GREMLIN Database
Q97UW2 - Uncharacterized protein
UniProt: Q97UW2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 502 (399)
Sequences: 6639 (4221)
Seq/√Len: 211.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
220_M262_V4.5441.00
184_V216_V4.1831.00
307_S360_D3.9541.00
307_S363_D3.9351.00
309_K360_D3.4361.00
258_K288_I3.3011.00
372_I417_K3.2621.00
332_V370_Y3.2441.00
402_E406_S3.2011.00
335_T339_N2.9531.00
217_E221_K2.8591.00
308_E329_D2.8251.00
369_E413_Y2.7381.00
309_K313_K2.7161.00
216_V227_V2.7081.00
256_E259_R2.6611.00
399_P402_E2.5811.00
255_A287_E2.5551.00
366_K370_Y2.5091.00
214_R217_E2.4891.00
331_I335_T2.4631.00
279_P337_I2.4261.00
209_L256_E2.4181.00
331_I339_N2.4051.00
255_A284_A2.4021.00
216_V257_L2.4011.00
143_D146_E2.3181.00
366_K369_E2.3021.00
459_E462_K2.2411.00
225_K263_D2.2301.00
365_I410_D2.2041.00
357_T360_D2.1891.00
283_K287_E2.1171.00
258_K294_E2.1101.00
362_E366_K2.0991.00
303_L367_L2.0521.00
249_A280_K2.0491.00
283_K341_S2.0441.00
361_V406_S1.9961.00
396_N399_P1.9781.00
77_V80_K1.9721.00
308_E320_F1.9691.00
320_F366_K1.9171.00
258_K289_A1.8971.00
372_I414_L1.8891.00
362_E406_S1.8851.00
320_F363_D1.8501.00
333_E336_A1.8471.00
249_A252_R1.8411.00
416_W420_L1.8141.00
184_V212_I1.8091.00
305_T364_S1.7941.00
382_P389_G1.7931.00
329_D333_E1.7921.00
207_F215_E1.7891.00
449_K452_K1.7821.00
332_V336_A1.7731.00
358_D399_P1.7651.00
330_L334_S1.7621.00
382_P394_R1.7611.00
49_P60_G1.7571.00
214_R218_V1.7531.00
336_A340_E1.7351.00
332_V371_I1.7231.00
85_F115_V1.7111.00
136_F147_V1.7091.00
329_D332_V1.7031.00
310_I313_K1.6821.00
70_D149_K1.6821.00
105_K108_E1.6761.00
150_K155_E1.6761.00
365_I406_S1.6561.00
379_W404_L1.6401.00
333_E337_I1.6341.00
208_P211_Y1.6241.00
360_D363_D1.6221.00
284_A288_I1.6051.00
431_A451_F1.6001.00
369_E410_D1.5961.00
213_M256_E1.5831.00
363_D366_K1.5821.00
121_A135_I1.5511.00
418_Y421_K1.5451.00
358_D362_E1.5321.00
255_A280_K1.5231.00
115_V134_V1.4991.00
286_A341_S1.4991.00
349_M368_V1.4921.00
320_F367_L1.4751.00
252_R280_K1.4571.00
195_W315_M1.4541.00
134_V151_L1.4451.00
279_P283_K1.4371.00
405_P409_W1.4321.00
213_M217_E1.4311.00
63_V117_G1.4281.00
299_P343_I1.4231.00
359_K363_D1.4211.00
288_I294_E1.4131.00
252_R256_E1.4101.00
218_V222_A1.3951.00
410_D414_L1.3921.00
255_A288_I1.3851.00
409_W413_Y1.3761.00
207_F211_Y1.3711.00
285_M295_K1.3621.00
339_N342_Y1.3611.00
330_L333_E1.3501.00
411_L414_L1.3491.00
263_D428_N1.3481.00
255_A259_R1.3451.00
248_D256_E1.3431.00
258_K284_A1.3371.00
90_T96_F1.3341.00
283_K337_I1.3201.00
