GREMLIN Database
Q97UW8 - Acetyl-CoA c-acetyltransferase (Acetoacetyl-CoA thiolase) (AcaB-9)
UniProt: Q97UW8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 395 (348)
Sequences: 15455 (8586)
Seq/√Len: 460.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
170_K174_Y3.4901.00
3_N222_E3.4571.00
224_V228_I3.3721.00
163_D299_E3.3401.00
102_A105_A3.0581.00
169_I189_M2.9631.00
90_I347_A2.8591.00
32_Q35_E2.8221.00
273_E279_K2.7481.00
170_K173_Y2.7081.00
222_E226_K2.7081.00
224_V227_K2.6821.00
177_K181_A2.6791.00
155_A200_Y2.6331.00
350_I369_G2.6231.00
30_V106_L2.4451.00
266_A270_A2.4271.00
9_T348_V2.4131.00
5_A225_A2.3831.00
97_I219_L2.3701.00
10_G36_E2.3171.00
33_A218_V2.2381.00
266_A384_Y2.2291.00
104_I220_A2.1801.00
233_V351_T2.1741.00
93_A105_A2.1311.00
160_K163_D2.1021.00
237_S270_A2.0711.00
7_I220_A2.0481.00
97_I221_S2.0341.00
26_A49_V2.0341.00
3_N234_W1.9981.00
272_I368_N1.9801.00
40_D43_E1.9541.00
354_L359_H1.9241.00
283_V328_V1.9061.00
162_E166_K1.8921.00
43_E228_I1.8081.00
192_Y205_L1.7891.00
153_Y159_M1.7841.00
215_A344_V1.7811.00
244_T252_D1.7631.00
298_Y305_K1.7441.00
298_Y326_V1.7361.00
103_D224_V1.7291.00
355_L387_I1.7251.00
103_D221_S1.6951.00
220_A224_V1.6921.00
263_A372_I1.6921.00
360_K368_N1.6891.00
237_S266_A1.6871.00
176_A180_Y1.6861.00
264_Q268_K1.6661.00
221_S224_V1.6541.00
353_Q357_R1.6471.00
191_E194_K1.6411.00
282_D359_H1.6411.00
329_D353_Q1.6321.00
278_W284_A1.6311.00
33_A37_A1.6281.00
169_I173_Y1.6221.00
179_P187_I1.6211.00
281_F284_A1.6201.00
156_K253_F1.6151.00
8_G37_A1.6071.00
182_Q329_D1.5981.00
49_V108_V1.5951.00
220_A225_A1.5931.00
77_M92_D1.5891.00
281_F370_M1.5871.00
350_I371_G1.5821.00
95_L101_E1.5751.00
234_W386_T1.5741.00
272_I281_F1.5731.00
5_A234_W1.5721.00
96_A102_A1.5561.00
24_E68_Y1.5471.00
217_I344_V1.5431.00
147_A199_A1.5371.00
166_K170_K1.5281.00
261_I264_Q1.5191.00
170_K305_K1.4931.00
26_A65_V1.4921.00
283_V353_Q1.4851.00
104_I224_V1.4791.00
166_K189_M1.4731.00
30_V65_V1.4691.00
112_Q115_Q1.4511.00
93_A219_L1.4461.00
31_K35_E1.4291.00
29_A216_A1.4241.00
353_Q356_Y1.4171.00
173_Y177_K1.4131.00
239_G265_Q1.4011.00
32_Q36_E1.3991.00
272_I384_Y1.3901.00
265_Q268_K1.3741.00
29_A214_A1.3711.00
185_K355_L1.3591.00
281_F384_Y1.3451.00
8_G33_A1.3421.00
351_T355_L1.3291.00
20_V28_E1.3281.00
267_Y278_W1.3271.00
151_S200_Y1.3241.00
14_F341_A1.3121.00
239_G266_A1.3121.00
61_P110_V1.3021.00
27_W68_Y1.2971.00
182_Q353_Q1.2831.00
84_S381_H1.2781.00
281_F368_N1.2771.00
91_R238_Q1.2711.00
73_P244_T1.2691.00
223_E227_K1.2691.00
91_R383_A1.2661.00
304_A325_P1.2651.00
284_A370_M1.2631.00
45_Q102_A1.2571.00
264_Q300_D1.2431.00
347_A385_V1.2371.00
90_I217_I1.2211.00
4_V219_L1.2201.00
159_M164_L1.2131.00
348_V352_R1.2061.00
163_D166_K1.2051.00
