GREMLIN Database
Q97UW5 - Alcohol dehydrogenase (Zn containing) (Adh-13)
UniProt: Q97UW5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 310 (287)
Sequences: 51778 (35219)
Seq/√Len: 2078.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
30_A125_E3.5361.00
28_N64_N3.3871.00
288_R291_E3.1841.00
30_A62_Y3.1801.00
26_R64_N2.8831.00
151_K175_S2.6841.00
124_L127_Y2.6541.00
284_Y295_K2.6251.00
170_K193_T2.6031.00
25_V116_L2.5981.00
28_N108_Q2.5561.00
147_K150_S2.5541.00
282_E295_K2.5451.00
126_K283_I2.5141.00
152_V169_L2.4731.00
28_N62_Y2.4041.00
21_H24_G2.3751.00
26_R110_I2.3191.00
122_D273_G2.2871.00
59_I104_G2.2711.00
64_N108_Q2.2551.00
184_G188_K2.2231.00
166_V192_V2.2071.00
43_K297_L2.1891.00
60_V125_E2.1611.00
270_K274_Y2.1561.00
185_E189_E2.1181.00
171_Y276_K2.1131.00
294_R298_E2.1011.00
185_E188_K2.1001.00
134_V164_H2.0811.00
285_E288_R2.0381.00
184_G195_V2.0251.00
295_K300_K1.9781.00
153_L203_F1.9631.00
119_L125_E1.9581.00
204_D223_K1.9561.00
227_I253_K1.9391.00
227_I255_V1.8861.00
26_R108_Q1.8831.00
17_N108_Q1.8551.00
291_E294_R1.8451.00
186_K189_E1.8391.00
291_E295_K1.8291.00
119_L128_A1.8041.00
157_A178_Y1.8021.00
155_T218_S1.7951.00
284_Y292_A1.7921.00
105_Y293_Y1.6931.00
222_L228_L1.6831.00
222_L252_H1.6581.00
206_I222_L1.6541.00
24_G112_P1.6541.00
144_A205_A1.6411.00
290_N294_R1.6351.00
23_V112_P1.6291.00
87_E119_L1.6191.00
24_G110_I1.6161.00
222_L226_G1.6061.00
29_V59_I1.5961.00
150_S227_I1.5841.00
175_S194_P1.5601.00
206_I218_S1.5521.00
31_Y126_K1.5491.00
157_A179_G1.5321.00
70_V113_E1.5311.00
171_Y271_L1.5281.00
90_C93_A1.4931.00
281_Y295_K1.4921.00
62_Y125_E1.4771.00
270_K273_G1.4661.00
20_P26_R1.4571.00
175_S193_T1.4501.00
20_P110_I1.4471.00
23_V67_P1.4281.00
165_L207_F1.4181.00
29_V109_V1.3831.00
151_K176_N1.3731.00
176_N194_P1.3711.00
42_W293_Y1.3601.00
181_S198_I1.3471.00
142_K264_E1.3471.00
23_V113_E1.3381.00
151_K204_D1.3271.00
184_G197_D1.3141.00
22_G66_R1.2881.00
66_R118_P1.2781.00
262_Q266_E1.2741.00
167_Q278_K1.2621.00
271_L276_K1.2571.00
111_V116_L1.2561.00
8_Q11_S1.2441.00
146_L174_I1.2391.00
180_L184_G1.2361.00
150_S204_D1.2281.00
22_G67_P1.2251.00
142_K267_E1.2151.00
131_M272_V1.2151.00
267_E270_K1.2081.00
7_T13_F1.2071.00
137_A165_L1.2021.00
31_Y125_E1.1931.00
169_L174_I1.1921.00
176_N181_S1.1901.00
139_H264_E1.1901.00
188_K195_V1.1891.00
177_V203_F1.1671.00
289_I307_L1.1671.00
210_V214_T1.1511.00
32_T105_Y1.1491.00
186_K302_L1.1281.00
151_K177_V1.1171.00
42_W297_L1.1151.00
34_I292_A1.1151.00
144_A229_V1.1071.00
146_L150_S1.1031.00
153_L180_L1.0991.00
294_R297_L1.0991.00
220_R245_A1.0941.00
127_Y278_K1.0851.00
295_K305_A1.0791.00
138_I267_E1.0791.00
143_L253_K1.0751.00
7_T11_S1.0731.00
267_E271_L1.0671.00
266_E270_K1.0561.00
163_I186_K1.0551.00
178_Y181_S1.0491.00
20_P24_G1.0441.00
105_Y289_I1.0391.00
9_F51_L1.0391.00
30_A60_V1.0371.00
284_Y288_R1.0371.00
134_V268_A1.0331.00
140_A231_I1.0311.00
137_A168_Y1.0261.00
143_L255_V1.0261.00
176_N180_L1.0251.00
39_L296_M1.0221.00
217_D220_R1.0171.00
157_A166_V1.0161.00
140_A207_F1.0101.00
150_S205_A1.0071.00
