Q97UW5 - SULSO - GREMLIN Contacts

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Q97UW5 - Alcohol dehydrogenase (Zn containing) (Adh-13)

UniProt:	Q97UW5	Sequences: MKAAILTQFNSPFIIGNAEPHGVGVRINVAYTGICGRDLVIWKGGFKNLKLPLILGHEIVGYYNGRPVAVYPNLYCGSCDYCKSGKENLCDNARILGEGEITGGYAEQVIVPERNLIPLPDDKLEKYAATMDPVATAIHASKLADLKKDSKVLVTGAGGGVGIHLVQYLKYLGISNVYGLSSKGEKLKELGVTPVSDIRGEKFDAIFELVGSKTINDSLRALKKEGILVLIGNTEGEPITLSRPAMSIMRQHKIVGSASYTQAEYEEAIKLVGYGKIKAIYEIYELERINEAYRKMLERKVLGRAILKVI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	310 (287)
Sequences:	51778 (35219)
Seq/√Len:	2078.9

ECOLI - YBDR RSPB YAHK AHR FRMA ADHP GATD ACUI YDJL YJJN YPHC IDND YDJJ YGGP TDH QOR1 YCJQ CURA
BACSU - YOGA YJMD ADHA ADHB DHSO BDHA YHFP TDH YYCR YFMJ
HALSA - Q9HP38 Q9HMB6 Q9HR85 Q9HQS8 GLCDH
SULSO - Q97UW5 Q7LXK1 Q97VW0 ADH Q97YT7 Q97V32 Q97WA1 GLCD1 Q97ZV3 GLCD2 Q97YM2 Q97XR4 Q97VV5 Q97W06 Q97TZ4 GLCD3 Q97VB8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
30_A	125_E	3.536	1.00
28_N	64_N	3.387	1.00
288_R	291_E	3.184	1.00
30_A	62_Y	3.180	1.00
26_R	64_N	2.883	1.00
151_K	175_S	2.684	1.00
124_L	127_Y	2.654	1.00
284_Y	295_K	2.625	1.00
170_K	193_T	2.603	1.00
25_V	116_L	2.598	1.00
28_N	108_Q	2.556	1.00
147_K	150_S	2.554	1.00
282_E	295_K	2.545	1.00
126_K	283_I	2.514	1.00
152_V	169_L	2.473	1.00
28_N	62_Y	2.404	1.00
21_H	24_G	2.375	1.00
26_R	110_I	2.319	1.00
122_D	273_G	2.287	1.00
59_I	104_G	2.271	1.00
64_N	108_Q	2.255	1.00
184_G	188_K	2.223	1.00
166_V	192_V	2.207	1.00
43_K	297_L	2.189	1.00
60_V	125_E	2.161	1.00
270_K	274_Y	2.156	1.00
185_E	189_E	2.118	1.00
171_Y	276_K	2.113	1.00
294_R	298_E	2.101	1.00
185_E	188_K	2.100	1.00
134_V	164_H	2.081	1.00
285_E	288_R	2.038	1.00
184_G	195_V	2.025	1.00
295_K	300_K	1.978	1.00
153_L	203_F	1.963	1.00
119_L	125_E	1.958	1.00
204_D	223_K	1.956	1.00
227_I	253_K	1.939	1.00
227_I	255_V	1.886	1.00
26_R	108_Q	1.883	1.00
17_N	108_Q	1.855	1.00
291_E	294_R	1.845	1.00
186_K	189_E	1.839	1.00
291_E	295_K	1.829	1.00
119_L	128_A	1.804	1.00
157_A	178_Y	1.802	1.00
155_T	218_S	1.795	1.00
284_Y	292_A	1.792	1.00
105_Y	293_Y	1.693	1.00
222_L	228_L	1.683	1.00
222_L	252_H	1.658	1.00
206_I	222_L	1.654	1.00
24_G	112_P	1.654	1.00
144_A	205_A	1.641	1.00
290_N	294_R	1.635	1.00
23_V	112_P	1.629	1.00
87_E	119_L	1.619	1.00
