GREMLIN Database
Q97UX2 - NAD-dependent malic enzyme (Malate oxidoreductase)
UniProt: Q97UX2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 432 (379)
Sequences: 4315 (1983)
Seq/√Len: 101.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
80_N113_K4.4831.00
123_K152_M4.3261.00
189_V210_F3.7641.00
349_E396_L3.7141.00
279_K283_S3.4701.00
347_T396_L3.1961.00
336_R340_D3.1851.00
223_P259_A3.1641.00
73_T113_K3.1571.00
391_S395_E3.1121.00
48_A51_K3.0471.00
255_E258_D2.9681.00
191_F202_A2.8731.00
117_E120_N2.8471.00
118_F122_V2.8281.00
183_D186_E2.8131.00
121_V124_A2.7851.00
312_K369_E2.6981.00
116_D148_K2.6901.00
52_D55_K2.6751.00
170_L208_Y2.6331.00
116_D119_T2.6261.00
279_K305_D2.6161.00
138_E141_K2.5921.00
261_S284_L2.5451.00
260_F277_I2.5401.00
201_A269_A2.5361.00
177_M187_S2.4571.00
55_K58_E2.4301.00
147_E151_S2.3371.00
226_A243_E2.3121.00
203_R240_W2.2911.00
304_Q321_F2.2851.00
220_S237_H2.2781.00
347_T398_L2.2571.00
71_D141_K2.2431.00
150_Q345_A2.1971.00
173_L265_A2.1481.00
148_K152_M2.0331.00
56_S62_R2.0201.00
228_R237_H2.0001.00
14_R58_E1.9601.00
203_R239_K1.9341.00
311_A314_V1.9261.00
44_E48_A1.9121.00
120_N124_A1.8781.00
115_A119_T1.8761.00
257_K281_W1.8751.00
341_S390_A1.8621.00
112_V117_E1.8471.00
207_K348_D1.8291.00
338_V346_I1.8231.00
202_A217_M1.8181.00
75_V81_I1.8031.00
44_E47_K1.7751.00
266_V277_I1.7721.00
174_I356_E1.7641.00
176_A290_I1.7621.00
279_K308_E1.7391.00
148_K151_S1.7131.00
392_K395_E1.7041.00
392_K396_L1.7031.00
221_K237_H1.6981.00
94_S105_A1.6911.00
192_Y276_V1.6751.00
57_F62_R1.6561.00
26_V37_I1.6441.00
356_E360_K1.6231.00
288_E312_K1.6141.00
199_I240_W1.5811.00
118_F145_I1.5701.00
170_L204_I1.5691.00
11_E15_K1.5681.00
169_I294_L1.5641.00
73_T80_N1.5631.00
226_A242_Y1.5611.00
150_Q348_D1.5521.00
178_I363_R1.5441.00
282_I291_V1.5361.00
167_A334_I1.5131.00
187_S265_A1.5011.00
110_I125_L1.4771.00
313_I372_I1.4741.00
257_K284_L1.4721.00
275_N305_D1.4691.00
172_G292_F1.4651.00
115_A144_Y1.4591.00
342_R400_R1.4441.00
298_V302_W1.4411.00
277_I284_L1.4321.00
350_M393_A1.4201.00
302_W305_D1.4121.00
278_K281_W1.4111.00
71_D138_E1.4011.00
257_K280_E1.4011.00
387_A391_S1.3961.00
271_T276_V1.3951.00
392_K398_L1.3951.00
281_W284_L1.3911.00
24_P28_I1.3891.00
112_V124_A1.3831.00
46_S81_I1.3801.00
216_V223_P1.3781.00
108_L125_L1.3530.99
141_K144_Y1.3460.99
301_I306_A1.3380.99
194_A217_M1.3340.99
120_N123_K1.3290.99
220_S271_T1.3260.99
