GREMLIN Database
Q97UX0 - 3-hydroxyacyl-CoA dehydrogenase (Hdb-2)
UniProt: Q97UX0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 370 (285)
Sequences: 6524 (3855)
Seq/√Len: 228.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
98_Q102_K3.4701.00
35_K39_N3.3741.00
74_G77_N3.1341.00
6_L79_L2.9201.00
268_D275_K2.8191.00
219_R230_E2.7391.00
89_I99_L2.7301.00
104_E130_K2.6681.00
60_E63_E2.4341.00
136_I166_T2.4091.00
90_P95_L2.3961.00
150_V170_I2.3251.00
275_K279_T2.2441.00
22_A69_I2.2441.00
5_V21_S2.2121.00
104_E129_V2.2001.00
131_R134_R2.1811.00
4_N27_N2.1601.00
133_E159_S2.1281.00
210_E213_A2.1251.00
269_L273_S2.1231.00
4_N81_E2.1201.00
21_S169_F2.1141.00
154_R160_D2.1021.00
160_D164_K2.0311.00
245_S261_E2.0081.00
115_T122_I1.9971.00
6_L82_I1.9761.00
89_I95_L1.9761.00
204_V214_I1.9741.00
107_L111_A1.9701.00
64_D68_R1.9401.00
42_I71_T1.9311.00
238_D272_K1.9131.00
85_S107_L1.8941.00
27_N68_R1.8921.00
53_Y62_V1.8801.00
12_T239_V1.8401.00
74_G78_E1.7901.00
97_R128_A1.7741.00
83_D108_P1.7621.00
21_S173_L1.7501.00
93_L124_E1.7401.00
46_K50_E1.7221.00
263_M268_D1.7201.00
152_I167_Y1.6961.00
72_I78_E1.6901.00
167_Y179_M1.6881.00
180_V188_V1.6821.00
110_N134_R1.6781.00
26_Y172_S1.6621.00
138_T170_I1.6451.00
262_E266_K1.6421.00
159_S162_T1.6331.00
138_T166_T1.6251.00
50_E54_E1.5921.00
38_L71_T1.5731.00
101_S128_A1.5731.00
5_V26_Y1.5641.00
42_I46_K1.5591.00
123_T156_S1.5501.00
93_L120_L1.5341.00
105_E130_K1.5301.00
241_Y261_E1.5261.00
19_E48_S1.5211.00
132_Q157_K1.5181.00
102_K105_E1.5181.00
4_N29_Y1.5061.00
10_A32_D1.5021.00
50_E62_V1.5011.00
100_F113_L1.4981.00
63_E67_G1.4901.00
241_Y264_T1.4891.00
10_A30_L1.4871.00
232_V240_N1.4621.00
34_S37_I1.4571.00
53_Y58_L1.4561.00
23_I65_V1.4541.00
125_I135_V1.4521.00
124_E127_S1.4411.00
39_N43_Q1.4401.00
108_P111_A1.4311.00
84_I166_T1.4271.00
167_Y171_K1.4231.00
98_Q101_S1.4201.00
261_E265_K1.4201.00
49_L65_V1.4141.00
35_K73_E1.4021.00
94_D97_R1.3831.00
107_L113_L1.3811.00
94_D98_Q1.3741.00
19_E23_I1.3651.00
163_V179_M1.3571.00
31_S75_L1.3521.00
241_Y245_S1.3391.00
245_S249_E1.3391.00
95_L98_Q1.3261.00
40_N44_K1.3171.00
46_K66_L1.3151.00
84_I169_F1.2991.00
129_V135_V1.2951.00
168_E172_S1.2931.00
15_H44_K1.2711.00
77_N80_R1.2681.00
97_R101_S1.2621.00
62_V66_L1.2601.00
168_E171_K1.2541.00
281_P284_K1.2451.00
119_S243_V1.2421.00
114_A136_I1.2401.00
170_I177_P1.2341.00
18_A30_L1.2281.00
27_N70_K1.2271.00
100_F125_I1.2231.00
38_L73_E1.2191.00
100_F103_L1.2171.00
155_G158_T1.2131.00
101_S105_E1.2081.00
29_Y72_I1.2001.00
5_V84_I1.1871.00
133_E157_K1.1841.00
37_I40_N1.1831.00
204_V211_Y1.1681.00
123_T183_D1.1661.00
154_R163_V1.1631.00
225_P231_L1.1501.00
8_V103_L1.1471.00
199_T206_K1.1381.00
43_Q47_W1.1381.00
137_G153_I1.1301.00
8_V99_L1.1271.00
46_K62_V1.1131.00
123_T155_G1.0961.00
112_I162_T1.0841.00
81_E108_P1.0711.00
93_L125_I1.0671.00
203_L208_I1.0621.00
164_K168_E1.0591.00
95_L99_L1.0551.00
218_A222_L1.0541.00
39_N42_I1.0541.00
61_S64_D1.0461.00
49_L62_V1.0451.00
84_I138_T1.0441.00
93_L97_R1.0371.00
