Q97UW8 - SULSO - GREMLIN Contacts

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Q97UW8 - Acetyl-CoA c-acetyltransferase (Acetoacetyl-CoA thiolase) (AcaB-9)

UniProt:	Q97UW8	Sequences: MRNVAIIGTGHTKFGVRTDVNLQELAWEAVKQALEEANIDQNEIQYFVVGNVGNWSSEELPAVIVGEYCNLTPKGTMRVEAACSTGSAAIRDAYLAIKSGEADIALVVGVEQMHQAPNPQVVELIGRAGGYFWEFENFGLTFPGYYALHASAYMAKYGMKEEDLGKIAIKNHYYGAKNPYAQFQKEITMEEYLKSKPVAYPLKLLDSSPITDGAAAIVLASEEVAKKITDSPVWIVSQGVASGTANLSRRTDFTHIEAAHIAAQQAYKRARIEFDNAWKNFDVADVHDCFTIAEIMAYEDLGFAKRGEGYLLAREEQTYIGGKIPVNVDGGLKAKGHPIGATGVSMAVSITRQLLYRAHKGTQVEVRNGMGITHNVGGTGHYAYVTIYSTRRPST	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	395 (348)
Sequences:	15455 (8586)
Seq/√Len:	460.2

ECOLI - ATOB PAAJ YQEF FADA FADI
BACSU - THL FADA YHFS
HALSA - Q9HRI8 Q9HQZ8 Q9HNK4
SULSO - Q97UW8 Q97VJ9 Q97WQ6 Q97VD4 Q97VU9 Q97UA5 Q97WQ7 Q7LXW2 Q97VV9 Q97W61

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
170_K	174_Y	3.490	1.00
3_N	222_E	3.457	1.00
224_V	228_I	3.372	1.00
163_D	299_E	3.340	1.00
102_A	105_A	3.058	1.00
169_I	189_M	2.963	1.00
90_I	347_A	2.859	1.00
32_Q	35_E	2.822	1.00
273_E	279_K	2.748	1.00
170_K	173_Y	2.708	1.00
222_E	226_K	2.708	1.00
224_V	227_K	2.682	1.00
177_K	181_A	2.679	1.00
155_A	200_Y	2.633	1.00
350_I	369_G	2.623	1.00
30_V	106_L	2.445	1.00
266_A	270_A	2.427	1.00
9_T	348_V	2.413	1.00
5_A	225_A	2.383	1.00
97_I	219_L	2.370	1.00
10_G	36_E	2.317	1.00
33_A	218_V	2.238	1.00
266_A	384_Y	2.229	1.00
104_I	220_A	2.180	1.00
233_V	351_T	2.174	1.00
93_A	105_A	2.131	1.00
160_K	163_D	2.102	1.00
237_S	270_A	2.071	1.00
7_I	220_A	2.048	1.00
97_I	221_S	2.034	1.00
26_A	49_V	2.034	1.00
3_N	234_W	1.998	1.00
272_I	368_N	1.980	1.00
40_D	43_E	1.954	1.00
354_L	359_H	1.924	1.00
283_V	328_V	1.906	1.00
162_E	166_K	1.892	1.00
43_E	228_I	1.808	1.00
192_Y	205_L	1.789	1.00
153_Y	159_M	1.784	1.00
215_A	344_V	1.781	1.00
244_T	252_D	1.763	1.00
298_Y	305_K	1.744	1.00
298_Y	326_V	1.736	1.00
103_D	224_V	1.729	1.00
355_L	387_I	1.725	1.00
103_D	221_S	1.695	1.00
220_A	224_V	1.692	1.00
263_A	372_I	1.692	1.00
360_K	368_N	1.689	1.00
237_S	266_A	1.687	1.00
176_A	180_Y	1.686	1.00
264_Q	268_K	1.666	1.00
221_S	224_V	1.654	1.00
353_Q	357_R	1.647	1.00
191_E	194_K	1.641	1.00
282_D	359_H	1.641	1.00