315_M387_P1.3181.00
297_V447_I1.3121.00
251_V284_A1.2961.00
401_L405_P1.2951.00
248_D252_R1.2911.00
441_S444_T1.2881.00
420_L423_T1.2821.00
330_L339_N1.2791.00
195_W387_P1.2761.00
217_E260_A1.2711.00
374_H418_Y1.2621.00
319_A330_L1.2601.00
313_K360_D1.2591.00
330_L335_T1.2581.00
93_A97_D1.2401.00
422_I427_G1.2391.00
308_E319_A1.2341.00
457_Y460_R1.2251.00
449_K454_I1.2251.00
218_V221_K1.2161.00
254_Y295_K1.2121.00
193_G201_P1.2091.00
107_K133_D1.2091.00
47_T60_G1.2061.00
359_K362_E1.1951.00
387_P390_L1.1931.00
338_M343_I1.1641.00
397_P401_L1.1571.00
439_I442_I1.1571.00
368_V407_R1.1541.00
460_R463_E1.1541.00
413_Y417_K1.1491.00
84_I112_L1.1481.00
227_V262_V1.1431.00
307_S310_I1.1421.00
313_K355_E1.1391.00
457_Y462_K1.1371.00
46_V49_P1.1241.00
149_K153_Q1.1191.00
146_E150_K1.1161.00
358_D406_S1.1091.00
297_V342_Y1.1081.00
332_V339_N1.1071.00
334_S339_N1.1061.00
285_M299_P1.0991.00
308_E312_N1.0961.00
260_A294_E1.0951.00
284_A295_K1.0941.00
313_K391_S1.0871.00
336_A370_Y1.0851.00
435_K438_F1.0841.00
158_P161_V1.0801.00
308_E363_D1.0801.00
445_Y449_K1.0781.00
414_L418_Y1.0761.00
209_L213_M1.0741.00
150_K154_G1.0711.00
379_W397_P1.0691.00
193_G203_T1.0661.00
431_A454_I1.0621.00
124_L127_D1.0621.00
158_P162_R1.0581.00
422_I425_R1.0511.00
117_G136_F1.0501.00
372_I418_Y1.0471.00
128_P132_A1.0451.00
456_W460_R1.0421.00
283_K286_A1.0411.00
116_V132_A1.0381.00
113_K151_L1.0351.00
355_E393_I1.0331.00
368_V376_P1.0301.00
453_T456_W1.0261.00
217_E256_E1.0261.00
67_N148_V1.0141.00
140_A143_D1.0141.00
397_P400_A1.0101.00
265_I294_E0.9981.00
332_V335_T0.9971.00
453_T457_Y0.9941.00
335_T340_E0.9931.00
320_F332_V0.9931.00
409_W412_L0.9891.00
138_G141_E0.9891.00
442_I446_M0.9801.00
288_I295_K0.9781.00
368_V373_D0.9731.00
335_T342_Y0.9731.00
347_Y376_P0.9721.00
134_V147_V0.9721.00
258_K295_K0.9711.00
439_I453_T0.9631.00
331_I340_E0.9621.00
220_M261_G0.9601.00
229_L257_L0.9591.00
113_K152_E0.9551.00
254_Y288_I0.9541.00
64_I74_I0.9531.00
46_V50_E0.9511.00
211_Y214_R0.9511.00
449_K453_T0.9501.00
379_W401_L0.9491.00
195_W353_Y0.9491.00
156_E161_V0.9460.99
210_D214_R0.9400.99
279_P282_V0.9400.99
408_Y411_L0.9350.99
428_N444_T0.9350.99
351_I361_V0.9320.99
159_R162_R0.9320.99
426_L463_E0.9270.99
105_K109_K0.9270.99
92_T99_L0.9240.99
299_P338_M0.9230.99
404_L408_Y0.9220.99
187_T204_F0.9210.99
280_K283_K0.9200.99
334_S337_I0.9180.99
346_C375_E0.9110.99
83_M113_K0.9090.99
125_E128_P0.9080.99
191_P239_A0.9070.99
242_L246_N0.9030.99
96_F99_L0.9020.99
57_T185_Q0.9010.99
262_V265_I0.8960.99
414_L417_K0.8960.99
