0.5291.00
169_A172_F0.5271.00
240_V243_L0.5261.00
61_Q64_V0.5261.00
11_V233_V0.5231.00
7_L214_W0.5221.00
66_T171_Q0.5211.00
17_N74_A0.5161.00
73_W145_N0.5131.00
185_I189_I0.5131.00
242_F254_L0.5131.00
114_V121_S0.5101.00
238_T241_E0.5101.00
31_I75_Y0.5061.00
235_I261_F0.5051.00
23_D27_F0.5041.00
97_I224_P0.5031.00
15_S237_T0.5031.00
59_V63_A0.5021.00
121_S124_I0.5021.00
125_L253_Q0.5011.00
152_F171_Q0.5011.00
213_L216_M0.5011.00
38_Y179_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2i68A 2 0.281 98.7 0.762 Contact Map
3b5dA 2 0.3686 98.6 0.77 Contact Map
4o93B 1 0.2737 10.4 0.943 Contact Map
4o9uB 2 0.2737 10.1 0.943 Contact Map
1u7gA 3 0.8102 3.7 0.954 Contact Map
4ub6R 1 0.1241 2.5 0.958 Contact Map
2cfqA 1 0.6095 2.4 0.958 Contact Map
4rngA 2 0.1752 1.6 0.962 Contact Map
2wswA 3 0.5511 1.5 0.962 Contact Map
4he8J 1 0.5547 1.3 0.964 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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