GREMLIN Database
Q97UW9 - Uncharacterized protein
UniProt: Q97UW9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 178 (139)
Sequences: 406 (261)
Seq/√Len: 22.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
77_C91_C4.6561.00
77_C80_C4.4771.00
71_K103_E4.0731.00
80_C91_C4.0721.00
91_C94_C3.7751.00
80_C94_C3.6271.00
77_C94_C3.5361.00
137_S156_K3.3601.00
110_I157_V3.2451.00
170_L173_E2.9810.99
33_V37_K2.8320.99
107_E158_K2.7750.99
70_G163_E2.5620.98
107_E137_S2.5350.98
63_F66_G2.4620.98
61_F65_E2.2760.97
73_L103_E2.2630.96
65_E69_E2.2600.96
108_G157_V2.2130.96
105_P137_S2.0750.94
79_K98_N2.0530.94
110_I151_V1.9230.91
64_F161_V1.9230.91
72_I85_F1.8090.89
110_I132_G1.6400.83
102_I109_E1.6050.82
77_C84_Y1.5880.81
69_E142_V1.5210.78
113_Y153_V1.4950.77
34_N37_K1.4930.77
108_G144_G1.3390.68
38_T41_P1.3380.68
66_G73_L1.2340.62
96_I150_E1.2280.61
66_G69_E1.2200.61
62_K87_P1.2100.60
87_P92_P1.1520.56
70_G168_G1.1480.56
73_L101_W1.0940.53
144_G172_Y1.0740.51
48_E132_G1.0720.51
68_R113_Y1.0310.48
140_V161_V1.0190.47
107_E142_V1.0020.46
151_V157_V1.0010.46
77_C88_Q0.9940.46
75_T101_W0.9890.45
41_P49_I0.9810.45
33_V36_Q0.9760.44
62_K101_W0.9700.44
76_K82_S0.9610.43
128_D141_N0.9580.43
106_K138_N0.9500.43
72_I134_A0.9410.42
74_A83_I0.9370.42
82_S93_K0.9350.42
52_R130_I0.9300.41
152_R170_L0.9290.41
36_Q39_N0.9190.41
69_E81_G0.9150.40
65_E111_V0.9080.40
58_K148_A0.9070.40
98_N168_G0.9040.40
116_V140_V0.9040.40
100_E151_V0.9030.40
60_I120_P0.8790.38
131_V153_V0.8780.38
55_I161_V0.8780.38
163_E173_E0.8750.38
111_V135_R0.8710.38
72_I100_E0.8640.37
78_P82_S0.8550.37
88_Q91_C0.8510.36
37_K41_P0.8450.36
155_M162_I0.8400.36
120_P127_Q0.8390.36
46_V68_R0.8340.35
115_V148_A0.8320.35
43_W47_R0.8300.35
39_N43_W0.8200.34
40_N150_E0.8170.34
71_K101_W0.8120.34
108_G137_S0.8090.34
63_F131_V0.8070.34
121_P141_N0.8050.33
135_R153_V0.8050.33
66_G86_P0.8020.33
59_R133_I0.7980.33
127_Q130_I0.7970.33
35_E110_I0.7890.32
169_Y172_Y0.7820.32
37_K40_N0.7780.32
92_P134_A0.7670.31
35_E40_N0.7670.31
85_F141_N0.7630.31
72_I141_N0.7560.31
51_L118_V0.7530.30
110_I144_G0.7480.30
75_T80_C0.7320.29
131_V162_I0.7210.29
40_N44_I0.7210.29
39_N96_I0.7200.28
91_C131_V0.7200.28
69_E147_R0.7170.28
60_I70_G0.7140.28
35_E38_T0.7120.28
41_P69_E0.7080.28
41_P45_D0.7060.28
65_E124_S0.7000.27
75_T112_A0.6990.27
59_R114_T0.6930.27
116_V144_G0.6910.27
54_Q89_D0.6900.27
76_K93_K0.6850.27
88_Q92_P0.6840.27
59_R75_T0.6820.26
76_K100_E0.6800.26
61_F95_K0.6760.26
101_W143_L0.6760.26
79_K134_A0.6740.26
132_G146_V0.6680.26
67_L108_G0.6640.25
83_I102_I0.6640.25
63_F73_L0.6610.25
102_I154_G0.6530.25
54_Q85_F0.6490.25
102_I155_M0.6440.24
78_P98_N0.6360.24
59_R89_D0.6340.24
95_K152_R0.6340.24
106_K159_L0.6330.24
73_L116_V0.6320.24
33_V42_L0.6320.24
63_F99_L0.6310.24
41_P82_S0.6260.24
87_P120_P0.6260.24
84_Y114_T0.6220.23
68_R155_M0.6200.23
73_L129_Y0.6200.23
55_I72_I0.6170.23
82_S150_E0.6170.23
168_G172_Y0.6150.23
162_I173_E0.6140.23
118_V147_R0.6100.23
103_E120_P0.6100.23
88_Q94_C0.6090.23
34_N38_T0.6080.23
54_Q106_K0.6070.23
35_E46_V0.6070.23
59_R117_N0.6040.22
63_F140_V0.6040.22
119_K131_V0.6010.22
110_I130_I0.5980.22
86_P151_V0.5980.22
45_D65_E0.5910.22
137_S146_V0.5910.22
111_V146_V0.5870.22
74_A85_F0.5850.22
122_S129_Y0.5840.22
104_M112_A0.5830.22
59_R83_I0.5820.21
80_C96_I0.5810.21
107_E146_V0.5790.21
60_I118_V0.5780.21
67_L144_G0.5720.21
38_T42_L0.5690.21
149_K152_R0.5680.21
113_Y130_I0.5660.21
86_P102_I0.5620.21
67_L172_Y0.5600.20
49_I156_K0.5600.20
129_Y145_W0.5600.20
35_E42_L0.5590.20
80_C101_W0.5580.20
106_K117_N0.5560.20
40_N82_S0.5530.20
113_Y151_V0.5530.20
70_G87_P0.5490.20
84_Y117_N0.5430.20
88_Q118_V0.5410.20
62_K73_L0.5390.20
111_V150_E0.5360.19
33_V38_T0.5340.19
65_E153_V0.5330.19
104_M117_N0.5300.19
78_P142_V0.5300.19
39_N42_L0.5290.19
65_E138_N0.5290.19
117_N136_M0.5260.19
40_N97_S0.5250.19
90_D171_T0.5220.19
38_T81_G0.5210.19
88_Q95_K0.5210.19
131_V148_A0.5200.19
104_M138_N0.5180.19
116_V120_P0.5180.19
80_C141_N0.5180.19
117_N139_G0.5160.19
88_Q133_I0.5160.19
95_K171_T0.5140.19
163_E166_P0.5140.19
165_K168_G0.5140.19
91_C99_L0.5060.18
36_Q166_P0.5040.18
97_S149_K0.5020.18
100_E146_V0.5010.18
53_Y58_K0.5010.18
59_R140_V0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3irbA 3 0.7584 100 0.442 Contact Map
2kdxA 1 0.5506 87.1 0.917 Contact Map
4d02A 2 0.1629 84.5 0.919 Contact Map
1lkoA 3 0.5843 84.3 0.92 Contact Map
5aunA 1 0.5506 83.5 0.921 Contact Map
3pwfA 4 0.4888 83.3 0.921 Contact Map
2lcqA 1 0.573 79.9 0.923 Contact Map
1yuzA 2 0.4888 78.7 0.924 Contact Map
1s24A 1 0.2022 71.7 0.929 Contact Map
4aybP 1 0.2135 64.4 0.932 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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