278_S281_T0.8950.99
306_G367_L0.8950.99
297_V444_T0.8920.99
210_D256_E0.8890.99
442_I448_D0.8880.99
444_T448_D0.8880.99
337_I340_E0.8870.99
209_L252_R0.8830.99
444_T447_I0.8800.99
365_I369_E0.8790.99
349_M376_P0.8770.99
334_S338_M0.8770.99
169_L173_P0.8740.99
358_D402_E0.8700.99
94_K98_E0.8700.99
441_S446_M0.8680.99
115_V136_F0.8660.99
64_I68_V0.8640.99
411_L415_S0.8620.99
456_W459_E0.8620.99
434_S439_I0.8600.99
310_I360_D0.8600.99
298_S346_C0.8590.99
236_L276_K0.8580.99
449_K462_K0.8520.99
331_I334_S0.8500.99
213_M257_L0.8500.99
263_D294_E0.8490.99
284_A287_E0.8460.99
251_V278_S0.8450.99
431_A462_K0.8440.99
149_K152_E0.8440.99
410_D413_Y0.8430.99
254_Y281_T0.8430.99
156_E162_R0.8430.99
177_N180_R0.8390.99
289_A294_E0.8390.99
309_K312_N0.8370.99
219_N224_I0.8370.99
428_N447_I0.8320.99
77_V106_L0.8300.99
428_N463_E0.8300.99
362_E365_I0.8290.99
367_L371_I0.8280.99
171_E211_Y0.8280.99
415_S419_D0.8280.99
96_F100_G0.8280.99
282_V338_M0.8250.99
209_L248_D0.8240.99
443_V447_I0.8240.99
250_I254_Y0.8140.98
182_G219_N0.8060.98
60_G64_I0.8050.98
264_Y267_F0.8040.98
439_I443_V0.8030.98
313_K353_Y0.8030.98
192_R233_D0.8010.98
251_V280_K0.8000.98
116_V128_P0.7980.98
349_M407_R0.7930.98
309_K363_D0.7930.98
441_S449_K0.7900.98
391_S394_R0.7880.98
209_L237_Y0.7870.98
242_L247_H0.7850.98
238_G241_R0.7850.98
88_G116_V0.7850.98
193_G315_M0.7800.98
439_I444_T0.7760.98
210_D217_E0.7750.98
334_S341_S0.7700.98
459_E463_E0.7690.98
122_W137_L0.7690.98
192_R236_L0.7680.98
368_V372_I0.7640.98
260_A263_D0.7640.98
92_T95_F0.7630.98
361_V407_R0.7620.98
454_I462_K0.7600.98
444_T449_K0.7570.98
168_K171_E0.7550.98
207_F212_I0.7520.97
204_F236_L0.7520.97
92_T98_E0.7510.97
452_K462_K0.7510.97
441_S445_Y0.7490.97
91_W95_F0.7490.97
67_N85_F0.7490.97
235_L272_A0.7470.97
458_F462_K0.7470.97
267_F285_M0.7440.97
48_T102_K0.7440.97
70_D146_E0.7430.97
441_S455_E0.7400.97
259_R288_I0.7390.97
331_I373_D0.7380.97
282_V337_I0.7380.97
252_R255_A0.7360.97
91_W96_F0.7320.97
195_W313_K0.7320.97
456_W462_K0.7320.97
92_T96_F0.7300.97
394_R400_A0.7300.97
393_I396_N0.7280.97
417_K420_L0.7270.97
209_L253_L0.7270.97
212_I253_L0.7270.97
66_I145_P0.7270.97
183_E228_S0.7230.97
91_W99_L0.7220.97
163_G166_P0.7220.97
97_D101_E0.7180.97
319_A329_D0.7180.97
184_V219_N0.7180.97
107_K112_L0.7170.97
78_S84_I0.7150.97
151_L154_G0.7150.97
175_I179_S0.7140.97
320_F370_Y0.7110.96
236_L275_V0.7110.96
331_I337_I0.7100.96
191_P203_T0.7100.96
196_F318_K0.7090.96
333_E339_N0.7080.96
132_A135_I0.7070.96
94_K101_E0.7060.96
406_S410_D0.7050.96
