GREMLIN Database
Q97UW6 - Acyl-CoA dehydrogenase (Acd-6)
UniProt: Q97UW6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 400 (370)
Sequences: 33753 (19163)
Seq/√Len: 996.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
156_K230_E4.0321.00
160_N228_D3.8371.00
303_E343_K3.4111.00
33_D54_K3.2581.00
153_I230_E2.9171.00
206_K227_E2.8971.00
152_K233_A2.8561.00
122_P127_D2.8541.00
113_E117_K2.8351.00
27_R85_E2.7611.00
40_K44_E2.7381.00
194_S236_L2.6961.00
75_D78_M2.6941.00
296_K347_R2.4111.00
275_T279_Q2.3451.00
122_P128_K2.2991.00
267_Q308_R2.2291.00
162_R225_A2.2191.00
286_P289_G2.0841.00
316_N320_R2.0671.00
179_A196_F2.0541.00
239_E242_N2.0501.00
28_E32_R2.0391.00
153_I156_K2.0241.00
113_E116_K2.0091.00
112_N115_Q1.9941.00
359_T364_E1.9631.00
277_S351_V1.9351.00
364_E368_R1.9241.00
84_E308_R1.9131.00
66_P108_L1.9071.00
242_N245_K1.8821.00
175_Y200_R1.8331.00
157_Y196_F1.7941.00
162_R223_E1.7871.00
339_D380_N1.7861.00
19_H78_M1.7711.00
54_K57_E1.7421.00
53_E57_E1.7331.00
270_L304_V1.7321.00
88_R271_E1.7201.00
153_I158_V1.7111.00
169_G222_A1.7091.00
267_Q271_E1.6931.00
152_K240_E1.6701.00
281_F286_P1.6671.00
131_A175_Y1.6401.00
151_K160_N1.6371.00
85_E88_R1.6311.00
292_M295_E1.6291.00
135_T165_F1.6221.00
232_P235_N1.6031.00
277_S293_V1.5941.00
317_L329_A1.5861.00
300_S344_V1.5851.00
202_W229_V1.5761.00
236_L240_E1.5691.00
158_V230_E1.5671.00
118_K234_E1.5651.00
158_V228_D1.5421.00
199_E235_N1.5391.00
118_K122_P1.5351.00
206_K225_A1.5281.00
67_E73_G1.5201.00
30_M89_V1.5121.00
313_W317_L1.5061.00
157_Y233_A1.5061.00
24_R28_E1.4971.00
20_E23_R1.4971.00
122_P125_R1.4951.00
160_N227_E1.4921.00
306_T336_Y1.4861.00
355_Y361_T1.4821.00
282_A290_F1.4721.00
19_H75_D1.4691.00
69_Y116_K1.4601.00
117_K121_T1.4581.00
136_E163_K1.4541.00
21_L24_R1.4521.00
285_S289_G1.4451.00
293_V351_V1.4381.00
307_A337_A1.4361.00
155_G233_A1.4341.00
269_A345_A1.4341.00
233_A236_L1.4271.00
152_K156_K1.4181.00
21_L25_A1.4121.00
90_W93_L1.4081.00
159_I196_F1.4001.00
272_R275_T1.3961.00
305_N313_W1.3931.00
272_R362_G1.3811.00
150_A196_F1.3751.00
268_A272_R1.3731.00
274_V278_T1.3721.00
199_E202_W1.3581.00
342_E374_R1.3571.00
114_E118_K1.3531.00
19_H81_I1.3511.00
88_R267_Q1.3491.00
84_E312_Y1.3401.00
343_K347_R1.3381.00
335_L380_N1.3351.00
346_I371_E1.3321.00
300_S347_R1.3291.00
170_G222_A1.3271.00
63_V82_A1.3221.00
212_E359_T1.3221.00
156_K233_A1.3201.00
77_L316_N1.3191.00
23_R85_E1.3191.00
26_V60_L1.3151.00
231_V235_N1.3071.00
49_K53_E1.3041.00
110_F249_A1.2961.00
114_E234_E1.2881.00
84_E267_Q1.2801.00
43_K212_E1.2741.00
123_V130_A1.2711.00
208_L225_A1.2661.00
208_L223_E1.2631.00
76_T319_D1.2571.00
299_E384_K1.2551.00
115_Q119_Y1.2541.00
155_G230_E1.2471.00
17_E20_E1.2431.00
133_A166_I1.2251.00
270_L274_V1.2251.00
152_K157_Y1.2231.00
41_G218_A1.2231.00
20_E24_R1.2201.00
266_A304_V1.2191.00
266_A344_V1.2051.00
304_V344_V1.2041.00
181_T194_S1.2011.00
121_T125_R1.2001.00
116_K120_V1.1991.00
