GREMLIN Database
Q97UW4 - Uncharacterized protein
UniProt: Q97UW4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 267 (226)
Sequences: 3025 (2235)
Seq/√Len: 148.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
186_V192_L3.4981.00
191_P194_E3.1831.00
217_L224_V3.1681.00
159_Y188_R3.0331.00
170_G203_L2.6611.00
143_V161_A2.5311.00
200_H222_E2.5201.00
84_I100_A2.5051.00
105_Y224_V2.4221.00
99_L217_L2.3661.00
192_L196_K2.2561.00
178_A182_I2.2091.00
89_S111_G2.1981.00
220_L223_V2.1441.00
19_R38_D2.1411.00
168_F222_E2.1161.00
100_A220_L2.0721.00
138_S141_S2.0701.00
99_L220_L2.0291.00
99_L102_D1.9901.00
83_A108_A1.9811.00
40_R44_G1.9381.00
86_V97_A1.9321.00
183_S187_K1.9221.00
87_V157_A1.8971.00
23_V50_I1.8951.00
28_G47_D1.8811.00
34_T47_D1.8571.00
159_Y163_K1.8171.00
143_V166_A1.8131.00
12_K16_E1.7821.00
33_R76_E1.7671.00
26_Y65_Q1.7441.00
134_E160_I1.6691.00
21_A58_L1.6691.00
132_L136_M1.6671.00
166_A169_V1.6621.00
155_I184_L1.6241.00
144_I203_L1.6161.00
178_A201_S1.5941.00
49_N53_I1.5851.00
84_I223_V1.5721.00
24_S33_R1.5541.00
139_E165_R1.5211.00
21_A75_I1.5171.00
37_S41_V1.5081.00
159_Y190_I1.5071.00
182_I195_I1.5061.00
28_G34_T1.5031.00
96_L144_I1.4651.00
98_K102_D1.4631.00
182_I199_L1.4621.00
18_K38_D1.4621.00
53_I68_L1.4591.00
9_L12_K1.4491.00
209_S228_R1.4401.00
96_L219_I1.4281.00
200_H226_D1.4261.00
137_V141_S1.4251.00
222_E225_L1.4231.00
158_L171_L1.4191.00
166_A198_R1.3941.00
182_I186_V1.3711.00
85_I137_V1.3631.00
137_V143_V1.3571.00
13_L18_K1.3431.00
225_L229_G1.3351.00
112_S148_E1.3331.00
95_F213_E1.3311.00
84_I142_I1.3011.00
194_E198_R1.2791.00
169_V199_L1.2731.00
103_M220_L1.2691.00
53_I66_K1.2621.00
161_A169_V1.2541.00
9_L13_L1.2221.00
23_V36_V1.2221.00
164_K198_R1.2141.00
28_G32_E1.2141.00
190_I194_E1.2131.00
98_K122_G1.2051.00
45_S49_N1.2021.00
44_G47_D1.1641.00
84_I144_I1.1561.00
53_I64_I1.1531.00
105_Y142_I1.1491.00
27_K72_K1.1471.00
179_A183_S1.1421.00
96_L220_L1.1401.00
41_V44_G1.1361.00
13_L20_F1.1351.00
23_V73_L1.1290.99
145_V161_A1.1190.99
13_L37_S1.1190.99
92_I174_S1.1100.99
85_I143_V1.1060.99
49_N52_E1.1030.99
127_S131_N1.0970.99
83_A141_S1.0900.99
176_K180_L1.0740.99
151_K177_R1.0620.99
112_S153_Y1.0620.99
171_L178_A1.0560.99
163_K194_E1.0540.99
155_I188_R1.0520.99
18_K37_S1.0520.99
142_I227_L1.0500.99
149_G153_Y1.0450.99
178_A199_L1.0440.99
163_K190_I1.0310.99
127_S130_L1.0230.99
103_M217_L1.0230.99
171_L181_M1.0180.99
21_A57_A1.0170.99