329_D	353_Q	1.632	1.00
278_W	284_A	1.631	1.00
33_A	37_A	1.628	1.00
169_I	173_Y	1.622	1.00
179_P	187_I	1.621	1.00
281_F	284_A	1.620	1.00
156_K	253_F	1.615	1.00
8_G	37_A	1.607	1.00
182_Q	329_D	1.598	1.00
49_V	108_V	1.595	1.00
220_A	225_A	1.593	1.00
77_M	92_D	1.589	1.00
281_F	370_M	1.587	1.00
350_I	371_G	1.582	1.00
95_L	101_E	1.575	1.00
234_W	386_T	1.574	1.00
272_I	281_F	1.573	1.00
5_A	234_W	1.572	1.00
96_A	102_A	1.556	1.00
24_E	68_Y	1.547	1.00
217_I	344_V	1.543	1.00
147_A	199_A	1.537	1.00
166_K	170_K	1.528	1.00
261_I	264_Q	1.519	1.00
170_K	305_K	1.493	1.00
26_A	65_V	1.492	1.00
283_V	353_Q	1.485	1.00
104_I	224_V	1.479	1.00
166_K	189_M	1.473	1.00
30_V	65_V	1.469	1.00
112_Q	115_Q	1.451	1.00
93_A	219_L	1.446	1.00
31_K	35_E	1.429	1.00
29_A	216_A	1.424	1.00
353_Q	356_Y	1.417	1.00
173_Y	177_K	1.413	1.00
239_G	265_Q	1.401	1.00
32_Q	36_E	1.399	1.00
272_I	384_Y	1.390	1.00
265_Q	268_K	1.374	1.00
29_A	214_A	1.371	1.00
185_K	355_L	1.359	1.00
281_F	384_Y	1.345	1.00
8_G	33_A	1.342	1.00
351_T	355_L	1.329	1.00
20_V	28_E	1.328	1.00
267_Y	278_W	1.327	1.00
151_S	200_Y	1.324	1.00
14_F	341_A	1.312	1.00
239_G	266_A	1.312	1.00
61_P	110_V	1.302	1.00
27_W	68_Y	1.297	1.00
182_Q	353_Q	1.283	1.00
84_S	381_H	1.278	1.00
281_F	368_N	1.277	1.00
91_R	238_Q	1.271	1.00
73_P	244_T	1.269	1.00
223_E	227_K	1.269	1.00
91_R	383_A	1.266	1.00
304_A	325_P	1.265	1.00
284_A	370_M	1.263	1.00
45_Q	102_A	1.257	1.00
264_Q	300_D	1.243	1.00
347_A	385_V	1.237	1.00
90_I	217_I	1.221	1.00
4_V	219_L	1.220	1.00
159_M	164_L	1.213	1.00
348_V	352_R	1.206	1.00
163_D	166_K	1.205	1.00
55_W	58_E	1.201	1.00
241_A	261_I	1.194	1.00
44_I	104_I	1.193	1.00
28_E	32_Q	1.191	1.00
49_V	216_A	1.187	1.00
328_V	353_Q	1.183	1.00
43_E	224_V	1.183	1.00
370_M	384_Y	1.181	1.00
161_E	203_K	1.181	1.00
51_N	54_N	1.177	1.00
360_K	386_T	1.177	1.00
106_L	218_V	1.175	1.00
273_E	280_N	1.175	1.00
148_L	200_Y	1.171	1.00
5_A	222_E	1.149	1.00
260_H	264_Q	1.149	1.00
14_F	335_K	1.138	1.00
45_Q	103_D	1.128	1.00
9_T	352_R	1.118	1.00
84_S	375_N	1.116	1.00
9_T	351_T	1.114	1.00
93_A	107_V	1.113	1.00
156_K	252_D	1.112	1.00
87_S	347_A	1.110	1.00
236_V	386_T	1.105	1.00
182_Q	356_Y	1.099	1.00
152_A	156_K	1.096	1.00
167_I	295_I	1.094	1.00