273_M348_A1.1981.00
200_R205_V1.1951.00
346_I374_R1.1941.00
260_A311_T1.1931.00
205_V229_V1.1911.00
75_D319_D1.1881.00
202_W235_N1.1871.00
341_A370_V1.1841.00
313_W316_N1.1831.00
80_A315_A1.1811.00
65_V124_A1.1801.00
74_G78_M1.1781.00
17_E21_L1.1741.00
254_T377_E1.1711.00
348_A363_V1.1691.00
252_D327_I1.1651.00
244_F248_M1.1631.00
151_K158_V1.1581.00
53_E56_K1.1531.00
23_R81_I1.1501.00
87_S94_S1.1491.00
268_A366_L1.1481.00
272_R352_H1.1461.00
128_K173_D1.1401.00
119_Y174_Y1.1381.00
118_K235_N1.1371.00
331_S383_Q1.1371.00
80_A260_A1.1361.00
317_L322_L1.1361.00
296_K381_D1.1311.00
301_L305_N1.1311.00
138_V147_Q1.1301.00
148_T159_I1.1271.00
204_G229_V1.1221.00
25_A58_I1.1181.00
285_S290_F1.1171.00
54_K58_I1.1131.00
149_V160_N1.1121.00
39_E43_K1.1121.00
37_Y41_G1.1121.00
178_T195_M1.1111.00
200_R207_V1.1051.00
115_Q197_I1.1041.00
307_A340_I1.1011.00
371_E374_R1.1001.00
111_G115_Q1.0941.00
342_E346_I1.0921.00
26_V30_M1.0851.00
159_I177_V1.0801.00
302_T332_M1.0791.00
177_V198_V1.0791.00
205_V224_L1.0751.00
68_Q117_K1.0671.00
303_E347_R1.0651.00
157_Y240_E1.0551.00
154_N230_E1.0511.00
230_E233_A1.0511.00
53_E127_D1.0491.00
263_V304_V1.0431.00
150_A179_A1.0421.00
130_A174_Y1.0401.00
56_K61_Y1.0381.00
374_R380_N1.0371.00
25_A60_L1.0361.00
133_A175_Y1.0351.00
178_T193_I1.0231.00
157_Y181_T1.0181.00
151_K228_D1.0181.00
114_E117_K1.0141.00
103_F130_A1.0121.00
177_V226_F1.0021.00
109_L249_A1.0011.00
159_I179_A0.9981.00
339_D343_K0.9971.00
335_L384_K0.9881.00
303_E340_I0.9871.00
50_E53_E0.9861.00
37_Y40_K0.9821.00
133_A226_F0.9771.00
278_T288_I0.9761.00
142_D145_G0.9751.00
345_A370_V0.9731.00
263_V311_T0.9711.00
262_G373_M0.9701.00
277_S287_L0.9671.00
196_F236_L0.9581.00
342_E367_L0.9531.00
274_V297_I0.9511.00
175_Y224_L0.9501.00
339_D374_R0.9471.00
29_F54_K0.9471.00
151_K182_S0.9441.00
309_L313_W0.9431.00
269_A366_L0.9421.00
175_Y205_V0.9351.00
194_S240_E0.9331.00
118_K199_E0.9241.00
27_R31_E0.9231.00
380_N384_K0.9231.00
103_F176_V0.9221.00
216_L372_V0.9191.00
299_E303_E0.9161.00
165_F355_Y0.9151.00
49_K173_D0.9131.00
65_V104_M0.9111.00
214_M367_L0.9101.00
203_K230_E0.9091.00
340_I343_K0.9081.00
29_F58_I0.9051.00
26_V82_A0.9031.00
42_E368_R0.9001.00
159_I231_V0.8981.00
115_Q235_N0.8981.00
169_G207_V0.8971.00
174_Y199_E0.8941.00
314_A333_A0.8901.00
110_F246_Y0.8891.00
68_Q113_E0.8861.00
277_S288_I0.8851.00
164_I223_E0.8851.00
131_A200_R0.8841.00
372_V376_Y0.8811.00
338_T380_N0.8781.00
68_Q71_G0.8761.00
301_L332_M0.8741.00
30_M86_I0.8731.00
339_D384_K0.8721.00
275_T278_T0.8701.00
77_L319_D0.8661.00
43_K359_T0.8641.00
271_E275_T0.8611.00
349_I367_L0.8601.00
303_E336_Y0.8511.00
277_S297_I0.8491.00
92_S218_A0.8471.00
295_E385_L0.8451.00
66_P69_Y0.8431.00
165_F358_A0.8421.00
180_R193_I0.8401.00
141_S382_I0.8401.00
265_V341_A0.8391.00
173_D201_E0.8391.00
112_N116_K0.8371.00
273_M351_V0.8351.00
131_A172_A0.8341.00
265_V366_L0.8341.00
134_N251_F0.8321.00