55_W58_E1.2011.00
241_A261_I1.1941.00
44_I104_I1.1931.00
28_E32_Q1.1911.00
49_V216_A1.1871.00
328_V353_Q1.1831.00
43_E224_V1.1831.00
370_M384_Y1.1811.00
161_E203_K1.1811.00
51_N54_N1.1771.00
360_K386_T1.1771.00
106_L218_V1.1751.00
273_E280_N1.1751.00
148_L200_Y1.1711.00
5_A222_E1.1491.00
260_H264_Q1.1491.00
14_F335_K1.1381.00
45_Q103_D1.1281.00
9_T352_R1.1181.00
84_S375_N1.1161.00
9_T351_T1.1141.00
93_A107_V1.1131.00
156_K252_D1.1121.00
87_S347_A1.1101.00
236_V386_T1.1051.00
182_Q356_Y1.0991.00
152_A156_K1.0961.00
167_I295_I1.0941.00
167_I294_E1.0921.00
179_P184_Q1.0841.00
278_W281_F1.0811.00
48_V105_A1.0801.00
237_S269_R1.0781.00
101_E269_R1.0711.00
5_A220_A1.0671.00
253_F256_I1.0571.00
185_K356_Y1.0561.00
263_A370_M1.0551.00
236_V368_N1.0511.00
188_T191_E1.0481.00
262_A382_Y1.0471.00
88_A92_D1.0461.00
169_I192_Y1.0411.00
283_V357_R1.0391.00
30_V71_L1.0361.00
90_I219_L1.0331.00
173_Y176_A1.0311.00
10_G32_Q1.0301.00
147_A198_V1.0291.00
189_M193_L1.0271.00
282_D325_P1.0271.00
256_I260_H1.0241.00
95_L99_S1.0241.00
358_A387_I1.0211.00
243_G256_I1.0211.00
241_A265_Q1.0171.00
270_A384_Y1.0161.00
98_K101_E1.0131.00
43_E227_K1.0101.00
345_S349_S0.9981.00
159_M295_I0.9941.00
27_W31_K0.9931.00
235_I383_A0.9911.00
8_G36_E0.9901.00
47_F66_G0.9881.00
14_F211_T0.9811.00
151_S155_A0.9781.00
50_G85_T0.9781.00
222_E234_W0.9761.00
3_N98_K0.9671.00
282_D354_L0.9651.00
21_N24_E0.9621.00
186_E349_S0.9521.00
195_S205_L0.9491.00
34_L71_L0.9411.00
129_G132_F0.9391.00
256_I300_D0.9371.00
328_V357_R0.9331.00
329_D356_Y0.9331.00
215_A341_A0.9271.00
162_E193_L0.9271.00
265_Q269_R0.9261.00
7_I230_D0.9251.00
29_A32_Q0.9171.00
157_Y256_I0.9171.00
286_V372_I0.9131.00
303_F326_V0.9111.00
94_Y235_I0.9101.00
118_N123_E0.9091.00
154_M292_I0.9051.00
13_K28_E0.8991.00
284_A303_F0.8971.00
237_S384_Y0.8941.00
9_T217_I0.8941.00
263_A301_L0.8871.00
131_Y134_E0.8861.00
4_V221_S0.8831.00
71_L74_K0.8821.00
157_Y300_D0.8811.00
132_F135_F0.8791.00
94_Y98_K0.8771.00
185_K352_R0.8751.00
48_V89_A0.8681.00
34_L39_I0.8661.00
12_T28_E0.8661.00
283_V350_I0.8641.00
48_V77_M0.8611.00
181_A356_Y0.8601.00
33_A106_L0.8591.00
153_Y296_M0.8551.00
195_S203_K0.8541.00
196_K204_L0.8521.00
48_V93_A0.8501.00
6_I385_V0.8501.00
197_P200_Y0.8481.00
346_M371_G0.8481.00
12_T29_A0.8451.00
152_A155_A0.8411.00
165_G206_D0.8401.00
67_E73_P0.8401.00
14_F345_S0.8391.00
291_T333_K0.8381.00
260_H300_D0.8381.00
368_N384_Y0.8371.00
96_A101_E0.8361.00
12_T25_L0.8351.00
119_P123_E0.8321.00
107_V217_I0.8241.00
4_V94_Y0.8241.00
215_A348_V0.8201.00
153_Y256_I0.8201.00
332_L342_T0.8161.00
223_E226_K0.8151.00
26_A108_V0.8131.00
359_H368_N0.8101.00
130_G134_E0.8101.00
43_E104_I0.8081.00
20_V24_E0.8081.00
220_A230_D0.8071.00
101_E238_Q0.8071.00