116_D120_N1.3160.99
219_D228_R1.3140.99
303_P314_V1.2920.99
198_N269_A1.2880.99
187_S210_F1.2880.99
151_S345_A1.2810.99
69_V122_V1.2790.99
57_F124_A1.2730.99
170_L355_S1.2660.99
47_K50_Y1.2620.99
110_I121_V1.2610.99
174_I208_Y1.2580.99
202_A215_I1.2570.99
108_L129_F1.2560.99
280_E283_S1.2540.99
184_P210_F1.2510.99
173_L205_L1.2470.99
348_D351_T1.2470.99
330_I334_I1.2370.99
119_T148_K1.2300.99
120_N152_M1.2200.99
166_A204_I1.2190.99
83_P86_A1.2150.99
330_I358_L1.2140.99
134_L157_V1.2100.99
347_T392_K1.2070.99
119_T155_I1.1990.99
233_H238_H1.1980.99
144_Y148_K1.1980.99
220_S224_L1.1960.99
192_Y218_I1.1850.98
278_K284_L1.1840.98
86_A109_P1.1840.98
54_D342_R1.1800.98
219_D237_H1.1660.98
197_S269_A1.1380.98
111_N126_E1.1330.98
227_D238_H1.1320.98
226_A251_W1.1250.98
55_K59_L1.1240.98
283_S309_A1.1200.98
363_R366_G1.1190.98
223_P252_E1.1150.98
282_I308_E1.1140.98
260_F284_L1.1130.98
224_L237_H1.1120.98
29_T33_D1.1060.98
206_A215_I1.1060.98
190_V263_A1.1020.98
302_W321_F1.0930.97
208_Y352_I1.0880.97
288_E369_E1.0860.97
340_D390_A1.0850.97
106_I128_S1.0760.97
256_I277_I1.0730.97
223_P255_E1.0690.97
110_I127_T1.0660.97
115_A148_K1.0650.97
307_K370_N1.0600.97
180_T313_I1.0560.97
341_S394_V1.0500.97
192_Y271_T1.0450.97
10_V13_S1.0300.96
87_M109_P1.0250.96
282_I301_I1.0190.96
305_D308_E1.0160.96
173_L292_F1.0160.96
217_M224_L1.0110.96
115_A145_I0.9950.96
112_V121_V0.9900.95
225_Y228_R0.9860.95
239_K243_E0.9860.95
61_S65_T0.9850.95
182_K187_S0.9840.95
286_N289_A0.9750.95
169_I205_L0.9740.95
307_K314_V0.9710.95
114_S117_E0.9660.95
46_S75_V0.9640.95
325_V373_I0.9640.95
307_K369_E0.9580.95
368_N371_Y0.9550.94
116_D152_M0.9530.94
279_K309_A0.9420.94
203_R243_E0.9420.94
382_F385_E0.9410.94
182_K264_D0.9410.94
190_V259_A0.9400.94
177_M184_P0.9380.94
50_Y86_A0.9360.94
343_A350_M0.9350.94
175_N359_A0.9290.94
132_I155_I0.9290.94
232_D237_H0.9280.94
217_M240_W0.9260.93
361_Y378_E0.9260.93
361_Y384_E0.9190.93
11_E14_R0.9170.93
344_K398_L0.9150.93
178_I360_K0.9120.93
333_A337_G0.9090.93
364_D368_N0.9080.93
208_Y356_E0.9050.93
306_A312_K0.9050.93
279_K282_I0.9040.93
361_Y380_E0.9010.93
70_T109_P0.9000.92
192_Y256_I0.8990.92
282_I305_D0.8960.92
306_A314_V0.8920.92
111_N127_T0.8910.92
47_K298_V0.8890.92
47_K51_K0.8870.92
342_R401_V0.8860.92
221_K230_D0.8860.92
117_E121_V0.8850.92
57_F342_R0.8810.92
207_K352_I0.8800.92
345_A398_L0.8780.92
168_A330_I0.8770.92