167_I	294_E	1.092	1.00
179_P	184_Q	1.084	1.00
278_W	281_F	1.081	1.00
48_V	105_A	1.080	1.00
237_S	269_R	1.078	1.00
101_E	269_R	1.071	1.00
5_A	220_A	1.067	1.00
253_F	256_I	1.057	1.00
185_K	356_Y	1.056	1.00
263_A	370_M	1.055	1.00
236_V	368_N	1.051	1.00
188_T	191_E	1.048	1.00
262_A	382_Y	1.047	1.00
88_A	92_D	1.046	1.00
169_I	192_Y	1.041	1.00
283_V	357_R	1.039	1.00
30_V	71_L	1.036	1.00
90_I	219_L	1.033	1.00
173_Y	176_A	1.031	1.00
10_G	32_Q	1.030	1.00
147_A	198_V	1.029	1.00
189_M	193_L	1.027	1.00
282_D	325_P	1.027	1.00
256_I	260_H	1.024	1.00
95_L	99_S	1.024	1.00
358_A	387_I	1.021	1.00
243_G	256_I	1.021	1.00
241_A	265_Q	1.017	1.00
270_A	384_Y	1.016	1.00
98_K	101_E	1.013	1.00
43_E	227_K	1.010	1.00
345_S	349_S	0.998	1.00
159_M	295_I	0.994	1.00
27_W	31_K	0.993	1.00
235_I	383_A	0.991	1.00
8_G	36_E	0.990	1.00
47_F	66_G	0.988	1.00
14_F	211_T	0.981	1.00
151_S	155_A	0.978	1.00
50_G	85_T	0.978	1.00
222_E	234_W	0.976	1.00
3_N	98_K	0.967	1.00
282_D	354_L	0.965	1.00
21_N	24_E	0.962	1.00
186_E	349_S	0.952	1.00
195_S	205_L	0.949	1.00
34_L	71_L	0.941	1.00
129_G	132_F	0.939	1.00
256_I	300_D	0.937	1.00
328_V	357_R	0.933	1.00
329_D	356_Y	0.933	1.00
215_A	341_A	0.927	1.00
162_E	193_L	0.927	1.00
265_Q	269_R	0.926	1.00
7_I	230_D	0.925	1.00
29_A	32_Q	0.917	1.00
157_Y	256_I	0.917	1.00
286_V	372_I	0.913	1.00
303_F	326_V	0.911	1.00
94_Y	235_I	0.910	1.00
118_N	123_E	0.909	1.00
154_M	292_I	0.905	1.00
13_K	28_E	0.899	1.00
284_A	303_F	0.897	1.00
237_S	384_Y	0.894	1.00
9_T	217_I	0.894	1.00
263_A	301_L	0.887	1.00
131_Y	134_E	0.886	1.00
4_V	221_S	0.883	1.00
71_L	74_K	0.882	1.00
157_Y	300_D	0.881	1.00
132_F	135_F	0.879	1.00
94_Y	98_K	0.877	1.00
185_K	352_R	0.875	1.00
48_V	89_A	0.868	1.00
34_L	39_I	0.866	1.00
12_T	28_E	0.866	1.00
283_V	350_I	0.864	1.00
48_V	77_M	0.861	1.00
181_A	356_Y	0.860	1.00
33_A	106_L	0.859	1.00
153_Y	296_M	0.855	1.00
195_S	203_K	0.854	1.00
196_K	204_L	0.852	1.00
48_V	93_A	0.850	1.00
6_I	385_V	0.850	1.00
197_P	200_Y	0.848	1.00
346_M	371_G	0.848	1.00
12_T	29_A	0.845	1.00
152_A	155_A	0.841	1.00
165_G	206_D	0.840	1.00
67_E	73_P	0.840	1.00
14_F	345_S	0.839	1.00
291_T	333_K	0.838	1.00
260_H	300_D	0.838	1.00
368_N	384_Y	0.837	1.00
96_A	101_E	0.836	1.00
12_T	25_L	0.835	1.00
