GREMLIN Database
Q97UW1 - Second ORF in transposon ISC1225
UniProt: Q97UW1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 296 (256)
Sequences: 198 (128)
Seq/√Len: 8.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
71_T216_Y5.9761.00
117_L215_S5.0140.99
43_I98_V3.8500.97
112_V136_V3.5780.95
7_R233_F3.2910.92
60_S66_S3.1030.89
82_L216_Y3.0510.88
192_T228_S2.8720.85
46_T220_K2.8610.85
22_L26_R2.7420.82
46_T59_G2.6470.80
119_A138_G2.6020.78
236_L240_L2.4850.75
244_F255_M2.4400.74
214_T217_R2.3580.71
105_I115_V2.3520.71
88_Q116_T2.3220.70
72_A84_A2.2200.66
181_R185_R2.2020.65
118_D209_R2.1700.64
50_W246_S2.1540.64
260_F263_L2.0620.60
122_Y139_V2.0400.59
80_V217_R2.0390.59
59_G228_S2.0270.59
67_W216_Y2.0000.58
222_F245_Y1.9550.56
192_T245_Y1.9200.54
41_I105_I1.9030.54
78_N128_K1.8800.53
42_S58_L1.8600.52
220_K245_Y1.8530.52
45_W112_V1.8170.50
205_Y212_I1.7310.47
216_Y226_T1.7200.46
46_T202_L1.7190.46
44_D213_E1.7020.45
47_T68_N1.6890.45
13_Q55_V1.6810.45
82_L242_M1.6570.44
98_V101_L1.6340.43
224_P237_I1.6180.42
192_T210_S1.6000.41
18_I21_L1.5890.41
120_G247_L1.5720.40
122_Y214_T1.5380.39
136_V174_Y1.5090.38
10_V65_N1.4830.37
216_Y227_S1.4790.37
118_D213_E1.4770.37
70_A101_L1.4680.36
101_L245_Y1.4470.35
69_Y122_Y1.4190.34
193_N245_Y1.4190.34
190_E193_N1.4180.34
209_R213_E1.4070.34
28_I233_F1.3950.33
252_K256_T1.3880.33
168_K212_I1.3830.33
71_T212_I1.3560.32
46_T228_S1.3470.32
72_A246_S1.3390.31
46_T80_V1.3340.31
66_S210_S1.3310.31
200_E203_K1.3240.31
205_Y213_E1.3200.31
64_G261_R1.3120.30
71_T238_F1.3100.30
88_Q98_V1.3100.30
195_D207_K1.3100.30
112_V170_R1.3060.30
214_T247_L1.2940.30
114_L221_A1.2920.30
117_L122_Y1.2830.29
220_K228_S1.2390.28
192_T222_F1.2370.28
11_E102_M1.2330.28
220_K238_F1.2290.28
190_E228_S1.2110.27
70_A135_F1.2050.27
135_F252_K1.2030.27
109_G236_L1.2020.27
50_W58_L1.2010.27
164_E187_V1.2010.27
110_L155_T1.1970.27
6_V224_P1.1960.27
98_V105_I1.1950.27
112_V216_Y1.1930.27
19_E23_E1.1890.26
259_E262_L1.1880.26
214_T250_V1.1800.26
112_V219_I1.1780.26
101_L216_Y1.1770.26
14_G18_I1.1760.26
127_L135_F1.1610.26
71_T239_V1.1610.26
44_D118_D1.1580.25
105_I135_F1.1310.25
225_F246_S1.1170.24
206_N246_S1.1130.24
228_S238_F1.1070.24
112_V182_G1.0980.24
110_L115_V1.0970.24
52_G69_Y1.0880.23
44_D209_R1.0830.23
193_N238_F1.0750.23
65_N249_T1.0670.23
67_W222_F1.0630.23
70_A216_Y1.0540.22
131_S161_H1.0530.22
13_Q21_L1.0520.22
70_A97_I1.0460.22
137_I194_L1.0350.22
136_V166_Q1.0340.22
6_V9_Y1.0320.22
19_E236_L1.0280.22
64_G212_I1.0200.21
72_A105_I1.0190.21
60_S240_L1.0190.21
79_M113_G1.0150.21
42_S126_V1.0090.21
147_Y150_F0.9990.21
206_N211_P0.9980.21
88_Q185_R0.9920.21
40_D116_T0.9920.21
44_D205_Y0.9910.21
81_L143_D0.9890.21
112_V195_D0.9880.21