123_K128_A1.0021.00
178_Y203_F0.9951.00
5_I54_I0.9861.00
153_L221_A0.9841.00
208_E211_G0.9821.00
216_N220_R0.9761.00
27_I61_G0.9741.00
183_K302_L0.9721.00
31_Y306_I0.9691.00
151_K203_F0.9661.00
153_L179_G0.9621.00
25_V113_E0.9601.00
155_T206_I0.9571.00
301_V305_A0.9561.00
28_N107_E0.9551.00
225_E251_Q0.9521.00
53_L102_T0.9491.00
176_N179_G0.9401.00
35_C58_E0.9371.00
32_T104_G0.9371.00
59_I109_V0.9351.00
247_S254_I0.9291.00
135_A264_E0.9291.00
182_S185_E0.9281.00
181_S184_G0.9241.00
245_A250_R0.9231.00
154_V169_L0.9201.00
11_S14_I0.9201.00
157_A187_L0.9081.00
155_T214_T0.9061.00
263_A267_E0.9061.00
271_L274_Y0.8911.00
17_N26_R0.8901.00
154_V165_L0.8901.00
117_I266_E0.8871.00
188_K194_P0.8861.00
242_S245_A0.8821.00
176_N193_T0.8821.00
67_P125_E0.8771.00
121_D273_G0.8721.00
152_V174_I0.8691.00
34_I296_M0.8681.00
21_H110_I0.8661.00
5_I15_I0.8611.00
33_G58_E0.8611.00
94_R119_L0.8591.00
141_S169_L0.8571.00
168_Y268_A0.8561.00
59_I90_C0.8521.00
209_L231_I0.8511.00
145_D227_I0.8511.00
137_A164_H0.8471.00
83_K86_K0.8451.00
105_Y307_L0.8441.00
263_A266_E0.8411.00
35_C57_H0.8391.00
104_G109_V0.8371.00
230_L254_I0.8361.00
247_S256_G0.8341.00
18_A110_I0.8341.00
206_I228_L0.8311.00
237_E240_T0.8281.00
155_T179_G0.8241.00
284_Y305_A0.8231.00
187_L192_V0.8221.00
168_Y271_L0.8221.00
37_R57_H0.8181.00
35_C38_D0.8151.00
218_S228_L0.8111.00
177_V194_P0.8081.00
65_G68_V0.8081.00
157_A181_S0.8041.00
280_I283_I0.8041.00
145_D253_K0.8031.00
189_E278_K0.8021.00
295_K298_E0.7991.00
174_I205_A0.7991.00
140_A165_L0.7981.00
146_L205_A0.7971.00
151_K201_E0.7941.00
181_S199_R0.7931.00
282_E291_E0.7921.00
60_V129_A0.7831.00
169_L176_N0.7811.00
19_E26_R0.7791.00
166_V178_Y0.7771.00
31_Y283_I0.7761.00
282_E305_A0.7751.00
123_K272_V0.7731.00
172_L267_E0.7691.00
166_V179_G0.7691.00
120_P273_G0.7681.00
117_I265_Y0.7661.00
269_I273_G0.7641.00
186_K190_L0.7591.00
39_L297_L0.7531.00
138_I268_A0.7491.00
145_D255_V0.7481.00
215_I228_L0.7431.00
296_M305_A0.7431.00
93_A118_P0.7391.00
29_V32_T0.7341.00
168_Y172_L0.7301.00
158_G187_L0.7291.00
138_I271_L0.7281.00
59_I97_G0.7271.00
184_G187_L0.7261.00
203_F206_I0.7261.00
166_V190_L0.7221.00
271_L275_G0.7201.00
167_Q190_L0.7181.00
203_F221_A0.7151.00
205_A229_V0.7151.00
284_Y307_L0.7141.00
178_Y192_V0.7141.00
224_K250_R0.7131.00
137_A141_S0.7101.00
139_H251_Q0.7081.00
247_S252_H0.7081.00
13_F290_N0.7051.00
23_V114_R0.7031.00
137_A161_V0.7011.00
208_E228_L0.7011.00
192_V195_V0.7011.00
49_L53_L0.6981.00
84_S88_N0.6951.00
133_P164_H0.6951.00
31_Y60_V0.6941.00
117_I269_I0.6911.00
213_K216_N0.6911.00
60_V119_L0.6891.00
37_R41_I0.6881.00
25_V63_Y0.6861.00
251_Q261_T0.6851.00
201_E223_K0.6851.00
87_E125_E0.6851.00
35_C133_P0.6841.00
149_D175_S0.6831.00
138_I264_E0.6751.00
194_P197_D0.6751.00
180_L198_I0.6731.00
40_V45_G0.6721.00
295_K301_V0.6711.00
89_L93_A0.6701.00
86_K225_E0.6701.00
10_N42_W0.6691.00
18_A24_G0.6671.00
70_V90_C0.6661.00
216_N245_A0.6651.00
136_T161_V0.6651.00
56_G105_Y0.6621.00
133_P160_G0.6621.00
245_A249_M0.6621.00
148_K173_G0.6601.00
59_I70_V0.6591.00
67_P121_D0.6571.00