57_A63_V1.0110.99
83_A106_Y1.0100.99
161_A166_A1.0050.99
97_A109_V0.9900.99
144_I223_V0.9900.99
85_I110_V0.9870.99
92_I172_L0.9800.99
104_G213_E0.9770.98
147_N154_D0.9730.98
82_P227_L0.9690.98
137_V166_A0.9690.98
40_R43_L0.9630.98
209_S214_E0.9610.98
57_A64_I0.9610.98
36_V54_A0.9600.98
85_I141_S0.9570.98
146_A174_S0.9300.98
177_R181_M0.9300.98
82_P142_I0.9290.98
11_S15_A0.9280.98
142_I167_R0.9190.98
182_I196_K0.9170.98
60_K64_I0.9130.98
115_V125_A0.9110.98
95_F98_K0.9020.97
105_Y227_L0.8990.97
36_V51_I0.8900.97
112_S149_G0.8890.97
25_I30_R0.8880.97
28_G31_L0.8820.97
31_L47_D0.8800.97
162_M190_I0.8780.97
97_A107_V0.8750.97
158_L199_L0.8720.97
86_V93_A0.8710.97
142_I168_F0.8690.97
120_F123_V0.8650.97
145_V171_L0.8640.97
46_L71_G0.8640.97
92_I215_I0.8620.97
84_I105_Y0.8590.97
85_I108_A0.8570.97
124_Y128_N0.8550.97
87_V143_V0.8540.96
145_V158_L0.8520.96
168_F203_L0.8470.96
81_R104_G0.8450.96
49_N68_L0.8440.96
54_A58_L0.8420.96
20_F35_I0.8380.96
151_K155_I0.8370.96
86_V96_L0.8370.96
94_R119_D0.8260.96
92_I146_A0.8250.96
211_T214_E0.8100.95
97_A123_V0.8070.95
10_I20_F0.8060.95
25_I31_L0.8060.95
100_A107_V0.8040.95
47_D68_L0.8030.95
151_K181_M0.7990.95
224_V228_R0.7980.95
149_G152_P0.7960.95
34_T68_L0.7950.95
83_A138_S0.7930.95
206_D231_T0.7900.95
46_L68_L0.7880.95
51_I55_L0.7870.94
98_K213_E0.7860.94
32_E47_D0.7840.94
170_G223_V0.7840.94
155_I159_Y0.7840.94
50_I73_L0.7830.94
169_V190_I0.7820.94
128_N133_L0.7800.94
205_L218_S0.7790.94
50_I54_A0.7760.94
207_I215_I0.7710.94
96_L146_A0.7680.94
171_L177_R0.7670.94
171_L201_S0.7610.93
221_S225_L0.7580.93
36_V50_I0.7480.93
25_I28_G0.7480.93
151_K172_L0.7470.93
26_Y70_D0.7460.93
45_S48_R0.7440.93
222_E226_D0.7430.93
56_E60_K0.7420.93
132_L135_Q0.7410.93
6_I35_I0.7410.93
179_A182_I0.7400.92
47_D70_D0.7400.92
116_K123_V0.7400.92
53_I56_E0.7380.92
67_D72_K0.7370.92
116_K120_F0.7360.92
52_E56_E0.7290.92
13_L35_I0.7260.92
101_I122_G0.7240.92
180_L184_L0.7230.92
92_I151_K0.7230.92
102_D213_E0.7210.91
100_A104_G0.7200.91
94_R98_K0.7200.91
45_S69_E0.7200.91
28_G45_S0.7190.91
206_D230_G0.7100.91
214_E224_V0.7080.91
84_I220_L0.7060.91
50_I68_L0.7030.90
205_L222_E0.7010.90
160_I164_K0.7000.90
48_R51_I0.7000.90
36_V58_L0.6970.90
90_G151_K0.6940.90
113_G117_E0.6910.90
95_F99_L0.6890.90
22_I78_I0.6880.89
21_A54_A0.6880.89
116_K119_D0.6870.89
8_P12_K0.6860.89
25_I47_D0.6850.89
153_Y181_M0.6850.89
39_G44_G0.6770.89
146_A172_L0.6770.89
151_K184_L0.6750.89