156_E160_V0.7040.96
174_P178_P0.7030.96
242_L248_D0.6990.96
91_W98_E0.6980.96
96_F103_V0.6980.96
309_K357_T0.6970.96
186_I234_M0.6950.96
220_M260_A0.6940.96
163_G167_R0.6930.96
434_S438_F0.6920.96
94_K97_D0.6900.96
347_Y373_D0.6880.96
214_R221_K0.6850.96
163_G169_L0.6850.96
54_K57_T0.6840.96
351_I407_R0.6840.96
452_K457_Y0.6840.96
164_R167_R0.6830.96
192_R275_V0.6830.96
84_I114_V0.6790.95
442_I445_Y0.6790.95
68_V74_I0.6780.95
61_T65_G0.6770.95
90_T123_Q0.6740.95
163_G170_D0.6740.95
50_E102_K0.6740.95
452_K456_W0.6740.95
166_P170_D0.6710.95
185_Q188_R0.6700.95
113_K134_V0.6700.95
84_I106_L0.6650.95
115_V147_V0.6650.95
166_P171_E0.6650.95
272_A277_L0.6650.95
405_P408_Y0.6640.95
72_R83_M0.6630.95
453_T458_F0.6620.95
75_E80_K0.6610.95
226_D266_N0.6610.95
342_Y425_R0.6610.95
364_S407_R0.6600.95
337_I341_S0.6590.95
313_K393_I0.6580.95
362_E402_E0.6570.94
423_T426_L0.6570.94
198_S201_P0.6560.94
86_G103_V0.6540.94
99_L103_V0.6530.94
376_P411_L0.6510.94
113_K148_V0.6510.94
275_V317_M0.6490.94
241_R246_N0.6460.94
454_I457_Y0.6450.94
330_L338_M0.6440.94
442_I447_I0.6440.94
107_K110_F0.6430.94
304_E316_K0.6400.94
148_V152_E0.6400.94
54_K232_D0.6400.94
241_R248_D0.6390.94
272_A301_V0.6340.93
440_R443_V0.6330.93
49_P87_G0.6330.93
351_I379_W0.6320.93
151_L155_E0.6300.93
445_Y448_D0.6300.93
344_F448_D0.6290.93
369_E414_L0.6290.93
391_S395_D0.6280.93
408_Y412_L0.6280.93
314_Y353_Y0.6280.93
344_F374_H0.6270.93
96_F102_K0.6240.93
68_V73_G0.6230.93
95_F102_K0.6220.93
418_Y422_I0.6210.93
303_L349_M0.6210.93
99_L116_V0.6200.93
150_K153_Q0.6200.93
306_G364_S0.6200.93
46_V78_S0.6180.93
441_S447_I0.6160.92
47_T64_I0.6160.92
279_P333_E0.6160.92
349_M364_S0.6140.92
406_S409_W0.6140.92
97_D100_G0.6120.92
63_V144_F0.6110.92
141_E188_R0.6100.92
368_V414_L0.6090.92
402_E405_P0.6090.92
299_P345_P0.6090.92
263_D289_A0.6080.92
394_R399_P0.6070.92
65_G69_H0.6070.92
91_W103_V0.6050.92
451_F454_I0.6040.92
412_L416_W0.6030.92
392_K395_D0.6030.92
450_V453_T0.6010.91
282_V341_S0.6000.91
353_Y391_S0.6000.91
300_V348_T0.5990.91
399_P403_R0.5990.91
342_Y421_K0.5950.91
98_E101_E0.5930.91
75_E81_L0.5920.91
454_I458_F0.5900.91
72_R149_K0.5890.91
59_K188_R0.5850.90
422_I447_I0.5850.90
174_P177_N0.5840.90
103_V116_V0.5830.90
164_R169_L0.5820.90
201_P385_V0.5820.90
201_P387_P0.5810.90
277_L281_T0.5800.90
192_R276_K0.5800.90
251_V281_T0.5790.90
206_S240_K0.5780.90
361_V365_I0.5770.90
441_S448_D0.5760.90
439_I445_Y0.5760.90
52_L55_V0.5740.89
106_L112_L0.5720.89
250_I281_T0.5720.89
287_E294_E0.5720.89
379_W400_A0.5710.89