293_Y297_L0.6571.00
66_R69_A0.6561.00
205_A227_I0.6561.00
179_G198_I0.6551.00
153_L206_I0.6541.00
39_L43_K0.6521.00
252_H256_G0.6511.00
214_T218_S0.6451.00
165_L231_I0.6431.00
34_I105_Y0.6411.00
166_V176_N0.6411.00
216_N240_T0.6411.00
142_K172_L0.6401.00
67_P70_V0.6371.00
62_Y67_P0.6351.00
9_F12_P0.6341.00
180_L195_V0.6311.00
237_E242_S0.6281.00
264_E267_E0.6271.00
8_Q14_I0.6261.00
155_T180_L0.6261.00
85_G88_N0.6261.00
117_I262_Q0.6231.00
214_T217_D0.6221.00
10_N13_F0.6221.00
140_A229_V0.6201.00
151_K202_K0.6201.00
144_A227_I0.6191.00
9_F44_G0.6181.00
130_T306_I0.6171.00
32_T307_L0.6171.00
265_Y269_I0.6161.00
142_K145_D0.6111.00
163_I190_L0.6061.00
112_P115_N0.6021.00
152_V205_A0.6011.00
282_E285_E0.6001.00
27_I116_L0.5971.00
158_G183_K0.5971.00
187_L195_V0.5971.00
69_A113_E0.5951.00
6_L9_F0.5931.00
36_G40_V0.5911.00
184_G198_I0.5891.00
229_V257_S0.5891.00
292_A307_L0.5891.00
20_P23_V0.5871.00
37_R40_V0.5871.00
272_V279_A0.5841.00
154_V166_V0.5811.00
183_K300_K0.5811.00
140_A257_S0.5801.00
113_E116_L0.5791.00
34_I307_L0.5791.00
148_K172_L0.5781.00
124_L128_A0.5761.00
164_H168_Y0.5731.00
266_E269_I0.5731.00
206_I221_A0.5691.00
139_H143_L0.5681.00
141_S168_Y0.5681.00
86_K118_P0.5671.00
125_E128_A0.5661.00
138_I172_L0.5651.00
50_K53_L0.5651.00
200_G203_F0.5651.00
151_K194_P0.5641.00
166_V187_L0.5581.00
275_G278_K0.5571.00
60_V128_A0.5561.00
177_V196_S0.5531.00
188_K192_V0.5521.00
35_C304_R0.5511.00
131_M268_A0.5511.00
202_K223_K0.5511.00
164_H277_I0.5491.00
91_D94_R0.5491.00
145_D172_L0.5491.00
12_P294_R0.5481.00
282_E288_R0.5481.00
6_L53_L0.5471.00
167_Q277_I0.5441.00
217_D221_A0.5431.00
33_G129_A0.5381.00
10_N14_I0.5381.00
284_Y291_E0.5371.00
280_I285_E0.5371.00
215_I230_L0.5361.00
141_S165_L0.5351.00
195_V198_I0.5351.00
142_K263_A0.5341.00
13_F294_R0.5331.00
95_I98_E0.5321.00
24_G113_E0.5321.00
135_A259_S0.5291.00
213_K217_D0.5281.00
19_E110_I0.5271.00
138_I168_Y0.5261.00
160_G163_I0.5261.00
66_R70_V0.5251.00
48_N51_L0.5241.00
126_K306_I0.5231.00
249_M258_A0.5231.00
151_K178_Y0.5211.00
130_T279_A0.5211.00
133_P304_R0.5201.00
134_V167_Q0.5191.00
6_L42_W0.5181.00
136_T231_I0.5181.00
17_N64_N0.5181.00
165_L209_L0.5171.00
253_K256_G0.5151.00
229_V255_V0.5141.00
29_V104_G0.5131.00
208_E232_G0.5131.00
132_D136_T0.5121.00
208_E214_T0.5111.00
170_K192_V0.5081.00
41_I46_F0.5071.00
15_I54_I0.5071.00
119_L123_K0.5061.00
10_N43_K0.5051.00
156_G209_L0.5051.00
134_V168_Y0.5051.00
164_H167_Q0.5041.00
272_V277_I0.5021.00
171_Y277_I0.5021.00
178_Y187_L0.5011.00
188_K191_G0.5011.00
223_K226_G0.5001.00
54_I103_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4gi2A 2 0.9968 100 0.219 Contact Map
1rjwA 4 0.9871 100 0.235 Contact Map
4ilkA 2 0.9742 100 0.236 Contact Map
1h2bA 4 0.9806 100 0.237 Contact Map
4oaqA 2 0.9903 100 0.24 Contact Map
4c4oA 4 0.9806 100 0.243 Contact Map
4ej6A 1 0.9806 100 0.244 Contact Map
2eihA 4 0.9935 100 0.245 Contact Map
4oh1A 4 0.971 100 0.247 Contact Map
3jv7A 4 0.9806 100 0.248 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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