Q97UW4 - SULSO - GREMLIN Contacts

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Q97UW4 - Uncharacterized protein

UniProt:	Q97UW4	Sequences: MSSCEIFPLISKLSAEGKRFAIVSIYKGNRLERTIVSDGRVLLGSLDRNIIEIALEALEKGKVIQKDLEDGKLVIEPIEPRPAIIVVGSGIIARFLAKLAIDMGYYVAVVGSGDVKEEDFSGVYAISNDLNLLEQMVSEDSIVIVANEGGKPYDIDALYIAMKKRARFVGLLASQKRAALMISLLVKRDIPLEEIKRRLHSPLGLDIGSKTAEEIALSILSEVVLDLRGGTGKRLQEVKNPYLLLDDALAGKIEDKCMFVPKSLSQQ	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	267 (226)
Sequences:	3025 (2235)
Seq/√Len:	148.7

ECOLI - YAGQ YQEB
BACSU - XDHA
SULSO - Q97UW4 Q97YN2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
186_V	192_L	3.498	1.00
191_P	194_E	3.183	1.00
217_L	224_V	3.168	1.00
159_Y	188_R	3.033	1.00
170_G	203_L	2.661	1.00
143_V	161_A	2.531	1.00
200_H	222_E	2.520	1.00
84_I	100_A	2.505	1.00
105_Y	224_V	2.422	1.00
99_L	217_L	2.366	1.00
192_L	196_K	2.256	1.00
178_A	182_I	2.209	1.00
89_S	111_G	2.198	1.00
220_L	223_V	2.144	1.00
19_R	38_D	2.141	1.00
168_F	222_E	2.116	1.00
100_A	220_L	2.072	1.00
138_S	141_S	2.070	1.00
99_L	220_L	2.029	1.00
99_L	102_D	1.990	1.00
83_A	108_A	1.981	1.00
40_R	44_G	1.938	1.00
86_V	97_A	1.932	1.00
183_S	187_K	1.922	1.00
87_V	157_A	1.897	1.00
23_V	50_I	1.895	1.00
28_G	47_D	1.881	1.00
34_T	47_D	1.857	1.00
159_Y	163_K	1.817	1.00
143_V	166_A	1.813	1.00
12_K	16_E	1.782	1.00
33_R	76_E	1.767	1.00
26_Y	65_Q	1.744	1.00
134_E	160_I	1.669	1.00
21_A	58_L	1.669	1.00
132_L	136_M	1.667	1.00
166_A	169_V	1.662	1.00
155_I	184_L	1.624	1.00
144_I	203_L	1.616	1.00
178_A	201_S	1.594	1.00
49_N	53_I	1.585	1.00
84_I	223_V	1.572	1.00
24_S	33_R	1.554	1.00
139_E	165_R	1.521	1.00
21_A	75_I	1.517	1.00
37_S	41_V	1.508	1.00
159_Y	190_I	1.507	1.00
182_I	195_I	1.506	1.00
28_G	34_T	1.503	1.00
96_L	144_I	1.465	1.00
98_K	102_D	1.463	1.00
182_I	199_L	1.462	1.00
18_K	38_D	1.462	1.00
53_I	68_L	1.459	1.00
9_L	12_K	1.449	1.00
209_S	228_R	1.440	1.00
96_L	219_I	1.428	1.00
200_H	226_D	1.426	1.00
137_V	141_S	1.425	1.00
222_E	225_L	1.423	1.00
158_L	171_L	1.419	1.00
166_A	198_R	1.394	1.00
182_I	186_V	1.371	1.00
85_I	137_V	1.363	1.00
137_V	143_V	1.357	1.00
13_L	18_K	1.343	1.00
225_L	229_G	1.335	1.00
112_S	148_E	1.333	1.00
95_F	213_E	1.331	1.00
84_I	142_I	1.301	1.00
194_E	198_R	1.279	1.00
169_V	199_L	1.273	1.00
103_M	220_L	1.269	1.00
53_I	66_K	1.262	1.00
161_A	169_V	1.254	1.00
9_L	13_L	1.222	1.00
23_V	36_V	1.222	1.00
164_K	198_R	1.214	1.00
28_G	32_E	1.214	1.00
190_I	194_E	1.213	1.00
98_K	122_G	1.205	1.00
45_S	49_N	1.202	1.00
44_G	47_D	1.164	1.00
84_I	144_I	1.156	1.00
53_I	64_I	1.153	1.00
105_Y	142_I	1.149	1.00
27_K	72_K	1.147	1.00
179_A	183_S	1.142	1.00
96_L	220_L	1.140	1.00
41_V	44_G	1.136	1.00
13_L	20_F	1.135	1.00
23_V	73_L	1.129	0.99
145_V	161_A	1.119	0.99
13_L	37_S	1.119	0.99
92_I	174_S	1.110	0.99
85_I	143_V	1.106	0.99
49_N	52_E	1.103	0.99
127_S	131_N	1.097	0.99
83_A	141_S	1.090	0.99
176_K	180_L	1.074	0.99
151_K	177_R	1.062	0.99
112_S	153_Y	1.062	0.99