217_L221_S0.6750.89
114_D119_D0.6740.88
214_E228_R0.6730.88
124_Y127_S0.6720.88
144_I168_F0.6690.88
90_G203_L0.6690.88
105_Y217_L0.6680.88
95_F102_D0.6670.88
111_G147_N0.6670.88
10_I35_I0.6660.88
157_A177_R0.6650.88
206_D232_G0.6630.88
56_E59_E0.6630.88
205_L208_G0.6580.87
186_V195_I0.6560.87
6_I22_I0.6560.87
91_I177_R0.6530.87
37_S43_L0.6520.87
148_E173_A0.6470.86
209_S218_S0.6460.86
193_E196_K0.6450.86
145_V203_L0.6430.86
137_V164_K0.6410.86
124_Y130_L0.6410.86
154_D212_A0.6400.86
109_V120_F0.6400.86
203_L219_I0.6370.86
113_G116_K0.6330.85
67_D70_D0.6280.85
149_G181_M0.6270.85
226_D229_G0.6270.85
37_S40_R0.6250.84
92_I177_R0.6250.84
10_I53_I0.6240.84
115_V120_F0.6210.84
57_A60_K0.6200.84
147_N151_K0.6200.84
29_N32_E0.6190.84
101_I106_Y0.6160.84
145_V154_D0.6160.84
26_Y30_R0.6160.84
172_L203_L0.6130.83
106_Y124_Y0.6120.83
164_K169_V0.6090.83
110_V172_L0.6010.82
128_N132_L0.5990.82
207_I214_E0.5960.82
146_A203_L0.5960.82
158_L169_V0.5930.81
157_A160_I0.5890.81
148_E172_L0.5880.81
9_L43_L0.5880.81
53_I57_A0.5880.81
147_N153_Y0.5860.81
86_V115_V0.5850.80
12_K15_A0.5830.80
146_A173_A0.5810.80
149_G161_A0.5770.79
177_R201_S0.5750.79
156_D159_Y0.5700.79
49_N69_E0.5700.79
129_D132_L0.5700.79
180_L183_S0.5680.78
95_F174_S0.5640.78
19_R58_L0.5620.78
10_I14_S0.5590.77
109_V123_V0.5580.77
174_S178_A0.5580.77
45_S68_L0.5560.77
151_K174_S0.5560.77
217_L223_V0.5480.76
189_D195_I0.5440.75
156_D188_R0.5440.75
154_D157_A0.5430.75
167_R226_D0.5430.75
30_R69_E0.5400.75
7_F10_I0.5400.75
8_P11_S0.5400.75
34_T54_A0.5390.75
28_G44_G0.5350.74
47_D54_A0.5340.74
36_V40_R0.5330.74
31_L45_S0.5330.74
112_S130_L0.5330.74
130_L156_D0.5310.74
95_F177_R0.5270.73
90_G177_R0.5260.73
223_V227_L0.5230.73
105_Y228_R0.5210.72
14_S20_F0.5200.72
47_D212_A0.5180.72
84_I107_V0.5180.72
34_T50_I0.5180.72
93_A109_V0.5170.72
147_N177_R0.5100.71
170_G173_A0.5050.70
10_I78_I0.5030.70
26_Y31_L0.5000.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2we8A 2 0.839 100 0.18 Contact Map
3on5A 4 0.8727 100 0.274 Contact Map
1id1A 2 0.5169 97.5 0.897 Contact Map
3fwzA 2 0.4981 97 0.903 Contact Map
1lssA 3 0.4682 96.9 0.906 Contact Map
2g1uA 2 0.4831 96.6 0.909 Contact Map
3l9wA 2 0.5655 96.6 0.909 Contact Map
3llvA 2 0.4569 96.4 0.91 Contact Map
3l4bC 2 0.5955 96.4 0.911 Contact Map
3c85A 2 0.5281 95.9 0.915 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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