342_E371_E0.8301.00
273_M352_H0.8301.00
37_Y50_E0.8281.00
373_M376_Y0.8231.00
340_I344_V0.8211.00
133_A177_V0.8201.00
29_F55_A0.8201.00
215_G369_D0.8161.00
305_N308_R0.8161.00
55_A60_L0.8151.00
25_A28_E0.8141.00
31_E88_R0.8131.00
69_Y113_E0.8111.00
349_I363_V0.8091.00
345_A366_L0.8091.00
265_V370_V0.8081.00
295_E299_E0.8071.00
266_A340_I0.8051.00
194_S241_G0.8051.00
23_R27_R0.8041.00
77_L312_Y0.8021.00
157_Y236_L0.8001.00
214_M364_E0.8001.00
226_F229_V0.7991.00
77_L81_I0.7981.00
128_K174_Y0.7971.00
174_Y197_I0.7971.00
196_F231_V0.7971.00
156_K234_E0.7961.00
156_K232_P0.7941.00
64_A79_T0.7941.00
258_V377_E0.7911.00
39_E365_R0.7911.00
207_V224_L0.7891.00
202_W205_V0.7861.00
305_N309_L0.7851.00
150_A157_Y0.7841.00
346_I367_L0.7841.00
150_A181_T0.7841.00
294_Q385_L0.7831.00
180_R183_P0.7801.00
216_L376_Y0.7791.00
296_K351_V0.7781.00
272_R366_L0.7751.00
263_V307_A0.7751.00
40_K43_K0.7741.00
148_T163_K0.7711.00
19_H77_L0.7711.00
182_S241_G0.7651.00
29_F33_D0.7651.00
259_A333_A0.7641.00
146_I178_T0.7641.00
302_T336_Y0.7621.00
300_S348_A0.7601.00
176_V195_M0.7581.00
273_M277_S0.7531.00
367_L371_E0.7471.00
133_A224_L0.7461.00
299_E347_R0.7441.00
276_Y355_Y0.7431.00
81_I85_E0.7431.00
50_E54_K0.7421.00
132_F247_A0.7401.00
345_A367_L0.7391.00
270_L301_L0.7381.00
51_V93_L0.7381.00
310_L332_M0.7381.00
299_E343_K0.7371.00
159_I198_V0.7361.00
49_K171_I0.7341.00
287_L290_F0.7321.00
119_Y197_I0.7301.00
68_Q116_K0.7291.00
88_R268_A0.7291.00
194_S238_G0.7271.00
136_E148_T0.7261.00
146_I193_I0.7241.00
31_E89_V0.7241.00
290_F294_Q0.7211.00
336_Y340_I0.7151.00
350_T371_E0.7131.00
259_A311_T0.7131.00
81_I312_Y0.7121.00
269_A348_A0.7121.00
302_T335_L0.7121.00
306_T310_L0.7111.00
343_K346_I0.7111.00
291_Q295_E0.7101.00
34_V51_V0.7071.00
31_E35_A0.7031.00
345_A363_V0.7031.00
153_I233_A0.7021.00
173_D200_R0.7011.00
134_N143_V0.7011.00
270_L391_T0.7001.00
310_L333_A0.7001.00
146_I180_R0.6991.00
267_Q301_L0.6981.00
63_V74_G0.6971.00
385_L389_R0.6951.00
119_Y235_N0.6931.00
201_E205_V0.6911.00
262_G338_T0.6901.00
104_M123_V0.6881.00
365_R369_D0.6881.00
176_V237_L0.6881.00
23_R84_E0.6871.00
383_Q386_V0.6841.00
68_Q73_G0.6831.00
30_M34_V0.6801.00
349_I356_G0.6781.00
341_A345_A0.6781.00
315_A319_D0.6761.00
123_V174_Y0.6751.00
51_V54_K0.6741.00
181_T240_E0.6721.00
324_N329_A0.6711.00
215_G357_V0.6701.00
119_Y128_K0.6701.00
379_A382_I0.6671.00
28_E31_E0.6651.00
259_A337_A0.6641.00
236_L239_E0.6641.00
311_T337_A0.6631.00
294_Q388_L0.6591.00
308_R312_Y0.6571.00
95_T216_L0.6541.00
303_E306_T0.6531.00
217_R359_T0.6531.00
65_V69_Y0.6521.00
242_N246_Y0.6521.00
155_G234_E0.6521.00
111_G116_K0.6511.00
178_T247_A0.6481.00
328_V390_E0.6461.00
310_L336_Y0.6451.00
154_N158_V0.6441.00
332_M387_I0.6431.00
162_R208_L0.6431.00
35_A38_V0.6411.00
352_H363_V0.6401.00
212_E217_R0.6401.00
166_I224_L0.6351.00
38_V365_R0.6341.00
42_E217_R0.6331.00
22_F82_A0.6321.00
152_K158_V0.6311.00
260_A264_G0.6291.00
18_K21_L0.6271.00