119_P	123_E	0.832	1.00
107_V	217_I	0.824	1.00
4_V	94_Y	0.824	1.00
215_A	348_V	0.820	1.00
153_Y	256_I	0.820	1.00
332_L	342_T	0.816	1.00
223_E	226_K	0.815	1.00
26_A	108_V	0.813	1.00
359_H	368_N	0.810	1.00
130_G	134_E	0.810	1.00
43_E	104_I	0.808	1.00
20_V	24_E	0.808	1.00
220_A	230_D	0.807	1.00
101_E	238_Q	0.807	1.00
170_K	306_R	0.807	1.00
231_S	355_L	0.806	1.00
46_Y	96_A	0.802	1.00
375_N	381_H	0.799	1.00
273_E	278_W	0.799	1.00
235_I	238_Q	0.798	1.00
81_A	88_A	0.795	1.00
130_G	133_W	0.795	1.00
222_E	225_A	0.794	1.00
256_I	296_M	0.794	1.00
128_A	132_F	0.791	1.00
127_R	130_G	0.790	1.00
174_Y	177_K	0.789	1.00
89_A	344_V	0.787	1.00
169_I	188_T	0.787	1.00
294_E	298_Y	0.786	1.00
162_E	189_M	0.785	1.00
243_G	261_I	0.784	1.00
127_R	131_Y	0.781	1.00
34_L	44_I	0.781	1.00
55_W	59_E	0.777	1.00
22_L	110_V	0.776	1.00
347_A	383_A	0.772	1.00
47_F	74_K	0.771	1.00
45_Q	265_Q	0.769	1.00
33_A	216_A	0.767	1.00
243_G	258_A	0.767	1.00
137_N	141_T	0.764	1.00
329_D	357_R	0.762	1.00
282_D	368_N	0.761	1.00
106_L	216_A	0.761	1.00
4_V	98_K	0.759	1.00
298_Y	303_F	0.758	1.00
177_K	180_Y	0.756	1.00
91_R	381_H	0.754	1.00
29_A	33_A	0.752	1.00
92_D	96_A	0.751	1.00
92_D	95_L	0.749	1.00
10_G	29_A	0.749	1.00
206_D	291_T	0.749	1.00
284_A	372_I	0.748	1.00
264_Q	301_L	0.741	1.00
31_K	41_Q	0.739	1.00
175_G	179_P	0.737	1.00
190_E	194_K	0.736	1.00
51_N	57_S	0.735	1.00
150_A	292_I	0.732	1.00
240_V	381_H	0.731	1.00
44_I	106_L	0.728	1.00
169_I	191_E	0.726	1.00
122_V	125_I	0.725	1.00
163_D	295_I	0.725	1.00
28_E	31_K	0.721	1.00
272_I	280_N	0.719	1.00
149_H	254_T	0.718	1.00
4_V	97_I	0.716	1.00
119_P	122_V	0.715	1.00
118_N	124_L	0.713	1.00
202_L	207_S	0.712	1.00
368_N	386_T	0.711	1.00
267_Y	272_I	0.709	1.00
95_L	98_K	0.705	1.00
6_I	351_T	0.705	1.00
87_S	383_A	0.704	1.00
123_E	128_A	0.700	1.00
279_K	325_P	0.700	1.00
114_H	212_D	0.699	1.00
34_L	41_Q	0.699	1.00
128_A	131_Y	0.699	1.00
71_L	106_L	0.698	1.00
148_L	152_A	0.696	1.00
49_V	62_A	0.694	1.00
52_V	339_I	0.692	1.00
135_F	145_Y	0.691	1.00
45_Q	105_A	0.690	1.00
286_V	297_A	0.688	1.00
175_G	334_A	0.687	1.00
87_S	371_G	0.683	1.00
51_N	61_P	0.681	1.00
351_T	385_V	0.681	1.00
279_K	302_G	0.670	1.00
153_Y	157_Y	0.668	1.00
263_A	382_Y	0.668	1.00
46_Y	240_V	0.668	1.00