285_M291_V0.8760.91
223_P254_K0.8760.91
277_I281_W0.8750.91
307_K310_G0.8730.91
393_A398_L0.8720.91
22_I106_I0.8700.91
48_A55_K0.8680.91
199_I217_M0.8650.91
31_Y375_R0.8650.91
192_Y266_V0.8650.91
61_S106_I0.8620.91
177_M182_K0.8600.91
225_Y232_D0.8560.91
173_L290_I0.8490.90
225_Y231_V0.8480.90
343_A389_V0.8460.90
188_K214_N0.8460.90
110_I118_F0.8450.90
360_K384_E0.8420.90
112_V118_F0.8360.89
337_G389_V0.8340.89
61_S125_L0.8340.89
69_V110_I0.8330.89
283_S308_E0.8310.89
257_K260_F0.8290.89
191_F267_V0.8280.89
231_V234_L0.8240.89
185_K211_K0.8180.88
225_Y230_D0.8180.88
220_S228_R0.8170.88
337_G343_A0.8170.88
180_T312_K0.8170.88
54_D117_E0.8160.88
29_T32_N0.8130.88
347_T350_M0.8120.88
303_P307_K0.8070.88
362_A371_Y0.8070.88
146_L163_Q0.8060.88
147_E150_Q0.8060.88
255_E259_A0.8050.88
337_G393_A0.8040.88
156_P338_V0.7990.87
180_T187_S0.7980.87
258_D261_S0.7970.87
337_G341_S0.7960.87
338_V350_M0.7920.87
24_P95_L0.7900.87
294_L315_A0.7840.86
218_I256_I0.7810.86
99_Y102_G0.7790.86
357_A360_K0.7790.86
292_F315_A0.7780.86
231_V237_H0.7770.86
354_A385_E0.7750.86
306_A310_G0.7740.86
275_N298_V0.7740.86
216_V259_A0.7730.85
341_S399_A0.7730.85
378_E381_A0.7730.85
189_V265_A0.7710.85
287_K311_A0.7700.85
87_M128_S0.7700.85
177_M180_T0.7640.85
167_A351_T0.7640.85
30_S377_D0.7610.85
352_I356_E0.7600.84
110_I115_A0.7570.84
99_Y379_W0.7570.84
204_I355_S0.7570.84
353_A392_K0.7550.84
39_T318_R0.7530.84
24_P99_Y0.7510.84
260_F281_W0.7490.84
218_I259_A0.7490.84
54_D400_R0.7490.84
190_V218_I0.7460.83
261_S280_E0.7460.83
349_E392_K0.7420.83
197_S201_A0.7410.83
225_Y253_A0.7400.83
282_I306_A0.7390.83
298_V305_D0.7390.83
241_K244_L0.7360.83
188_K252_E0.7360.83
42_V46_S0.7350.82
10_V14_R0.7320.82
292_F325_V0.7310.82
83_P111_N0.7300.82
119_T132_I0.7290.82
360_K363_R0.7280.82
31_Y377_D0.7260.82
45_V59_L0.7260.82
383_Y387_A0.7210.81
394_V402_K0.7210.81
16_Y21_E0.7200.81
187_S264_D0.7180.81
9_A13_S0.7170.81
216_V242_Y0.7130.80
144_Y147_E0.7120.80
184_P187_S0.7100.80
218_I223_P0.7090.80
179_L369_E0.7080.80
360_K388_A0.7070.80
118_F121_V0.7060.80
364_D384_E0.7030.80
174_I184_P0.7020.79
69_V109_P0.7020.79
382_F386_A0.6990.79
227_D232_D0.6990.79
257_K261_S0.6990.79
12_L15_K0.6980.79
28_I95_L0.6980.79
121_V125_L0.6960.79
363_R367_I0.6920.78
223_P260_F0.6900.78
65_T128_S0.6890.78
103_V382_F0.6890.78
176_A179_L0.6890.78
275_N302_W0.6870.78
119_T134_L0.6850.78
315_A372_I0.6850.78