92_M136_V0.9850.20
42_S75_K0.9830.20
189_R249_T0.9760.20
249_T252_K0.9750.20
80_V113_G0.9700.20
9_Y230_K0.9690.20
72_A255_M0.9680.20
234_R248_Y0.9670.20
190_E236_L0.9660.20
42_S59_G0.9640.20
122_Y247_L0.9600.20
101_L219_I0.9570.20
214_T218_N0.9520.20
193_N210_S0.9500.20
57_G231_F0.9480.19
88_Q198_K0.9380.19
47_T120_G0.9380.19
39_V197_P0.9380.19
127_L191_A0.9340.19
233_F237_I0.9320.19
192_T220_K0.9310.19
74_T248_Y0.9300.19
43_I133_F0.9290.19
101_L193_N0.9280.19
14_G115_V0.9280.19
29_S172_L0.9240.19
87_P135_F0.9180.19
23_E58_L0.9170.19
113_G210_S0.9160.19
241_A258_E0.9100.18
82_L122_Y0.8950.18
117_L120_G0.8950.18
76_Y239_V0.8880.18
58_L84_A0.8770.18
49_T244_F0.8750.18
110_L133_F0.8720.18
251_F254_V0.8660.17
47_T66_S0.8660.17
4_Q7_R0.8640.17
70_A126_V0.8630.17
43_I70_A0.8630.17
24_S126_V0.8620.17
64_G102_M0.8600.17
69_Y143_D0.8550.17
116_T138_G0.8540.17
69_Y175_G0.8530.17
29_S218_N0.8520.17
174_Y202_L0.8480.17
238_F245_Y0.8330.17
176_K181_R0.8300.17
121_F213_E0.8260.17
64_G112_V0.8240.16
5_T42_S0.8230.16
210_S236_L0.8210.16
219_I238_F0.8190.16
149_E153_E0.8160.16
89_V102_M0.8150.16
4_Q11_E0.8130.16
152_G164_E0.8120.16
46_T135_F0.8100.16
65_N214_T0.8060.16
117_L210_S0.8050.16
121_F226_T0.8040.16
80_V210_S0.8010.16
56_E177_E0.8010.16
173_V215_S0.8000.16
8_N12_E0.7980.16
86_V214_T0.7950.16
210_S228_S0.7930.16
123_T229_T0.7910.16
53_K152_G0.7890.16
11_E158_S0.7850.16
84_A102_M0.7840.16
19_E25_M0.7820.16
14_G22_L0.7770.15
119_A235_E0.7640.15
21_L25_M0.7630.15
155_T173_V0.7600.15
108_M153_E0.7600.15
193_N240_L0.7590.15
126_V216_Y0.7570.15
193_N222_F0.7560.15
82_L219_I0.7510.15
74_T88_Q0.7480.15
47_T247_L0.7470.15
19_E81_L0.7440.15
126_V214_T0.7440.15
135_F193_N0.7410.15
221_A244_F0.7360.15
98_V135_F0.7350.15
229_T236_L0.7330.15
23_E26_R0.7280.14
18_I69_Y0.7280.14
10_V18_I0.7280.14
48_K84_A0.7280.14
127_L205_Y0.7210.14
128_K206_N0.7210.14
9_Y12_E0.7210.14
86_V100_L0.7200.14
223_L235_E0.7160.14
45_W88_Q0.7140.14
65_N130_I0.7130.14
69_Y205_Y0.7130.14
37_K111_K0.7120.14
171_L206_N0.7100.14
93_S123_T0.7080.14
54_P141_V0.7040.14
8_N206_N0.7020.14
72_A102_M0.6990.14
82_L215_S0.6970.14
46_T190_E0.6960.14
171_L239_V0.6920.14
190_E252_K0.6910.14
207_K232_I0.6890.14
95_D129_F0.6890.14
196_L232_I0.6890.14
21_L191_A0.6880.14
211_P241_A0.6880.14
101_L135_F0.6870.14
69_Y236_L0.6850.14
10_V77_Q0.6830.14
104_Q224_P0.6830.14
83_L90_N0.6800.13
15_T27_R0.6790.13
113_G241_A0.6780.13
80_V139_V0.6770.13
206_N216_Y0.6760.13
29_S134_K0.6750.13
112_V155_T0.6730.13
22_L92_M0.6730.13
4_Q104_Q0.6690.13
118_D205_Y0.6680.13
21_L24_S0.6660.13
36_V109_G0.6650.13
25_M207_K0.6650.13
67_W71_T0.6650.13
33_L201_V0.6640.13
5_T220_K0.6620.13
184_D191_A0.6620.13
120_G140_P0.6600.13
67_W191_A0.6580.13
49_T157_N0.6580.13