122_I137_G1.0331.00
21_S86_I1.0321.00
218_A228_I1.0321.00
103_L107_L1.0311.00
114_A138_T1.0251.00
269_L272_K1.0151.00
36_D39_N1.0151.00
10_A41_A1.0121.00
75_L106_L1.0111.00
31_S72_I0.9991.00
6_L29_Y0.9941.00
97_R125_I0.9901.00
211_Y229_F0.9901.00
136_I162_T0.9851.00
70_K78_E0.9781.00
31_S102_K0.9781.00
79_L82_I0.9771.00
4_N82_I0.9741.00
230_E234_Y0.9691.00
92_K242_Y0.9601.00
282_S286_I0.9521.00
258_K262_E0.9521.00
83_D110_N0.9501.00
196_I224_F0.9411.00
102_K106_L0.9391.00
51_K54_E0.9391.00
171_K177_P0.9351.00
75_L102_K0.9331.00
237_V264_T0.9311.00
50_E53_Y0.9221.00
43_Q46_K0.9221.00
29_Y81_E0.9221.00
26_Y169_F0.9211.00
205_E257_C0.9161.00
259_T277_F0.9151.00
48_S52_L0.9111.00
148_Q176_I0.9080.99
241_Y265_K0.8990.99
152_I177_P0.8970.99
176_I216_A0.8830.99
154_R179_M0.8810.99
201_C277_F0.8810.99
267_G273_S0.8760.99
44_K48_S0.8670.99
136_I152_I0.8640.99
126_A135_V0.8600.99
115_T137_G0.8590.99
52_L57_N0.8560.99
157_K268_D0.8550.99
29_Y78_E0.8520.99
29_Y70_K0.8520.99
20_V24_A0.8510.99
30_L41_A0.8470.99
284_K287_K0.8460.99
46_K63_E0.8440.99
121_P183_D0.8400.99
169_F173_L0.8380.99
44_K47_W0.8350.99
65_V68_R0.8340.99
140_F173_L0.8290.99
120_L124_E0.8230.99
8_V31_S0.8180.99
189_V217_V0.8150.99
19_E145_V0.8150.99
109_N130_K0.8110.99
30_L71_T0.8110.99
138_T169_F0.8060.99
22_A65_V0.8010.99
197_I232_V0.7980.99
235_T240_N0.7910.99
97_R127_S0.7900.99
52_L58_L0.7880.99
78_E81_E0.7870.99
75_L99_L0.7810.98
15_H41_A0.7780.98
33_V37_I0.7760.98
178_I217_V0.7750.98
162_T165_Q0.7730.98
161_D164_K0.7710.98
209_C214_I0.7690.98
97_R124_E0.7670.98
45_V48_S0.7640.98
104_E131_R0.7640.98
15_H40_N0.7620.98
104_E135_V0.7620.98
75_L79_L0.7570.98
115_T125_I0.7540.98
202_M206_K0.7490.98
84_I114_A0.7480.98
198_T257_C0.7430.98
50_E60_E0.7430.98
238_D269_L0.7390.98
41_A71_T0.7340.98
108_P134_R0.7330.98
264_T269_L0.7310.98
138_T152_I0.7310.98
193_L231_L0.7260.98
283_N286_I0.7230.97
262_E265_K0.7200.97
5_V169_F0.7190.97
216_A219_R0.7190.97
12_T142_N0.7160.97
2_I5_V0.7150.97
121_P124_E0.7150.97
100_F129_V0.7150.97
285_Y288_P0.7140.97
63_E66_L0.7110.97
232_V237_V0.7110.97
13_M116_N0.7080.97
202_M255_Y0.7020.97
189_V222_L0.7000.97
193_L197_I0.6950.97
113_L129_V0.6930.97
203_L214_I0.6930.97
197_I240_N0.6920.97
258_K261_E0.6910.97
237_V240_N0.6890.97
47_W50_E0.6860.97
236_G272_K0.6860.97
161_D165_Q0.6850.96
178_I188_V0.6840.96
142_N235_T0.6840.96
202_M257_C0.6830.96
185_P246_A0.6820.96
2_I165_Q0.6780.96
77_N106_L0.6780.96
47_W51_K0.6780.96
112_I136_I0.6760.96
38_L42_I0.6740.96
17_I88_A0.6740.96
141_F149_L0.6710.96
284_K288_P0.6710.96
7_V18_A0.6670.96
41_A45_V0.6670.96
62_V65_V0.6660.96
202_M205_E0.6640.96
79_L106_L0.6640.96
158_T162_T0.6630.96
164_K179_M0.6630.96
190_N195_R0.6630.96
65_V69_I0.6620.96
205_E258_K0.6610.96
169_F172_S0.6600.96
226_M234_Y0.6600.96
213_A216_A0.6520.95
195_R198_T0.6500.95
204_V229_F0.6480.95
279_T284_K0.6480.95
118_S190_N0.6460.95
54_E57_N0.6440.95
120_L246_A0.6410.95
33_V95_L0.6410.95
122_I183_D0.6400.95
52_L146_L0.6380.95
8_V79_L0.6330.95