181_T184_P0.6231.00
170_G220_N0.6231.00
106_P250_T0.6231.00
189_R192_G0.6191.00
148_T226_F0.6181.00
335_L387_I0.6171.00
283_F290_F0.6171.00
183_P192_G0.6161.00
256_V315_A0.6151.00
104_M120_V0.6141.00
66_P71_G0.6121.00
49_K129_V0.6091.00
273_M300_S0.6051.00
46_T49_K0.6021.00
282_A287_L0.6011.00
22_F78_M0.6001.00
296_K299_E0.5991.00
169_G224_L0.5991.00
137_P162_R0.5991.00
293_V297_I0.5941.00
27_R88_R0.5941.00
266_A307_A0.5921.00
233_A240_E0.5921.00
180_R192_G0.5901.00
303_E339_D0.5881.00
293_V296_K0.5881.00
106_P110_F0.5881.00
27_R89_V0.5881.00
252_D330_A0.5851.00
296_K350_T0.5821.00
22_F26_V0.5811.00
118_K121_T0.5791.00
182_S192_G0.5771.00
307_A336_Y0.5761.00
354_G357_V0.5751.00
149_V183_P0.5751.00
276_Y361_T0.5741.00
268_A271_E0.5731.00
213_T221_T0.5731.00
313_W329_A0.5721.00
55_A93_L0.5721.00
263_V267_Q0.5681.00
69_Y117_K0.5671.00
18_K78_M0.5671.00
34_V93_L0.5671.00
305_N310_L0.5671.00
196_F235_N0.5671.00
148_T161_G0.5651.00
268_A362_G0.5651.00
198_V226_F0.5631.00
280_R283_F0.5631.00
79_T257_G0.5611.00
45_G212_E0.5611.00
76_T318_F0.5601.00
171_I220_N0.5601.00
69_Y121_T0.5571.00
205_V226_F0.5561.00
300_S351_V0.5561.00
91_A265_V0.5561.00
342_E370_V0.5531.00
307_A333_A0.5531.00
302_T306_T0.5531.00
177_V229_V0.5521.00
107_I111_G0.5521.00
209_N223_E0.5511.00
149_V182_S0.5491.00
310_L314_A0.5491.00
45_G217_R0.5481.00
108_L116_K0.5481.00
198_V229_V0.5481.00
338_T373_M0.5471.00
301_L391_T0.5461.00
174_Y235_N0.5461.00
299_E339_D0.5461.00
267_Q304_V0.5441.00
362_G365_R0.5441.00
371_E375_I0.5421.00
134_N178_T0.5421.00
25_A72_Q0.5401.00
196_F233_A0.5391.00
62_G72_Q0.5391.00
152_K196_F0.5381.00
60_L82_A0.5381.00
41_G90_W0.5381.00
383_Q387_I0.5381.00
81_I84_E0.5371.00
281_F289_G0.5361.00
39_E362_G0.5351.00
62_G124_A0.5351.00
280_R354_G0.5341.00
156_K235_N0.5341.00
45_G359_T0.5321.00
307_A344_V0.5311.00
148_T177_V0.5311.00
167_T221_T0.5291.00
181_T196_F0.5291.00
217_R369_D0.5281.00
287_L293_V0.5281.00
256_V311_T0.5271.00
335_L339_D0.5271.00
266_A269_A0.5261.00
152_K155_G0.5241.00
103_F106_P0.5241.00
139_A147_Q0.5221.00
240_E243_G0.5211.00
276_Y279_Q0.5211.00
382_I385_L0.5211.00
148_T179_A0.5211.00
80_A312_Y0.5191.00
251_F254_T0.5161.00
290_F293_V0.5161.00
303_E307_A0.5151.00
157_Y231_V0.5141.00
299_E302_T0.5131.00
106_P246_Y0.5131.00
89_V268_A0.5091.00
300_S340_I0.5071.00
152_K230_E0.5051.00
239_E246_Y0.5041.00
350_T381_D0.5031.00
251_F255_R0.5021.00
152_K182_S0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4l1fA 4 0.9475 100 0.135 Contact Map
2d29A 4 0.96 100 0.137 Contact Map
4p13A 4 0.9675 100 0.137 Contact Map
1ivhA 4 0.96 100 0.139 Contact Map
4rm7A 4 0.9325 100 0.141 Contact Map
1ukwA 4 0.9475 100 0.144 Contact Map
2jifA 4 0.95 100 0.145 Contact Map
1bucA 4 0.945 100 0.147 Contact Map
4m9aA 4 0.9375 100 0.147 Contact Map
3pfdA 4 0.925 100 0.149 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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