213_E234_R0.6570.13
135_F238_F0.6570.13
50_W229_T0.6570.13
127_L137_I0.6540.13
163_K168_K0.6530.13
211_P217_R0.6520.13
7_R13_Q0.6510.13
20_K165_E0.6430.13
36_V201_V0.6410.13
111_K134_K0.6410.13
214_T232_I0.6380.13
78_N244_F0.6370.13
47_T60_S0.6340.13
41_I75_K0.6330.13
233_F247_L0.6310.13
245_Y252_K0.6270.12
44_D212_I0.6270.12
141_V151_D0.6270.12
4_Q22_L0.6260.12
47_T71_T0.6260.12
227_S239_V0.6260.12
135_F230_K0.6250.12
38_E168_K0.6220.12
71_T101_L0.6220.12
119_A158_S0.6200.12
61_S171_L0.6150.12
22_L25_M0.6150.12
59_G87_P0.6150.12
52_G55_V0.6150.12
24_S196_L0.6130.12
138_G252_K0.6120.12
121_F217_R0.6110.12
102_M203_K0.6090.12
102_M251_F0.6060.12
154_Y233_F0.6000.12
205_Y209_R0.5990.12
126_V212_I0.5980.12
15_T28_I0.5980.12
99_K228_S0.5980.12
66_S249_T0.5960.12
84_A229_T0.5930.12
78_N137_I0.5920.12
92_M239_V0.5920.12
210_S245_Y0.5920.12
29_S171_L0.5880.12
189_R243_I0.5880.12
136_V205_Y0.5880.12
58_L98_V0.5850.12
43_I226_T0.5850.12
101_L105_I0.5830.12
42_S190_E0.5830.12
102_M127_L0.5830.12
10_V50_W0.5820.12
7_R17_V0.5820.12
35_G72_A0.5790.12
232_I250_V0.5790.12
29_S250_V0.5780.12
26_R47_T0.5760.12
58_L146_I0.5750.12
133_F239_V0.5740.12
138_G254_V0.5730.12
16_E88_Q0.5720.12
51_Y63_K0.5710.12
193_N220_K0.5700.12
57_G86_V0.5620.11
164_E230_K0.5580.11
23_E171_L0.5580.11
59_G166_Q0.5580.11
87_P244_F0.5560.11
43_I156_T0.5550.11
236_L242_M0.5530.11
14_G91_G0.5520.11
61_S66_S0.5520.11
127_L130_I0.5510.11
84_A117_L0.5500.11
52_G122_Y0.5480.11
136_V202_L0.5480.11
26_R117_L0.5460.11
89_V247_L0.5450.11
11_E122_Y0.5440.11
19_E117_L0.5420.11
193_N228_S0.5410.11
7_R11_E0.5410.11
42_S74_T0.5400.11
138_G226_T0.5390.11
69_Y253_N0.5380.11
55_V126_V0.5340.11
130_I133_F0.5340.11
68_N120_G0.5320.11
35_G229_T0.5300.11
67_W106_V0.5300.11
206_N225_F0.5270.11
8_N117_L0.5250.11
23_E224_P0.5240.11
115_V181_R0.5230.11
242_M245_Y0.5230.11
58_L91_G0.5220.11
202_L252_K0.5220.11
20_K64_G0.5190.11
172_L201_V0.5190.11
89_V165_E0.5190.11
121_F205_Y0.5180.11
5_T16_E0.5170.11
210_S222_F0.5140.11
193_N216_Y0.5140.11
185_R188_L0.5100.11
76_Y252_K0.5090.11
25_M119_A0.5050.10
172_L222_F0.5040.10
120_G144_V0.5040.10
174_Y206_N0.5030.10
152_G260_F0.5020.10
43_I126_V0.5020.10
196_L240_L0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1musA 2 0.9189 99.3 0.844 Contact Map
1f6yA 2 0.6892 28.4 0.963 Contact Map
2yciX 2 0.6892 24.4 0.965 Contact Map
4xb4A 1 0.3345 14.3 0.968 Contact Map
4o1eA 2 0.6993 13.4 0.968 Contact Map
2ia0A 2 0.4054 8.9 0.971 Contact Map
1cxqA 2 0.4628 8.8 0.971 Contact Map
2vxzA 1 0.3851 8.3 0.971 Contact Map
4mq3A 1 0.4155 6.3 0.973 Contact Map
3flkA 3 0.1993 5.7 0.973 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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