170_K306_R0.8071.00
231_S355_L0.8061.00
46_Y96_A0.8021.00
375_N381_H0.7991.00
273_E278_W0.7991.00
235_I238_Q0.7981.00
81_A88_A0.7951.00
130_G133_W0.7951.00
222_E225_A0.7941.00
256_I296_M0.7941.00
128_A132_F0.7911.00
127_R130_G0.7901.00
174_Y177_K0.7891.00
89_A344_V0.7871.00
169_I188_T0.7871.00
294_E298_Y0.7861.00
162_E189_M0.7851.00
243_G261_I0.7841.00
127_R131_Y0.7811.00
34_L44_I0.7811.00
55_W59_E0.7771.00
22_L110_V0.7761.00
347_A383_A0.7721.00
47_F74_K0.7711.00
45_Q265_Q0.7691.00
33_A216_A0.7671.00
243_G258_A0.7671.00
137_N141_T0.7641.00
329_D357_R0.7621.00
282_D368_N0.7611.00
106_L216_A0.7611.00
4_V98_K0.7591.00
298_Y303_F0.7581.00
177_K180_Y0.7561.00
91_R381_H0.7541.00
29_A33_A0.7521.00
92_D96_A0.7511.00
92_D95_L0.7491.00
10_G29_A0.7491.00
206_D291_T0.7491.00
284_A372_I0.7481.00
264_Q301_L0.7411.00
31_K41_Q0.7391.00
175_G179_P0.7371.00
190_E194_K0.7361.00
51_N57_S0.7351.00
150_A292_I0.7321.00
240_V381_H0.7311.00
44_I106_L0.7281.00
169_I191_E0.7261.00
122_V125_I0.7251.00
163_D295_I0.7251.00
28_E31_K0.7211.00
272_I280_N0.7191.00
149_H254_T0.7181.00
4_V97_I0.7161.00
119_P122_V0.7151.00
118_N124_L0.7131.00
202_L207_S0.7121.00
368_N386_T0.7111.00
267_Y272_I0.7091.00
95_L98_K0.7051.00
6_I351_T0.7051.00
87_S383_A0.7041.00
123_E128_A0.7001.00
279_K325_P0.7001.00
114_H212_D0.6991.00
34_L41_Q0.6991.00
128_A131_Y0.6991.00
71_L106_L0.6981.00
148_L152_A0.6961.00
49_V62_A0.6941.00
52_V339_I0.6921.00
135_F145_Y0.6911.00
45_Q105_A0.6901.00
286_V297_A0.6881.00
175_G334_A0.6871.00
87_S371_G0.6831.00
51_N61_P0.6811.00
351_T385_V0.6811.00
279_K302_G0.6701.00
153_Y157_Y0.6681.00
263_A382_Y0.6681.00
46_Y240_V0.6681.00
177_K182_Q0.6651.00
296_M300_D0.6651.00
96_A105_A0.6641.00
30_V69_C0.6641.00
81_A240_V0.6641.00
354_L369_G0.6631.00
48_V92_D0.6631.00
21_N115_Q0.6621.00
278_W303_F0.6621.00
125_I128_A0.6611.00
172_H176_A0.6611.00
176_A179_P0.6601.00
118_N122_V0.6591.00
138_F141_T0.6551.00
24_E27_W0.6551.00
236_V270_A0.6521.00
172_H333_K0.6511.00
165_G193_L0.6501.00
103_D269_R0.6501.00
150_A154_M0.6471.00
142_F145_Y0.6471.00
75_G240_V0.6461.00
263_A286_V0.6461.00
49_V65_V0.6441.00
30_V216_A0.6441.00
23_Q68_Y0.6441.00
219_L235_I0.6421.00
10_G33_A0.6421.00
5_A221_S0.6360.99
118_N121_V0.6350.99
104_I228_I0.6340.99
137_N140_L0.6340.99
103_D227_K0.6340.99
124_L127_R0.6330.99
189_M192_Y0.6330.99
37_A218_V0.6320.99
239_G269_R0.6310.99
7_I225_A0.6300.99
20_V115_Q0.6270.99
263_A278_W0.6210.99
294_E326_V0.6190.99
31_K69_C0.6180.99
79_V92_D0.6180.99
31_K70_N0.6170.99
244_T253_F0.6170.99
217_I348_V0.6150.99
44_I71_L0.6130.99
159_M163_D0.6130.99
26_A110_V0.6120.99
198_V204_L0.6110.99
34_L38_N0.6100.99
266_A370_M0.6100.99
27_W69_C0.6090.99
5_A224_V0.6080.99
93_A102_A0.6080.99
272_I370_M0.6070.99