24_G	110_I	1.616	1.00
222_L	226_G	1.606	1.00
29_V	59_I	1.596	1.00
150_S	227_I	1.584	1.00
175_S	194_P	1.560	1.00
206_I	218_S	1.552	1.00
31_Y	126_K	1.549	1.00
157_A	179_G	1.532	1.00
70_V	113_E	1.531	1.00
171_Y	271_L	1.528	1.00
90_C	93_A	1.493	1.00
281_Y	295_K	1.492	1.00
62_Y	125_E	1.477	1.00
270_K	273_G	1.466	1.00
20_P	26_R	1.457	1.00
175_S	193_T	1.450	1.00
20_P	110_I	1.447	1.00
23_V	67_P	1.428	1.00
165_L	207_F	1.418	1.00
29_V	109_V	1.383	1.00
151_K	176_N	1.373	1.00
176_N	194_P	1.371	1.00
42_W	293_Y	1.360	1.00
181_S	198_I	1.347	1.00
142_K	264_E	1.347	1.00
23_V	113_E	1.338	1.00
151_K	204_D	1.327	1.00
184_G	197_D	1.314	1.00
22_G	66_R	1.288	1.00
66_R	118_P	1.278	1.00
262_Q	266_E	1.274	1.00
167_Q	278_K	1.262	1.00
271_L	276_K	1.257	1.00
111_V	116_L	1.256	1.00
8_Q	11_S	1.244	1.00
146_L	174_I	1.239	1.00
180_L	184_G	1.236	1.00
150_S	204_D	1.228	1.00
22_G	67_P	1.225	1.00
142_K	267_E	1.215	1.00
131_M	272_V	1.215	1.00
267_E	270_K	1.208	1.00
7_T	13_F	1.207	1.00
137_A	165_L	1.202	1.00
31_Y	125_E	1.193	1.00
169_L	174_I	1.192	1.00
176_N	181_S	1.190	1.00
139_H	264_E	1.190	1.00
188_K	195_V	1.189	1.00
177_V	203_F	1.167	1.00
289_I	307_L	1.167	1.00
210_V	214_T	1.151	1.00
32_T	105_Y	1.149	1.00
186_K	302_L	1.128	1.00
151_K	177_V	1.117	1.00
42_W	297_L	1.115	1.00
34_I	292_A	1.115	1.00
144_A	229_V	1.107	1.00
146_L	150_S	1.103	1.00
153_L	180_L	1.099	1.00
294_R	297_L	1.099	1.00
220_R	245_A	1.094	1.00
127_Y	278_K	1.085	1.00
295_K	305_A	1.079	1.00
138_I	267_E	1.079	1.00
143_L	253_K	1.075	1.00
7_T	11_S	1.073	1.00
267_E	271_L	1.067	1.00
266_E	270_K	1.056	1.00
163_I	186_K	1.055	1.00
178_Y	181_S	1.049	1.00
20_P	24_G	1.044	1.00
105_Y	289_I	1.039	1.00
9_F	51_L	1.039	1.00
30_A	60_V	1.037	1.00
284_Y	288_R	1.037	1.00
134_V	268_A	1.033	1.00
140_A	231_I	1.031	1.00
137_A	168_Y	1.026	1.00
143_L	255_V	1.026	1.00
176_N	180_L	1.025	1.00
39_L	296_M	1.022	1.00
217_D	220_R	1.017	1.00
157_A	166_V	1.016	1.00
140_A	207_F	1.010	1.00
150_S	205_A	1.007	1.00
123_K	128_A	1.002	1.00
178_Y	203_F	0.995	1.00
5_I	54_I	0.986	1.00
153_L	221_A	0.984	1.00
208_E	211_G	0.982	1.00
216_N	220_R	0.976	1.00
27_I	61_G	0.974	1.00
183_K	302_L	0.972	1.00
31_Y	306_I	0.969	1.00
151_K	203_F	0.966	1.00
153_L	179_G	0.962	1.00
25_V	113_E	0.960	1.00
155_T	206_I	0.957	1.00
301_V	305_A	0.956	1.00