177_K	182_Q	0.665	1.00
296_M	300_D	0.665	1.00
96_A	105_A	0.664	1.00
30_V	69_C	0.664	1.00
81_A	240_V	0.664	1.00
354_L	369_G	0.663	1.00
48_V	92_D	0.663	1.00
21_N	115_Q	0.662	1.00
278_W	303_F	0.662	1.00
125_I	128_A	0.661	1.00
172_H	176_A	0.661	1.00
176_A	179_P	0.660	1.00
118_N	122_V	0.659	1.00
138_F	141_T	0.655	1.00
24_E	27_W	0.655	1.00
236_V	270_A	0.652	1.00
172_H	333_K	0.651	1.00
165_G	193_L	0.650	1.00
103_D	269_R	0.650	1.00
150_A	154_M	0.647	1.00
142_F	145_Y	0.647	1.00
75_G	240_V	0.646	1.00
263_A	286_V	0.646	1.00
49_V	65_V	0.644	1.00
30_V	216_A	0.644	1.00
23_Q	68_Y	0.644	1.00
219_L	235_I	0.642	1.00
10_G	33_A	0.642	1.00
5_A	221_S	0.636	0.99
118_N	121_V	0.635	0.99
104_I	228_I	0.634	0.99
137_N	140_L	0.634	0.99
103_D	227_K	0.634	0.99
124_L	127_R	0.633	0.99
189_M	192_Y	0.633	0.99
37_A	218_V	0.632	0.99
239_G	269_R	0.631	0.99
7_I	225_A	0.630	0.99
20_V	115_Q	0.627	0.99
263_A	278_W	0.621	0.99
294_E	326_V	0.619	0.99
31_K	69_C	0.618	0.99
79_V	92_D	0.618	0.99
31_K	70_N	0.617	0.99
244_T	253_F	0.617	0.99
217_I	348_V	0.615	0.99
44_I	71_L	0.613	0.99
159_M	163_D	0.613	0.99
26_A	110_V	0.612	0.99
198_V	204_L	0.611	0.99
34_L	38_N	0.610	0.99
266_A	370_M	0.610	0.99
27_W	69_C	0.609	0.99
5_A	224_V	0.608	0.99
93_A	102_A	0.608	0.99
272_I	370_M	0.607	0.99
66_G	71_L	0.604	0.99
20_V	112_Q	0.603	0.99
268_K	273_E	0.600	0.99
77_M	88_A	0.599	0.99
220_A	228_I	0.599	0.99
113_M	339_I	0.598	0.99
263_A	297_A	0.597	0.99
264_Q	302_G	0.597	0.99
125_I	135_F	0.595	0.99
46_Y	81_A	0.595	0.99
236_V	272_I	0.593	0.99
168_A	291_T	0.592	0.99
335_K	345_S	0.592	0.99
41_Q	72_T	0.591	0.99
90_I	107_V	0.591	0.99
282_D	360_K	0.590	0.99
66_G	76_T	0.587	0.99
127_R	132_F	0.587	0.99
174_Y	305_K	0.585	0.99
165_G	189_M	0.585	0.99
119_P	124_L	0.582	0.99
350_I	373_T	0.581	0.99
261_I	265_Q	0.581	0.99
289_C	337_H	0.579	0.99
150_A	202_L	0.579	0.99
108_V	216_A	0.578	0.99
54_N	78_R	0.576	0.99
342_T	346_M	0.576	0.99
135_F	141_T	0.575	0.99
233_V	354_L	0.574	0.99
65_V	69_C	0.574	0.99
159_M	299_E	0.574	0.99
293_A	297_A	0.573	0.99
166_K	305_K	0.572	0.99
147_A	201_P	0.571	0.99
188_T	192_Y	0.571	0.99
23_Q	57_S	0.570	0.99
34_L	37_A	0.567	0.99
347_A	371_G	0.565	0.99
98_K	238_Q	0.564	0.99
65_V	110_V	0.563	0.99