66_G71_L0.6040.99
20_V112_Q0.6030.99
268_K273_E0.6000.99
77_M88_A0.5990.99
220_A228_I0.5990.99
113_M339_I0.5980.99
263_A297_A0.5970.99
264_Q302_G0.5970.99
125_I135_F0.5950.99
46_Y81_A0.5950.99
236_V272_I0.5930.99
168_A291_T0.5920.99
335_K345_S0.5920.99
41_Q72_T0.5910.99
90_I107_V0.5910.99
282_D360_K0.5900.99
66_G76_T0.5870.99
127_R132_F0.5870.99
174_Y305_K0.5850.99
165_G189_M0.5850.99
119_P124_L0.5820.99
350_I373_T0.5810.99
261_I265_Q0.5810.99
289_C337_H0.5790.99
150_A202_L0.5790.99
108_V216_A0.5780.99
54_N78_R0.5760.99
342_T346_M0.5760.99
135_F141_T0.5750.99
233_V354_L0.5740.99
65_V69_C0.5740.99
159_M299_E0.5740.99
293_A297_A0.5730.99
166_K305_K0.5720.99
147_A201_P0.5710.99
188_T192_Y0.5710.99
23_Q57_S0.5700.99
34_L37_A0.5670.99
347_A371_G0.5650.99
98_K238_Q0.5640.99
65_V110_V0.5630.99
358_A368_N0.5620.99
298_Y304_A0.5620.99
30_V47_F0.5600.99
229_T232_P0.5600.99
157_Y296_M0.5580.99
123_E126_G0.5580.99
60_L379_T0.5580.99
259_A374_H0.5580.99
46_Y102_A0.5570.99
30_V34_L0.5570.99
7_I224_V0.5570.99
175_G335_K0.5560.99
39_I218_V0.5550.99
47_F106_L0.5550.99
6_I219_L0.5550.99
10_G37_A0.5530.99
267_Y270_A0.5530.99
280_N368_N0.5500.99
375_N379_T0.5500.99
88_A96_A0.5470.98
45_Q74_K0.5470.98
88_A91_R0.5450.98
172_H209_P0.5430.98
295_I299_E0.5430.98
19_D115_Q0.5410.98
341_A344_V0.5410.98
262_A266_A0.5380.98
121_V124_L0.5350.98
168_A192_Y0.5350.98
263_A267_Y0.5340.98
107_V344_V0.5340.98
17_R20_V0.5330.98
151_S202_L0.5320.98
170_K294_E0.5320.98
292_I296_M0.5310.98
168_A172_H0.5310.98
90_I235_I0.5300.98
53_G116_A0.5300.98
120_Q125_I0.5300.98
96_A99_S0.5300.98
89_A107_V0.5300.98
140_L143_P0.5280.98
177_K360_K0.5270.98
157_Y299_E0.5240.98
166_K169_I0.5230.98
158_G299_E0.5230.98
299_E302_G0.5220.98
5_A228_I0.5220.98
154_M159_M0.5200.98
286_V294_E0.5200.98
90_I344_V0.5200.98
173_Y186_E0.5190.98
173_Y189_M0.5180.98
124_L128_A0.5170.98
131_Y135_F0.5170.98
145_Y148_L0.5170.98
88_A240_V0.5160.98
46_Y105_A0.5150.98
52_V82_A0.5150.98
126_G135_F0.5140.98
7_I104_I0.5140.98
182_Q357_R0.5110.98
87_S373_T0.5110.98
167_I331_G0.5090.98
222_E232_P0.5090.98
87_S381_H0.5080.98
48_V96_A0.5080.98
267_Y281_F0.5080.98
123_E127_R0.5070.98
335_K349_S0.5050.97
56_S59_E0.5040.97
85_T340_G0.5030.97
331_G334_A0.5020.97
187_I205_L0.5010.97
63_V67_E0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zbgA 2 0.9671 100 0.237 Contact Map
4u4eA 1 0.8911 100 0.313 Contact Map
1ulqA 4 0.8911 100 0.356 Contact Map
1wdkC 2 0.881 100 0.357 Contact Map
2vu1A 4 0.8886 100 0.36 Contact Map
4e1lA 4 0.8709 100 0.361 Contact Map
4n46A 4 0.8886 100 0.363 Contact Map
2wu9A 2 0.8835 100 0.367 Contact Map
3goaA 2 0.8658 100 0.367 Contact Map
3ss6A 4 0.8861 100 0.372 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0104 seconds.