28_N	107_E	0.955	1.00
225_E	251_Q	0.952	1.00
53_L	102_T	0.949	1.00
176_N	179_G	0.940	1.00
35_C	58_E	0.937	1.00
32_T	104_G	0.937	1.00
59_I	109_V	0.935	1.00
247_S	254_I	0.929	1.00
135_A	264_E	0.929	1.00
182_S	185_E	0.928	1.00
181_S	184_G	0.924	1.00
245_A	250_R	0.923	1.00
154_V	169_L	0.920	1.00
11_S	14_I	0.920	1.00
157_A	187_L	0.908	1.00
155_T	214_T	0.906	1.00
263_A	267_E	0.906	1.00
271_L	274_Y	0.891	1.00
17_N	26_R	0.890	1.00
154_V	165_L	0.890	1.00
117_I	266_E	0.887	1.00
188_K	194_P	0.886	1.00
242_S	245_A	0.882	1.00
176_N	193_T	0.882	1.00
67_P	125_E	0.877	1.00
121_D	273_G	0.872	1.00
152_V	174_I	0.869	1.00
34_I	296_M	0.868	1.00
21_H	110_I	0.866	1.00
5_I	15_I	0.861	1.00
33_G	58_E	0.861	1.00
94_R	119_L	0.859	1.00
141_S	169_L	0.857	1.00
168_Y	268_A	0.856	1.00
59_I	90_C	0.852	1.00
209_L	231_I	0.851	1.00
145_D	227_I	0.851	1.00
137_A	164_H	0.847	1.00
83_K	86_K	0.845	1.00
105_Y	307_L	0.844	1.00
263_A	266_E	0.841	1.00
35_C	57_H	0.839	1.00
104_G	109_V	0.837	1.00
230_L	254_I	0.836	1.00
247_S	256_G	0.834	1.00
18_A	110_I	0.834	1.00
206_I	228_L	0.831	1.00
237_E	240_T	0.828	1.00
155_T	179_G	0.824	1.00
284_Y	305_A	0.823	1.00
187_L	192_V	0.822	1.00
168_Y	271_L	0.822	1.00
37_R	57_H	0.818	1.00
35_C	38_D	0.815	1.00
218_S	228_L	0.811	1.00
177_V	194_P	0.808	1.00
65_G	68_V	0.808	1.00
157_A	181_S	0.804	1.00
280_I	283_I	0.804	1.00
145_D	253_K	0.803	1.00
189_E	278_K	0.802	1.00
295_K	298_E	0.799	1.00
174_I	205_A	0.799	1.00
140_A	165_L	0.798	1.00
146_L	205_A	0.797	1.00
151_K	201_E	0.794	1.00
181_S	199_R	0.793	1.00
282_E	291_E	0.792	1.00
60_V	129_A	0.783	1.00
169_L	176_N	0.781	1.00
19_E	26_R	0.779	1.00
166_V	178_Y	0.777	1.00
31_Y	283_I	0.776	1.00
282_E	305_A	0.775	1.00
123_K	272_V	0.773	1.00
172_L	267_E	0.769	1.00
166_V	179_G	0.769	1.00
120_P	273_G	0.768	1.00
117_I	265_Y	0.766	1.00
269_I	273_G	0.764	1.00
186_K	190_L	0.759	1.00
39_L	297_L	0.753	1.00
138_I	268_A	0.749	1.00
145_D	255_V	0.748	1.00
215_I	228_L	0.743	1.00
296_M	305_A	0.743	1.00
93_A	118_P	0.739	1.00
29_V	32_T	0.734	1.00
168_Y	172_L	0.730	1.00
158_G	187_L	0.729	1.00
138_I	271_L	0.728	1.00
59_I	97_G	0.727	1.00
184_G	187_L	0.726	1.00
203_F	206_I	0.726	1.00
166_V	190_L	0.722	1.00
271_L	275_G	0.720	1.00
167_Q	190_L	0.718	1.00
203_F	221_A	0.715	1.00
205_A	229_V	0.715	1.00
284_Y	307_L	0.714	1.00