111_N114_S0.6820.77
230_D233_H0.6810.77
227_D244_L0.6800.77
147_E239_K0.6800.77
123_K148_K0.6800.77
12_L36_L0.6790.77
42_V78_L0.6780.77
108_L128_S0.6780.77
334_I338_V0.6770.77
123_K155_I0.6770.77
169_I201_A0.6770.77
191_F217_M0.6760.77
184_P208_Y0.6740.77
303_P316_T0.6720.76
225_Y254_K0.6680.76
178_I367_I0.6680.76
198_N294_L0.6670.76
98_K104_D0.6660.76
46_S78_L0.6630.75
22_I65_T0.6630.75
390_A394_V0.6610.75
116_D144_Y0.6590.75
73_T141_K0.6550.75
242_Y259_A0.6540.74
20_I61_S0.6540.74
176_A292_F0.6520.74
388_A391_S0.6490.74
208_Y355_S0.6480.74
227_D253_A0.6460.74
334_I346_I0.6450.73
62_R128_S0.6420.73
215_I370_N0.6420.73
259_A263_A0.6400.73
289_A312_K0.6390.73
224_L230_D0.6390.73
67_A122_V0.6380.73
69_V118_F0.6370.73
224_L241_K0.6360.72
115_A141_K0.6340.72
252_E259_A0.6340.72
357_A384_E0.6340.72
22_I94_S0.6330.72
61_S94_S0.6320.72
179_L313_I0.6320.72
349_E395_E0.6290.72
167_A330_I0.6270.71
203_R348_D0.6260.71
39_T70_T0.6250.71
188_K263_A0.6250.71
181_N185_K0.6250.71
238_H241_K0.6240.71
394_V399_A0.6210.71
62_R342_R0.6200.71
252_E255_E0.6170.70
21_E25_K0.6170.70
108_L111_N0.6150.70
173_L189_V0.6150.70
230_D238_H0.6150.70
199_I237_H0.6150.70
29_T99_Y0.6140.70
14_R55_K0.6140.70
110_I124_A0.6130.70
96_L328_S0.6120.70
132_I157_V0.6120.70
226_A238_H0.6110.69
117_E124_A0.6110.69
74_R78_L0.6110.69
55_K62_R0.6110.69
206_A243_E0.6100.69
57_F63_W0.6090.69
214_N252_E0.6090.69
192_Y277_I0.6070.69
174_I177_M0.6050.69
125_L132_I0.6030.68
9_A12_L0.6030.68
78_L81_I0.6020.68
310_G314_V0.6000.68
49_I85_A0.5970.68
391_S394_V0.5970.68
56_S83_P0.5950.67
131_G346_I0.5950.67
74_R139_S0.5940.67
205_L267_V0.5930.67
23_Y102_G0.5930.67
108_L118_F0.5930.67
66_I335_F0.5930.67
119_T145_I0.5920.67
278_K305_D0.5920.67
341_S393_A0.5920.67
189_V209_G0.5900.67
14_R59_L0.5890.67
256_I266_V0.5890.67
71_D83_P0.5870.66
188_K216_V0.5860.66
231_V238_H0.5860.66
113_K118_F0.5860.66
277_I291_V0.5860.66
366_G371_Y0.5850.66
218_I260_F0.5850.66
238_H242_Y0.5840.66
283_S289_A0.5840.66
97_F133_N0.5830.66
224_L228_R0.5830.66
50_Y75_V0.5830.66
170_L184_P0.5820.66
240_W244_L0.5820.66
189_V205_L0.5820.66
80_N111_N0.5820.66
207_K349_E0.5790.65
177_M290_I0.5770.65
115_A121_V0.5760.65
180_T290_I0.5760.65
68_V105_A0.5730.65
330_I385_E0.5700.64
222_G268_A0.5690.64
32_N36_L0.5680.64
108_L122_V0.5670.64
223_P227_D0.5670.64
336_R383_Y0.5670.64
353_A356_E0.5660.64
365_R368_N0.5660.64
192_Y217_M0.5660.64
