GREMLIN Database
Q97UW0 - 4-carboxymucolactone decarboxylase (PcaC)
UniProt: Q97UW0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 139 (122)
Sequences: 2526 (1577)
Seq/√Len: 142.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
65_P68_I5.7181.00
100_E134_K3.9851.00
87_K128_E3.9511.00
78_S110_V3.0441.00
71_L106_V2.6541.00
24_K66_K2.6261.00
67_K102_E2.5861.00
107_L126_A2.3421.00
47_E51_I2.2811.00
94_I133_L2.0901.00
21_V24_K2.0661.00
93_A98_C2.0631.00
21_V59_T2.0471.00
60_R105_E2.0451.00
23_K32_E1.9731.00
91_K133_L1.8761.00
20_E24_K1.8641.00
44_E104_K1.7111.00
87_K125_I1.7021.00
107_L123_F1.6871.00
90_V126_A1.6381.00
74_I93_A1.6301.00
126_A130_I1.6281.00
14_L56_L1.5571.00
111_G119_A1.5271.00
83_Q121_D1.4831.00
74_I86_L1.4601.00
44_E47_E1.4041.00
45_L123_F1.3691.00
95_R133_L1.2921.00
23_K28_R1.2881.00
35_L38_T1.2841.00
70_S96_N1.2841.00
32_E36_S1.2681.00
82_R118_A1.2591.00
21_V66_K1.2571.00
53_A112_A1.2271.00
28_R32_E1.2081.00
17_K20_E1.2071.00
17_K59_T1.2061.00
99_T102_E1.1981.00
76_I79_C1.1661.00
90_V103_I1.1400.99
100_E130_I1.1380.99
129_A133_L1.1310.99
44_E108_L1.1170.99
85_E121_D1.1100.99
51_I56_L1.0980.99
13_K17_K1.0960.99
74_I103_I1.0960.99
78_S107_L1.0870.99
52_F56_L1.0840.99
75_G106_V1.0350.99
112_A116_L1.0310.99
12_K16_E1.0180.99
15_Y19_L1.0070.99
70_S89_H1.0070.99
19_L23_K1.0000.99
84_N121_D1.0000.99
26_M88_L0.9920.98
26_M54_W0.9690.98
13_K16_E0.9570.98
78_S122_S0.9280.98
39_T127_Q0.9160.97
72_I75_G0.9070.97
103_I126_A0.9020.97
79_C114_C0.8980.97
16_E19_L0.8960.97
94_I130_I0.8890.97
46_Q50_T0.8880.97
83_Q125_I0.8850.97
68_I71_L0.8840.97
112_A119_A0.8790.97
68_I102_E0.8780.97
15_Y50_T0.8730.97
39_T42_N0.8660.96
101_E104_K0.8590.96
76_I80_L0.8580.96
90_V129_A0.8520.96
114_C118_A0.8450.96
41_F104_K0.8400.96
103_I130_I0.8390.96
49_V53_A0.8290.95
16_E20_E0.8250.95
38_T43_R0.8120.95
75_G78_S0.8040.94
80_L118_A0.8010.94
58_W70_S0.8010.94
14_L51_I0.7980.94
48_M56_L0.7940.94
12_K20_E0.7920.94
22_R50_T0.7860.94
76_I110_V0.7840.94
73_N77_L0.7750.93
91_K132_E0.7670.93
15_Y47_E0.7540.92
77_L86_L0.7460.92
36_S39_T0.7430.92
45_L49_V0.7360.91
64_I72_I0.7360.91
52_F116_L0.7330.91
69_R73_N0.7310.91
91_K129_A0.7160.90
49_V116_L0.7120.90
104_K123_F0.7100.90
40_D43_R0.6990.89
74_I107_L0.6930.89
60_R108_L0.6900.89
107_L119_A0.6900.89
74_I98_C0.6880.88
107_L122_S0.6860.88
109_Q113_Y0.6770.88
68_I98_C0.6720.87
26_M30_Y0.6690.87
100_E133_L0.6680.87
42_N127_Q0.6650.87
104_K126_A0.6630.87
67_K98_C0.6610.86
33_K36_S0.6570.86
25_V66_K0.6540.86
72_I76_I0.6510.86
15_Y51_I0.6490.85
71_L98_C0.6470.85
45_L120_M0.6410.85
130_I134_K0.6410.85
127_Q131_K0.6360.84
52_F57_I0.6330.84
116_L120_M0.6330.84
128_E132_E0.6330.84
52_F112_A0.6310.84
53_A116_L0.6260.83
93_A103_I0.6250.83
45_L119_A0.6190.83
93_A96_N0.6170.82
79_C110_V0.6170.82
42_N104_K0.6140.82
52_F109_Q0.6140.82
48_M52_F0.6140.82
33_K37_Q0.6120.82
43_R47_E0.6120.82
73_N109_Q0.6110.82
131_K134_K0.6110.82
55_G59_T0.6100.82
128_E131_K0.6020.81
25_V54_W0.6010.81
54_W85_E0.5980.80
82_R121_D0.5950.80
86_L90_V0.5900.80
84_N87_K0.5880.79
104_K127_Q0.5860.79
130_I133_L0.5840.79
42_N108_L0.5690.77
121_D124_R0.5670.77
75_G114_C0.5670.77
27_G31_V0.5660.77
75_G79_C0.5640.76
91_K95_R0.5610.76
19_L35_L0.5600.76
74_I90_V0.5590.76
19_L28_R0.5550.75
111_G116_L0.5530.75
15_Y35_L0.5530.75
75_G98_C0.5520.75
84_N124_R0.5510.75
38_T42_N0.5510.75
110_V114_C0.5490.75
45_L111_G0.5480.74
62_D105_E0.5460.74
94_I100_E0.5340.73
53_A73_N0.5310.72
88_L92_G0.5260.71
26_M92_G0.5240.71
30_Y34_S0.5210.71
34_S38_T0.5190.70
69_R126_A0.5180.70
89_H117_P0.5150.70
48_M112_A0.5130.70
70_S109_Q0.5120.69
72_I106_V0.5100.69
17_K21_V0.5090.69
52_F111_G0.5020.68
108_L123_F0.5000.68
24_K36_S0.5000.68
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4g9qA 3 0.8777 99.9 0.361 Contact Map
2af7A 6 0.8777 99.9 0.386 Contact Map
2q0tA 3 0.9424 99.9 0.456 Contact Map
1p8cA 6 0.8201 99.7 0.545 Contact Map
3d7iA 6 0.705 99.7 0.545 Contact Map
2qeuA 6 0.9137 99.7 0.555 Contact Map
3beyA 6 0.6763 99.7 0.567 Contact Map
1vkeA 6 0.8129 99.6 0.571 Contact Map
2cwqA 4 0.8561 99.5 0.61 Contact Map
2ouwA 6 0.9209 99.3 0.654 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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