178_Y	192_V	0.714	1.00
224_K	250_R	0.713	1.00
137_A	141_S	0.710	1.00
139_H	251_Q	0.708	1.00
247_S	252_H	0.708	1.00
13_F	290_N	0.705	1.00
23_V	114_R	0.703	1.00
137_A	161_V	0.701	1.00
208_E	228_L	0.701	1.00
192_V	195_V	0.701	1.00
49_L	53_L	0.698	1.00
84_S	88_N	0.695	1.00
133_P	164_H	0.695	1.00
31_Y	60_V	0.694	1.00
117_I	269_I	0.691	1.00
213_K	216_N	0.691	1.00
60_V	119_L	0.689	1.00
37_R	41_I	0.688	1.00
25_V	63_Y	0.686	1.00
251_Q	261_T	0.685	1.00
201_E	223_K	0.685	1.00
87_E	125_E	0.685	1.00
35_C	133_P	0.684	1.00
149_D	175_S	0.683	1.00
138_I	264_E	0.675	1.00
194_P	197_D	0.675	1.00
180_L	198_I	0.673	1.00
40_V	45_G	0.672	1.00
295_K	301_V	0.671	1.00
89_L	93_A	0.670	1.00
86_K	225_E	0.670	1.00
10_N	42_W	0.669	1.00
18_A	24_G	0.667	1.00
70_V	90_C	0.666	1.00
216_N	245_A	0.665	1.00
136_T	161_V	0.665	1.00
56_G	105_Y	0.662	1.00
133_P	160_G	0.662	1.00
245_A	249_M	0.662	1.00
148_K	173_G	0.660	1.00
59_I	70_V	0.659	1.00
67_P	121_D	0.657	1.00
293_Y	297_L	0.657	1.00
66_R	69_A	0.656	1.00
205_A	227_I	0.656	1.00
179_G	198_I	0.655	1.00
153_L	206_I	0.654	1.00
39_L	43_K	0.652	1.00
252_H	256_G	0.651	1.00
214_T	218_S	0.645	1.00
165_L	231_I	0.643	1.00
34_I	105_Y	0.641	1.00
166_V	176_N	0.641	1.00
216_N	240_T	0.641	1.00
142_K	172_L	0.640	1.00
67_P	70_V	0.637	1.00
62_Y	67_P	0.635	1.00
9_F	12_P	0.634	1.00
180_L	195_V	0.631	1.00
237_E	242_S	0.628	1.00
264_E	267_E	0.627	1.00
8_Q	14_I	0.626	1.00
155_T	180_L	0.626	1.00
85_G	88_N	0.626	1.00
117_I	262_Q	0.623	1.00
214_T	217_D	0.622	1.00
10_N	13_F	0.622	1.00
140_A	229_V	0.620	1.00
151_K	202_K	0.620	1.00
144_A	227_I	0.619	1.00
9_F	44_G	0.618	1.00
130_T	306_I	0.617	1.00
32_T	307_L	0.617	1.00
265_Y	269_I	0.616	1.00
142_K	145_D	0.611	1.00
163_I	190_L	0.606	1.00
112_P	115_N	0.602	1.00
152_V	205_A	0.601	1.00
282_E	285_E	0.600	1.00
27_I	116_L	0.597	1.00
158_G	183_K	0.597	1.00
187_L	195_V	0.597	1.00
69_A	113_E	0.595	1.00
6_L	9_F	0.593	1.00
36_G	40_V	0.591	1.00
184_G	198_I	0.589	1.00
229_V	257_S	0.589	1.00
292_A	307_L	0.589	1.00
20_P	23_V	0.587	1.00
37_R	40_V	0.587	1.00
272_V	279_A	0.584	1.00
154_V	166_V	0.581	1.00
183_K	300_K	0.581	1.00
140_A	257_S	0.580	1.00
113_E	116_L	0.579	1.00
34_I	307_L	0.579	1.00
148_K	172_L	0.578	1.00
124_L	128_A	0.576	1.00
164_H	168_Y	0.573	1.00
266_E	269_I	0.573	1.00