358_A	368_N	0.562	0.99
298_Y	304_A	0.562	0.99
30_V	47_F	0.560	0.99
229_T	232_P	0.560	0.99
157_Y	296_M	0.558	0.99
123_E	126_G	0.558	0.99
60_L	379_T	0.558	0.99
259_A	374_H	0.558	0.99
46_Y	102_A	0.557	0.99
30_V	34_L	0.557	0.99
7_I	224_V	0.557	0.99
175_G	335_K	0.556	0.99
39_I	218_V	0.555	0.99
47_F	106_L	0.555	0.99
6_I	219_L	0.555	0.99
10_G	37_A	0.553	0.99
267_Y	270_A	0.553	0.99
280_N	368_N	0.550	0.99
375_N	379_T	0.550	0.99
88_A	96_A	0.547	0.98
45_Q	74_K	0.547	0.98
88_A	91_R	0.545	0.98
172_H	209_P	0.543	0.98
295_I	299_E	0.543	0.98
19_D	115_Q	0.541	0.98
341_A	344_V	0.541	0.98
262_A	266_A	0.538	0.98
121_V	124_L	0.535	0.98
168_A	192_Y	0.535	0.98
263_A	267_Y	0.534	0.98
107_V	344_V	0.534	0.98
17_R	20_V	0.533	0.98
151_S	202_L	0.532	0.98
170_K	294_E	0.532	0.98
292_I	296_M	0.531	0.98
168_A	172_H	0.531	0.98
90_I	235_I	0.530	0.98
53_G	116_A	0.530	0.98
120_Q	125_I	0.530	0.98
96_A	99_S	0.530	0.98
89_A	107_V	0.530	0.98
140_L	143_P	0.528	0.98
177_K	360_K	0.527	0.98
157_Y	299_E	0.524	0.98
166_K	169_I	0.523	0.98
158_G	299_E	0.523	0.98
299_E	302_G	0.522	0.98
5_A	228_I	0.522	0.98
154_M	159_M	0.520	0.98
286_V	294_E	0.520	0.98
90_I	344_V	0.520	0.98
173_Y	186_E	0.519	0.98
173_Y	189_M	0.518	0.98
124_L	128_A	0.517	0.98
131_Y	135_F	0.517	0.98
145_Y	148_L	0.517	0.98
88_A	240_V	0.516	0.98
46_Y	105_A	0.515	0.98
52_V	82_A	0.515	0.98
126_G	135_F	0.514	0.98
7_I	104_I	0.514	0.98
182_Q	357_R	0.511	0.98
87_S	373_T	0.511	0.98
167_I	331_G	0.509	0.98
222_E	232_P	0.509	0.98
87_S	381_H	0.508	0.98
48_V	96_A	0.508	0.98
267_Y	281_F	0.508	0.98
123_E	127_R	0.507	0.98
335_K	349_S	0.505	0.97
56_S	59_E	0.504	0.97
85_T	340_G	0.503	0.97
331_G	334_A	0.502	0.97
187_I	205_L	0.501	0.97
63_V	67_E	0.500	0.97

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3zbgA	2	0.9671	100	0.237	Contact Map
4u4eA	1	0.8911	100	0.313	Contact Map
1ulqA	4	0.8911	100	0.356	Contact Map
1wdkC	2	0.881	100	0.357	Contact Map
2vu1A	4	0.8886	100	0.36	Contact Map
4e1lA	4	0.8709	100	0.361	Contact Map
4n46A	4	0.8886	100	0.363	Contact Map
2wu9A	2	0.8835	100	0.367	Contact Map
3goaA	2	0.8658	100	0.367	Contact Map
3ss6A	4	0.8861	100	0.372	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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