455_E460_R0.5690.89
416_W419_D0.5680.89
446_M449_K0.5650.89
51_K55_V0.5640.89
279_P330_L0.5640.89
271_S298_S0.5630.89
128_P135_I0.5630.89
145_P148_V0.5630.89
376_P414_L0.5620.89
139_H196_F0.5620.89
277_L282_V0.5620.89
113_K119_A0.5610.88
166_P173_P0.5600.88
413_Y416_W0.5600.88
445_Y451_F0.5600.88
348_T383_L0.5590.88
398_L402_E0.5590.88
220_M265_I0.5590.88
176_I180_R0.5570.88
449_K459_E0.5570.88
235_L277_L0.5570.88
139_H205_I0.5560.88
309_K359_K0.5550.88
95_F99_L0.5540.88
156_E159_R0.5520.88
233_D276_K0.5510.88
249_A278_S0.5500.87
171_E214_R0.5500.87
331_I342_Y0.5490.87
336_A339_N0.5490.87
192_R317_M0.5490.87
92_T100_G0.5470.87
70_D145_P0.5470.87
152_E155_E0.5460.87
452_K459_E0.5460.87
75_E78_S0.5450.87
91_W198_S0.5450.87
49_P55_V0.5450.87
450_V454_I0.5440.87
93_A99_L0.5440.87
421_K425_R0.5430.87
353_Y388_M0.5420.87
113_K116_V0.5420.87
210_D242_L0.5420.87
60_G63_V0.5410.87
404_L407_R0.5410.87
145_P149_K0.5400.86
458_F463_E0.5400.86
49_P52_L0.5390.86
400_A404_L0.5380.86
277_L334_S0.5350.86
298_S449_K0.5350.86
442_I449_K0.5340.86
282_V334_S0.5340.86
394_R397_P0.5330.86
306_G363_D0.5330.86
182_G224_I0.5320.86
309_K355_E0.5310.86
163_G168_K0.5290.85
271_S303_L0.5270.85
169_L172_I0.5260.85
60_G87_G0.5260.85
438_F441_S0.5260.85
251_V255_A0.5250.85
123_Q384_P0.5250.85
68_V175_I0.5240.85
196_F315_M0.5240.85
82_S110_F0.5240.85
164_R168_K0.5230.85
184_V227_V0.5230.85
51_K54_K0.5220.85
454_I460_R0.5210.84
335_T345_P0.5210.84
362_E369_E0.5210.84
434_S437_P0.5210.84
94_K99_L0.5200.84
167_R170_D0.5190.84
449_K460_R0.5190.84
62_K65_G0.5190.84
234_M267_F0.5120.83
50_E99_L0.5110.83
254_Y258_K0.5110.83
257_L265_I0.5110.83
335_T338_M0.5100.83
240_K247_H0.5090.83
271_S300_V0.5080.83
368_V411_L0.5070.83
453_T462_K0.5060.83
136_F140_A0.5060.83
358_D403_R0.5050.83
100_G103_V0.5040.83
339_N372_I0.5040.83
372_I421_K0.5040.83
166_P169_L0.5030.82
140_A147_V0.5030.82
95_F98_E0.5020.82
144_F148_V0.5020.82
235_L377_I0.5020.82
333_E340_E0.5010.82
300_V383_L0.5010.82
101_E104_S0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4jc0A 1 0.8088 100 0.536 Contact Map
2qgqA 1 0.5239 100 0.685 Contact Map
1oltA 1 0.6793 100 0.753 Contact Map
4u0oB 1 0.5199 99.9 0.781 Contact Map
4fhdA 1 0.5996 99.9 0.795 Contact Map
4wcxA 1 0.7012 99.9 0.799 Contact Map
1r30A 2 0.5936 99.9 0.803 Contact Map
3iixA 1 0.6474 99.9 0.804 Contact Map
3t7vA 1 0.6394 99.9 0.812 Contact Map
4rtbA 2 0.6892 99.9 0.813 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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