206_I	221_A	0.569	1.00
139_H	143_L	0.568	1.00
141_S	168_Y	0.568	1.00
86_K	118_P	0.567	1.00
125_E	128_A	0.566	1.00
138_I	172_L	0.565	1.00
50_K	53_L	0.565	1.00
200_G	203_F	0.565	1.00
151_K	194_P	0.564	1.00
166_V	187_L	0.558	1.00
275_G	278_K	0.557	1.00
60_V	128_A	0.556	1.00
177_V	196_S	0.553	1.00
188_K	192_V	0.552	1.00
35_C	304_R	0.551	1.00
131_M	268_A	0.551	1.00
202_K	223_K	0.551	1.00
164_H	277_I	0.549	1.00
91_D	94_R	0.549	1.00
145_D	172_L	0.549	1.00
12_P	294_R	0.548	1.00
282_E	288_R	0.548	1.00
6_L	53_L	0.547	1.00
167_Q	277_I	0.544	1.00
217_D	221_A	0.543	1.00
33_G	129_A	0.538	1.00
10_N	14_I	0.538	1.00
284_Y	291_E	0.537	1.00
280_I	285_E	0.537	1.00
215_I	230_L	0.536	1.00
141_S	165_L	0.535	1.00
195_V	198_I	0.535	1.00
142_K	263_A	0.534	1.00
13_F	294_R	0.533	1.00
95_I	98_E	0.532	1.00
24_G	113_E	0.532	1.00
135_A	259_S	0.529	1.00
213_K	217_D	0.528	1.00
19_E	110_I	0.527	1.00
138_I	168_Y	0.526	1.00
160_G	163_I	0.526	1.00
66_R	70_V	0.525	1.00
48_N	51_L	0.524	1.00
126_K	306_I	0.523	1.00
249_M	258_A	0.523	1.00
151_K	178_Y	0.521	1.00
130_T	279_A	0.521	1.00
133_P	304_R	0.520	1.00
134_V	167_Q	0.519	1.00
6_L	42_W	0.518	1.00
136_T	231_I	0.518	1.00
17_N	64_N	0.518	1.00
165_L	209_L	0.517	1.00
253_K	256_G	0.515	1.00
229_V	255_V	0.514	1.00
29_V	104_G	0.513	1.00
208_E	232_G	0.513	1.00
132_D	136_T	0.512	1.00
208_E	214_T	0.511	1.00
170_K	192_V	0.508	1.00
41_I	46_F	0.507	1.00
15_I	54_I	0.507	1.00
119_L	123_K	0.506	1.00
10_N	43_K	0.505	1.00
156_G	209_L	0.505	1.00
134_V	168_Y	0.505	1.00
164_H	167_Q	0.504	1.00
272_V	277_I	0.502	1.00
171_Y	277_I	0.502	1.00
178_Y	187_L	0.501	1.00
188_K	191_G	0.501	1.00
223_K	226_G	0.500	1.00
54_I	103_G	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
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HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4gi2A	2	0.9968	100	0.219	Contact Map
1rjwA	4	0.9871	100	0.235	Contact Map
4ilkA	2	0.9742	100	0.236	Contact Map
1h2bA	4	0.9806	100	0.237	Contact Map
4oaqA	2	0.9903	100	0.24	Contact Map
4c4oA	4	0.9806	100	0.243	Contact Map
4ej6A	1	0.9806	100	0.244	Contact Map
2eihA	4	0.9935	100	0.245	Contact Map
4oh1A	4	0.971	100	0.247	Contact Map
3jv7A	4	0.9806	100	0.248	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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