32_D37_I0.6310.94
6_L31_S0.6300.94
24_A174_R0.6290.94
105_E108_P0.6280.94
244_S261_E0.6240.94
2_I26_Y0.6240.94
193_L235_T0.6200.94
194_L197_I0.6200.94
229_F277_F0.6190.94
107_L134_R0.6170.94
166_T170_I0.6160.94
164_K167_Y0.6110.93
134_R162_T0.6100.93
10_A18_A0.6100.93
3_R172_S0.6090.93
141_F189_V0.6090.93
85_S103_L0.6080.93
248_M256_P0.6070.93
64_D67_G0.6070.93
29_Y82_I0.6070.93
234_Y271_V0.6050.93
153_I187_F0.6050.93
134_R161_D0.6000.93
231_L235_T0.5990.93
201_C232_V0.5980.93
92_K95_L0.5970.93
82_I85_S0.5970.93
245_S248_M0.5970.93
237_V263_M0.5960.93
23_I49_L0.5950.93
197_I201_C0.5940.93
137_G183_D0.5930.92
235_T239_V0.5930.92
165_Q172_S0.5910.92
53_Y60_E0.5900.92
204_V259_T0.5900.92
99_L102_K0.5890.92
205_E259_T0.5890.92
245_S256_P0.5880.92
256_P260_L0.5870.92
5_V86_I0.5840.92
194_L240_N0.5830.92
154_R181_N0.5810.92
167_Y177_P0.5790.92
211_Y278_Y0.5780.91
192_I196_I0.5770.91
132_Q155_G0.5740.91
31_S79_L0.5730.91
3_R83_D0.5720.91
19_E52_L0.5720.91
19_E49_L0.5700.91
197_I235_T0.5690.91
212_T216_A0.5680.91
112_I165_Q0.5670.91
103_L106_L0.5660.91
281_P285_Y0.5640.90
271_V280_Y0.5620.90
141_F147_M0.5610.90
134_R159_S0.5590.90
114_A166_T0.5580.90
21_S26_Y0.5550.90
181_N184_V0.5530.90
109_N131_R0.5520.90
217_V222_L0.5490.89
189_V193_L0.5490.89
23_I52_L0.5490.89
282_S285_Y0.5480.89
2_I112_I0.5480.89
45_V69_I0.5460.89
242_Y246_A0.5450.89
39_N46_K0.5450.89
198_T254_A0.5450.89
198_T202_M0.5450.89
263_M277_F0.5450.89
90_P142_N0.5440.89
283_N287_K0.5420.89
129_V132_Q0.5390.88
150_V177_P0.5390.88
242_Y245_S0.5380.88
201_C260_L0.5370.88
281_P286_I0.5360.88
84_I112_I0.5360.88
197_I244_S0.5350.88
58_L65_V0.5340.88
48_S145_V0.5330.88
229_F232_V0.5330.88
74_G102_K0.5310.88
146_L225_P0.5270.87
110_N165_Q0.5260.87
281_P288_P0.5250.87
117_T137_G0.5250.87
232_V277_F0.5250.87
189_V195_R0.5240.87
85_S111_A0.5240.87
209_C213_A0.5230.87
23_I58_L0.5220.87
112_I166_T0.5210.87
54_E60_E0.5200.87
235_T246_A0.5200.87
201_C259_T0.5180.86
126_A155_G0.5180.86
191_R199_T0.5180.86
48_S146_L0.5180.86
36_D40_N0.5180.86
127_S157_K0.5170.86
200_A229_F0.5160.86
77_N102_K0.5150.86
33_V90_P0.5140.86
263_M275_K0.5130.86
163_V167_Y0.5130.86
7_V17_I0.5130.86
259_T263_M0.5120.86
50_E66_L0.5110.86
165_Q169_F0.5110.86
136_I163_V0.5110.86
185_P247_M0.5070.85
237_V269_L0.5060.85
21_S28_V0.5050.85
196_I222_L0.5050.85
189_V231_L0.5040.85
176_I220_Y0.5030.85
165_Q168_E0.5030.85
206_K255_Y0.5030.85
32_D38_L0.5030.85
196_I228_I0.5020.85
226_M231_L0.5020.85
20_V145_V0.5010.85
39_N73_E0.5000.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1wdkA 2 0.9784 100 0.267 Contact Map
4b3hA 1 0.9865 100 0.268 Contact Map
2wtbA 1 0.9189 100 0.271 Contact Map
3zwcA 1 0.9865 100 0.28 Contact Map
3k6jA 1 0.9676 100 0.284 Contact Map
1zcjA 1 0.9865 100 0.288 Contact Map
3mogA 3 0.9946 100 0.343 Contact Map
4j0eA 2 0.7541 100 0.45 Contact Map
1f0yA 2 0.7568 100 0.468 Contact Map
4r1nA 2 0.7541 100 0.481 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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