171_L	178_A	1.056	0.99
163_K	194_E	1.054	0.99
155_I	188_R	1.052	0.99
18_K	37_S	1.052	0.99
142_I	227_L	1.050	0.99
149_G	153_Y	1.045	0.99
178_A	199_L	1.044	0.99
163_K	190_I	1.031	0.99
127_S	130_L	1.023	0.99
103_M	217_L	1.023	0.99
171_L	181_M	1.018	0.99
21_A	57_A	1.017	0.99
57_A	63_V	1.011	0.99
83_A	106_Y	1.010	0.99
161_A	166_A	1.005	0.99
97_A	109_V	0.990	0.99
144_I	223_V	0.990	0.99
85_I	110_V	0.987	0.99
92_I	172_L	0.980	0.99
104_G	213_E	0.977	0.98
147_N	154_D	0.973	0.98
82_P	227_L	0.969	0.98
137_V	166_A	0.969	0.98
40_R	43_L	0.963	0.98
209_S	214_E	0.961	0.98
57_A	64_I	0.961	0.98
36_V	54_A	0.960	0.98
85_I	141_S	0.957	0.98
146_A	174_S	0.930	0.98
177_R	181_M	0.930	0.98
82_P	142_I	0.929	0.98
11_S	15_A	0.928	0.98
142_I	167_R	0.919	0.98
182_I	196_K	0.917	0.98
60_K	64_I	0.913	0.98
115_V	125_A	0.911	0.98
95_F	98_K	0.902	0.97
105_Y	227_L	0.899	0.97
36_V	51_I	0.890	0.97
112_S	149_G	0.889	0.97
25_I	30_R	0.888	0.97
28_G	31_L	0.882	0.97
31_L	47_D	0.880	0.97
162_M	190_I	0.878	0.97
97_A	107_V	0.875	0.97
158_L	199_L	0.872	0.97
86_V	93_A	0.871	0.97
142_I	168_F	0.869	0.97
120_F	123_V	0.865	0.97
145_V	171_L	0.864	0.97
46_L	71_G	0.864	0.97
92_I	215_I	0.862	0.97
84_I	105_Y	0.859	0.97
85_I	108_A	0.857	0.97
124_Y	128_N	0.855	0.97
87_V	143_V	0.854	0.96
145_V	158_L	0.852	0.96
168_F	203_L	0.847	0.96
81_R	104_G	0.845	0.96
49_N	68_L	0.844	0.96
54_A	58_L	0.842	0.96
20_F	35_I	0.838	0.96
151_K	155_I	0.837	0.96
86_V	96_L	0.837	0.96
94_R	119_D	0.826	0.96
92_I	146_A	0.825	0.96
211_T	214_E	0.810	0.95
97_A	123_V	0.807	0.95
10_I	20_F	0.806	0.95
25_I	31_L	0.806	0.95
100_A	107_V	0.804	0.95
47_D	68_L	0.803	0.95
151_K	181_M	0.799	0.95
224_V	228_R	0.798	0.95
149_G	152_P	0.796	0.95
34_T	68_L	0.795	0.95
83_A	138_S	0.793	0.95
206_D	231_T	0.790	0.95
46_L	68_L	0.788	0.95
51_I	55_L	0.787	0.94
98_K	213_E	0.786	0.94
32_E	47_D	0.784	0.94
170_G	223_V	0.784	0.94
155_I	159_Y	0.784	0.94
50_I	73_L	0.783	0.94
169_V	190_I	0.782	0.94
128_N	133_L	0.780	0.94
205_L	218_S	0.779	0.94
50_I	54_A	0.776	0.94
207_I	215_I	0.771	0.94
96_L	146_A	0.768	0.94
171_L	177_R	0.767	0.94
171_L	201_S	0.761	0.93
221_S	225_L	0.758	0.93
36_V	50_I	0.748	0.93
25_I	28_G	0.748	0.93
151_K	172_L	0.747	0.93
26_Y	70_D	0.746	0.93
45_S	48_R	0.744	0.93
222_E	226_D	0.743	0.93
56_E	60_K	0.742	0.93
132_L	135_Q	0.741	0.93
6_I	35_I	0.741	0.93
179_A	182_I	0.740	0.92
47_D	70_D	0.740	0.92
116_K	123_V	0.740	0.92
53_I	56_E	0.738	0.92
67_D	72_K	0.737	0.92
116_K	120_F	0.736	0.92
52_E	56_E	0.729	0.92
13_L	35_I	0.726	0.92
101_I	122_G	0.724	0.92
180_L	184_L	0.723	0.92
92_I	151_K	0.723	0.92
102_D	213_E	0.721	0.91
100_A	104_G	0.720	0.91
94_R	98_K	0.720	0.91
45_S	69_E	0.720	0.91
28_G	45_S	0.719	0.91
206_D	230_G	0.710	0.91
214_E	224_V	0.708	0.91
84_I	220_L	0.706	0.91
50_I	68_L	0.703	0.90
205_L	222_E	0.701	0.90
160_I	164_K	0.700	0.90
48_R	51_I	0.700	0.90
36_V	58_L	0.697	0.90
90_G	151_K	0.694	0.90
113_G	117_E	0.691	0.90
95_F	99_L	0.689	0.90
22_I	78_I	0.688	0.89