203_R206_A0.5650.63
46_S86_A0.5640.63
380_E384_E0.5640.63
49_I91_E0.5630.63
199_I234_L0.5600.63
147_E203_R0.5590.63
72_G82_G0.5560.62
366_G378_E0.5510.62
237_H241_K0.5510.62
304_Q307_K0.5510.62
215_I240_W0.5510.62
302_W314_V0.5500.61
223_P258_D0.5500.61
210_F215_I0.5500.61
357_A388_A0.5490.61
47_K86_A0.5490.61
196_A237_H0.5490.61
12_L16_Y0.5480.61
228_R231_V0.5480.61
201_A267_V0.5470.61
194_A220_S0.5460.61
133_N158_W0.5450.61
131_G294_L0.5450.61
277_I282_I0.5440.61
20_I95_L0.5440.61
210_F265_A0.5430.60
229_E232_D0.5420.60
25_K61_S0.5410.60
64_N340_D0.5410.60
64_N103_V0.5390.60
97_F131_G0.5390.60
394_V403_K0.5390.60
61_S104_D0.5380.60
225_Y238_H0.5360.59
345_A349_E0.5360.59
100_L377_D0.5360.59
179_L368_N0.5350.59
350_M398_L0.5350.59
240_W243_E0.5330.59
87_M107_P0.5330.59
10_V59_L0.5330.59
229_E234_L0.5320.59
39_T331_F0.5320.59
122_V132_I0.5320.59
16_Y25_K0.5310.59
344_K400_R0.5310.59
52_D56_S0.5310.59
328_S376_M0.5310.59
175_N372_I0.5300.59
353_A393_A0.5300.59
174_I359_A0.5290.58
28_I37_I0.5280.58
218_I281_W0.5260.58
71_D112_V0.5260.58
380_E383_Y0.5260.58
303_P312_K0.5250.58
244_L253_A0.5250.58
221_K224_L0.5230.58
262_G286_N0.5230.58
296_N327_N0.5220.57
138_E144_Y0.5220.57
172_G372_I0.5210.57
386_A390_A0.5210.57
296_N326_N0.5200.57
134_L155_I0.5200.57
303_P306_A0.5200.57
128_S342_R0.5190.57
61_S95_L0.5170.57
232_D238_H0.5160.57
103_V336_R0.5160.57
74_R88_P0.5150.56
353_A388_A0.5150.56
34_F328_S0.5140.56
28_I99_Y0.5140.56
173_L187_S0.5120.56
326_N331_F0.5120.56
107_P333_A0.5120.56
50_Y70_T0.5120.56
158_W197_S0.5110.56
376_M382_F0.5100.56
199_I221_K0.5100.56
260_F266_V0.5100.56
95_L99_Y0.5090.56
202_A240_W0.5090.56
199_I220_S0.5060.55
393_A399_A0.5060.55
253_A259_A0.5050.55
218_I295_A0.5050.55
131_G156_P0.5050.55
225_Y244_L0.5040.55
72_G78_L0.5030.55
139_S196_A0.5020.55
113_K141_K0.5010.54
230_D234_L0.5010.54
384_E387_A0.5000.54
283_S291_V0.5000.54
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1gq2A 6 0.9722 100 0.138 Contact Map
1o0sA 4 0.9722 100 0.139 Contact Map
1pj3A 4 0.9769 100 0.149 Contact Map
3nv9A 2 0.9907 100 0.214 Contact Map
1vl6A 4 0.8657 100 0.31 Contact Map
2a9fA 2 0.8843 100 0.385 Contact Map
2dvmA 2 0.9745 100 0.399 Contact Map
1v8bA 4 0.831 100 0.8 Contact Map
4ppmA 2 0.0648 99.9 0.852 Contact Map
4xijA 1 0.5833 99.6 0.904 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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