21_A	54_A	0.688	0.89
116_K	119_D	0.687	0.89
8_P	12_K	0.686	0.89
25_I	47_D	0.685	0.89
153_Y	181_M	0.685	0.89
39_G	44_G	0.677	0.89
146_A	172_L	0.677	0.89
151_K	184_L	0.675	0.89
217_L	221_S	0.675	0.89
114_D	119_D	0.674	0.88
214_E	228_R	0.673	0.88
124_Y	127_S	0.672	0.88
144_I	168_F	0.669	0.88
90_G	203_L	0.669	0.88
105_Y	217_L	0.668	0.88
95_F	102_D	0.667	0.88
111_G	147_N	0.667	0.88
10_I	35_I	0.666	0.88
157_A	177_R	0.665	0.88
206_D	232_G	0.663	0.88
56_E	59_E	0.663	0.88
205_L	208_G	0.658	0.87
186_V	195_I	0.656	0.87
6_I	22_I	0.656	0.87
91_I	177_R	0.653	0.87
37_S	43_L	0.652	0.87
148_E	173_A	0.647	0.86
209_S	218_S	0.646	0.86
193_E	196_K	0.645	0.86
145_V	203_L	0.643	0.86
137_V	164_K	0.641	0.86
124_Y	130_L	0.641	0.86
154_D	212_A	0.640	0.86
109_V	120_F	0.640	0.86
203_L	219_I	0.637	0.86
113_G	116_K	0.633	0.85
67_D	70_D	0.628	0.85
149_G	181_M	0.627	0.85
226_D	229_G	0.627	0.85
37_S	40_R	0.625	0.84
92_I	177_R	0.625	0.84
10_I	53_I	0.624	0.84
115_V	120_F	0.621	0.84
57_A	60_K	0.620	0.84
147_N	151_K	0.620	0.84
29_N	32_E	0.619	0.84
101_I	106_Y	0.616	0.84
145_V	154_D	0.616	0.84
26_Y	30_R	0.616	0.84
172_L	203_L	0.613	0.83
106_Y	124_Y	0.612	0.83
164_K	169_V	0.609	0.83
110_V	172_L	0.601	0.82
128_N	132_L	0.599	0.82
207_I	214_E	0.596	0.82
146_A	203_L	0.596	0.82
158_L	169_V	0.593	0.81
157_A	160_I	0.589	0.81
148_E	172_L	0.588	0.81
9_L	43_L	0.588	0.81
53_I	57_A	0.588	0.81
147_N	153_Y	0.586	0.81
86_V	115_V	0.585	0.80
12_K	15_A	0.583	0.80
146_A	173_A	0.581	0.80
149_G	161_A	0.577	0.79
177_R	201_S	0.575	0.79
156_D	159_Y	0.570	0.79
49_N	69_E	0.570	0.79
129_D	132_L	0.570	0.79
180_L	183_S	0.568	0.78
95_F	174_S	0.564	0.78
19_R	58_L	0.562	0.78
10_I	14_S	0.559	0.77
109_V	123_V	0.558	0.77
174_S	178_A	0.558	0.77
45_S	68_L	0.556	0.77
151_K	174_S	0.556	0.77
217_L	223_V	0.548	0.76
189_D	195_I	0.544	0.75
156_D	188_R	0.544	0.75
154_D	157_A	0.543	0.75
167_R	226_D	0.543	0.75
30_R	69_E	0.540	0.75
7_F	10_I	0.540	0.75
8_P	11_S	0.540	0.75
34_T	54_A	0.539	0.75
28_G	44_G	0.535	0.74
47_D	54_A	0.534	0.74
36_V	40_R	0.533	0.74
31_L	45_S	0.533	0.74
112_S	130_L	0.533	0.74
130_L	156_D	0.531	0.74
95_F	177_R	0.527	0.73
90_G	177_R	0.526	0.73
223_V	227_L	0.523	0.73
105_Y	228_R	0.521	0.72
14_S	20_F	0.520	0.72
47_D	212_A	0.518	0.72
84_I	107_V	0.518	0.72
34_T	50_I	0.518	0.72
93_A	109_V	0.517	0.72
147_N	177_R	0.510	0.71
170_G	173_A	0.505	0.70
10_I	78_I	0.503	0.70
26_Y	31_L	0.500	0.69

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2we8A	2	0.839	100	0.18	Contact Map
3on5A	4	0.8727	100	0.274	Contact Map
1id1A	2	0.5169	97.5	0.897	Contact Map
3fwzA	2	0.4981	97	0.903	Contact Map
1lssA	3	0.4682	96.9	0.906	Contact Map
2g1uA	2	0.4831	96.6	0.909	Contact Map
3l9wA	2	0.5655	96.6	0.909	Contact Map
3llvA	2	0.4569	96.4	0.91	Contact Map
3l4bC	2	0.5955	96.4	0.911	Contact Map
3c85A	2	0.5281	95.9	0.915	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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